Leucine-rich repeat-containing protein 29

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIU4_LEIBR

TriTrypDb:

LbrM.31.1810 , LBRM2903_310027600

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	23
GO:0042995	cell projection	2	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0110165	cellular anatomical entity	1	23
GO:0120025	plasma membrane bounded cell projection	3	23
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0000151	ubiquitin ligase complex	3	2
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AIU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	3
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016787	hydrolase activity	2	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.419
CLV_NRD_NRD_1	31	33	PF00675	0.554
CLV_NRD_NRD_1	397	399	PF00675	0.302
CLV_NRD_NRD_1	503	505	PF00675	0.454
CLV_PCSK_KEX2_1	294	296	PF00082	0.292
CLV_PCSK_KEX2_1	397	399	PF00082	0.442
CLV_PCSK_KEX2_1	503	505	PF00082	0.341
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.292
CLV_PCSK_PC7_1	290	296	PF00082	0.294
CLV_PCSK_SKI1_1	159	163	PF00082	0.383
CLV_PCSK_SKI1_1	188	192	PF00082	0.463
CLV_PCSK_SKI1_1	261	265	PF00082	0.454
CLV_PCSK_SKI1_1	273	277	PF00082	0.250
CLV_PCSK_SKI1_1	294	298	PF00082	0.334
CLV_PCSK_SKI1_1	443	447	PF00082	0.273
CLV_PCSK_SKI1_1	503	507	PF00082	0.327
CLV_PCSK_SKI1_1	545	549	PF00082	0.363
DEG_APCC_DBOX_1	18	26	PF00400	0.317
DEG_SCF_FBW7_1	401	408	PF00400	0.253
DOC_CDC14_PxL_1	254	262	PF14671	0.299
DOC_CDC14_PxL_1	72	80	PF14671	0.350
DOC_CYCLIN_RxL_1	165	174	PF00134	0.450
DOC_CYCLIN_RxL_1	256	268	PF00134	0.464
DOC_CYCLIN_RxL_1	95	106	PF00134	0.421
DOC_MAPK_MEF2A_6	256	264	PF00069	0.300
DOC_MAPK_MEF2A_6	484	493	PF00069	0.432
DOC_MAPK_MEF2A_6	510	518	PF00069	0.277
DOC_MAPK_RevD_3	279	295	PF00069	0.272
DOC_USP7_MATH_1	358	362	PF00917	0.223
DOC_USP7_MATH_1	405	409	PF00917	0.291
DOC_USP7_MATH_1	473	477	PF00917	0.436
DOC_WW_Pin1_4	363	368	PF00397	0.420
DOC_WW_Pin1_4	401	406	PF00397	0.522
LIG_14-3-3_CanoR_1	117	122	PF00244	0.411
LIG_14-3-3_CanoR_1	188	194	PF00244	0.415
LIG_14-3-3_CanoR_1	19	28	PF00244	0.459
LIG_14-3-3_CanoR_1	223	230	PF00244	0.435
LIG_14-3-3_CanoR_1	234	240	PF00244	0.369
LIG_Actin_WH2_2	257	275	PF00022	0.241
LIG_Clathr_ClatBox_1	479	483	PF01394	0.429
LIG_FHA_1	190	196	PF00498	0.387
LIG_FHA_1	257	263	PF00498	0.360
LIG_FHA_1	54	60	PF00498	0.343
LIG_FHA_1	541	547	PF00498	0.352
LIG_FHA_2	123	129	PF00498	0.531
LIG_FHA_2	196	202	PF00498	0.457
LIG_FHA_2	310	316	PF00498	0.475
LIG_FHA_2	424	430	PF00498	0.444
LIG_FHA_2	473	479	PF00498	0.228
LIG_LIR_Gen_1	120	129	PF02991	0.222
LIG_LIR_Gen_1	145	156	PF02991	0.376
LIG_LIR_Gen_1	285	296	PF02991	0.334
LIG_LIR_Gen_1	448	455	PF02991	0.263
LIG_LIR_Gen_1	483	493	PF02991	0.233
LIG_LIR_Gen_1	494	502	PF02991	0.273
LIG_LIR_Gen_1	520	529	PF02991	0.296
LIG_LIR_Nem_3	120	124	PF02991	0.237
LIG_LIR_Nem_3	145	151	PF02991	0.368
LIG_LIR_Nem_3	206	211	PF02991	0.451
LIG_LIR_Nem_3	285	291	PF02991	0.315
LIG_LIR_Nem_3	430	436	PF02991	0.291
LIG_LIR_Nem_3	448	452	PF02991	0.199
LIG_LIR_Nem_3	483	489	PF02991	0.244
LIG_LIR_Nem_3	492	498	PF02991	0.257
LIG_LIR_Nem_3	520	526	PF02991	0.310
LIG_MYND_3	75	79	PF01753	0.225
LIG_NRBOX	259	265	PF00104	0.267
LIG_SH2_CRK	495	499	PF00017	0.292
LIG_SH2_GRB2like	148	151	PF00017	0.253
LIG_SH2_NCK_1	495	499	PF00017	0.245
LIG_SH2_NCK_1	523	527	PF00017	0.296
LIG_SH2_SRC	523	526	PF00017	0.298
LIG_SH2_STAP1	523	527	PF00017	0.296
LIG_SH2_STAT5	123	126	PF00017	0.387
LIG_SH2_STAT5	148	151	PF00017	0.253
LIG_SH2_STAT5	495	498	PF00017	0.348
LIG_SH2_STAT5	528	531	PF00017	0.305
LIG_SH3_3	10	16	PF00018	0.466
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.228
LIG_SUMO_SIM_par_1	191	198	PF11976	0.338
LIG_TRAF2_1	351	354	PF00917	0.278
LIG_TYR_ITIM	146	151	PF00017	0.260
LIG_TYR_ITIM	493	498	PF00017	0.447
LIG_UBA3_1	146	153	PF00899	0.439
LIG_UBA3_1	330	337	PF00899	0.320
LIG_UBA3_1	511	517	PF00899	0.271
LIG_WRC_WIRS_1	118	123	PF05994	0.238
LIG_WRC_WIRS_1	421	426	PF05994	0.207
LIG_WRC_WIRS_1	446	451	PF05994	0.213
MOD_CK1_1	189	195	PF00069	0.403
MOD_CK1_1	304	310	PF00069	0.518
MOD_CK1_1	336	342	PF00069	0.351
MOD_CK1_1	383	389	PF00069	0.466
MOD_CK1_1	53	59	PF00069	0.307
MOD_CK2_1	348	354	PF00069	0.475
MOD_CK2_1	459	465	PF00069	0.285
MOD_GlcNHglycan	201	204	PF01048	0.310
MOD_GlcNHglycan	277	280	PF01048	0.290
MOD_GlcNHglycan	303	306	PF01048	0.508
MOD_GlcNHglycan	59	62	PF01048	0.288
MOD_GSK3_1	128	135	PF00069	0.391
MOD_GSK3_1	151	158	PF00069	0.335
MOD_GSK3_1	191	198	PF00069	0.396
MOD_GSK3_1	264	271	PF00069	0.483
MOD_GSK3_1	332	339	PF00069	0.377
MOD_GSK3_1	363	370	PF00069	0.305
MOD_GSK3_1	379	386	PF00069	0.399
MOD_GSK3_1	401	408	PF00069	0.439
MOD_GSK3_1	410	417	PF00069	0.390
MOD_GSK3_1	489	496	PF00069	0.393
MOD_GSK3_1	53	60	PF00069	0.370
MOD_N-GLC_1	215	220	PF02516	0.428
MOD_N-GLC_1	301	306	PF02516	0.469
MOD_N-GLC_1	37	42	PF02516	0.357
MOD_N-GLC_1	540	545	PF02516	0.369
MOD_NEK2_1	127	132	PF00069	0.308
MOD_NEK2_1	140	145	PF00069	0.390
MOD_NEK2_1	151	156	PF00069	0.331
MOD_NEK2_1	195	200	PF00069	0.378
MOD_NEK2_1	241	246	PF00069	0.337
MOD_NEK2_1	262	267	PF00069	0.427
MOD_NEK2_1	298	303	PF00069	0.536
MOD_NEK2_1	333	338	PF00069	0.295
MOD_NEK2_1	34	39	PF00069	0.466
MOD_NEK2_1	357	362	PF00069	0.448
MOD_NEK2_1	369	374	PF00069	0.378
MOD_NEK2_1	379	384	PF00069	0.384
MOD_NEK2_1	445	450	PF00069	0.440
MOD_NEK2_1	491	496	PF00069	0.355
MOD_NEK2_1	83	88	PF00069	0.325
MOD_NEK2_2	380	385	PF00069	0.536
MOD_PIKK_1	140	146	PF00454	0.287
MOD_PIKK_1	540	546	PF00454	0.326
MOD_PKA_1	503	509	PF00069	0.235
MOD_PKA_2	18	24	PF00069	0.424
MOD_PKA_2	222	228	PF00069	0.464
MOD_PKA_2	503	509	PF00069	0.425
MOD_PKA_2	86	92	PF00069	0.405
MOD_Plk_1	179	185	PF00069	0.417
MOD_Plk_1	215	221	PF00069	0.377
MOD_Plk_1	267	273	PF00069	0.241
MOD_Plk_1	301	307	PF00069	0.565
MOD_Plk_2-3	348	354	PF00069	0.378
MOD_Plk_4	117	123	PF00069	0.519
MOD_Plk_4	129	135	PF00069	0.321
MOD_Plk_4	142	148	PF00069	0.525
MOD_Plk_4	179	185	PF00069	0.381
MOD_Plk_4	195	201	PF00069	0.404
MOD_Plk_4	241	247	PF00069	0.394
MOD_Plk_4	548	554	PF00069	0.413
MOD_ProDKin_1	363	369	PF00069	0.417
MOD_ProDKin_1	401	407	PF00069	0.528
MOD_SUMO_rev_2	280	289	PF00179	0.305
MOD_SUMO_rev_2	408	418	PF00179	0.333
TRG_AP2beta_CARGO_1	285	295	PF09066	0.280
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.372
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.229
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.322
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.270
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.325
TRG_ENDOCYTIC_2	148	151	PF00928	0.253
TRG_ENDOCYTIC_2	495	498	PF00928	0.462
TRG_ENDOCYTIC_2	523	526	PF00928	0.301
TRG_ER_diArg_1	396	398	PF00400	0.510
TRG_ER_diArg_1	502	504	PF00400	0.358
TRG_ER_diArg_1	85	88	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F4	Leptomonas seymouri	27%	100%
A0A0N1P921	Leptomonas seymouri	24%	68%
A0A0S4JR64	Bodo saltans	24%	85%
A0A1X0NG16	Trypanosomatidae	25%	95%
A0A1X0P4M6	Trypanosomatidae	25%	95%
A0A3Q8IGD6	Leishmania donovani	77%	68%
A0A3S5H7C2	Leishmania donovani	25%	100%
A0A3S5ISR4	Trypanosoma rangeli	28%	66%
A4HCY0	Leishmania braziliensis	25%	100%
A4I0G3	Leishmania infantum	25%	100%
A4I6T8	Leishmania infantum	77%	68%
C9ZRQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AEF0	Leishmania major	24%	71%
E9AWC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	68%
Q4Q6A2	Leishmania major	76%	100%
Q4QB46	Leishmania major	25%	100%
Q4QD45	Leishmania major	26%	82%
Q4QJ80	Leishmania major	26%	97%
V5BKI3	Trypanosoma cruzi	26%	66%
V5BMQ2	Trypanosoma cruzi	24%	99%