LeishMANIAdb
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Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calponin-homology (CH) domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIU9_LEIBR
TriTrypDb:
LbrM.32.0680 , LBRM2903_320011900 *
Length:
805

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIU9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU9

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 1
GO:0009987 cellular process 1 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.621
CLV_C14_Caspase3-7 35 39 PF00656 0.599
CLV_NRD_NRD_1 161 163 PF00675 0.634
CLV_NRD_NRD_1 202 204 PF00675 0.536
CLV_NRD_NRD_1 209 211 PF00675 0.583
CLV_NRD_NRD_1 290 292 PF00675 0.536
CLV_NRD_NRD_1 49 51 PF00675 0.402
CLV_NRD_NRD_1 695 697 PF00675 0.611
CLV_NRD_NRD_1 755 757 PF00675 0.396
CLV_PCSK_FUR_1 206 210 PF00082 0.674
CLV_PCSK_KEX2_1 161 163 PF00082 0.634
CLV_PCSK_KEX2_1 208 210 PF00082 0.589
CLV_PCSK_KEX2_1 290 292 PF00082 0.569
CLV_PCSK_KEX2_1 352 354 PF00082 0.664
CLV_PCSK_KEX2_1 49 51 PF00082 0.402
CLV_PCSK_KEX2_1 695 697 PF00082 0.611
CLV_PCSK_KEX2_1 755 757 PF00082 0.396
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.553
CLV_PCSK_SKI1_1 147 151 PF00082 0.576
CLV_PCSK_SKI1_1 198 202 PF00082 0.506
CLV_PCSK_SKI1_1 209 213 PF00082 0.648
CLV_PCSK_SKI1_1 233 237 PF00082 0.444
CLV_PCSK_SKI1_1 290 294 PF00082 0.459
CLV_PCSK_SKI1_1 318 322 PF00082 0.654
CLV_PCSK_SKI1_1 368 372 PF00082 0.496
CLV_PCSK_SKI1_1 389 393 PF00082 0.573
CLV_PCSK_SKI1_1 473 477 PF00082 0.508
DEG_APCC_DBOX_1 359 367 PF00400 0.623
DEG_APCC_DBOX_1 472 480 PF00400 0.502
DEG_APCC_DBOX_1 728 736 PF00400 0.378
DEG_SPOP_SBC_1 120 124 PF00917 0.640
DEG_SPOP_SBC_1 127 131 PF00917 0.571
DOC_CKS1_1 475 480 PF01111 0.749
DOC_CYCLIN_RxL_1 144 151 PF00134 0.476
DOC_CYCLIN_RxL_1 203 216 PF00134 0.672
DOC_CYCLIN_RxL_1 314 323 PF00134 0.481
DOC_CYCLIN_RxL_1 364 375 PF00134 0.505
DOC_MAPK_DCC_7 473 481 PF00069 0.502
DOC_MAPK_DCC_7 520 528 PF00069 0.567
DOC_MAPK_gen_1 355 363 PF00069 0.751
DOC_MAPK_MEF2A_6 314 321 PF00069 0.502
DOC_MAPK_MEF2A_6 520 528 PF00069 0.567
DOC_MAPK_MEF2A_6 729 736 PF00069 0.409
DOC_MAPK_NFAT4_5 314 322 PF00069 0.478
DOC_PP1_RVXF_1 316 322 PF00149 0.723
DOC_PP1_RVXF_1 366 373 PF00149 0.460
DOC_PP1_RVXF_1 711 718 PF00149 0.362
DOC_PP2B_LxvP_1 510 513 PF13499 0.665
DOC_PP2B_LxvP_1 526 529 PF13499 0.703
DOC_USP7_MATH_1 127 131 PF00917 0.703
DOC_USP7_MATH_1 15 19 PF00917 0.669
DOC_USP7_MATH_1 391 395 PF00917 0.576
DOC_USP7_MATH_1 430 434 PF00917 0.784
DOC_USP7_MATH_1 443 447 PF00917 0.663
DOC_USP7_MATH_1 450 454 PF00917 0.722
DOC_USP7_MATH_1 527 531 PF00917 0.801
DOC_USP7_MATH_1 748 752 PF00917 0.381
DOC_USP7_MATH_1 782 786 PF00917 0.628
DOC_WW_Pin1_4 116 121 PF00397 0.623
DOC_WW_Pin1_4 474 479 PF00397 0.649
DOC_WW_Pin1_4 50 55 PF00397 0.538
DOC_WW_Pin1_4 550 555 PF00397 0.628
DOC_WW_Pin1_4 740 745 PF00397 0.532
DOC_WW_Pin1_4 778 783 PF00397 0.531
DOC_WW_Pin1_4 795 800 PF00397 0.513
LIG_14-3-3_CanoR_1 242 246 PF00244 0.550
LIG_14-3-3_CanoR_1 66 75 PF00244 0.668
LIG_14-3-3_CanoR_1 695 703 PF00244 0.613
LIG_14-3-3_CanoR_1 77 87 PF00244 0.438
LIG_APCC_ABBA_1 21 26 PF00400 0.766
LIG_BRCT_BRCA1_1 530 534 PF00533 0.805
LIG_CaM_IQ_9 564 580 PF13499 0.727
LIG_deltaCOP1_diTrp_1 182 190 PF00928 0.572
LIG_deltaCOP1_diTrp_1 308 313 PF00928 0.593
LIG_deltaCOP1_diTrp_1 768 773 PF00928 0.514
LIG_eIF4E_1 766 772 PF01652 0.311
LIG_FHA_1 424 430 PF00498 0.802
LIG_FHA_1 653 659 PF00498 0.522
LIG_FHA_1 782 788 PF00498 0.523
LIG_FHA_1 96 102 PF00498 0.672
LIG_FHA_2 310 316 PF00498 0.696
LIG_FHA_2 551 557 PF00498 0.559
LIG_FHA_2 741 747 PF00498 0.527
LIG_FHA_2 774 780 PF00498 0.428
LIG_LIR_Apic_2 403 409 PF02991 0.754
LIG_LIR_Apic_2 776 780 PF02991 0.500
LIG_LIR_Gen_1 182 191 PF02991 0.671
LIG_LIR_Gen_1 262 271 PF02991 0.634
LIG_LIR_Gen_1 652 661 PF02991 0.502
LIG_LIR_Gen_1 768 777 PF02991 0.460
LIG_LIR_Gen_1 781 791 PF02991 0.515
LIG_LIR_Gen_1 798 805 PF02991 0.436
LIG_LIR_Nem_3 192 196 PF02991 0.541
LIG_LIR_Nem_3 226 230 PF02991 0.514
LIG_LIR_Nem_3 262 267 PF02991 0.639
LIG_LIR_Nem_3 38 44 PF02991 0.517
LIG_LIR_Nem_3 463 468 PF02991 0.599
LIG_LIR_Nem_3 559 565 PF02991 0.643
LIG_LIR_Nem_3 627 633 PF02991 0.638
LIG_LIR_Nem_3 652 657 PF02991 0.508
LIG_LIR_Nem_3 682 688 PF02991 0.476
LIG_LIR_Nem_3 768 772 PF02991 0.453
LIG_LIR_Nem_3 781 786 PF02991 0.532
LIG_LIR_Nem_3 798 804 PF02991 0.424
LIG_MYND_1 474 478 PF01753 0.651
LIG_NRBOX 731 737 PF00104 0.502
LIG_PCNA_PIPBox_1 247 256 PF02747 0.546
LIG_PCNA_PIPBox_1 303 312 PF02747 0.586
LIG_PCNA_yPIPBox_3 242 254 PF02747 0.550
LIG_PCNA_yPIPBox_3 34 42 PF02747 0.641
LIG_PCNA_yPIPBox_3 96 110 PF02747 0.631
LIG_Pex14_1 769 773 PF04695 0.546
LIG_Pex14_2 223 227 PF04695 0.617
LIG_RPA_C_Fungi 237 249 PF08784 0.416
LIG_SH2_CRK 51 55 PF00017 0.536
LIG_SH2_PTP2 13 16 PF00017 0.666
LIG_SH2_PTP2 777 780 PF00017 0.510
LIG_SH2_SRC 13 16 PF00017 0.666
LIG_SH2_SRC 43 46 PF00017 0.378
LIG_SH2_SRC 777 780 PF00017 0.510
LIG_SH2_STAP1 230 234 PF00017 0.515
LIG_SH2_STAP1 611 615 PF00017 0.400
LIG_SH2_STAT5 115 118 PF00017 0.621
LIG_SH2_STAT5 13 16 PF00017 0.666
LIG_SH2_STAT5 339 342 PF00017 0.668
LIG_SH2_STAT5 43 46 PF00017 0.607
LIG_SH2_STAT5 587 590 PF00017 0.590
LIG_SH2_STAT5 660 663 PF00017 0.492
LIG_SH2_STAT5 766 769 PF00017 0.479
LIG_SH2_STAT5 777 780 PF00017 0.497
LIG_SH2_STAT5 79 82 PF00017 0.523
LIG_SH3_3 417 423 PF00018 0.618
LIG_SH3_3 468 474 PF00018 0.609
LIG_SH3_3 626 632 PF00018 0.519
LIG_SH3_3 681 687 PF00018 0.422
LIG_SH3_3 9 15 PF00018 0.724
LIG_SUMO_SIM_anti_2 598 604 PF11976 0.573
LIG_SUMO_SIM_anti_2 730 737 PF11976 0.480
LIG_TRAF2_1 743 746 PF00917 0.394
LIG_TRFH_1 740 744 PF08558 0.481
LIG_UBA3_1 714 719 PF00899 0.504
MOD_CK1_1 126 132 PF00069 0.733
MOD_CK1_1 192 198 PF00069 0.637
MOD_CK1_1 241 247 PF00069 0.650
MOD_CK1_1 304 310 PF00069 0.489
MOD_CK1_1 348 354 PF00069 0.742
MOD_CK1_1 393 399 PF00069 0.773
MOD_CK1_1 400 406 PF00069 0.700
MOD_CK1_1 418 424 PF00069 0.607
MOD_CK1_1 433 439 PF00069 0.607
MOD_CK1_1 453 459 PF00069 0.758
MOD_CK1_1 668 674 PF00069 0.531
MOD_CK1_1 781 787 PF00069 0.521
MOD_CK1_1 95 101 PF00069 0.572
MOD_CK2_1 309 315 PF00069 0.696
MOD_CK2_1 595 601 PF00069 0.575
MOD_CK2_1 740 746 PF00069 0.520
MOD_CK2_1 782 788 PF00069 0.489
MOD_CMANNOS 310 313 PF00535 0.591
MOD_GlcNHglycan 125 128 PF01048 0.669
MOD_GlcNHglycan 17 20 PF01048 0.674
MOD_GlcNHglycan 347 350 PF01048 0.735
MOD_GlcNHglycan 417 420 PF01048 0.804
MOD_GlcNHglycan 445 448 PF01048 0.603
MOD_GlcNHglycan 452 455 PF01048 0.611
MOD_GlcNHglycan 503 506 PF01048 0.573
MOD_GlcNHglycan 666 670 PF01048 0.547
MOD_GSK3_1 116 123 PF00069 0.630
MOD_GSK3_1 237 244 PF00069 0.662
MOD_GSK3_1 297 304 PF00069 0.547
MOD_GSK3_1 341 348 PF00069 0.640
MOD_GSK3_1 393 400 PF00069 0.734
MOD_GSK3_1 448 455 PF00069 0.703
MOD_GSK3_1 497 504 PF00069 0.574
MOD_GSK3_1 546 553 PF00069 0.582
MOD_GSK3_1 694 701 PF00069 0.479
MOD_GSK3_1 778 785 PF00069 0.524
MOD_N-GLC_1 216 221 PF02516 0.496
MOD_N-GLC_1 341 346 PF02516 0.662
MOD_N-GLC_1 443 448 PF02516 0.565
MOD_N-GLC_1 492 497 PF02516 0.572
MOD_N-GLC_1 534 539 PF02516 0.642
MOD_N-GLC_1 583 588 PF02516 0.450
MOD_N-GLC_1 722 727 PF02516 0.664
MOD_NEK2_1 113 118 PF00069 0.605
MOD_NEK2_1 121 126 PF00069 0.662
MOD_NEK2_1 138 143 PF00069 0.657
MOD_NEK2_1 223 228 PF00069 0.647
MOD_NEK2_1 285 290 PF00069 0.664
MOD_NEK2_1 492 497 PF00069 0.581
MOD_NEK2_1 498 503 PF00069 0.571
MOD_NEK2_1 534 539 PF00069 0.570
MOD_NEK2_1 679 684 PF00069 0.480
MOD_NEK2_1 773 778 PF00069 0.550
MOD_NEK2_1 78 83 PF00069 0.620
MOD_NEK2_2 506 511 PF00069 0.620
MOD_NEK2_2 649 654 PF00069 0.506
MOD_NEK2_2 748 753 PF00069 0.382
MOD_PIKK_1 285 291 PF00454 0.505
MOD_PIKK_1 299 305 PF00454 0.637
MOD_PIKK_1 619 625 PF00454 0.532
MOD_PIKK_1 722 728 PF00454 0.661
MOD_PK_1 625 631 PF00069 0.510
MOD_PKA_2 241 247 PF00069 0.550
MOD_PKA_2 412 418 PF00069 0.597
MOD_PKA_2 421 427 PF00069 0.564
MOD_PKA_2 694 700 PF00069 0.610
MOD_Plk_1 331 337 PF00069 0.585
MOD_Plk_1 492 498 PF00069 0.571
MOD_Plk_1 534 540 PF00069 0.586
MOD_Plk_1 583 589 PF00069 0.451
MOD_Plk_1 679 685 PF00069 0.514
MOD_Plk_1 722 728 PF00069 0.661
MOD_Plk_1 748 754 PF00069 0.617
MOD_Plk_4 241 247 PF00069 0.650
MOD_Plk_4 249 255 PF00069 0.515
MOD_Plk_4 27 33 PF00069 0.716
MOD_Plk_4 36 42 PF00069 0.474
MOD_Plk_4 412 418 PF00069 0.555
MOD_Plk_4 498 504 PF00069 0.570
MOD_Plk_4 506 512 PF00069 0.613
MOD_Plk_4 537 543 PF00069 0.578
MOD_Plk_4 583 589 PF00069 0.451
MOD_Plk_4 625 631 PF00069 0.510
MOD_Plk_4 730 736 PF00069 0.395
MOD_Plk_4 748 754 PF00069 0.517
MOD_Plk_4 773 779 PF00069 0.442
MOD_Plk_4 782 788 PF00069 0.557
MOD_ProDKin_1 116 122 PF00069 0.625
MOD_ProDKin_1 474 480 PF00069 0.646
MOD_ProDKin_1 50 56 PF00069 0.538
MOD_ProDKin_1 550 556 PF00069 0.628
MOD_ProDKin_1 740 746 PF00069 0.532
MOD_ProDKin_1 778 784 PF00069 0.525
MOD_ProDKin_1 795 801 PF00069 0.509
MOD_SUMO_for_1 718 721 PF00179 0.419
MOD_SUMO_rev_2 257 262 PF00179 0.529
TRG_DiLeu_BaEn_1 315 320 PF01217 0.711
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.678
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.676
TRG_DiLeu_BaLyEn_6 710 715 PF01217 0.353
TRG_DiLeu_BaLyEn_6 789 794 PF01217 0.574
TRG_DiLeu_LyEn_5 315 320 PF01217 0.471
TRG_ENDOCYTIC_2 13 16 PF00928 0.666
TRG_ENDOCYTIC_2 264 267 PF00928 0.641
TRG_ENDOCYTIC_2 465 468 PF00928 0.693
TRG_ENDOCYTIC_2 685 688 PF00928 0.492
TRG_ER_diArg_1 160 162 PF00400 0.628
TRG_ER_diArg_1 206 209 PF00400 0.571
TRG_ER_diArg_1 290 292 PF00400 0.540
TRG_ER_diArg_1 355 358 PF00400 0.735
TRG_ER_diArg_1 48 50 PF00400 0.426
TRG_ER_diArg_1 65 68 PF00400 0.568
TRG_ER_diArg_1 694 696 PF00400 0.606
TRG_NES_CRM1_1 730 746 PF08389 0.484
TRG_NLS_MonoExtN_4 201 207 PF00514 0.402
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 318 323 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 368 373 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 792 796 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Y4 Leptomonas seymouri 56% 96%
A0A3Q8IFA7 Leishmania donovani 78% 99%
A4I7M2 Leishmania infantum 78% 99%
E9B2I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
Q4Q5M3 Leishmania major 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS