Putative chromosomal passenger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromosomal passenger complex protein 1

Species:

Leishmania braziliensis

UniProt:

E9AIU2_LEIBR

TriTrypDb:

LbrM.30.3530 , LBRM2903_300042500

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	1
GO:0032133	chromosome passenger complex	3	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9AIU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIU2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0051225	spindle assembly	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1903047	mitotic cell cycle process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	133	135	PF00082	0.579
CLV_PCSK_KEX2_1	163	165	PF00082	0.427
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.677
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.427
CLV_PCSK_SKI1_1	105	109	PF00082	0.698
CLV_PCSK_SKI1_1	195	199	PF00082	0.584
CLV_PCSK_SKI1_1	49	53	PF00082	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.604
DEG_SCF_FBW7_1	109	114	PF00400	0.595
DOC_CKS1_1	5	10	PF01111	0.328
DOC_CYCLIN_RxL_1	43	53	PF00134	0.554
DOC_PP1_RVXF_1	134	140	PF00149	0.509
DOC_PP1_RVXF_1	47	53	PF00149	0.527
DOC_USP7_MATH_1	196	200	PF00917	0.458
DOC_USP7_MATH_1	33	37	PF00917	0.645
DOC_USP7_MATH_1	62	66	PF00917	0.620
DOC_USP7_MATH_1	97	101	PF00917	0.708
DOC_WW_Pin1_4	105	110	PF00397	0.628
DOC_WW_Pin1_4	123	128	PF00397	0.686
DOC_WW_Pin1_4	4	9	PF00397	0.484
DOC_WW_Pin1_4	77	82	PF00397	0.609
DOC_WW_Pin1_4	86	91	PF00397	0.642
LIG_Actin_WH2_2	182	200	PF00022	0.533
LIG_BRCT_BRCA1_1	186	190	PF00533	0.389
LIG_BRCT_BRCA1_1	36	40	PF00533	0.637
LIG_BRCT_BRCA1_1	99	103	PF00533	0.736
LIG_CSL_BTD_1	5	8	PF09270	0.511
LIG_deltaCOP1_diTrp_1	209	215	PF00928	0.459
LIG_EVH1_1	29	33	PF00568	0.520
LIG_FHA_1	46	52	PF00498	0.464
LIG_FHA_1	5	11	PF00498	0.524
LIG_FHA_1	68	74	PF00498	0.677
LIG_FHA_2	214	220	PF00498	0.413
LIG_LIR_Nem_3	13	19	PF02991	0.426
LIG_LIR_Nem_3	178	184	PF02991	0.484
LIG_LIR_Nem_3	187	193	PF02991	0.406
LIG_Pex14_2	177	181	PF04695	0.498
LIG_SH2_NCK_1	44	48	PF00017	0.546
LIG_SH2_STAT5	229	232	PF00017	0.542
LIG_SH2_STAT5	54	57	PF00017	0.502
LIG_SH3_1	27	33	PF00018	0.631
LIG_SH3_2	127	132	PF14604	0.473
LIG_SH3_3	124	130	PF00018	0.590
LIG_SH3_3	134	140	PF00018	0.576
LIG_SH3_3	2	8	PF00018	0.441
LIG_SH3_3	27	33	PF00018	0.504
LIG_SH3_3	91	97	PF00018	0.678
LIG_TRAF2_1	216	219	PF00917	0.406
MOD_CDK_SPxK_1	77	83	PF00069	0.587
MOD_CDK_SPxxK_3	86	93	PF00069	0.730
MOD_CK1_1	99	105	PF00069	0.760
MOD_CK2_1	213	219	PF00069	0.434
MOD_GlcNHglycan	200	203	PF01048	0.560
MOD_GlcNHglycan	206	209	PF01048	0.446
MOD_GlcNHglycan	60	63	PF01048	0.572
MOD_GSK3_1	107	114	PF00069	0.728
MOD_GSK3_1	138	145	PF00069	0.439
MOD_GSK3_1	148	155	PF00069	0.475
MOD_GSK3_1	209	216	PF00069	0.625
MOD_GSK3_1	58	65	PF00069	0.540
MOD_GSK3_1	99	106	PF00069	0.763
MOD_N-GLC_1	123	128	PF02516	0.536
MOD_N-GLC_1	204	209	PF02516	0.568
MOD_NEK2_1	103	108	PF00069	0.708
MOD_NEK2_1	148	153	PF00069	0.493
MOD_NEK2_1	175	180	PF00069	0.527
MOD_PIKK_1	175	181	PF00454	0.527
MOD_PIKK_1	232	238	PF00454	0.440
MOD_PIKK_1	62	68	PF00454	0.523
MOD_PK_1	116	122	PF00069	0.613
MOD_Plk_2-3	213	219	PF00069	0.479
MOD_Plk_4	184	190	PF00069	0.419
MOD_ProDKin_1	105	111	PF00069	0.628
MOD_ProDKin_1	123	129	PF00069	0.683
MOD_ProDKin_1	4	10	PF00069	0.474
MOD_ProDKin_1	77	83	PF00069	0.611
MOD_ProDKin_1	86	92	PF00069	0.644
MOD_SUMO_for_1	20	23	PF00179	0.456
TRG_ER_diArg_1	134	137	PF00400	0.618
TRG_NLS_MonoExtC_3	131	136	PF00514	0.641
TRG_NLS_MonoExtN_4	129	136	PF00514	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC57	Leptomonas seymouri	70%	95%
A0A0S4JHT6	Bodo saltans	41%	86%
A0A1X0P1C3	Trypanosomatidae	52%	94%
A0A3Q8IC98	Leishmania donovani	89%	99%
A0A3R7L355	Trypanosoma rangeli	50%	95%
A4I639	Leishmania infantum	89%	99%
C9ZRF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	93%
E9B1C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q6U0	Leishmania major	90%	100%
V5BX18	Trypanosoma cruzi	50%	95%