Amastin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIT0_LEIBR

TriTrypDb:

LbrM.28.1550 , LBRM2903_280021500

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AIT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.524
CLV_NRD_NRD_1	193	195	PF00675	0.591
CLV_NRD_NRD_1	197	199	PF00675	0.616
CLV_NRD_NRD_1	234	236	PF00675	0.453
CLV_NRD_NRD_1	284	286	PF00675	0.442
CLV_NRD_NRD_1	413	415	PF00675	0.522
CLV_PCSK_KEX2_1	151	153	PF00082	0.621
CLV_PCSK_KEX2_1	197	199	PF00082	0.549
CLV_PCSK_KEX2_1	233	235	PF00082	0.492
CLV_PCSK_KEX2_1	284	286	PF00082	0.442
CLV_PCSK_KEX2_1	340	342	PF00082	0.482
CLV_PCSK_KEX2_1	413	415	PF00082	0.569
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.621
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.492
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.482
CLV_PCSK_PC7_1	230	236	PF00082	0.457
CLV_PCSK_SKI1_1	152	156	PF00082	0.649
CLV_PCSK_SKI1_1	49	53	PF00082	0.472
CLV_PCSK_SKI1_1	8	12	PF00082	0.496
DEG_SCF_FBW7_1	103	110	PF00400	0.837
DEG_SPOP_SBC_1	145	149	PF00917	0.670
DOC_CKS1_1	115	120	PF01111	0.732
DOC_CKS1_1	161	166	PF01111	0.670
DOC_CKS1_1	267	272	PF01111	0.817
DOC_MAPK_gen_1	230	240	PF00069	0.655
DOC_PP2B_LxvP_1	524	527	PF13499	0.290
DOC_PP2B_PxIxI_1	526	532	PF00149	0.414
DOC_PP4_MxPP_1	344	347	PF00568	0.564
DOC_USP7_MATH_1	145	149	PF00917	0.691
DOC_USP7_MATH_1	150	154	PF00917	0.724
DOC_USP7_MATH_1	55	59	PF00917	0.691
DOC_USP7_MATH_1	99	103	PF00917	0.832
DOC_WW_Pin1_4	103	108	PF00397	0.835
DOC_WW_Pin1_4	114	119	PF00397	0.771
DOC_WW_Pin1_4	126	131	PF00397	0.698
DOC_WW_Pin1_4	146	151	PF00397	0.614
DOC_WW_Pin1_4	160	165	PF00397	0.768
DOC_WW_Pin1_4	198	203	PF00397	0.720
DOC_WW_Pin1_4	221	226	PF00397	0.759
DOC_WW_Pin1_4	266	271	PF00397	0.685
DOC_WW_Pin1_4	453	458	PF00397	0.460
LIG_14-3-3_CanoR_1	100	106	PF00244	0.832
LIG_14-3-3_CanoR_1	197	202	PF00244	0.720
LIG_14-3-3_CanoR_1	465	474	PF00244	0.438
LIG_14-3-3_CanoR_1	49	55	PF00244	0.650
LIG_Actin_WH2_2	439	456	PF00022	0.369
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_EH1_1	430	438	PF00400	0.513
LIG_FHA_1	313	319	PF00498	0.590
LIG_FHA_1	382	388	PF00498	0.346
LIG_FHA_1	410	416	PF00498	0.383
LIG_FHA_1	433	439	PF00498	0.411
LIG_FHA_1	457	463	PF00498	0.621
LIG_FHA_1	519	525	PF00498	0.347
LIG_FHA_1	526	532	PF00498	0.371
LIG_GBD_Chelix_1	369	377	PF00786	0.261
LIG_GBD_Chelix_1	379	387	PF00786	0.222
LIG_LIR_Apic_2	158	164	PF02991	0.761
LIG_LIR_Apic_2	196	202	PF02991	0.648
LIG_LIR_Apic_2	315	320	PF02991	0.692
LIG_LIR_Gen_1	351	362	PF02991	0.540
LIG_LIR_Gen_1	482	490	PF02991	0.411
LIG_LIR_Gen_1	77	85	PF02991	0.798
LIG_LIR_LC3C_4	374	379	PF02991	0.261
LIG_LIR_LC3C_4	435	438	PF02991	0.261
LIG_LIR_Nem_3	266	271	PF02991	0.734
LIG_LIR_Nem_3	315	319	PF02991	0.674
LIG_LIR_Nem_3	351	357	PF02991	0.531
LIG_LIR_Nem_3	396	400	PF02991	0.346
LIG_LIR_Nem_3	482	486	PF02991	0.384
LIG_LIR_Nem_3	77	82	PF02991	0.801
LIG_MYND_1	320	324	PF01753	0.663
LIG_PDZ_Class_2	530	535	PF00595	0.579
LIG_PTB_Apo_2	320	327	PF02174	0.579
LIG_PTB_Apo_2	488	495	PF02174	0.238
LIG_PTB_Phospho_1	488	494	PF10480	0.238
LIG_Rb_pABgroove_1	5	13	PF01858	0.587
LIG_SH2_CRK	161	165	PF00017	0.757
LIG_SH2_CRK	268	272	PF00017	0.635
LIG_SH2_CRK	494	498	PF00017	0.276
LIG_SH2_NCK_1	161	165	PF00017	0.757
LIG_SH2_NCK_1	199	203	PF00017	0.649
LIG_SH2_NCK_1	268	272	PF00017	0.815
LIG_SH2_PTP2	317	320	PF00017	0.685
LIG_SH2_STAP1	250	254	PF00017	0.655
LIG_SH2_STAT3	250	253	PF00017	0.654
LIG_SH2_STAT3	262	265	PF00017	0.617
LIG_SH2_STAT3	39	42	PF00017	0.645
LIG_SH2_STAT5	268	271	PF00017	0.818
LIG_SH2_STAT5	288	291	PF00017	0.690
LIG_SH2_STAT5	317	320	PF00017	0.685
LIG_SH2_STAT5	353	356	PF00017	0.631
LIG_SH2_STAT5	367	370	PF00017	0.398
LIG_SH2_STAT5	409	412	PF00017	0.398
LIG_SH2_STAT5	439	442	PF00017	0.261
LIG_SH2_STAT5	494	497	PF00017	0.238
LIG_SH3_1	112	118	PF00018	0.664
LIG_SH3_3	112	118	PF00018	0.813
LIG_SH3_3	124	130	PF00018	0.696
LIG_SH3_3	177	183	PF00018	0.735
LIG_SUMO_SIM_anti_2	374	381	PF11976	0.460
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.327
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.513
LIG_SUMO_SIM_par_1	374	381	PF11976	0.371
LIG_SUMO_SIM_par_1	458	464	PF11976	0.508
LIG_SUMO_SIM_par_1	527	532	PF11976	0.510
LIG_Vh1_VBS_1	362	380	PF01044	0.438
LIG_WRC_WIRS_1	14	19	PF05994	0.800
LIG_WRC_WIRS_1	51	56	PF05994	0.652
MOD_CDC14_SPxK_1	149	152	PF00782	0.665
MOD_CDK_SPK_2	103	108	PF00069	0.835
MOD_CDK_SPK_2	146	151	PF00069	0.670
MOD_CDK_SPxK_1	146	152	PF00069	0.700
MOD_CK1_1	15	21	PF00069	0.748
MOD_CK1_1	159	165	PF00069	0.794
MOD_CK1_1	213	219	PF00069	0.706
MOD_CK1_1	256	262	PF00069	0.644
MOD_CK1_1	332	338	PF00069	0.695
MOD_CK1_1	381	387	PF00069	0.411
MOD_CK1_1	407	413	PF00069	0.391
MOD_CK1_1	432	438	PF00069	0.400
MOD_CK1_1	456	462	PF00069	0.540
MOD_CK2_1	13	19	PF00069	0.728
MOD_CK2_1	238	244	PF00069	0.767
MOD_CK2_1	55	61	PF00069	0.682
MOD_Cter_Amidation	208	211	PF01082	0.500
MOD_GlcNHglycan	130	133	PF01048	0.526
MOD_GlcNHglycan	152	155	PF01048	0.550
MOD_GlcNHglycan	158	161	PF01048	0.533
MOD_GlcNHglycan	212	215	PF01048	0.564
MOD_GlcNHglycan	225	228	PF01048	0.495
MOD_GlcNHglycan	39	42	PF01048	0.620
MOD_GlcNHglycan	468	471	PF01048	0.261
MOD_GlcNHglycan	57	60	PF01048	0.577
MOD_GlcNHglycan	76	79	PF01048	0.491
MOD_GlcNHglycan	86	89	PF01048	0.475
MOD_GSK3_1	140	147	PF00069	0.700
MOD_GSK3_1	156	163	PF00069	0.712
MOD_GSK3_1	249	256	PF00069	0.792
MOD_GSK3_1	378	385	PF00069	0.411
MOD_GSK3_1	403	410	PF00069	0.332
MOD_GSK3_1	49	56	PF00069	0.732
MOD_GSK3_1	61	68	PF00069	0.734
MOD_GSK3_1	99	106	PF00069	0.765
MOD_LATS_1	208	214	PF00433	0.657
MOD_N-GLC_1	156	161	PF02516	0.568
MOD_N-GLC_1	508	513	PF02516	0.546
MOD_N-GLC_2	392	394	PF02516	0.480
MOD_N-GLC_2	402	404	PF02516	0.494
MOD_N-GLC_2	493	495	PF02516	0.438
MOD_NEK2_1	371	376	PF00069	0.364
MOD_NEK2_1	466	471	PF00069	0.261
MOD_NEK2_1	508	513	PF00069	0.389
MOD_NEK2_1	54	59	PF00069	0.767
MOD_NEK2_2	189	194	PF00069	0.664
MOD_PIKK_1	140	146	PF00454	0.665
MOD_PIKK_1	249	255	PF00454	0.655
MOD_PIKK_1	382	388	PF00454	0.346
MOD_PKA_1	197	203	PF00069	0.672
MOD_PKA_1	210	216	PF00069	0.680
MOD_PKA_2	197	203	PF00069	0.721
MOD_PKA_2	248	254	PF00069	0.679
MOD_PKA_2	332	338	PF00069	0.611
MOD_PKA_2	99	105	PF00069	0.832
MOD_Plk_1	12	18	PF00069	0.792
MOD_Plk_1	156	162	PF00069	0.659
MOD_Plk_1	404	410	PF00069	0.414
MOD_Plk_1	508	514	PF00069	0.387
MOD_Plk_2-3	13	19	PF00069	0.725
MOD_Plk_2-3	20	26	PF00069	0.740
MOD_Plk_2-3	61	67	PF00069	0.652
MOD_Plk_4	312	318	PF00069	0.702
MOD_Plk_4	371	377	PF00069	0.261
MOD_Plk_4	378	384	PF00069	0.420
MOD_Plk_4	393	399	PF00069	0.290
MOD_Plk_4	472	478	PF00069	0.290
MOD_Plk_4	509	515	PF00069	0.472
MOD_Plk_4	518	524	PF00069	0.401
MOD_Plk_4	93	99	PF00069	0.826
MOD_ProDKin_1	103	109	PF00069	0.837
MOD_ProDKin_1	114	120	PF00069	0.771
MOD_ProDKin_1	126	132	PF00069	0.698
MOD_ProDKin_1	146	152	PF00069	0.616
MOD_ProDKin_1	160	166	PF00069	0.767
MOD_ProDKin_1	198	204	PF00069	0.719
MOD_ProDKin_1	221	227	PF00069	0.759
MOD_ProDKin_1	266	272	PF00069	0.682
MOD_ProDKin_1	453	459	PF00069	0.460
MOD_SUMO_rev_2	18	28	PF00179	0.632
TRG_ENDOCYTIC_2	268	271	PF00928	0.659
TRG_ENDOCYTIC_2	316	319	PF00928	0.670
TRG_ENDOCYTIC_2	356	359	PF00928	0.625
TRG_ENDOCYTIC_2	367	370	PF00928	0.411
TRG_ENDOCYTIC_2	494	497	PF00928	0.238
TRG_ER_diArg_1	197	199	PF00400	0.765
TRG_ER_diArg_1	283	285	PF00400	0.693
TRG_ER_diArg_1	413	415	PF00400	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU6	Leptomonas seymouri	39%	100%
A0A3S7X1I0	Leishmania donovani	60%	99%
A4I3L9	Leishmania infantum	60%	99%
E9AZV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
Q4Q8C6	Leishmania major	57%	100%