Autophagy-related protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein APG9, putative

Species:

Leishmania braziliensis

UniProt:

E9AIS5_LEIBR

TriTrypDb:

LbrM.27.0480 , LBRM2903_270010200

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0034045	phagophore assembly site membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0000407	phagophore assembly site	2	1
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

E9AIS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006869	lipid transport	5	12
GO:0006914	autophagy	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0061919	process utilizing autophagic mechanism	2	12
GO:0071702	organic substance transport	4	12
GO:0000422	autophagy of mitochondrion	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0044804	autophagy of nucleus	4	1
GO:0044805	late nucleophagy	5	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1903008	organelle disassembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.476
CLV_C14_Caspase3-7	529	533	PF00656	0.673
CLV_C14_Caspase3-7	667	671	PF00656	0.639
CLV_NRD_NRD_1	163	165	PF00675	0.194
CLV_NRD_NRD_1	371	373	PF00675	0.267
CLV_NRD_NRD_1	613	615	PF00675	0.390
CLV_NRD_NRD_1	653	655	PF00675	0.482
CLV_PCSK_KEX2_1	163	165	PF00082	0.194
CLV_PCSK_KEX2_1	371	373	PF00082	0.253
CLV_PCSK_KEX2_1	567	569	PF00082	0.346
CLV_PCSK_KEX2_1	613	615	PF00082	0.241
CLV_PCSK_KEX2_1	653	655	PF00082	0.482
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.346
CLV_PCSK_SKI1_1	29	33	PF00082	0.295
CLV_PCSK_SKI1_1	653	657	PF00082	0.384
CLV_PCSK_SKI1_1	701	705	PF00082	0.473
CLV_Separin_Metazoa	124	128	PF03568	0.459
DEG_APCC_DBOX_1	639	647	PF00400	0.564
DOC_CDC14_PxL_1	413	421	PF14671	0.403
DOC_CKS1_1	151	156	PF01111	0.434
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.276
DOC_MAPK_gen_1	11	19	PF00069	0.632
DOC_MAPK_gen_1	463	470	PF00069	0.251
DOC_MAPK_gen_1	567	576	PF00069	0.517
DOC_MAPK_gen_1	613	619	PF00069	0.438
DOC_MAPK_MEF2A_6	463	470	PF00069	0.334
DOC_MAPK_MEF2A_6	488	496	PF00069	0.431
DOC_MAPK_MEF2A_6	567	576	PF00069	0.517
DOC_PP2B_LxvP_1	477	480	PF13499	0.258
DOC_PP2B_LxvP_1	94	97	PF13499	0.313
DOC_PP4_FxxP_1	151	154	PF00568	0.513
DOC_PP4_FxxP_1	209	212	PF00568	0.513
DOC_PP4_FxxP_1	386	389	PF00568	0.337
DOC_USP7_MATH_1	513	517	PF00917	0.512
DOC_USP7_MATH_1	548	552	PF00917	0.706
DOC_USP7_MATH_1	645	649	PF00917	0.707
DOC_USP7_MATH_2	528	534	PF00917	0.619
DOC_USP7_UBL2_3	303	307	PF12436	0.275
DOC_USP7_UBL2_3	567	571	PF12436	0.535
DOC_WW_Pin1_4	150	155	PF00397	0.410
DOC_WW_Pin1_4	247	252	PF00397	0.454
DOC_WW_Pin1_4	596	601	PF00397	0.691
DOC_WW_Pin1_4	626	631	PF00397	0.579
LIG_14-3-3_CanoR_1	101	105	PF00244	0.297
LIG_14-3-3_CanoR_1	14	18	PF00244	0.630
LIG_14-3-3_CanoR_1	157	161	PF00244	0.397
LIG_14-3-3_CanoR_1	279	283	PF00244	0.513
LIG_14-3-3_CanoR_1	29	38	PF00244	0.534
LIG_14-3-3_CanoR_1	322	332	PF00244	0.242
LIG_14-3-3_CanoR_1	361	370	PF00244	0.313
LIG_14-3-3_CanoR_1	372	380	PF00244	0.276
LIG_14-3-3_CanoR_1	6	10	PF00244	0.665
LIG_Actin_WH2_2	2	20	PF00022	0.623
LIG_Actin_WH2_2	575	591	PF00022	0.588
LIG_Actin_WH2_2	690	707	PF00022	0.454
LIG_APCC_ABBA_1	332	337	PF00400	0.210
LIG_APCC_ABBAyCdc20_2	331	337	PF00400	0.313
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BRCT_BRCA1_1	205	209	PF00533	0.516
LIG_CaM_NSCaTE_8	45	52	PF13499	0.357
LIG_Clathr_ClatBox_1	225	229	PF01394	0.513
LIG_deltaCOP1_diTrp_1	327	332	PF00928	0.265
LIG_eIF4E_1	289	295	PF01652	0.363
LIG_FHA_1	129	135	PF00498	0.396
LIG_FHA_1	147	153	PF00498	0.367
LIG_FHA_1	180	186	PF00498	0.447
LIG_FHA_1	253	259	PF00498	0.434
LIG_FHA_1	278	284	PF00498	0.494
LIG_FHA_1	30	36	PF00498	0.497
LIG_FHA_1	374	380	PF00498	0.272
LIG_FHA_1	405	411	PF00498	0.313
LIG_FHA_1	56	62	PF00498	0.363
LIG_FHA_1	623	629	PF00498	0.700
LIG_FHA_1	671	677	PF00498	0.701
LIG_FHA_2	428	434	PF00498	0.254
LIG_FHA_2	502	508	PF00498	0.513
LIG_FHA_2	593	599	PF00498	0.718
LIG_FHA_2	600	606	PF00498	0.679
LIG_FHA_2	655	661	PF00498	0.761
LIG_FHA_2	683	689	PF00498	0.603
LIG_HP1_1	480	484	PF01393	0.170
LIG_IRF3_LxIS_1	387	394	PF10401	0.241
LIG_LIR_Apic_2	148	154	PF02991	0.420
LIG_LIR_Apic_2	206	212	PF02991	0.513
LIG_LIR_Apic_2	385	389	PF02991	0.337
LIG_LIR_Gen_1	120	129	PF02991	0.227
LIG_LIR_Gen_1	259	268	PF02991	0.442
LIG_LIR_Gen_1	423	432	PF02991	0.263
LIG_LIR_Gen_1	451	462	PF02991	0.212
LIG_LIR_Gen_1	578	583	PF02991	0.470
LIG_LIR_Gen_1	58	67	PF02991	0.430
LIG_LIR_Nem_3	102	108	PF02991	0.276
LIG_LIR_Nem_3	130	136	PF02991	0.445
LIG_LIR_Nem_3	173	177	PF02991	0.528
LIG_LIR_Nem_3	187	193	PF02991	0.406
LIG_LIR_Nem_3	259	265	PF02991	0.429
LIG_LIR_Nem_3	401	406	PF02991	0.262
LIG_LIR_Nem_3	451	457	PF02991	0.234
LIG_LIR_Nem_3	578	582	PF02991	0.471
LIG_LIR_Nem_3	58	62	PF02991	0.424
LIG_MYND_1	417	421	PF01753	0.157
LIG_Pex14_2	100	104	PF04695	0.254
LIG_Pex14_2	15	19	PF04695	0.606
LIG_Pex14_2	293	297	PF04695	0.282
LIG_Pex14_2	55	59	PF04695	0.357
LIG_Pex14_2	68	72	PF04695	0.213
LIG_Rb_pABgroove_1	256	264	PF01858	0.410
LIG_REV1ctd_RIR_1	459	469	PF16727	0.313
LIG_SH2_CRK	413	417	PF00017	0.306
LIG_SH2_CRK	441	445	PF00017	0.275
LIG_SH2_NCK_1	335	339	PF00017	0.220
LIG_SH2_NCK_1	413	417	PF00017	0.414
LIG_SH2_NCK_1	441	445	PF00017	0.360
LIG_SH2_NCK_1	454	458	PF00017	0.267
LIG_SH2_PTP2	248	251	PF00017	0.454
LIG_SH2_PTP2	299	302	PF00017	0.389
LIG_SH2_SRC	231	234	PF00017	0.484
LIG_SH2_SRC	454	457	PF00017	0.254
LIG_SH2_STAP1	36	40	PF00017	0.471
LIG_SH2_STAT3	132	135	PF00017	0.513
LIG_SH2_STAT5	133	136	PF00017	0.465
LIG_SH2_STAT5	231	234	PF00017	0.410
LIG_SH2_STAT5	248	251	PF00017	0.451
LIG_SH2_STAT5	299	302	PF00017	0.322
LIG_SH2_STAT5	316	319	PF00017	0.213
LIG_SH2_STAT5	36	39	PF00017	0.473
LIG_SH2_STAT5	98	101	PF00017	0.313
LIG_SH3_2	215	220	PF14604	0.513
LIG_SH3_3	209	215	PF00018	0.513
LIG_SH3_3	7	13	PF00018	0.592
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.302
LIG_SUMO_SIM_anti_2	491	497	PF11976	0.397
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.446
LIG_SUMO_SIM_par_1	181	187	PF11976	0.357
LIG_SUMO_SIM_par_1	231	237	PF11976	0.513
LIG_TRAF2_1	527	530	PF00917	0.614
LIG_TYR_ITIM	314	319	PF00017	0.389
LIG_UBA3_1	301	307	PF00899	0.189
LIG_Vh1_VBS_1	111	129	PF01044	0.170
LIG_WRC_WIRS_1	383	388	PF05994	0.277
LIG_WRC_WIRS_1	56	61	PF05994	0.305
LIG_WRC_WIRS_1	576	581	PF05994	0.291
MOD_CDK_SPxxK_3	150	157	PF00069	0.258
MOD_CDK_SPxxK_3	596	603	PF00069	0.461
MOD_CK1_1	252	258	PF00069	0.277
MOD_CK1_1	516	522	PF00069	0.421
MOD_CK1_1	540	546	PF00069	0.718
MOD_CK1_1	575	581	PF00069	0.293
MOD_CK1_1	584	590	PF00069	0.414
MOD_CK1_1	599	605	PF00069	0.664
MOD_CK1_1	629	635	PF00069	0.677
MOD_CK1_1	639	645	PF00069	0.653
MOD_CK1_1	648	654	PF00069	0.674
MOD_CK1_1	695	701	PF00069	0.484
MOD_CK2_1	167	173	PF00069	0.277
MOD_CK2_1	427	433	PF00069	0.434
MOD_CK2_1	592	598	PF00069	0.571
MOD_CK2_1	654	660	PF00069	0.614
MOD_CK2_1	682	688	PF00069	0.534
MOD_CK2_1	76	82	PF00069	0.386
MOD_GlcNHglycan	169	172	PF01048	0.286
MOD_GlcNHglycan	203	206	PF01048	0.389
MOD_GlcNHglycan	21	24	PF01048	0.451
MOD_GlcNHglycan	364	367	PF01048	0.365
MOD_GlcNHglycan	393	396	PF01048	0.181
MOD_GlcNHglycan	448	451	PF01048	0.244
MOD_GlcNHglycan	50	53	PF01048	0.389
MOD_GlcNHglycan	539	542	PF01048	0.707
MOD_GlcNHglycan	549	553	PF01048	0.447
MOD_GlcNHglycan	631	634	PF01048	0.636
MOD_GlcNHglycan	672	676	PF01048	0.629
MOD_GSK3_1	113	120	PF00069	0.344
MOD_GSK3_1	146	153	PF00069	0.318
MOD_GSK3_1	179	186	PF00069	0.234
MOD_GSK3_1	360	367	PF00069	0.389
MOD_GSK3_1	378	385	PF00069	0.262
MOD_GSK3_1	536	543	PF00069	0.633
MOD_GSK3_1	592	599	PF00069	0.611
MOD_GSK3_1	622	629	PF00069	0.603
MOD_GSK3_1	655	662	PF00069	0.651
MOD_N-GLC_1	530	535	PF02516	0.664
MOD_N-GLC_1	536	541	PF02516	0.693
MOD_N-GLC_2	375	377	PF02516	0.170
MOD_NEK2_1	100	105	PF00069	0.302
MOD_NEK2_1	113	118	PF00069	0.186
MOD_NEK2_1	128	133	PF00069	0.255
MOD_NEK2_1	19	24	PF00069	0.526
MOD_NEK2_1	193	198	PF00069	0.356
MOD_NEK2_1	241	246	PF00069	0.365
MOD_NEK2_1	257	262	PF00069	0.201
MOD_NEK2_1	31	36	PF00069	0.312
MOD_NEK2_1	317	322	PF00069	0.327
MOD_NEK2_1	360	365	PF00069	0.451
MOD_NEK2_1	391	396	PF00069	0.273
MOD_NEK2_1	406	411	PF00069	0.217
MOD_NEK2_1	473	478	PF00069	0.340
MOD_NEK2_1	5	10	PF00069	0.534
MOD_NEK2_1	500	505	PF00069	0.357
MOD_NEK2_1	55	60	PF00069	0.272
MOD_NEK2_1	692	697	PF00069	0.354
MOD_NEK2_1	704	709	PF00069	0.412
MOD_NEK2_2	13	18	PF00069	0.416
MOD_NEK2_2	398	403	PF00069	0.170
MOD_NEK2_2	645	650	PF00069	0.743
MOD_PIKK_1	29	35	PF00454	0.305
MOD_PIKK_1	317	323	PF00454	0.412
MOD_PIKK_1	581	587	PF00454	0.322
MOD_PIKK_1	622	628	PF00454	0.456
MOD_PIKK_1	692	698	PF00454	0.443
MOD_PK_1	203	209	PF00069	0.389
MOD_PK_1	488	494	PF00069	0.254
MOD_PK_1	613	619	PF00069	0.284
MOD_PKA_1	613	619	PF00069	0.284
MOD_PKA_1	653	659	PF00069	0.488
MOD_PKA_2	100	106	PF00069	0.383
MOD_PKA_2	13	19	PF00069	0.554
MOD_PKA_2	156	162	PF00069	0.329
MOD_PKA_2	278	284	PF00069	0.389
MOD_PKA_2	360	366	PF00069	0.397
MOD_PKA_2	5	11	PF00069	0.599
MOD_PKA_2	613	619	PF00069	0.548
MOD_PKA_2	639	645	PF00069	0.683
MOD_PKA_2	653	659	PF00069	0.648
MOD_PKA_2	704	710	PF00069	0.601
MOD_PKA_2	716	722	PF00069	0.672
MOD_Plk_1	516	522	PF00069	0.533
MOD_Plk_1	572	578	PF00069	0.464
MOD_Plk_1	634	640	PF00069	0.576
MOD_Plk_4	100	106	PF00069	0.307
MOD_Plk_4	128	134	PF00069	0.371
MOD_Plk_4	249	255	PF00069	0.327
MOD_Plk_4	257	263	PF00069	0.283
MOD_Plk_4	278	284	PF00069	0.293
MOD_Plk_4	31	37	PF00069	0.376
MOD_Plk_4	382	388	PF00069	0.310
MOD_Plk_4	398	404	PF00069	0.277
MOD_Plk_4	406	412	PF00069	0.313
MOD_Plk_4	457	463	PF00069	0.329
MOD_Plk_4	5	11	PF00069	0.614
MOD_Plk_4	501	507	PF00069	0.334
MOD_Plk_4	55	61	PF00069	0.265
MOD_Plk_4	550	556	PF00069	0.697
MOD_Plk_4	695	701	PF00069	0.393
MOD_ProDKin_1	150	156	PF00069	0.244
MOD_ProDKin_1	247	253	PF00069	0.305
MOD_ProDKin_1	596	602	PF00069	0.629
MOD_ProDKin_1	626	632	PF00069	0.481
TRG_DiLeu_BaEn_2	123	129	PF01217	0.258
TRG_ENDOCYTIC_2	123	126	PF00928	0.203
TRG_ENDOCYTIC_2	299	302	PF00928	0.265
TRG_ENDOCYTIC_2	316	319	PF00928	0.225
TRG_ENDOCYTIC_2	335	338	PF00928	0.140
TRG_ENDOCYTIC_2	413	416	PF00928	0.306
TRG_ENDOCYTIC_2	426	429	PF00928	0.299
TRG_ENDOCYTIC_2	454	457	PF00928	0.290
TRG_ER_diArg_1	162	164	PF00400	0.185
TRG_ER_diArg_1	359	362	PF00400	0.293
TRG_ER_diArg_1	370	372	PF00400	0.217
TRG_ER_diArg_1	465	468	PF00400	0.400
TRG_ER_diArg_1	612	614	PF00400	0.506
TRG_ER_diArg_1	617	620	PF00400	0.519
TRG_ER_diArg_1	653	655	PF00400	0.625
TRG_NES_CRM1_1	217	229	PF08389	0.258
TRG_Pf-PMV_PEXEL_1	467	472	PF00026	0.170

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S4	Leptomonas seymouri	65%	100%
A0A0S4JRE4	Bodo saltans	28%	92%
A0A1X0P5B9	Trypanosomatidae	35%	100%
A0A3S5H7H3	Leishmania donovani	83%	99%
A0A422NTE4	Trypanosoma rangeli	35%	100%
D0A5N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AD16	Leishmania major	81%	100%
E9AHC0	Leishmania infantum	83%	99%
E9AYU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
P0CM40	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	20%	83%
P0CM41	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	20%	83%
Q8RUS5	Arabidopsis thaliana	21%	84%
V5B7I2	Trypanosoma cruzi	34%	100%