C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIT5_LEIBR

TriTrypDb:

LbrM.29.0620 , LBRM2903_290012400

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT5

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.566
CLV_C14_Caspase3-7	424	428	PF00656	0.605
CLV_NRD_NRD_1	114	116	PF00675	0.718
CLV_NRD_NRD_1	154	156	PF00675	0.589
CLV_NRD_NRD_1	187	189	PF00675	0.536
CLV_NRD_NRD_1	190	192	PF00675	0.549
CLV_NRD_NRD_1	220	222	PF00675	0.493
CLV_NRD_NRD_1	230	232	PF00675	0.557
CLV_NRD_NRD_1	284	286	PF00675	0.770
CLV_NRD_NRD_1	301	303	PF00675	0.668
CLV_NRD_NRD_1	37	39	PF00675	0.599
CLV_NRD_NRD_1	451	453	PF00675	0.789
CLV_NRD_NRD_1	580	582	PF00675	0.693
CLV_NRD_NRD_1	585	587	PF00675	0.651
CLV_PCSK_FUR_1	188	192	PF00082	0.632
CLV_PCSK_KEX2_1	189	191	PF00082	0.602
CLV_PCSK_KEX2_1	219	221	PF00082	0.504
CLV_PCSK_KEX2_1	232	234	PF00082	0.588
CLV_PCSK_KEX2_1	284	286	PF00082	0.770
CLV_PCSK_KEX2_1	301	303	PF00082	0.575
CLV_PCSK_KEX2_1	37	39	PF00082	0.599
CLV_PCSK_KEX2_1	451	453	PF00082	0.789
CLV_PCSK_KEX2_1	580	582	PF00082	0.693
CLV_PCSK_KEX2_1	585	587	PF00082	0.651
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.641
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.588
CLV_PCSK_PC7_1	280	286	PF00082	0.569
CLV_PCSK_PC7_1	581	587	PF00082	0.652
CLV_PCSK_SKI1_1	432	436	PF00082	0.595
CLV_PCSK_SKI1_1	446	450	PF00082	0.756
CLV_PCSK_SKI1_1	561	565	PF00082	0.716
CLV_PCSK_SKI1_1	619	623	PF00082	0.587
DEG_SCF_FBW7_2	468	474	PF00400	0.574
DEG_SCF_TRCP1_1	483	489	PF00400	0.564
DEG_SPOP_SBC_1	356	360	PF00917	0.550
DEG_SPOP_SBC_1	519	523	PF00917	0.584
DOC_CKS1_1	468	473	PF01111	0.571
DOC_CKS1_1	73	78	PF01111	0.569
DOC_MAPK_gen_1	158	168	PF00069	0.630
DOC_MAPK_gen_1	231	242	PF00069	0.661
DOC_PP1_RVXF_1	430	437	PF00149	0.607
DOC_PP4_FxxP_1	305	308	PF00568	0.747
DOC_SPAK_OSR1_1	614	618	PF12202	0.537
DOC_USP7_MATH_1	247	251	PF00917	0.717
DOC_USP7_MATH_1	259	263	PF00917	0.777
DOC_USP7_MATH_1	3	7	PF00917	0.707
DOC_USP7_MATH_1	350	354	PF00917	0.646
DOC_USP7_MATH_1	356	360	PF00917	0.748
DOC_USP7_MATH_1	369	373	PF00917	0.598
DOC_USP7_MATH_1	39	43	PF00917	0.494
DOC_USP7_MATH_1	481	485	PF00917	0.813
DOC_USP7_MATH_1	519	523	PF00917	0.810
DOC_USP7_MATH_1	8	12	PF00917	0.639
DOC_USP7_MATH_1	92	96	PF00917	0.588
DOC_USP7_UBL2_3	400	404	PF12436	0.347
DOC_WW_Pin1_4	249	254	PF00397	0.712
DOC_WW_Pin1_4	283	288	PF00397	0.727
DOC_WW_Pin1_4	290	295	PF00397	0.651
DOC_WW_Pin1_4	342	347	PF00397	0.750
DOC_WW_Pin1_4	381	386	PF00397	0.602
DOC_WW_Pin1_4	467	472	PF00397	0.571
DOC_WW_Pin1_4	521	526	PF00397	0.822
DOC_WW_Pin1_4	54	59	PF00397	0.768
DOC_WW_Pin1_4	556	561	PF00397	0.547
DOC_WW_Pin1_4	72	77	PF00397	0.575
LIG_14-3-3_CanoR_1	151	159	PF00244	0.591
LIG_14-3-3_CanoR_1	233	242	PF00244	0.649
LIG_14-3-3_CanoR_1	596	603	PF00244	0.553
LIG_14-3-3_CanoR_1	79	85	PF00244	0.759
LIG_BIR_III_2	545	549	PF00653	0.548
LIG_FHA_1	301	307	PF00498	0.571
LIG_FHA_1	326	332	PF00498	0.649
LIG_FHA_2	29	35	PF00498	0.718
LIG_FHA_2	333	339	PF00498	0.534
LIG_FHA_2	422	428	PF00498	0.574
LIG_FHA_2	468	474	PF00498	0.822
LIG_FHA_2	487	493	PF00498	0.496
LIG_FHA_2	557	563	PF00498	0.545
LIG_FHA_2	590	596	PF00498	0.580
LIG_LIR_Apic_2	303	308	PF02991	0.585
LIG_LIR_Gen_1	141	152	PF02991	0.465
LIG_LIR_Gen_1	438	448	PF02991	0.527
LIG_LIR_Gen_1	45	54	PF02991	0.579
LIG_LIR_Gen_1	592	601	PF02991	0.568
LIG_LIR_Nem_3	141	147	PF02991	0.509
LIG_LIR_Nem_3	438	444	PF02991	0.520
LIG_LIR_Nem_3	45	49	PF02991	0.556
LIG_LIR_Nem_3	592	597	PF02991	0.581
LIG_LIR_Nem_3	620	624	PF02991	0.399
LIG_Pex14_1	36	40	PF04695	0.627
LIG_PTAP_UEV_1	308	313	PF05743	0.654
LIG_REV1ctd_RIR_1	613	623	PF16727	0.498
LIG_SH2_CRK	144	148	PF00017	0.592
LIG_SH2_CRK	22	26	PF00017	0.635
LIG_SH2_CRK	40	44	PF00017	0.674
LIG_SH2_STAP1	135	139	PF00017	0.425
LIG_SH2_STAP1	22	26	PF00017	0.751
LIG_SH2_STAP1	430	434	PF00017	0.716
LIG_SH2_STAT3	184	187	PF00017	0.534
LIG_SH2_STAT5	121	124	PF00017	0.531
LIG_SH2_STAT5	144	147	PF00017	0.515
LIG_SH2_STAT5	184	187	PF00017	0.534
LIG_SH2_STAT5	406	409	PF00017	0.376
LIG_SH3_1	288	294	PF00018	0.600
LIG_SH3_1	373	379	PF00018	0.593
LIG_SH3_1	585	591	PF00018	0.611
LIG_SH3_1	70	76	PF00018	0.560
LIG_SH3_2	368	373	PF14604	0.508
LIG_SH3_2	504	509	PF14604	0.553
LIG_SH3_3	170	176	PF00018	0.539
LIG_SH3_3	210	216	PF00018	0.499
LIG_SH3_3	288	294	PF00018	0.715
LIG_SH3_3	306	312	PF00018	0.749
LIG_SH3_3	365	371	PF00018	0.670
LIG_SH3_3	373	379	PF00018	0.629
LIG_SH3_3	4	10	PF00018	0.692
LIG_SH3_3	459	465	PF00018	0.827
LIG_SH3_3	47	53	PF00018	0.586
LIG_SH3_3	501	507	PF00018	0.787
LIG_SH3_3	532	538	PF00018	0.764
LIG_SH3_3	544	550	PF00018	0.721
LIG_SH3_3	584	590	PF00018	0.623
LIG_SH3_3	70	76	PF00018	0.637
LIG_SUMO_SIM_par_1	51	57	PF11976	0.490
LIG_TRAF2_1	130	133	PF00917	0.625
LIG_TRAF2_1	313	316	PF00917	0.788
LIG_TRAF2_1	470	473	PF00917	0.722
LIG_TRAF2_2	313	318	PF00917	0.595
MOD_CDK_SPK_2	283	288	PF00069	0.560
MOD_CDK_SPK_2	381	386	PF00069	0.602
MOD_CDK_SPK_2	556	561	PF00069	0.547
MOD_CDK_SPxxK_3	381	388	PF00069	0.596
MOD_CDK_SPxxK_3	72	79	PF00069	0.563
MOD_CK1_1	252	258	PF00069	0.725
MOD_CK1_1	260	266	PF00069	0.728
MOD_CK1_1	267	273	PF00069	0.726
MOD_CK1_1	293	299	PF00069	0.687
MOD_CK1_1	317	323	PF00069	0.740
MOD_CK1_1	327	333	PF00069	0.648
MOD_CK1_1	357	363	PF00069	0.739
MOD_CK1_1	77	83	PF00069	0.798
MOD_CK2_1	270	276	PF00069	0.808
MOD_CK2_1	28	34	PF00069	0.728
MOD_CK2_1	283	289	PF00069	0.801
MOD_CK2_1	39	45	PF00069	0.676
MOD_CK2_1	439	445	PF00069	0.775
MOD_CK2_1	467	473	PF00069	0.676
MOD_CK2_1	481	487	PF00069	0.713
MOD_CK2_1	556	562	PF00069	0.546
MOD_CK2_1	589	595	PF00069	0.583
MOD_CK2_1	8	14	PF00069	0.734
MOD_Cter_Amidation	299	302	PF01082	0.569
MOD_GlcNHglycan	180	184	PF01048	0.451
MOD_GlcNHglycan	257	260	PF01048	0.710
MOD_GlcNHglycan	309	312	PF01048	0.701
MOD_GlcNHglycan	352	355	PF01048	0.761
MOD_GlcNHglycan	441	444	PF01048	0.758
MOD_GlcNHglycan	483	486	PF01048	0.718
MOD_GlcNHglycan	494	497	PF01048	0.637
MOD_GlcNHglycan	551	554	PF01048	0.707
MOD_GlcNHglycan	81	84	PF01048	0.765
MOD_GlcNHglycan	86	89	PF01048	0.790
MOD_GSK3_1	107	114	PF00069	0.575
MOD_GSK3_1	150	157	PF00069	0.403
MOD_GSK3_1	245	252	PF00069	0.666
MOD_GSK3_1	255	262	PF00069	0.718
MOD_GSK3_1	263	270	PF00069	0.725
MOD_GSK3_1	290	297	PF00069	0.684
MOD_GSK3_1	317	324	PF00069	0.675
MOD_GSK3_1	342	349	PF00069	0.776
MOD_GSK3_1	350	357	PF00069	0.743
MOD_GSK3_1	421	428	PF00069	0.597
MOD_GSK3_1	74	81	PF00069	0.787
MOD_GSK3_1	93	100	PF00069	0.454
MOD_N-GLC_1	379	384	PF02516	0.562
MOD_NEK2_1	178	183	PF00069	0.563
MOD_NEK2_2	150	155	PF00069	0.511
MOD_NEK2_2	39	44	PF00069	0.677
MOD_PIKK_1	191	197	PF00454	0.529
MOD_PIKK_1	321	327	PF00454	0.733
MOD_PK_1	509	515	PF00069	0.567
MOD_PKA_2	150	156	PF00069	0.588
MOD_PKA_2	267	273	PF00069	0.728
MOD_PKA_2	300	306	PF00069	0.570
MOD_PKA_2	595	601	PF00069	0.560
MOD_PKA_2	78	84	PF00069	0.825
MOD_PKB_1	231	239	PF00069	0.714
MOD_Plk_1	179	185	PF00069	0.453
MOD_Plk_1	236	242	PF00069	0.650
MOD_Plk_1	426	432	PF00069	0.686
MOD_Plk_1	486	492	PF00069	0.623
MOD_Plk_1	561	567	PF00069	0.708
MOD_Plk_2-3	128	134	PF00069	0.362
MOD_Plk_2-3	595	601	PF00069	0.560
MOD_Plk_4	236	242	PF00069	0.597
MOD_Plk_4	589	595	PF00069	0.583
MOD_ProDKin_1	249	255	PF00069	0.712
MOD_ProDKin_1	283	289	PF00069	0.728
MOD_ProDKin_1	290	296	PF00069	0.651
MOD_ProDKin_1	342	348	PF00069	0.752
MOD_ProDKin_1	381	387	PF00069	0.595
MOD_ProDKin_1	467	473	PF00069	0.572
MOD_ProDKin_1	521	527	PF00069	0.819
MOD_ProDKin_1	54	60	PF00069	0.772
MOD_ProDKin_1	556	562	PF00069	0.546
MOD_ProDKin_1	72	78	PF00069	0.574
MOD_SUMO_for_1	200	203	PF00179	0.534
MOD_SUMO_for_1	413	416	PF00179	0.249
MOD_SUMO_rev_2	11	18	PF00179	0.464
MOD_SUMO_rev_2	128	136	PF00179	0.358
TRG_DiLeu_BaEn_1	164	169	PF01217	0.644
TRG_DiLeu_BaEn_1	605	610	PF01217	0.509
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.660
TRG_ENDOCYTIC_2	144	147	PF00928	0.515
TRG_ENDOCYTIC_2	22	25	PF00928	0.754
TRG_ENDOCYTIC_2	40	43	PF00928	0.666
TRG_ENDOCYTIC_2	594	597	PF00928	0.627
TRG_ER_diArg_1	188	191	PF00400	0.592
TRG_ER_diArg_1	219	221	PF00400	0.504
TRG_ER_diArg_1	230	233	PF00400	0.567
TRG_ER_diArg_1	283	285	PF00400	0.760
TRG_ER_diArg_1	301	304	PF00400	0.637
TRG_ER_diArg_1	36	38	PF00400	0.651
TRG_ER_diArg_1	385	388	PF00400	0.584
TRG_ER_diArg_1	450	452	PF00400	0.752
TRG_ER_diArg_1	585	587	PF00400	0.661
TRG_NLS_Bipartite_1	219	236	PF00514	0.536
TRG_NLS_MonoCore_2	187	192	PF00514	0.629
TRG_NLS_MonoCore_2	231	236	PF00514	0.637
TRG_NLS_MonoExtC_3	154	159	PF00514	0.609
TRG_NLS_MonoExtC_3	188	193	PF00514	0.632
TRG_NLS_MonoExtC_3	230	235	PF00514	0.632
TRG_NLS_MonoExtN_4	188	193	PF00514	0.632
TRG_NLS_MonoExtN_4	231	236	PF00514	0.709
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y7	Leptomonas seymouri	49%	100%
A0A3Q8IDJ2	Leishmania donovani	69%	99%
A4I4B3	Leishmania infantum	71%	99%
C9ZL55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ADR3	Leishmania major	72%	100%
E9AM17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%