DDE Tnp4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIT7_LEIBR

TriTrypDb:

LbrM.29.1960 , LBRM2903_290026000

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.634
CLV_NRD_NRD_1	292	294	PF00675	0.438
CLV_NRD_NRD_1	46	48	PF00675	0.605
CLV_PCSK_KEX2_1	15	17	PF00082	0.634
CLV_PCSK_KEX2_1	216	218	PF00082	0.507
CLV_PCSK_KEX2_1	275	277	PF00082	0.465
CLV_PCSK_KEX2_1	46	48	PF00082	0.605
CLV_PCSK_KEX2_1	81	83	PF00082	0.668
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.507
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.465
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.676
CLV_PCSK_SKI1_1	15	19	PF00082	0.556
CLV_PCSK_SKI1_1	275	279	PF00082	0.595
DEG_SPOP_SBC_1	263	267	PF00917	0.452
DEG_SPOP_SBC_1	67	71	PF00917	0.550
DOC_CKS1_1	108	113	PF01111	0.322
DOC_CKS1_1	39	44	PF01111	0.480
DOC_MAPK_gen_1	92	101	PF00069	0.439
DOC_MAPK_MEF2A_6	327	334	PF00069	0.430
DOC_PP1_SILK_1	226	231	PF00149	0.467
DOC_PP4_FxxP_1	17	20	PF00568	0.477
DOC_PP4_FxxP_1	306	309	PF00568	0.342
DOC_USP7_MATH_1	241	245	PF00917	0.388
DOC_USP7_MATH_1	258	262	PF00917	0.417
DOC_USP7_MATH_1	263	267	PF00917	0.588
DOC_USP7_MATH_1	283	287	PF00917	0.531
DOC_USP7_MATH_1	66	70	PF00917	0.469
DOC_WW_Pin1_4	107	112	PF00397	0.361
DOC_WW_Pin1_4	184	189	PF00397	0.554
DOC_WW_Pin1_4	21	26	PF00397	0.680
DOC_WW_Pin1_4	259	264	PF00397	0.528
DOC_WW_Pin1_4	335	340	PF00397	0.406
DOC_WW_Pin1_4	38	43	PF00397	0.482
LIG_14-3-3_CanoR_1	126	133	PF00244	0.552
LIG_14-3-3_CanoR_1	276	280	PF00244	0.588
LIG_14-3-3_CanoR_1	352	357	PF00244	0.340
LIG_14-3-3_CanoR_1	46	54	PF00244	0.596
LIG_BIR_II_1	1	5	PF00653	0.460
LIG_BIR_III_1	1	5	PF00653	0.460
LIG_BIR_III_3	1	5	PF00653	0.460
LIG_BRCT_BRCA1_1	34	38	PF00533	0.562
LIG_FHA_1	195	201	PF00498	0.550
LIG_FHA_1	276	282	PF00498	0.441
LIG_FHA_1	340	346	PF00498	0.461
LIG_FHA_2	164	170	PF00498	0.539
LIG_LIR_Apic_2	303	309	PF02991	0.311
LIG_LIR_Gen_1	115	124	PF02991	0.297
LIG_LIR_Nem_3	115	120	PF02991	0.300
LIG_LIR_Nem_3	146	151	PF02991	0.467
LIG_LIR_Nem_3	204	210	PF02991	0.427
LIG_LIR_Nem_3	310	315	PF02991	0.343
LIG_LYPXL_yS_3	148	151	PF13949	0.480
LIG_NRBOX	119	125	PF00104	0.438
LIG_PTB_Apo_2	173	180	PF02174	0.353
LIG_SH2_NCK_1	248	252	PF00017	0.387
LIG_SH2_SRC	248	251	PF00017	0.425
LIG_SH2_STAP1	248	252	PF00017	0.404
LIG_SH3_3	19	25	PF00018	0.479
LIG_SH3_3	36	42	PF00018	0.482
LIG_SUMO_SIM_par_1	28	33	PF11976	0.478
MOD_CK1_1	21	27	PF00069	0.701
MOD_CK1_1	262	268	PF00069	0.664
MOD_CK1_1	287	293	PF00069	0.558
MOD_CK1_1	77	83	PF00069	0.628
MOD_CK2_1	163	169	PF00069	0.543
MOD_Cter_Amidation	273	276	PF01082	0.505
MOD_GlcNHglycan	104	107	PF01048	0.402
MOD_GlcNHglycan	243	246	PF01048	0.386
MOD_GlcNHglycan	34	37	PF01048	0.602
MOD_GlcNHglycan	50	53	PF01048	0.521
MOD_GlcNHglycan	82	85	PF01048	0.563
MOD_GSK3_1	161	168	PF00069	0.781
MOD_GSK3_1	258	265	PF00069	0.511
MOD_GSK3_1	283	290	PF00069	0.455
MOD_GSK3_1	335	342	PF00069	0.433
MOD_GSK3_1	48	55	PF00069	0.570
MOD_NEK2_1	102	107	PF00069	0.360
MOD_NEK2_1	179	184	PF00069	0.481
MOD_NEK2_1	264	269	PF00069	0.475
MOD_NEK2_1	30	35	PF00069	0.692
MOD_NEK2_2	339	344	PF00069	0.460
MOD_PIKK_1	149	155	PF00454	0.547
MOD_PIKK_1	156	162	PF00454	0.593
MOD_PKA_1	275	281	PF00069	0.450
MOD_PKA_1	46	52	PF00069	0.480
MOD_PKA_2	125	131	PF00069	0.550
MOD_PKA_2	275	281	PF00069	0.584
MOD_PKA_2	46	52	PF00069	0.560
MOD_PKA_2	94	100	PF00069	0.454
MOD_Plk_4	18	24	PF00069	0.478
MOD_ProDKin_1	107	113	PF00069	0.354
MOD_ProDKin_1	184	190	PF00069	0.570
MOD_ProDKin_1	21	27	PF00069	0.681
MOD_ProDKin_1	259	265	PF00069	0.541
MOD_ProDKin_1	335	341	PF00069	0.398
MOD_ProDKin_1	38	44	PF00069	0.481
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.368
TRG_DiLeu_LyEn_5	146	151	PF01217	0.467
TRG_ENDOCYTIC_2	148	151	PF00928	0.480
TRG_ENDOCYTIC_2	248	251	PF00928	0.329
TRG_ER_diArg_1	15	17	PF00400	0.685
TRG_ER_diArg_1	320	323	PF00400	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV2	Leptomonas seymouri	41%	91%
A0A3Q8IIX3	Leishmania donovani	69%	99%
A0A422NNG7	Trypanosoma rangeli	33%	100%
E9AE61	Leishmania major	67%	100%
E9ALM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%