Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIV0_LEIBR

TriTrypDb:

LbrM.32.1580 , LBRM2903_320021900

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.475
CLV_NRD_NRD_1	148	150	PF00675	0.487
CLV_NRD_NRD_1	307	309	PF00675	0.566
CLV_NRD_NRD_1	318	320	PF00675	0.537
CLV_NRD_NRD_1	385	387	PF00675	0.405
CLV_NRD_NRD_1	48	50	PF00675	0.572
CLV_NRD_NRD_1	548	550	PF00675	0.398
CLV_NRD_NRD_1	670	672	PF00675	0.316
CLV_PCSK_KEX2_1	147	149	PF00082	0.497
CLV_PCSK_KEX2_1	23	25	PF00082	0.469
CLV_PCSK_KEX2_1	307	309	PF00082	0.439
CLV_PCSK_KEX2_1	318	320	PF00082	0.475
CLV_PCSK_KEX2_1	48	50	PF00082	0.575
CLV_PCSK_KEX2_1	548	550	PF00082	0.512
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.590
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.492
CLV_PCSK_SKI1_1	184	188	PF00082	0.527
CLV_PCSK_SKI1_1	218	222	PF00082	0.401
CLV_PCSK_SKI1_1	318	322	PF00082	0.533
CLV_PCSK_SKI1_1	37	41	PF00082	0.615
CLV_PCSK_SKI1_1	414	418	PF00082	0.474
CLV_PCSK_SKI1_1	527	531	PF00082	0.405
CLV_PCSK_SKI1_1	589	593	PF00082	0.427
CLV_Separin_Metazoa	495	499	PF03568	0.322
DOC_CDC14_PxL_1	552	560	PF14671	0.300
DOC_CYCLIN_RxL_1	215	224	PF00134	0.396
DOC_MAPK_gen_1	147	154	PF00069	0.457
DOC_MAPK_gen_1	671	679	PF00069	0.483
DOC_MAPK_MEF2A_6	147	154	PF00069	0.378
DOC_MAPK_MEF2A_6	255	264	PF00069	0.494
DOC_MAPK_MEF2A_6	373	380	PF00069	0.273
DOC_USP7_MATH_1	105	109	PF00917	0.581
DOC_USP7_MATH_1	150	154	PF00917	0.572
DOC_USP7_MATH_1	156	160	PF00917	0.496
DOC_USP7_MATH_1	22	26	PF00917	0.513
DOC_USP7_MATH_1	322	326	PF00917	0.495
DOC_USP7_MATH_1	418	422	PF00917	0.356
DOC_USP7_MATH_1	473	477	PF00917	0.692
DOC_USP7_MATH_1	515	519	PF00917	0.507
DOC_USP7_MATH_1	571	575	PF00917	0.473
DOC_USP7_MATH_1	653	657	PF00917	0.446
DOC_USP7_MATH_1	93	97	PF00917	0.639
DOC_WW_Pin1_4	126	131	PF00397	0.621
DOC_WW_Pin1_4	273	278	PF00397	0.398
DOC_WW_Pin1_4	482	487	PF00397	0.650
DOC_WW_Pin1_4	57	62	PF00397	0.623
LIG_14-3-3_CanoR_1	149	155	PF00244	0.415
LIG_14-3-3_CanoR_1	319	327	PF00244	0.473
LIG_14-3-3_CanoR_1	405	409	PF00244	0.392
LIG_14-3-3_CanoR_1	527	536	PF00244	0.446
LIG_14-3-3_CanoR_1	583	593	PF00244	0.462
LIG_14-3-3_CanoR_1	634	639	PF00244	0.449
LIG_14-3-3_CanoR_1	643	649	PF00244	0.356
LIG_14-3-3_CanoR_1	671	679	PF00244	0.491
LIG_Actin_WH2_2	428	445	PF00022	0.490
LIG_BRCT_BRCA1_1	605	609	PF00533	0.361
LIG_Clathr_ClatBox_1	608	612	PF01394	0.342
LIG_EH1_1	3	11	PF00400	0.532
LIG_eIF4E_1	363	369	PF01652	0.476
LIG_FHA_1	109	115	PF00498	0.726
LIG_FHA_1	127	133	PF00498	0.605
LIG_FHA_1	14	20	PF00498	0.590
LIG_FHA_1	274	280	PF00498	0.395
LIG_FHA_1	398	404	PF00498	0.546
LIG_FHA_1	411	417	PF00498	0.489
LIG_FHA_1	506	512	PF00498	0.493
LIG_FHA_1	538	544	PF00498	0.362
LIG_FHA_1	58	64	PF00498	0.601
LIG_FHA_1	623	629	PF00498	0.402
LIG_FHA_1	73	79	PF00498	0.597
LIG_FHA_2	155	161	PF00498	0.527
LIG_FHA_2	405	411	PF00498	0.529
LIG_FHA_2	526	532	PF00498	0.426
LIG_FHA_2	585	591	PF00498	0.448
LIG_FHA_2	83	89	PF00498	0.721
LIG_LIR_Gen_1	120	131	PF02991	0.483
LIG_LIR_Gen_1	177	187	PF02991	0.385
LIG_LIR_Gen_1	30	39	PF02991	0.550
LIG_LIR_Gen_1	540	547	PF02991	0.450
LIG_LIR_Gen_1	624	632	PF02991	0.407
LIG_LIR_Nem_3	120	126	PF02991	0.604
LIG_LIR_Nem_3	185	191	PF02991	0.414
LIG_LIR_Nem_3	30	36	PF02991	0.494
LIG_LIR_Nem_3	390	396	PF02991	0.553
LIG_LIR_Nem_3	540	545	PF02991	0.452
LIG_LIR_Nem_3	624	629	PF02991	0.437
LIG_NRBOX	216	222	PF00104	0.284
LIG_NRBOX	506	512	PF00104	0.491
LIG_PCNA_yPIPBox_3	307	321	PF02747	0.548
LIG_Pex14_2	271	275	PF04695	0.429
LIG_RPA_C_Fungi	629	641	PF08784	0.415
LIG_SH2_CRK	345	349	PF00017	0.310
LIG_SH2_CRK	626	630	PF00017	0.451
LIG_SH2_GRB2like	207	210	PF00017	0.492
LIG_SH2_NCK_1	170	174	PF00017	0.398
LIG_SH2_PTP2	33	36	PF00017	0.474
LIG_SH2_SRC	343	346	PF00017	0.436
LIG_SH2_STAP1	280	284	PF00017	0.338
LIG_SH2_STAP1	626	630	PF00017	0.308
LIG_SH2_STAP1	83	87	PF00017	0.495
LIG_SH2_STAT3	207	210	PF00017	0.492
LIG_SH2_STAT5	207	210	PF00017	0.404
LIG_SH2_STAT5	233	236	PF00017	0.384
LIG_SH2_STAT5	33	36	PF00017	0.643
LIG_SH2_STAT5	343	346	PF00017	0.546
LIG_SH2_STAT5	363	366	PF00017	0.251
LIG_SH2_STAT5	38	41	PF00017	0.592
LIG_SH2_STAT5	395	398	PF00017	0.519
LIG_SH2_STAT5	578	581	PF00017	0.498
LIG_SH3_2	136	141	PF14604	0.578
LIG_SH3_3	133	139	PF00018	0.575
LIG_SH3_3	264	270	PF00018	0.429
LIG_SH3_3	330	336	PF00018	0.568
LIG_SH3_3	344	350	PF00018	0.369
LIG_SH3_3	366	372	PF00018	0.313
LIG_SH3_3	480	486	PF00018	0.492
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.373
LIG_SUMO_SIM_par_1	503	508	PF11976	0.324
LIG_TRAF2_1	158	161	PF00917	0.421
LIG_TRFH_1	440	444	PF08558	0.493
LIG_UBA3_1	379	387	PF00899	0.454
MOD_CK1_1	108	114	PF00069	0.725
MOD_CK1_1	168	174	PF00069	0.593
MOD_CK1_1	177	183	PF00069	0.329
MOD_CK1_1	313	319	PF00069	0.549
MOD_CK1_1	401	407	PF00069	0.666
MOD_CK1_1	491	497	PF00069	0.389
MOD_CK1_1	557	563	PF00069	0.363
MOD_CK2_1	154	160	PF00069	0.426
MOD_CK2_1	168	174	PF00069	0.439
MOD_CK2_1	177	183	PF00069	0.373
MOD_CK2_1	404	410	PF00069	0.470
MOD_CK2_1	473	479	PF00069	0.789
MOD_CK2_1	525	531	PF00069	0.456
MOD_CK2_1	584	590	PF00069	0.467
MOD_CK2_1	651	657	PF00069	0.421
MOD_CK2_1	82	88	PF00069	0.494
MOD_GlcNHglycan	29	32	PF01048	0.589
MOD_GlcNHglycan	358	361	PF01048	0.460
MOD_GlcNHglycan	444	447	PF01048	0.399
MOD_GlcNHglycan	471	474	PF01048	0.611
MOD_GlcNHglycan	500	503	PF01048	0.525
MOD_GlcNHglycan	605	608	PF01048	0.355
MOD_GlcNHglycan	99	102	PF01048	0.682
MOD_GSK3_1	150	157	PF00069	0.468
MOD_GSK3_1	216	223	PF00069	0.399
MOD_GSK3_1	397	404	PF00069	0.525
MOD_GSK3_1	418	425	PF00069	0.583
MOD_GSK3_1	469	476	PF00069	0.720
MOD_GSK3_1	537	544	PF00069	0.424
MOD_GSK3_1	567	574	PF00069	0.440
MOD_GSK3_1	630	637	PF00069	0.418
MOD_GSK3_1	72	79	PF00069	0.515
MOD_GSK3_1	82	89	PF00069	0.565
MOD_GSK3_1	93	100	PF00069	0.648
MOD_N-GLC_1	221	226	PF02516	0.482
MOD_NEK2_1	12	17	PF00069	0.523
MOD_NEK2_1	154	159	PF00069	0.500
MOD_NEK2_1	220	225	PF00069	0.451
MOD_NEK2_1	284	289	PF00069	0.396
MOD_NEK2_1	321	326	PF00069	0.532
MOD_NEK2_1	525	530	PF00069	0.389
MOD_NEK2_1	621	626	PF00069	0.431
MOD_NEK2_1	630	635	PF00069	0.337
MOD_NEK2_1	663	668	PF00069	0.394
MOD_NEK2_1	94	99	PF00069	0.528
MOD_PIKK_1	310	316	PF00454	0.553
MOD_PIKK_1	515	521	PF00454	0.337
MOD_PIKK_1	537	543	PF00454	0.451
MOD_PK_1	477	483	PF00069	0.511
MOD_PKA_2	404	410	PF00069	0.513
MOD_PKA_2	442	448	PF00069	0.485
MOD_PKA_2	670	676	PF00069	0.319
MOD_Plk_1	505	511	PF00069	0.419
MOD_Plk_2-3	258	264	PF00069	0.392
MOD_Plk_4	118	124	PF00069	0.478
MOD_Plk_4	150	156	PF00069	0.417
MOD_Plk_4	174	180	PF00069	0.368
MOD_Plk_4	322	328	PF00069	0.410
MOD_Plk_4	448	454	PF00069	0.366
MOD_Plk_4	541	547	PF00069	0.403
MOD_Plk_4	59	65	PF00069	0.674
MOD_ProDKin_1	126	132	PF00069	0.623
MOD_ProDKin_1	273	279	PF00069	0.391
MOD_ProDKin_1	482	488	PF00069	0.644
MOD_ProDKin_1	57	63	PF00069	0.628
MOD_SUMO_rev_2	366	375	PF00179	0.306
TRG_DiLeu_BaEn_1	506	511	PF01217	0.289
TRG_ENDOCYTIC_2	123	126	PF00928	0.518
TRG_ENDOCYTIC_2	233	236	PF00928	0.473
TRG_ENDOCYTIC_2	33	36	PF00928	0.546
TRG_ENDOCYTIC_2	345	348	PF00928	0.340
TRG_ENDOCYTIC_2	626	629	PF00928	0.399
TRG_ER_diArg_1	148	150	PF00400	0.488
TRG_ER_diArg_1	317	319	PF00400	0.534
TRG_ER_diArg_1	440	443	PF00400	0.457
TRG_ER_diArg_1	547	549	PF00400	0.486
TRG_NES_CRM1_1	506	519	PF08389	0.581
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE35	Leptomonas seymouri	59%	100%
A0A1X0NVV3	Trypanosomatidae	35%	100%
A0A3Q8IT90	Leishmania donovani	76%	100%
A4I7V9	Leishmania infantum	76%	100%
D0AA22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q5E0	Leishmania major	76%	100%
V5BJJ3	Trypanosoma cruzi	36%	100%