SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

E9AIT8_LEIBR

TriTrypDb:

LbrM.29.2510 , LBRM2903_290032200

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT8

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.507
CLV_C14_Caspase3-7	415	419	PF00656	0.654
CLV_C14_Caspase3-7	615	619	PF00656	0.690
CLV_C14_Caspase3-7	620	624	PF00656	0.683
CLV_NRD_NRD_1	111	113	PF00675	0.567
CLV_NRD_NRD_1	243	245	PF00675	0.246
CLV_NRD_NRD_1	357	359	PF00675	0.298
CLV_NRD_NRD_1	382	384	PF00675	0.288
CLV_NRD_NRD_1	6	8	PF00675	0.626
CLV_NRD_NRD_1	620	622	PF00675	0.766
CLV_PCSK_FUR_1	380	384	PF00082	0.351
CLV_PCSK_KEX2_1	111	113	PF00082	0.447
CLV_PCSK_KEX2_1	12	14	PF00082	0.623
CLV_PCSK_KEX2_1	357	359	PF00082	0.317
CLV_PCSK_KEX2_1	382	384	PF00082	0.257
CLV_PCSK_KEX2_1	90	92	PF00082	0.426
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.447
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.619
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.469
CLV_PCSK_PC7_1	107	113	PF00082	0.425
CLV_PCSK_SKI1_1	117	121	PF00082	0.408
CLV_PCSK_SKI1_1	335	339	PF00082	0.287
CLV_PCSK_SKI1_1	382	386	PF00082	0.284
CLV_PCSK_SKI1_1	595	599	PF00082	0.495
DEG_SPOP_SBC_1	558	562	PF00917	0.475
DOC_ANK_TNKS_1	501	508	PF00023	0.319
DOC_CKS1_1	522	527	PF01111	0.258
DOC_CYCLIN_RxL_1	434	446	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	221	224	PF00134	0.514
DOC_MAPK_gen_1	495	503	PF00069	0.409
DOC_MAPK_MEF2A_6	595	602	PF00069	0.466
DOC_MAPK_NFAT4_5	595	603	PF00069	0.503
DOC_PP1_RVXF_1	97	104	PF00149	0.500
DOC_PP2B_LxvP_1	221	224	PF13499	0.514
DOC_PP2B_LxvP_1	441	444	PF13499	0.360
DOC_PP2B_LxvP_1	598	601	PF13499	0.490
DOC_PP4_FxxP_1	519	522	PF00568	0.369
DOC_PP4_MxPP_1	140	143	PF00568	0.348
DOC_USP7_MATH_1	296	300	PF00917	0.471
DOC_USP7_MATH_1	50	54	PF00917	0.420
DOC_USP7_MATH_1	573	577	PF00917	0.495
DOC_USP7_UBL2_3	8	12	PF12436	0.670
DOC_WW_Pin1_4	312	317	PF00397	0.506
DOC_WW_Pin1_4	321	326	PF00397	0.373
DOC_WW_Pin1_4	419	424	PF00397	0.500
DOC_WW_Pin1_4	521	526	PF00397	0.445
DOC_WW_Pin1_4	532	537	PF00397	0.485
LIG_14-3-3_CanoR_1	114	120	PF00244	0.454
LIG_14-3-3_CanoR_1	13	20	PF00244	0.604
LIG_14-3-3_CanoR_1	271	281	PF00244	0.556
LIG_14-3-3_CanoR_1	357	361	PF00244	0.509
LIG_14-3-3_CanoR_1	434	438	PF00244	0.509
LIG_Actin_WH2_2	228	246	PF00022	0.446
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BIR_III_2	408	412	PF00653	0.400
LIG_BIR_III_4	418	422	PF00653	0.598
LIG_BRCT_BRCA1_1	486	490	PF00533	0.381
LIG_BRCT_BRCA1_1	61	65	PF00533	0.476
LIG_BRCT_BRCA1_1	83	87	PF00533	0.465
LIG_Clathr_ClatBox_1	145	149	PF01394	0.468
LIG_Clathr_ClatBox_1	526	530	PF01394	0.256
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.446
LIG_deltaCOP1_diTrp_1	47	51	PF00928	0.388
LIG_FHA_1	163	169	PF00498	0.436
LIG_FHA_1	284	290	PF00498	0.457
LIG_FHA_1	306	312	PF00498	0.478
LIG_FHA_1	313	319	PF00498	0.447
LIG_FHA_1	332	338	PF00498	0.457
LIG_FHA_1	368	374	PF00498	0.483
LIG_FHA_1	379	385	PF00498	0.422
LIG_FHA_1	420	426	PF00498	0.510
LIG_FHA_1	522	528	PF00498	0.428
LIG_FHA_1	544	550	PF00498	0.588
LIG_FHA_1	78	84	PF00498	0.459
LIG_FHA_2	131	137	PF00498	0.355
LIG_FHA_2	210	216	PF00498	0.446
LIG_FHA_2	331	337	PF00498	0.475
LIG_FHA_2	341	347	PF00498	0.418
LIG_FHA_2	618	624	PF00498	0.627
LIG_Integrin_RGD_1	107	109	PF01839	0.478
LIG_LIR_Apic_2	517	522	PF02991	0.389
LIG_LIR_Gen_1	226	236	PF02991	0.451
LIG_LIR_Gen_1	308	317	PF02991	0.547
LIG_LIR_Gen_1	446	454	PF02991	0.449
LIG_LIR_Gen_1	46	55	PF02991	0.383
LIG_LIR_Gen_1	487	496	PF02991	0.509
LIG_LIR_Nem_3	217	222	PF02991	0.451
LIG_LIR_Nem_3	226	231	PF02991	0.437
LIG_LIR_Nem_3	446	452	PF02991	0.455
LIG_LIR_Nem_3	46	51	PF02991	0.315
LIG_LIR_Nem_3	487	493	PF02991	0.385
LIG_LIR_Nem_3	538	542	PF02991	0.338
LIG_MAD2	153	161	PF02301	0.457
LIG_MYND_1	220	224	PF01753	0.514
LIG_NRBOX	168	174	PF00104	0.506
LIG_PTB_Apo_2	28	35	PF02174	0.407
LIG_SH2_SRC	362	365	PF00017	0.553
LIG_SH2_STAP1	449	453	PF00017	0.464
LIG_SH2_STAT5	131	134	PF00017	0.375
LIG_SH2_STAT5	465	468	PF00017	0.357
LIG_SH2_STAT5	539	542	PF00017	0.304
LIG_SH2_STAT5	570	573	PF00017	0.359
LIG_SH2_STAT5	82	85	PF00017	0.338
LIG_SH3_1	90	96	PF00018	0.409
LIG_SH3_3	217	223	PF00018	0.446
LIG_SH3_3	313	319	PF00018	0.413
LIG_SH3_3	510	516	PF00018	0.374
LIG_SH3_3	519	525	PF00018	0.372
LIG_SH3_3	562	568	PF00018	0.520
LIG_SH3_3	90	96	PF00018	0.423
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.460
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.371
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.258
LIG_SUMO_SIM_par_1	524	530	PF11976	0.430
LIG_TRAF2_1	133	136	PF00917	0.364
LIG_TRAF2_1	605	608	PF00917	0.719
LIG_TRFH_1	219	223	PF08558	0.446
LIG_UBA3_1	269	277	PF00899	0.487
LIG_WRC_WIRS_1	75	80	PF05994	0.240
MOD_CK1_1	163	169	PF00069	0.446
MOD_CK1_1	275	281	PF00069	0.487
MOD_CK1_1	285	291	PF00069	0.404
MOD_CK1_1	46	52	PF00069	0.470
MOD_CK1_1	543	549	PF00069	0.589
MOD_CK1_1	617	623	PF00069	0.739
MOD_CK2_1	130	136	PF00069	0.357
MOD_CK2_1	602	608	PF00069	0.644
MOD_CMANNOS	250	253	PF00535	0.246
MOD_GlcNHglycan	123	126	PF01048	0.420
MOD_GlcNHglycan	173	176	PF01048	0.254
MOD_GlcNHglycan	237	240	PF01048	0.246
MOD_GlcNHglycan	277	280	PF01048	0.351
MOD_GlcNHglycan	298	301	PF01048	0.351
MOD_GlcNHglycan	56	59	PF01048	0.256
MOD_GSK3_1	130	137	PF00069	0.387
MOD_GSK3_1	235	242	PF00069	0.446
MOD_GSK3_1	321	328	PF00069	0.486
MOD_GSK3_1	331	338	PF00069	0.440
MOD_GSK3_1	352	359	PF00069	0.485
MOD_GSK3_1	46	53	PF00069	0.424
MOD_GSK3_1	537	544	PF00069	0.378
MOD_GSK3_1	553	560	PF00069	0.475
MOD_GSK3_1	77	84	PF00069	0.409
MOD_N-GLC_1	115	120	PF02516	0.515
MOD_N-GLC_1	187	192	PF02516	0.174
MOD_N-GLC_1	419	424	PF02516	0.645
MOD_N-GLC_1	497	502	PF02516	0.270
MOD_NEK2_1	103	108	PF00069	0.438
MOD_NEK2_1	261	266	PF00069	0.453
MOD_NEK2_1	302	307	PF00069	0.490
MOD_NEK2_1	352	357	PF00069	0.458
MOD_NEK2_1	433	438	PF00069	0.496
MOD_NEK2_1	557	562	PF00069	0.410
MOD_NEK2_2	239	244	PF00069	0.446
MOD_NEK2_2	272	277	PF00069	0.532
MOD_PIKK_1	163	169	PF00454	0.446
MOD_PIKK_1	261	267	PF00454	0.457
MOD_PIKK_1	472	478	PF00454	0.475
MOD_PIKK_1	77	83	PF00454	0.507
MOD_PK_1	412	418	PF00069	0.422
MOD_PKA_2	243	249	PF00069	0.446
MOD_PKA_2	356	362	PF00069	0.503
MOD_PKA_2	433	439	PF00069	0.483
MOD_PKA_2	574	580	PF00069	0.297
MOD_PKB_1	410	418	PF00069	0.672
MOD_Plk_1	115	121	PF00069	0.515
MOD_Plk_1	187	193	PF00069	0.374
MOD_Plk_1	214	220	PF00069	0.464
MOD_Plk_1	335	341	PF00069	0.412
MOD_Plk_1	46	52	PF00069	0.437
MOD_Plk_1	497	503	PF00069	0.263
MOD_Plk_2-3	611	617	PF00069	0.507
MOD_Plk_4	136	142	PF00069	0.339
MOD_Plk_4	336	342	PF00069	0.467
MOD_Plk_4	346	352	PF00069	0.460
MOD_Plk_4	362	368	PF00069	0.444
MOD_Plk_4	412	418	PF00069	0.420
MOD_Plk_4	489	495	PF00069	0.437
MOD_Plk_4	553	559	PF00069	0.419
MOD_Plk_4	74	80	PF00069	0.320
MOD_ProDKin_1	312	318	PF00069	0.506
MOD_ProDKin_1	321	327	PF00069	0.373
MOD_ProDKin_1	419	425	PF00069	0.489
MOD_ProDKin_1	521	527	PF00069	0.442
MOD_ProDKin_1	532	538	PF00069	0.480
MOD_SUMO_rev_2	345	350	PF00179	0.534
MOD_SUMO_rev_2	84	92	PF00179	0.487
TRG_DiLeu_BaEn_2	46	52	PF01217	0.425
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.455
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.457
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.487
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.378
TRG_ENDOCYTIC_2	449	452	PF00928	0.470
TRG_ENDOCYTIC_2	539	542	PF00928	0.525
TRG_ER_diArg_1	112	115	PF00400	0.351
TRG_ER_diArg_1	380	383	PF00400	0.477
TRG_NES_CRM1_1	431	445	PF08389	0.414
TRG_NLS_MonoCore_2	110	115	PF00514	0.589
TRG_NLS_MonoExtC_3	11	17	PF00514	0.654
TRG_NLS_MonoExtN_4	111	116	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.246

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y2	Leptomonas seymouri	71%	99%
A0A0N1HZE7	Leptomonas seymouri	29%	81%
A0A0S4IKI3	Bodo saltans	51%	94%
A0A1X0P924	Trypanosomatidae	54%	92%
A0A3Q8IJ07	Leishmania donovani	86%	100%
A0A3S5IQZ3	Trypanosoma rangeli	57%	100%
C9ZKZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AEB6	Leishmania major	85%	100%
E9AHJ5	Leishmania infantum	85%	100%
E9ALH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	93%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	93%
Q08J23	Homo sapiens	37%	83%
Q1HFZ0	Mus musculus	39%	84%
Q4V7N2	Xenopus laevis	37%	91%
Q5ZLV4	Gallus gallus	34%	80%
Q9W4M9	Drosophila melanogaster	34%	85%
V5BSK4	Trypanosoma cruzi	54%	100%