Threonylcarbamoyl-AMP synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family, putative

Species:

Leishmania braziliensis

UniProt:

E9AIT1_LEIBR

TriTrypDb:

LbrM.28.2260 , LBRM2903_280029000

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AIT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006450	regulation of translational fidelity	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003725	double-stranded RNA binding	5	12
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0061710	L-threonylcarbamoyladenylate synthase	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	12
GO:0000049	tRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.499
CLV_NRD_NRD_1	199	201	PF00675	0.280
CLV_NRD_NRD_1	71	73	PF00675	0.188
CLV_PCSK_KEX2_1	13	15	PF00082	0.499
CLV_PCSK_KEX2_1	199	201	PF00082	0.293
CLV_PCSK_KEX2_1	46	48	PF00082	0.227
CLV_PCSK_KEX2_1	71	73	PF00082	0.188
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.227
CLV_PCSK_SKI1_1	332	336	PF00082	0.288
DEG_APCC_KENBOX_2	348	352	PF00400	0.366
DOC_CKS1_1	255	260	PF01111	0.452
DOC_MAPK_gen_1	199	205	PF00069	0.293
DOC_MAPK_gen_1	276	283	PF00069	0.539
DOC_MAPK_HePTP_8	128	140	PF00069	0.227
DOC_MAPK_MEF2A_6	131	140	PF00069	0.329
DOC_MAPK_MEF2A_6	199	207	PF00069	0.414
DOC_PP1_RVXF_1	333	340	PF00149	0.482
DOC_USP7_MATH_1	104	108	PF00917	0.259
DOC_USP7_MATH_1	141	145	PF00917	0.293
DOC_USP7_MATH_1	153	157	PF00917	0.293
DOC_USP7_UBL2_3	188	192	PF12436	0.402
DOC_WW_Pin1_4	149	154	PF00397	0.293
DOC_WW_Pin1_4	236	241	PF00397	0.510
DOC_WW_Pin1_4	245	250	PF00397	0.441
DOC_WW_Pin1_4	254	259	PF00397	0.441
DOC_WW_Pin1_4	306	311	PF00397	0.527
LIG_14-3-3_CanoR_1	200	206	PF00244	0.309
LIG_14-3-3_CanoR_1	250	256	PF00244	0.433
LIG_14-3-3_CanoR_1	47	52	PF00244	0.223
LIG_BIR_II_1	1	5	PF00653	0.379
LIG_BRCT_BRCA1_1	335	339	PF00533	0.482
LIG_Clathr_ClatBox_1	170	174	PF01394	0.309
LIG_FHA_1	127	133	PF00498	0.355
LIG_FHA_1	27	33	PF00498	0.293
LIG_FHA_1	284	290	PF00498	0.492
LIG_FHA_1	326	332	PF00498	0.499
LIG_FHA_1	368	374	PF00498	0.480
LIG_FHA_1	55	61	PF00498	0.282
LIG_FHA_2	217	223	PF00498	0.462
LIG_FHA_2	5	11	PF00498	0.490
LIG_GBD_Chelix_1	85	93	PF00786	0.414
LIG_LIR_Gen_1	304	310	PF02991	0.486
LIG_LIR_Gen_1	316	327	PF02991	0.446
LIG_LIR_LC3C_4	191	196	PF02991	0.429
LIG_LIR_Nem_3	147	151	PF02991	0.285
LIG_LIR_Nem_3	290	294	PF02991	0.502
LIG_LIR_Nem_3	316	322	PF02991	0.471
LIG_LIR_Nem_3	336	342	PF02991	0.310
LIG_Pex14_2	341	345	PF04695	0.462
LIG_SH2_STAP1	160	164	PF00017	0.414
LIG_SH2_STAT5	118	121	PF00017	0.414
LIG_SH2_STAT5	273	276	PF00017	0.502
LIG_SH2_STAT5	294	297	PF00017	0.527
LIG_SH2_STAT5	49	52	PF00017	0.446
LIG_SH3_1	103	109	PF00018	0.351
LIG_SH3_3	103	109	PF00018	0.329
LIG_SH3_3	133	139	PF00018	0.296
LIG_SH3_3	22	28	PF00018	0.293
LIG_SH3_3	246	252	PF00018	0.461
LIG_SH3_3	53	59	PF00018	0.409
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.299
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.328
LIG_SUMO_SIM_par_1	169	174	PF11976	0.314
LIG_SUMO_SIM_par_1	23	31	PF11976	0.320
LIG_SUMO_SIM_par_1	284	290	PF11976	0.482
MOD_CDK_SPK_2	245	250	PF00069	0.435
MOD_CK1_1	144	150	PF00069	0.285
MOD_CK1_1	152	158	PF00069	0.272
MOD_CK1_1	254	260	PF00069	0.452
MOD_CK1_1	301	307	PF00069	0.479
MOD_CK1_1	367	373	PF00069	0.482
MOD_CK2_1	216	222	PF00069	0.556
MOD_CK2_1	4	10	PF00069	0.407
MOD_GlcNHglycan	115	118	PF01048	0.312
MOD_GlcNHglycan	143	146	PF01048	0.287
MOD_GlcNHglycan	266	269	PF01048	0.296
MOD_GlcNHglycan	366	369	PF01048	0.276
MOD_GlcNHglycan	42	45	PF01048	0.414
MOD_GSK3_1	149	156	PF00069	0.188
MOD_GSK3_1	250	257	PF00069	0.432
MOD_NEK2_1	229	234	PF00069	0.527
MOD_NEK2_1	264	269	PF00069	0.490
MOD_NEK2_1	283	288	PF00069	0.463
MOD_NEK2_1	298	303	PF00069	0.489
MOD_NEK2_1	40	45	PF00069	0.414
MOD_NEK2_2	28	33	PF00069	0.293
MOD_NEK2_2	327	332	PF00069	0.527
MOD_PIKK_1	153	159	PF00454	0.188
MOD_PKA_2	298	304	PF00069	0.527
MOD_PKA_2	325	331	PF00069	0.452
MOD_Plk_1	182	188	PF00069	0.293
MOD_Plk_4	203	209	PF00069	0.511
MOD_Plk_4	251	257	PF00069	0.487
MOD_Plk_4	28	34	PF00069	0.293
MOD_Plk_4	283	289	PF00069	0.461
MOD_Plk_4	333	339	PF00069	0.455
MOD_Plk_4	96	102	PF00069	0.299
MOD_ProDKin_1	149	155	PF00069	0.293
MOD_ProDKin_1	236	242	PF00069	0.510
MOD_ProDKin_1	245	251	PF00069	0.441
MOD_ProDKin_1	254	260	PF00069	0.441
MOD_ProDKin_1	306	312	PF00069	0.527
MOD_SUMO_for_1	187	190	PF00179	0.414
MOD_SUMO_rev_2	184	194	PF00179	0.402
TRG_AP2beta_CARGO_1	316	326	PF09066	0.419
TRG_DiLeu_BaEn_1	190	195	PF01217	0.440
TRG_DiLeu_BaEn_1	350	355	PF01217	0.462
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.293
TRG_ENDOCYTIC_2	160	163	PF00928	0.414
TRG_ENDOCYTIC_2	305	308	PF00928	0.452
TRG_ER_diArg_1	12	14	PF00400	0.496
TRG_ER_diArg_1	198	200	PF00400	0.293
TRG_ER_diArg_1	70	72	PF00400	0.188
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P4	Leptomonas seymouri	78%	100%
A0A0S4J813	Bodo saltans	45%	80%
A0A1X0NQV4	Trypanosomatidae	54%	100%
A0A3R7RHL4	Trypanosoma rangeli	53%	100%
A0A3S5H7J7	Leishmania donovani	88%	99%
A4I3T5	Leishmania infantum	89%	99%
D0A873	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B027	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q859	Leishmania major	88%	100%
Q970S6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
V5BC26	Trypanosoma cruzi	55%	99%