Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIU6_LEIBR

TriTrypDb:

LbrM.31.2081 , LBRM2903_310030600

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AIU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.737
CLV_C14_Caspase3-7	29	33	PF00656	0.453
CLV_NRD_NRD_1	127	129	PF00675	0.493
CLV_NRD_NRD_1	167	169	PF00675	0.452
CLV_PCSK_KEX2_1	127	129	PF00082	0.493
CLV_PCSK_KEX2_1	167	169	PF00082	0.448
CLV_PCSK_PC7_1	163	169	PF00082	0.455
CLV_PCSK_SKI1_1	5	9	PF00082	0.584
CLV_PCSK_SKI1_1	91	95	PF00082	0.574
DEG_SPOP_SBC_1	185	189	PF00917	0.642
DEG_SPOP_SBC_1	26	30	PF00917	0.478
DEG_SPOP_SBC_1	33	37	PF00917	0.496
DOC_CKS1_1	142	147	PF01111	0.627
DOC_USP7_MATH_1	18	22	PF00917	0.447
DOC_USP7_MATH_1	185	189	PF00917	0.748
DOC_USP7_MATH_1	47	51	PF00917	0.599
DOC_USP7_MATH_1	95	99	PF00917	0.711
DOC_WW_Pin1_4	141	146	PF00397	0.700
DOC_WW_Pin1_4	36	41	PF00397	0.518
LIG_14-3-3_CanoR_1	127	137	PF00244	0.632
LIG_14-3-3_CanoR_1	155	159	PF00244	0.644
LIG_14-3-3_CanoR_1	170	175	PF00244	0.614
LIG_APCC_ABBA_1	80	85	PF00400	0.529
LIG_BIR_III_2	175	179	PF00653	0.689
LIG_FHA_1	142	148	PF00498	0.647
LIG_FHA_1	151	157	PF00498	0.645
LIG_FHA_1	164	170	PF00498	0.773
LIG_FHA_2	129	135	PF00498	0.679
LIG_FHA_2	201	207	PF00498	0.635
LIG_FHA_2	27	33	PF00498	0.478
LIG_LIR_Apic_2	4	9	PF02991	0.378
LIG_LIR_Nem_3	219	224	PF02991	0.713
LIG_SH2_NCK_1	120	124	PF00017	0.754
LIG_SH2_PTP2	6	9	PF00017	0.472
LIG_SH2_STAP1	232	236	PF00017	0.657
LIG_SH2_STAT5	10	13	PF00017	0.476
LIG_SH2_STAT5	6	9	PF00017	0.484
LIG_SH2_STAT5	79	82	PF00017	0.686
LIG_SH3_3	177	183	PF00018	0.706
LIG_SUMO_SIM_par_1	182	190	PF11976	0.638
LIG_TRAF2_1	131	134	PF00917	0.736
LIG_TRAF2_1	203	206	PF00917	0.641
LIG_TRAF2_1	235	238	PF00917	0.815
LIG_WRC_WIRS_1	59	64	PF05994	0.247
MOD_CK1_1	13	19	PF00069	0.402
MOD_CK1_1	187	193	PF00069	0.742
MOD_CK1_1	260	266	PF00069	0.641
MOD_CK2_1	127	133	PF00069	0.732
MOD_CK2_1	18	24	PF00069	0.507
MOD_CK2_1	186	192	PF00069	0.753
MOD_CK2_1	200	206	PF00069	0.639
MOD_CK2_1	232	238	PF00069	0.717
MOD_CK2_1	32	38	PF00069	0.449
MOD_GlcNHglycan	150	153	PF01048	0.477
MOD_GlcNHglycan	16	19	PF01048	0.625
MOD_GlcNHglycan	189	192	PF01048	0.447
MOD_GlcNHglycan	227	230	PF01048	0.612
MOD_GlcNHglycan	234	237	PF01048	0.563
MOD_GlcNHglycan	97	100	PF01048	0.493
MOD_GSK3_1	10	17	PF00069	0.486
MOD_GSK3_1	150	157	PF00069	0.760
MOD_GSK3_1	159	166	PF00069	0.662
MOD_GSK3_1	24	31	PF00069	0.473
MOD_GSK3_1	257	264	PF00069	0.646
MOD_GSK3_1	32	39	PF00069	0.464
MOD_GSK3_1	95	102	PF00069	0.686
MOD_NEK2_1	1	6	PF00069	0.383
MOD_NEK2_1	11	16	PF00069	0.375
MOD_NEK2_1	184	189	PF00069	0.672
MOD_NEK2_1	230	235	PF00069	0.765
MOD_NEK2_1	25	30	PF00069	0.447
MOD_NEK2_1	94	99	PF00069	0.623
MOD_PIKK_1	101	107	PF00454	0.637
MOD_PKA_1	127	133	PF00069	0.633
MOD_PKA_2	127	133	PF00069	0.633
MOD_PKA_2	154	160	PF00069	0.668
MOD_PKB_1	161	169	PF00069	0.688
MOD_Plk_1	133	139	PF00069	0.629
MOD_ProDKin_1	141	147	PF00069	0.701
MOD_ProDKin_1	36	42	PF00069	0.518
TRG_ENDOCYTIC_2	77	80	PF00928	0.699
TRG_ER_diArg_1	160	163	PF00400	0.765
TRG_ER_diArg_1	167	170	PF00400	0.711
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFE3	Leishmania donovani	54%	100%
A4I6W0	Leishmania infantum	55%	100%
E9B1Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q676	Leishmania major	50%	100%