LeishMANIAdb
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Secondary thiamine-phosphate synthase enzyme

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secondary thiamine-phosphate synthase enzyme
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIU8_LEIBR
TriTrypDb:
LbrM.32.0611 , LBRM2903_320011300
Length:
101

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_FUR_1 33 37 PF00082 0.321
CLV_PCSK_KEX2_1 35 37 PF00082 0.567
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.567
DEG_APCC_DBOX_1 58 66 PF00400 0.520
DEG_Nend_UBRbox_1 1 4 PF02207 0.517
DOC_CYCLIN_yCln2_LP_2 58 64 PF00134 0.333
DOC_USP7_MATH_1 64 68 PF00917 0.552
DOC_USP7_MATH_1 90 94 PF00917 0.587
DOC_WW_Pin1_4 86 91 PF00397 0.593
LIG_BRCT_BRCA1_1 65 69 PF00533 0.591
LIG_FHA_1 5 11 PF00498 0.488
LIG_FHA_1 53 59 PF00498 0.543
LIG_FHA_2 17 23 PF00498 0.387
LIG_LIR_Gen_1 25 34 PF02991 0.487
LIG_LIR_Nem_3 25 31 PF02991 0.488
LIG_PCNA_yPIPBox_3 24 36 PF02747 0.505
LIG_SH2_NCK_1 28 32 PF00017 0.483
LIG_SH3_3 58 64 PF00018 0.333
LIG_TRAF2_1 89 92 PF00917 0.380
MOD_CK1_1 40 46 PF00069 0.526
MOD_CK1_1 76 82 PF00069 0.569
MOD_CK2_1 14 20 PF00069 0.534
MOD_CK2_1 47 53 PF00069 0.536
MOD_CK2_1 86 92 PF00069 0.528
MOD_GSK3_1 10 17 PF00069 0.468
MOD_GSK3_1 72 79 PF00069 0.497
MOD_GSK3_1 86 93 PF00069 0.527
MOD_NEK2_1 1 6 PF00069 0.493
MOD_NEK2_1 47 52 PF00069 0.500
MOD_NEK2_2 64 69 PF00069 0.323
MOD_Plk_1 76 82 PF00069 0.514
MOD_Plk_2-3 16 22 PF00069 0.369
MOD_Plk_4 10 16 PF00069 0.453
MOD_Plk_4 53 59 PF00069 0.518
MOD_Plk_4 64 70 PF00069 0.567
MOD_ProDKin_1 86 92 PF00069 0.604
MOD_SUMO_rev_2 87 96 PF00179 0.488
TRG_ENDOCYTIC_2 28 31 PF00928 0.495
TRG_ENDOCYTIC_2 85 88 PF00928 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P7X3 Trypanosomatidae 32% 85%
A0A3S7X569 Leishmania donovani 83% 100%
A0A422N1C7 Trypanosoma rangeli 32% 80%
A4I7N5 Leishmania infantum 83% 100%
D0A0C0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 81%
E9B2H0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q5N6 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS