Putative glutaredoxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin-like protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIS6_LEIBR

TriTrypDb:

LbrM.27.0881 , LBRM2903_270014600

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS6

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034599	cellular response to oxidative stress	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	9
GO:0019153	protein-disulfide reductase (glutathione) activity	4	9
GO:0097573	obsolete glutathione oxidoreductase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0015038	glutathione disulfide oxidoreductase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	93	95	PF00082	0.355
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.355
CLV_PCSK_SKI1_1	29	33	PF00082	0.330
DOC_MAPK_DCC_7	62	71	PF00069	0.248
DOC_MAPK_MEF2A_6	62	71	PF00069	0.248
DOC_PP1_RVXF_1	11	18	PF00149	0.318
DOC_PP2B_PxIxI_1	66	72	PF00149	0.353
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_FHA_1	34	40	PF00498	0.251
LIG_FHA_2	2	8	PF00498	0.516
LIG_PTB_Apo_2	69	76	PF02174	0.353
LIG_SH3_3	17	23	PF00018	0.318
MOD_CK1_1	30	36	PF00069	0.412
MOD_CK2_1	1	7	PF00069	0.550
MOD_CK2_1	77	83	PF00069	0.358
MOD_GlcNHglycan	33	36	PF01048	0.272
MOD_GlcNHglycan	87	90	PF01048	0.534
MOD_GSK3_1	23	30	PF00069	0.295
MOD_NEK2_1	1	6	PF00069	0.403
MOD_PK_1	27	33	PF00069	0.236
MOD_Plk_4	27	33	PF00069	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF5	Leptomonas seymouri	66%	99%
A0A0N1PD78	Leptomonas seymouri	28%	90%
A0A0S4JTJ5	Bodo saltans	24%	77%
A0A0S4JUD4	Bodo saltans	48%	100%
A0A0S4JWT8	Bodo saltans	31%	99%
A0A0S4KNN2	Bodo saltans	32%	100%
A0A1X0NXP8	Trypanosomatidae	31%	90%
A0A3Q8IG95	Leishmania donovani	72%	89%
A0A3S7WVZ7	Leishmania donovani	28%	90%
A0A422NLI8	Trypanosoma rangeli	31%	90%
A4HYU2	Leishmania infantum	28%	90%
B7ZFT1	Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)	36%	95%
C9ZIB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
D0A5S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AD58	Leishmania major	73%	100%
E9AHF3	Leishmania infantum	72%	89%
E9AIF1	Leishmania braziliensis	28%	100%
E9AUN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E9AYY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	88%
O23421	Arabidopsis thaliana	26%	94%
O36032	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	95%
O81187	Vernicia fordii	34%	92%
P0AC62	Escherichia coli (strain K12)	36%	100%
P0AC63	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AC64	Escherichia coli O157:H7	36%	100%
P12309	Sus scrofa	31%	91%
P12864	Oryctolagus cuniculus	34%	91%
P17695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	67%
P25373	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	87%
P35754	Homo sapiens	35%	91%
P55142	Oryza sativa subsp. japonica	33%	86%
P55143	Ricinus communis	34%	94%
P74593	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	88%
Q0DAE4	Oryza sativa subsp. japonica	32%	71%
Q2R075	Oryza sativa subsp. japonica	30%	88%
Q4QCU5	Leishmania major	28%	100%
Q4UKL7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	37%	94%
Q54GP8	Dictyostelium discoideum	31%	96%
Q68XG4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	35%	92%
Q6H628	Oryza sativa subsp. japonica	31%	73%
Q6K953	Oryza sativa subsp. japonica	36%	72%
Q8L8T2	Arabidopsis thaliana	34%	77%
Q8L8Z8	Arabidopsis thaliana	27%	94%
Q8LFQ6	Arabidopsis thaliana	34%	71%
Q92J02	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	37%	94%
Q9ESH6	Rattus norvegicus	32%	90%
Q9FNE2	Arabidopsis thaliana	31%	86%
Q9FVX1	Arabidopsis thaliana	38%	74%
Q9HU55	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	100%
Q9LYC8	Arabidopsis thaliana	28%	94%
Q9QUH0	Mus musculus	33%	90%
Q9SA68	Arabidopsis thaliana	33%	94%
Q9UTI2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	87%
Q9ZDW1	Rickettsia prowazekii (strain Madrid E)	36%	100%
Q9ZR41	Solanum lycopersicum	31%	89%