Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIT6_LEIBR

TriTrypDb:

LbrM.29.0890 , LBRM2903_290015300

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	344	346	PF00675	0.718
CLV_NRD_NRD_1	39	41	PF00675	0.584
CLV_NRD_NRD_1	495	497	PF00675	0.593
CLV_PCSK_KEX2_1	326	328	PF00082	0.554
CLV_PCSK_KEX2_1	38	40	PF00082	0.597
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.554
CLV_PCSK_SKI1_1	362	366	PF00082	0.692
CLV_PCSK_SKI1_1	414	418	PF00082	0.690
DEG_COP1_1	401	408	PF00400	0.538
DEG_SPOP_SBC_1	19	23	PF00917	0.779
DEG_SPOP_SBC_1	441	445	PF00917	0.520
DOC_CDC14_PxL_1	311	319	PF14671	0.519
DOC_CKS1_1	400	405	PF01111	0.799
DOC_CYCLIN_RxL_1	359	369	PF00134	0.690
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.522
DOC_MAPK_gen_1	54	62	PF00069	0.481
DOC_MAPK_MEF2A_6	84	93	PF00069	0.514
DOC_MAPK_RevD_3	312	327	PF00069	0.530
DOC_PP1_RVXF_1	360	367	PF00149	0.790
DOC_PP1_RVXF_1	412	419	PF00149	0.440
DOC_PP2B_LxvP_1	357	360	PF13499	0.785
DOC_SPAK_OSR1_1	286	290	PF12202	0.534
DOC_USP7_MATH_1	19	23	PF00917	0.792
DOC_USP7_MATH_1	199	203	PF00917	0.691
DOC_USP7_MATH_1	205	209	PF00917	0.741
DOC_USP7_MATH_1	313	317	PF00917	0.520
DOC_USP7_MATH_1	404	408	PF00917	0.730
DOC_USP7_MATH_1	423	427	PF00917	0.713
DOC_USP7_MATH_1	47	51	PF00917	0.664
DOC_USP7_MATH_1	501	505	PF00917	0.531
DOC_USP7_MATH_1	56	60	PF00917	0.637
DOC_USP7_UBL2_3	478	482	PF12436	0.599
DOC_WW_Pin1_4	200	205	PF00397	0.618
DOC_WW_Pin1_4	221	226	PF00397	0.751
DOC_WW_Pin1_4	227	232	PF00397	0.691
DOC_WW_Pin1_4	291	296	PF00397	0.652
DOC_WW_Pin1_4	332	337	PF00397	0.583
DOC_WW_Pin1_4	393	398	PF00397	0.698
DOC_WW_Pin1_4	399	404	PF00397	0.703
DOC_WW_Pin1_4	425	430	PF00397	0.551
DOC_WW_Pin1_4	67	72	PF00397	0.783
LIG_14-3-3_CanoR_1	217	225	PF00244	0.651
LIG_14-3-3_CanoR_1	271	279	PF00244	0.397
LIG_14-3-3_CanoR_1	327	336	PF00244	0.551
LIG_14-3-3_CanoR_1	345	353	PF00244	0.528
LIG_14-3-3_CanoR_1	362	367	PF00244	0.730
LIG_14-3-3_CanoR_1	459	467	PF00244	0.550
LIG_14-3-3_CterR_2	509	514	PF00244	0.569
LIG_BRCT_BRCA1_1	202	206	PF00533	0.495
LIG_BRCT_BRCA1_1	268	272	PF00533	0.523
LIG_BRCT_BRCA1_1	51	55	PF00533	0.549
LIG_FHA_1	154	160	PF00498	0.605
LIG_FHA_1	32	38	PF00498	0.804
LIG_FHA_1	400	406	PF00498	0.675
LIG_FHA_1	428	434	PF00498	0.588
LIG_FHA_1	474	480	PF00498	0.704
LIG_FHA_1	88	94	PF00498	0.500
LIG_FHA_2	3	9	PF00498	0.542
LIG_FHA_2	363	369	PF00498	0.790
LIG_FHA_2	72	78	PF00498	0.768
LIG_LIR_Gen_1	276	287	PF02991	0.566
LIG_LIR_Nem_3	183	188	PF02991	0.474
LIG_LIR_Nem_3	269	275	PF02991	0.549
LIG_LIR_Nem_3	276	282	PF02991	0.521
LIG_LYPXL_SIV_4	274	282	PF13949	0.377
LIG_MYND_1	315	319	PF01753	0.511
LIG_SH2_CRK	311	315	PF00017	0.526
LIG_SH2_CRK	44	48	PF00017	0.605
LIG_SH2_NCK_1	311	315	PF00017	0.526
LIG_SH2_STAP1	252	256	PF00017	0.514
LIG_SH2_STAP1	275	279	PF00017	0.544
LIG_SH2_STAT5	275	278	PF00017	0.406
LIG_SH3_2	231	236	PF14604	0.554
LIG_SH3_3	228	234	PF00018	0.770
LIG_SH3_3	294	300	PF00018	0.697
LIG_SH3_3	400	406	PF00018	0.663
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.346
LIG_SUMO_SIM_anti_2	58	65	PF11976	0.525
LIG_TRAF2_1	111	114	PF00917	0.631
LIG_TRAF2_1	175	178	PF00917	0.576
MOD_CDK_SPK_2	227	232	PF00069	0.768
MOD_CK1_1	141	147	PF00069	0.458
MOD_CK1_1	150	156	PF00069	0.649
MOD_CK1_1	208	214	PF00069	0.678
MOD_CK1_1	22	28	PF00069	0.671
MOD_CK1_1	220	226	PF00069	0.631
MOD_CK1_1	291	297	PF00069	0.600
MOD_CK1_1	31	37	PF00069	0.739
MOD_CK1_1	338	344	PF00069	0.777
MOD_CK1_1	442	448	PF00069	0.685
MOD_CK1_1	461	467	PF00069	0.474
MOD_CK1_1	489	495	PF00069	0.753
MOD_CK2_1	108	114	PF00069	0.622
MOD_CK2_1	2	8	PF00069	0.546
MOD_CK2_1	237	243	PF00069	0.594
MOD_CK2_1	362	368	PF00069	0.790
MOD_CK2_1	69	75	PF00069	0.778
MOD_DYRK1A_RPxSP_1	293	297	PF00069	0.686
MOD_GlcNHglycan	151	155	PF01048	0.459
MOD_GlcNHglycan	195	198	PF01048	0.621
MOD_GlcNHglycan	213	216	PF01048	0.761
MOD_GlcNHglycan	219	222	PF01048	0.647
MOD_GlcNHglycan	24	27	PF01048	0.652
MOD_GlcNHglycan	251	255	PF01048	0.533
MOD_GlcNHglycan	387	390	PF01048	0.637
MOD_GlcNHglycan	503	506	PF01048	0.585
MOD_GSK3_1	18	25	PF00069	0.716
MOD_GSK3_1	213	220	PF00069	0.602
MOD_GSK3_1	221	228	PF00069	0.563
MOD_GSK3_1	250	257	PF00069	0.363
MOD_GSK3_1	266	273	PF00069	0.372
MOD_GSK3_1	28	35	PF00069	0.822
MOD_GSK3_1	289	296	PF00069	0.618
MOD_GSK3_1	327	334	PF00069	0.690
MOD_GSK3_1	340	347	PF00069	0.537
MOD_GSK3_1	358	365	PF00069	0.706
MOD_GSK3_1	376	383	PF00069	0.640
MOD_GSK3_1	387	394	PF00069	0.630
MOD_GSK3_1	417	424	PF00069	0.599
MOD_GSK3_1	425	432	PF00069	0.586
MOD_GSK3_1	437	444	PF00069	0.630
MOD_GSK3_1	473	480	PF00069	0.727
MOD_GSK3_1	65	72	PF00069	0.768
MOD_N-GLC_1	211	216	PF02516	0.579
MOD_N-GLC_1	489	494	PF02516	0.553
MOD_NEK2_1	193	198	PF00069	0.571
MOD_NEK2_1	226	231	PF00069	0.711
MOD_NEK2_1	288	293	PF00069	0.576
MOD_NEK2_1	385	390	PF00069	0.541
MOD_NEK2_1	417	422	PF00069	0.576
MOD_NEK2_1	439	444	PF00069	0.723
MOD_NEK2_1	62	67	PF00069	0.639
MOD_NEK2_1	93	98	PF00069	0.506
MOD_NEK2_2	503	508	PF00069	0.525
MOD_PIKK_1	266	272	PF00454	0.521
MOD_PIKK_1	340	346	PF00454	0.674
MOD_PIKK_1	459	465	PF00454	0.541
MOD_PKA_1	326	332	PF00069	0.549
MOD_PKA_2	147	153	PF00069	0.565
MOD_PKA_2	216	222	PF00069	0.606
MOD_PKA_2	270	276	PF00069	0.407
MOD_PKA_2	326	332	PF00069	0.607
MOD_PKA_2	344	350	PF00069	0.507
MOD_PKA_2	458	464	PF00069	0.545
MOD_PKA_2	56	62	PF00069	0.635
MOD_PKB_1	484	492	PF00069	0.552
MOD_Plk_1	163	169	PF00069	0.446
MOD_Plk_1	32	38	PF00069	0.748
MOD_Plk_1	383	389	PF00069	0.540
MOD_Plk_1	87	93	PF00069	0.510
MOD_Plk_2-3	75	81	PF00069	0.733
MOD_Plk_4	163	169	PF00069	0.505
MOD_Plk_4	313	319	PF00069	0.686
MOD_Plk_4	362	368	PF00069	0.790
MOD_Plk_4	404	410	PF00069	0.562
MOD_Plk_4	417	423	PF00069	0.467
MOD_Plk_4	429	435	PF00069	0.534
MOD_Plk_4	93	99	PF00069	0.591
MOD_ProDKin_1	200	206	PF00069	0.613
MOD_ProDKin_1	221	227	PF00069	0.754
MOD_ProDKin_1	291	297	PF00069	0.659
MOD_ProDKin_1	332	338	PF00069	0.585
MOD_ProDKin_1	393	399	PF00069	0.700
MOD_ProDKin_1	425	431	PF00069	0.553
MOD_ProDKin_1	67	73	PF00069	0.782
TRG_DiLeu_BaEn_1	58	63	PF01217	0.469
TRG_ENDOCYTIC_2	311	314	PF00928	0.530
TRG_ER_diArg_1	284	287	PF00400	0.375
TRG_ER_diArg_1	37	40	PF00400	0.685
TRG_ER_diArg_1	484	487	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I162	Leptomonas seymouri	40%	81%
A0A3Q8IR74	Leishmania donovani	70%	100%
E9ADT9	Leishmania major	68%	100%
E9AHI3	Leishmania infantum	70%	100%
E9ALZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%