Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIS9_LEIBR

TriTrypDb:

LbrM.28.0020 , LBRM2903_280005400

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.465
CLV_C14_Caspase3-7	284	288	PF00656	0.455
CLV_C14_Caspase3-7	41	45	PF00656	0.374
CLV_NRD_NRD_1	1	3	PF00675	0.690
CLV_NRD_NRD_1	105	107	PF00675	0.323
CLV_NRD_NRD_1	14	16	PF00675	0.489
CLV_NRD_NRD_1	141	143	PF00675	0.473
CLV_NRD_NRD_1	261	263	PF00675	0.374
CLV_NRD_NRD_1	293	295	PF00675	0.499
CLV_NRD_NRD_1	376	378	PF00675	0.339
CLV_NRD_NRD_1	512	514	PF00675	0.602
CLV_NRD_NRD_1	545	547	PF00675	0.561
CLV_PCSK_KEX2_1	105	107	PF00082	0.323
CLV_PCSK_KEX2_1	14	16	PF00082	0.473
CLV_PCSK_KEX2_1	141	143	PF00082	0.345
CLV_PCSK_KEX2_1	211	213	PF00082	0.243
CLV_PCSK_KEX2_1	376	378	PF00082	0.339
CLV_PCSK_KEX2_1	51	53	PF00082	0.480
CLV_PCSK_KEX2_1	544	546	PF00082	0.619
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.243
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.480
CLV_PCSK_PC7_1	10	16	PF00082	0.531
CLV_PCSK_PC7_1	101	107	PF00082	0.315
CLV_PCSK_PC7_1	540	546	PF00082	0.523
CLV_PCSK_SKI1_1	15	19	PF00082	0.388
CLV_PCSK_SKI1_1	181	185	PF00082	0.498
CLV_PCSK_SKI1_1	212	216	PF00082	0.256
CLV_PCSK_SKI1_1	3	7	PF00082	0.620
CLV_PCSK_SKI1_1	457	461	PF00082	0.528
CLV_PCSK_SKI1_1	497	501	PF00082	0.375
CLV_PCSK_SKI1_1	540	544	PF00082	0.462
CLV_PCSK_SKI1_1	96	100	PF00082	0.467
DEG_APCC_DBOX_1	28	36	PF00400	0.374
DEG_Nend_UBRbox_1	1	4	PF02207	0.558
DOC_CYCLIN_RxL_1	10	22	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.432
DOC_MAPK_gen_1	211	217	PF00069	0.281
DOC_MAPK_gen_1	267	276	PF00069	0.391
DOC_MAPK_gen_1	294	303	PF00069	0.349
DOC_MAPK_gen_1	373	381	PF00069	0.350
DOC_MAPK_gen_1	411	419	PF00069	0.345
DOC_MAPK_gen_1	445	453	PF00069	0.632
DOC_MAPK_gen_1	457	465	PF00069	0.505
DOC_MAPK_MEF2A_6	201	210	PF00069	0.409
DOC_MIT_MIM_1	371	381	PF04212	0.266
DOC_PP2B_LxvP_1	190	193	PF13499	0.462
DOC_PP4_FxxP_1	217	220	PF00568	0.345
DOC_PP4_FxxP_1	398	401	PF00568	0.453
DOC_PP4_FxxP_1	55	58	PF00568	0.293
DOC_SPAK_OSR1_1	377	381	PF12202	0.471
DOC_USP7_UBL2_3	445	449	PF12436	0.559
DOC_WW_Pin1_4	265	270	PF00397	0.573
DOC_WW_Pin1_4	535	540	PF00397	0.427
LIG_14-3-3_CanoR_1	14	20	PF00244	0.494
LIG_14-3-3_CanoR_1	169	175	PF00244	0.411
LIG_14-3-3_CanoR_1	447	452	PF00244	0.554
LIG_14-3-3_CterR_2	544	548	PF00244	0.557
LIG_Actin_RPEL_3	70	89	PF02755	0.371
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.354
LIG_FHA_1	155	161	PF00498	0.449
LIG_FHA_1	394	400	PF00498	0.535
LIG_FHA_1	421	427	PF00498	0.451
LIG_FHA_1	448	454	PF00498	0.428
LIG_FHA_1	83	89	PF00498	0.488
LIG_FHA_2	108	114	PF00498	0.462
LIG_GBD_Chelix_1	492	500	PF00786	0.438
LIG_LIR_Apic_2	382	387	PF02991	0.262
LIG_LIR_Apic_2	396	401	PF02991	0.377
LIG_LIR_Gen_1	107	117	PF02991	0.243
LIG_LIR_Gen_1	163	171	PF02991	0.298
LIG_LIR_Gen_1	333	344	PF02991	0.473
LIG_LIR_Gen_1	44	55	PF02991	0.339
LIG_LIR_LC3C_4	299	302	PF02991	0.335
LIG_LIR_Nem_3	107	111	PF02991	0.317
LIG_LIR_Nem_3	148	153	PF02991	0.338
LIG_LIR_Nem_3	163	167	PF02991	0.292
LIG_LIR_Nem_3	170	174	PF02991	0.323
LIG_LIR_Nem_3	280	285	PF02991	0.571
LIG_LIR_Nem_3	333	339	PF02991	0.459
LIG_LIR_Nem_3	44	50	PF02991	0.334
LIG_LIR_Nem_3	469	473	PF02991	0.478
LIG_LIR_Nem_3	501	507	PF02991	0.585
LIG_LIR_Nem_3	78	83	PF02991	0.361
LIG_LYPXL_yS_3	504	507	PF13949	0.569
LIG_LYPXL_yS_3	80	83	PF13949	0.370
LIG_Pex14_1	213	217	PF04695	0.332
LIG_PTB_Apo_2	124	131	PF02174	0.329
LIG_PTB_Apo_2	270	277	PF02174	0.434
LIG_SH2_CRK	194	198	PF00017	0.484
LIG_SH2_CRK	298	302	PF00017	0.342
LIG_SH2_CRK	384	388	PF00017	0.355
LIG_SH2_CRK	47	51	PF00017	0.453
LIG_SH2_NCK_1	384	388	PF00017	0.483
LIG_SH2_PTP2	164	167	PF00017	0.436
LIG_SH2_STAP1	298	302	PF00017	0.342
LIG_SH2_STAP1	370	374	PF00017	0.397
LIG_SH2_STAT5	129	132	PF00017	0.369
LIG_SH2_STAT5	146	149	PF00017	0.258
LIG_SH2_STAT5	150	153	PF00017	0.314
LIG_SH2_STAT5	164	167	PF00017	0.210
LIG_SH2_STAT5	34	37	PF00017	0.321
LIG_SH2_STAT5	92	95	PF00017	0.480
LIG_SH3_3	179	185	PF00018	0.365
LIG_SH3_3	299	305	PF00018	0.228
LIG_SH3_3	317	323	PF00018	0.404
LIG_SH3_3	359	365	PF00018	0.383
LIG_SH3_3	499	505	PF00018	0.443
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.446
LIG_SUMO_SIM_par_1	3	8	PF11976	0.458
LIG_TRAF2_1	305	308	PF00917	0.467
LIG_UBA3_1	207	211	PF00899	0.447
LIG_WRC_WIRS_1	168	173	PF05994	0.318
MOD_CDK_SPK_2	265	270	PF00069	0.455
MOD_CDK_SPK_2	535	540	PF00069	0.427
MOD_CK1_1	170	176	PF00069	0.462
MOD_CK1_1	200	206	PF00069	0.412
MOD_CK1_1	272	278	PF00069	0.576
MOD_CK1_1	42	48	PF00069	0.393
MOD_CK2_1	169	175	PF00069	0.389
MOD_CK2_1	535	541	PF00069	0.487
MOD_GlcNHglycan	10	13	PF01048	0.548
MOD_GlcNHglycan	232	235	PF01048	0.342
MOD_GlcNHglycan	26	29	PF01048	0.468
MOD_GlcNHglycan	310	313	PF01048	0.453
MOD_GlcNHglycan	390	393	PF01048	0.570
MOD_GSK3_1	265	272	PF00069	0.480
MOD_N-GLC_1	119	124	PF02516	0.340
MOD_N-GLC_1	272	277	PF02516	0.435
MOD_NEK2_1	119	124	PF00069	0.337
MOD_NEK2_1	167	172	PF00069	0.325
MOD_NEK2_1	351	356	PF00069	0.343
MOD_NEK2_1	526	531	PF00069	0.481
MOD_PIKK_1	133	139	PF00454	0.327
MOD_PIKK_1	200	206	PF00454	0.501
MOD_PIKK_1	322	328	PF00454	0.342
MOD_PIKK_1	82	88	PF00454	0.347
MOD_PK_1	422	428	PF00069	0.462
MOD_PKA_2	388	394	PF00069	0.546
MOD_Plk_1	119	125	PF00069	0.333
MOD_Plk_1	154	160	PF00069	0.322
MOD_Plk_1	21	27	PF00069	0.449
MOD_Plk_1	272	278	PF00069	0.437
MOD_Plk_2-3	107	113	PF00069	0.467
MOD_Plk_4	42	48	PF00069	0.337
MOD_Plk_4	87	93	PF00069	0.249
MOD_ProDKin_1	265	271	PF00069	0.564
MOD_ProDKin_1	535	541	PF00069	0.427
MOD_SUMO_rev_2	369	374	PF00179	0.369
TRG_DiLeu_BaEn_1	155	160	PF01217	0.333
TRG_DiLeu_BaEn_1	163	168	PF01217	0.271
TRG_DiLeu_BaEn_1	205	210	PF01217	0.442
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.518
TRG_ENDOCYTIC_2	150	153	PF00928	0.329
TRG_ENDOCYTIC_2	164	167	PF00928	0.267
TRG_ENDOCYTIC_2	194	197	PF00928	0.483
TRG_ENDOCYTIC_2	298	301	PF00928	0.346
TRG_ENDOCYTIC_2	34	37	PF00928	0.311
TRG_ENDOCYTIC_2	47	50	PF00928	0.309
TRG_ENDOCYTIC_2	504	507	PF00928	0.569
TRG_ENDOCYTIC_2	80	83	PF00928	0.370
TRG_ER_diArg_1	104	106	PF00400	0.308
TRG_ER_diArg_1	14	16	PF00400	0.532
TRG_ER_diArg_1	140	142	PF00400	0.486
TRG_ER_diArg_1	253	256	PF00400	0.515
TRG_ER_diArg_1	376	378	PF00400	0.339
TRG_ER_diArg_1	394	397	PF00400	0.364
TRG_ER_diArg_1	543	546	PF00400	0.543
TRG_NLS_MonoExtC_3	293	299	PF00514	0.535
TRG_NLS_MonoExtC_3	410	416	PF00514	0.458
TRG_NLS_MonoExtN_4	293	298	PF00514	0.397
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B7	Leptomonas seymouri	73%	100%
A0A0S4IYT6	Bodo saltans	49%	90%
A0A1X0NV91	Trypanosomatidae	56%	99%
A0A3Q8IEE9	Leishmania donovani	85%	100%
A0A422NKU0	Trypanosoma rangeli	54%	99%
A4I374	Leishmania infantum	85%	100%
D0A7Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AZG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8R9	Leishmania major	85%	100%
V5AS03	Trypanosoma cruzi	53%	99%