Golgi apparatus membrane protein TVP23 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF846), putative

Species:

Leishmania braziliensis

UniProt:

E9AIS7_LEIBR

TriTrypDb:

LbrM.27.2050 , LBRM2903_270027000

Length:

239

Annotations

LeishMANIAdb annotations

Homologous to Golgi proteins of other Eukaryotes

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AIS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009306	protein secretion	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032940	secretion by cell	3	1
GO:0033036	macromolecule localization	2	1
GO:0035592	establishment of protein localization to extracellular region	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071692	protein localization to extracellular region	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.366
CLV_PCSK_KEX2_1	196	198	PF00082	0.335
CLV_PCSK_SKI1_1	106	110	PF00082	0.114
CLV_PCSK_SKI1_1	86	90	PF00082	0.308
DOC_MAPK_MEF2A_6	70	78	PF00069	0.352
DOC_MAPK_MEF2A_6	86	95	PF00069	0.371
DOC_MAPK_NFAT4_5	86	94	PF00069	0.308
DOC_WW_Pin1_4	32	37	PF00397	0.690
LIG_14-3-3_CanoR_1	111	117	PF00244	0.416
LIG_Actin_WH2_2	71	88	PF00022	0.308
LIG_BRCT_BRCA1_1	79	83	PF00533	0.442
LIG_deltaCOP1_diTrp_1	146	151	PF00928	0.428
LIG_EH1_1	68	76	PF00400	0.169
LIG_FHA_1	103	109	PF00498	0.207
LIG_FHA_1	126	132	PF00498	0.458
LIG_FHA_1	20	26	PF00498	0.557
LIG_FHA_1	92	98	PF00498	0.347
LIG_GBD_Chelix_1	71	79	PF00786	0.326
LIG_GBD_Chelix_1	89	97	PF00786	0.371
LIG_LIR_Nem_3	146	152	PF02991	0.408
LIG_LIR_Nem_3	171	175	PF02991	0.220
LIG_NRBOX	178	184	PF00104	0.405
LIG_NRBOX	74	80	PF00104	0.386
LIG_PCNA_yPIPBox_3	194	207	PF02747	0.525
LIG_Pex14_2	189	193	PF04695	0.308
LIG_Pex14_2	65	69	PF04695	0.247
LIG_PTB_Apo_2	144	151	PF02174	0.453
LIG_SH2_GRB2like	145	148	PF00017	0.453
LIG_SH2_PTP2	87	90	PF00017	0.282
LIG_SH2_STAP1	145	149	PF00017	0.498
LIG_SH2_STAT5	10	13	PF00017	0.643
LIG_SH2_STAT5	192	195	PF00017	0.457
LIG_SH2_STAT5	32	35	PF00017	0.714
LIG_SH2_STAT5	87	90	PF00017	0.298
LIG_Sin3_3	180	187	PF02671	0.166
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.320
LIG_SUMO_SIM_par_1	88	94	PF11976	0.324
LIG_TYR_ITIM	85	90	PF00017	0.308
LIG_UBA3_1	78	86	PF00899	0.166
LIG_Vh1_VBS_1	64	82	PF01044	0.308
LIG_WRC_WIRS_1	169	174	PF05994	0.259
LIG_WRC_WIRS_1	203	208	PF05994	0.548
LIG_WRC_WIRS_1	221	226	PF05994	0.588
MOD_CK2_1	131	137	PF00069	0.498
MOD_CMANNOS	148	151	PF00535	0.257
MOD_GlcNHglycan	184	187	PF01048	0.308
MOD_GlcNHglycan	79	82	PF01048	0.442
MOD_GSK3_1	102	109	PF00069	0.239
MOD_GSK3_1	202	209	PF00069	0.579
MOD_GSK3_1	5	12	PF00069	0.580
MOD_N-GLC_1	106	111	PF02516	0.203
MOD_N-GLC_1	231	236	PF02516	0.334
MOD_N-GLC_1	30	35	PF02516	0.533
MOD_NEK2_1	102	107	PF00069	0.308
MOD_NEK2_1	150	155	PF00069	0.289
MOD_NEK2_1	182	187	PF00069	0.291
MOD_NEK2_1	206	211	PF00069	0.541
MOD_NEK2_1	25	30	PF00069	0.720
MOD_NEK2_1	77	82	PF00069	0.228
MOD_NEK2_1	91	96	PF00069	0.260
MOD_PIKK_1	125	131	PF00454	0.453
MOD_PIKK_1	206	212	PF00454	0.573
MOD_Plk_4	202	208	PF00069	0.546
MOD_Plk_4	220	226	PF00069	0.589
MOD_Plk_4	5	11	PF00069	0.540
MOD_ProDKin_1	32	38	PF00069	0.690
TRG_ENDOCYTIC_2	87	90	PF00928	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK7	Leptomonas seymouri	59%	96%
A0A0S4JUW4	Bodo saltans	54%	100%
A0A1X0NSV4	Trypanosomatidae	47%	96%
A0A3R7KD75	Trypanosoma rangeli	57%	98%
A0A3S7X0W9	Leishmania donovani	86%	98%
A1CW41	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	35%	100%
A3LRT4	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	100%
A4I2Z7	Leishmania infantum	86%	98%
A5DRE8	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	100%
A6NH52	Homo sapiens	37%	100%
A6SFL7	Botryotinia fuckeliana (strain B05.10)	37%	100%
B0Y4Q8	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	35%	100%
C9ZJE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADG9	Leishmania major	86%	100%
Q0UV43	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	34%	100%
Q18449	Caenorhabditis elegans	32%	100%
Q4WQJ5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	100%
Q54LC9	Dictyostelium discoideum	36%	92%
Q5APA2	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	90%
Q6C7V5	Yarrowia lipolytica (strain CLIB 122 / E 150)	34%	100%
Q7SGB6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q86I95	Dictyostelium discoideum	41%	100%
Q8IQC1	Drosophila melanogaster	37%	100%
Q8LEK2	Arabidopsis thaliana	38%	100%
Q9Y7K7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%