tRNA (adenine(58)-N(1))-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA methyltransferase complex GCD14 subunit, putative

Species:

Leishmania braziliensis

UniProt:

E9AIT3_LEIBR

TriTrypDb:

LbrM.28.2600 , LBRM2903_280032700

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0031515	tRNA (m1A) methyltransferase complex	6	12
GO:0032991	protein-containing complex	1	12
GO:0034708	methyltransferase complex	4	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043527	tRNA methyltransferase complex	5	12
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AIT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT3

Function

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Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008175	tRNA methyltransferase activity	5	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016426	tRNA (adenine) methyltransferase activity	6	12
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140098	catalytic activity, acting on RNA	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.423
CLV_NRD_NRD_1	154	156	PF00675	0.202
CLV_NRD_NRD_1	305	307	PF00675	0.403
CLV_PCSK_KEX2_1	154	156	PF00082	0.209
CLV_PCSK_KEX2_1	274	276	PF00082	0.405
CLV_PCSK_KEX2_1	304	306	PF00082	0.389
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.405
CLV_PCSK_PC7_1	150	156	PF00082	0.238
CLV_PCSK_SKI1_1	54	58	PF00082	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.377

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA18	Leptomonas seymouri	83%	100%
A0A0S4IUX6	Bodo saltans	59%	95%
A0A1X0NRB0	Trypanosomatidae	64%	98%
A0A3Q8IIA8	Leishmania donovani	89%	95%
A0A3R7LPM7	Trypanosoma rangeli	63%	100%
A4I3X1	Leishmania infantum	89%	95%
A6H791	Bos taurus	36%	100%
D0A938	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	80%
E9B061	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	95%
O14307	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	92%

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