18S rRNA aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein TSR3, putative

Species:

Leishmania braziliensis

UniProt:

E9AIV1_LEIBR

TriTrypDb:

LbrM.32.2170 , LBRM2903_320028200

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AIV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIV1

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	12
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	12
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0031118	rRNA pseudouridine synthesis	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0030490	maturation of SSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0106388	18S rRNA aminocarboxypropyltransferase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140102	catalytic activity, acting on a rRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901681	sulfur compound binding	2	12
GO:1904047	S-adenosyl-L-methionine binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.738
CLV_NRD_NRD_1	119	121	PF00675	0.410
CLV_NRD_NRD_1	217	219	PF00675	0.466
CLV_NRD_NRD_1	236	238	PF00675	0.633
CLV_NRD_NRD_1	261	263	PF00675	0.769
CLV_PCSK_KEX2_1	217	219	PF00082	0.467
CLV_PCSK_KEX2_1	236	238	PF00082	0.543
CLV_PCSK_SKI1_1	184	188	PF00082	0.410
DEG_SCF_FBW7_1	81	88	PF00400	0.324
DEG_SPOP_SBC_1	25	29	PF00917	0.701
DOC_CKS1_1	82	87	PF01111	0.290
DOC_CYCLIN_RxL_1	215	226	PF00134	0.601
DOC_CYCLIN_RxL_1	65	76	PF00134	0.307
DOC_MAPK_gen_1	61	71	PF00069	0.288
DOC_USP7_MATH_1	270	274	PF00917	0.736
DOC_WW_Pin1_4	283	288	PF00397	0.505
DOC_WW_Pin1_4	81	86	PF00397	0.290
DOC_WW_Pin1_4	89	94	PF00397	0.290
LIG_14-3-3_CanoR_1	123	127	PF00244	0.410
LIG_14-3-3_CanoR_1	73	77	PF00244	0.417
LIG_Actin_WH2_2	59	75	PF00022	0.390
LIG_BIR_III_2	115	119	PF00653	0.347
LIG_BRCT_BRCA1_1	74	78	PF00533	0.468
LIG_eIF4E_1	206	212	PF01652	0.295
LIG_FHA_1	154	160	PF00498	0.367
LIG_FHA_1	207	213	PF00498	0.396
LIG_FHA_1	86	92	PF00498	0.375
LIG_FHA_2	250	256	PF00498	0.564
LIG_LIR_Nem_3	108	114	PF02991	0.290
LIG_LIR_Nem_3	177	182	PF02991	0.288
LIG_LIR_Nem_3	75	81	PF02991	0.361
LIG_MYND_1	127	131	PF01753	0.290
LIG_Pex14_1	175	179	PF04695	0.252
LIG_Rb_LxCxE_1	145	164	PF01857	0.290
LIG_SH2_CRK	141	145	PF00017	0.290
LIG_SH2_STAT5	172	175	PF00017	0.324
LIG_SH2_STAT5	206	209	PF00017	0.449
LIG_SH3_3	34	40	PF00018	0.624
LIG_SH3_3	79	85	PF00018	0.290
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.353
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.405
LIG_TRAF2_1	275	278	PF00917	0.723
MOD_CDK_SPxxK_3	89	96	PF00069	0.410
MOD_CK1_1	249	255	PF00069	0.534
MOD_CK2_1	107	113	PF00069	0.349
MOD_CK2_1	171	177	PF00069	0.319
MOD_CK2_1	239	245	PF00069	0.629
MOD_CK2_1	270	276	PF00069	0.656
MOD_Cter_Amidation	260	263	PF01082	0.513
MOD_Cter_Amidation	59	62	PF01082	0.290
MOD_GlcNHglycan	101	104	PF01048	0.410
MOD_GlcNHglycan	124	127	PF01048	0.437
MOD_GlcNHglycan	195	198	PF01048	0.375
MOD_GlcNHglycan	199	202	PF01048	0.353
MOD_GlcNHglycan	21	24	PF01048	0.608
MOD_GlcNHglycan	28	31	PF01048	0.628
MOD_GlcNHglycan	281	284	PF01048	0.665
MOD_GlcNHglycan	3	6	PF01048	0.720
MOD_GlcNHglycan	58	61	PF01048	0.305
MOD_GlcNHglycan	85	88	PF01048	0.410
MOD_GSK3_1	1	8	PF00069	0.478
MOD_GSK3_1	171	178	PF00069	0.318
MOD_GSK3_1	193	200	PF00069	0.361
MOD_GSK3_1	26	33	PF00069	0.651
MOD_GSK3_1	265	272	PF00069	0.775
MOD_GSK3_1	277	284	PF00069	0.732
MOD_GSK3_1	81	88	PF00069	0.304
MOD_N-GLC_2	56	58	PF02516	0.347
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	122	127	PF00069	0.410
MOD_NEK2_1	153	158	PF00069	0.365
MOD_NEK2_2	175	180	PF00069	0.285
MOD_NEK2_2	246	251	PF00069	0.470
MOD_PKA_2	122	128	PF00069	0.410
MOD_PKA_2	142	148	PF00069	0.305
MOD_PKA_2	72	78	PF00069	0.419
MOD_PKB_1	16	24	PF00069	0.468
MOD_PKB_1	237	245	PF00069	0.444
MOD_Plk_1	107	113	PF00069	0.290
MOD_Plk_1	197	203	PF00069	0.394
MOD_Plk_4	153	159	PF00069	0.184
MOD_Plk_4	175	181	PF00069	0.299
MOD_ProDKin_1	283	289	PF00069	0.504
MOD_ProDKin_1	81	87	PF00069	0.290
MOD_ProDKin_1	89	95	PF00069	0.290
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.290
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.290
TRG_ER_diArg_1	236	239	PF00400	0.595
TRG_NES_CRM1_1	151	165	PF08389	0.410
TRG_NLS_MonoExtN_4	118	124	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ2	Leptomonas seymouri	84%	100%
A0A0S4JEU2	Bodo saltans	64%	100%
A0A1X0NUA5	Trypanosomatidae	65%	100%
A0A3S7X5P4	Leishmania donovani	83%	99%
A0A422NB90	Trypanosoma rangeli	67%	86%
A4I818	Leishmania infantum	82%	99%
D0AA84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B2X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q10409	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
Q12094	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	94%
Q4Q580	Leishmania major	81%	100%
Q9UJK0	Homo sapiens	39%	94%
V5BG92	Trypanosoma cruzi	65%	100%