FtsJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FtsJ-like methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

E9AIU3_LEIBR

TriTrypDb:

LbrM.31.0820 , LBRM2903_310015500

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AIU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	13
GO:0032259	methylation	2	13
GO:0000154	rRNA modification	6	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0051301	cell division	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0008171	O-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	6	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0016436	rRNA (uridine) methyltransferase activity	6	1
GO:0062105	RNA 2'-O-methyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	159	165	PF00089	0.178
CLV_NRD_NRD_1	161	163	PF00675	0.272
CLV_PCSK_KEX2_1	161	163	PF00082	0.265
CLV_PCSK_KEX2_1	180	182	PF00082	0.243
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.249
CLV_PCSK_SKI1_1	221	225	PF00082	0.325
DEG_Nend_Nbox_1	1	3	PF02207	0.369
DOC_CYCLIN_RxL_1	3	15	PF00134	0.399
DOC_MAPK_DCC_7	193	203	PF00069	0.554
DOC_PP4_FxxP_1	285	288	PF00568	0.501
DOC_USP7_MATH_1	104	108	PF00917	0.530
DOC_USP7_MATH_1	234	238	PF00917	0.519
DOC_USP7_MATH_1	280	284	PF00917	0.612
DOC_USP7_MATH_1	52	56	PF00917	0.452
DOC_WW_Pin1_4	102	107	PF00397	0.554
DOC_WW_Pin1_4	192	197	PF00397	0.440
LIG_14-3-3_CanoR_1	108	118	PF00244	0.567
LIG_14-3-3_CanoR_1	137	142	PF00244	0.559
LIG_14-3-3_CanoR_1	184	192	PF00244	0.545
LIG_14-3-3_CanoR_1	225	233	PF00244	0.479
LIG_14-3-3_CanoR_1	256	265	PF00244	0.622
LIG_14-3-3_CanoR_1	277	287	PF00244	0.571
LIG_14-3-3_CanoR_1	3	11	PF00244	0.469
LIG_14-3-3_CanoR_1	53	58	PF00244	0.509
LIG_FHA_1	111	117	PF00498	0.470
LIG_FHA_1	218	224	PF00498	0.533
LIG_FHA_1	227	233	PF00498	0.489
LIG_FHA_1	257	263	PF00498	0.553
LIG_FHA_2	25	31	PF00498	0.482
LIG_LIR_Apic_2	283	288	PF02991	0.535
LIG_LIR_Nem_3	15	20	PF02991	0.445
LIG_LIR_Nem_3	6	11	PF02991	0.434
LIG_NRBOX	149	155	PF00104	0.540
LIG_PCNA_yPIPBox_3	147	161	PF02747	0.529
LIG_SH2_CRK	323	327	PF00017	0.374
LIG_SH2_SRC	323	326	PF00017	0.361
LIG_SH2_STAT3	2	5	PF00017	0.540
LIG_SH2_STAT5	243	246	PF00017	0.531
LIG_SH3_3	164	170	PF00018	0.529
LIG_SH3_3	260	266	PF00018	0.662
LIG_SH3_3	285	291	PF00018	0.382
LIG_SH3_3	319	325	PF00018	0.570
LIG_SH3_3	65	71	PF00018	0.473
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.458
LIG_SUMO_SIM_par_1	60	65	PF11976	0.540
LIG_SUMO_SIM_par_1	9	15	PF11976	0.469
MOD_CDC14_SPxK_1	105	108	PF00782	0.554
MOD_CDK_SPxK_1	102	108	PF00069	0.554
MOD_CK1_1	107	113	PF00069	0.513
MOD_CK1_1	186	192	PF00069	0.539
MOD_CK1_1	276	282	PF00069	0.688
MOD_CK1_1	283	289	PF00069	0.522
MOD_CK2_1	232	238	PF00069	0.540
MOD_GlcNHglycan	150	153	PF01048	0.252
MOD_GlcNHglycan	189	192	PF01048	0.315
MOD_GlcNHglycan	280	283	PF01048	0.543
MOD_GlcNHglycan	5	8	PF01048	0.259
MOD_GSK3_1	100	107	PF00069	0.512
MOD_GSK3_1	108	115	PF00069	0.551
MOD_GSK3_1	183	190	PF00069	0.515
MOD_GSK3_1	232	239	PF00069	0.527
MOD_GSK3_1	276	283	PF00069	0.648
MOD_GSK3_1	48	55	PF00069	0.458
MOD_LATS_1	98	104	PF00433	0.378
MOD_NEK2_1	109	114	PF00069	0.378
MOD_NEK2_1	139	144	PF00069	0.440
MOD_NEK2_1	148	153	PF00069	0.440
MOD_NEK2_1	217	222	PF00069	0.520
MOD_NEK2_1	232	237	PF00069	0.472
MOD_NEK2_2	280	285	PF00069	0.614
MOD_OFUCOSY	304	311	PF10250	0.483
MOD_PIKK_1	110	116	PF00454	0.485
MOD_PK_1	137	143	PF00069	0.554
MOD_PKA_2	107	113	PF00069	0.378
MOD_PKA_2	183	189	PF00069	0.549
MOD_PKA_2	217	223	PF00069	0.378
MOD_PKA_2	255	261	PF00069	0.597
MOD_PKA_2	276	282	PF00069	0.699
MOD_PKA_2	52	58	PF00069	0.509
MOD_PKB_1	271	279	PF00069	0.600
MOD_Plk_4	128	134	PF00069	0.466
MOD_Plk_4	24	30	PF00069	0.517
MOD_Plk_4	280	286	PF00069	0.600
MOD_ProDKin_1	102	108	PF00069	0.554
MOD_ProDKin_1	192	198	PF00069	0.440
TRG_ENDOCYTIC_2	17	20	PF00928	0.496
TRG_ENDOCYTIC_2	323	326	PF00928	0.361
TRG_ER_diArg_1	160	162	PF00400	0.440
TRG_PTS1	328	331	PF00515	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S5	Leptomonas seymouri	54%	93%
A0A0S4IVN5	Bodo saltans	32%	99%
A0A0S4IYL1	Bodo saltans	34%	98%
A0A1X0NJE7	Trypanosomatidae	34%	100%
A0A3R7L564	Trypanosoma rangeli	38%	100%
A0A3S7X469	Leishmania donovani	75%	99%
A0A422NPF8	Trypanosoma rangeli	24%	88%
A4I6F9	Leishmania infantum	75%	99%
C9ZN77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ACB3	Leishmania major	23%	100%
E9B1L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
O36015	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P38238	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q54VA8	Dictyostelium discoideum	22%	100%
Q9BHC8	Leishmania major	76%	100%
Q9UET6	Homo sapiens	22%	100%
V5ANC5	Trypanosoma cruzi	37%	93%
V5BCX7	Trypanosoma cruzi	25%	80%