Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIS4_LEIBR

TriTrypDb:

LbrM.27.0150 , LBRM2903_270006700

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.585
CLV_NRD_NRD_1	59	61	PF00675	0.391
CLV_NRD_NRD_1	96	98	PF00675	0.619
CLV_PCSK_KEX2_1	58	60	PF00082	0.405
CLV_PCSK_KEX2_1	96	98	PF00082	0.626
CLV_PCSK_SKI1_1	17	21	PF00082	0.633
CLV_PCSK_SKI1_1	170	174	PF00082	0.618
CLV_PCSK_SKI1_1	205	209	PF00082	0.600
DOC_USP7_MATH_1	141	145	PF00917	0.574
DOC_USP7_MATH_1	147	151	PF00917	0.577
DOC_USP7_MATH_1	39	43	PF00917	0.529
DOC_USP7_MATH_1	48	52	PF00917	0.706
DOC_USP7_MATH_1	80	84	PF00917	0.556
DOC_WW_Pin1_4	19	24	PF00397	0.566
LIG_14-3-3_CanoR_1	134	138	PF00244	0.729
LIG_14-3-3_CanoR_1	17	23	PF00244	0.632
LIG_14-3-3_CanoR_1	37	47	PF00244	0.481
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BIR_III_4	140	144	PF00653	0.673
LIG_FHA_1	146	152	PF00498	0.528
LIG_FHA_1	30	36	PF00498	0.572
LIG_FHA_2	113	119	PF00498	0.510
LIG_FHA_2	155	161	PF00498	0.482
LIG_FHA_2	180	186	PF00498	0.607
LIG_LIR_Nem_3	110	116	PF02991	0.611
LIG_SH2_CRK	113	117	PF00017	0.651
LIG_SH2_STAT5	226	229	PF00017	0.560
LIG_SH2_STAT5	240	243	PF00017	0.541
LIG_SH3_3	100	106	PF00018	0.585
LIG_WRC_WIRS_1	188	193	PF05994	0.615
MOD_CK1_1	18	24	PF00069	0.604
MOD_CK1_1	187	193	PF00069	0.646
MOD_CK1_1	29	35	PF00069	0.678
MOD_CK1_1	38	44	PF00069	0.567
MOD_CK1_1	51	57	PF00069	0.567
MOD_CK2_1	179	185	PF00069	0.608
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	140	144	PF01048	0.728
MOD_GlcNHglycan	37	40	PF01048	0.628
MOD_GSK3_1	141	148	PF00069	0.572
MOD_GSK3_1	15	22	PF00069	0.701
MOD_GSK3_1	187	194	PF00069	0.674
MOD_GSK3_1	26	33	PF00069	0.491
MOD_GSK3_1	35	42	PF00069	0.469
MOD_N-GLC_1	15	20	PF02516	0.521
MOD_NEK2_1	132	137	PF00069	0.728
MOD_NEK2_1	189	194	PF00069	0.592
MOD_NEK2_2	147	152	PF00069	0.513
MOD_PIKK_1	122	128	PF00454	0.533
MOD_PKA_2	133	139	PF00069	0.611
MOD_PKA_2	233	239	PF00069	0.572
MOD_Plk_1	15	21	PF00069	0.632
MOD_Plk_1	184	190	PF00069	0.432
MOD_Plk_4	133	139	PF00069	0.680
MOD_Plk_4	141	147	PF00069	0.522
MOD_Plk_4	184	190	PF00069	0.464
MOD_Plk_4	51	57	PF00069	0.577
MOD_ProDKin_1	19	25	PF00069	0.564
MOD_SUMO_for_1	119	122	PF00179	0.465
TRG_ENDOCYTIC_2	113	116	PF00928	0.519
TRG_ER_diArg_1	57	60	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK2	Leptomonas seymouri	38%	100%
A0A3Q8ID42	Leishmania donovani	69%	100%
A4I362	Leishmania infantum	71%	100%
E9ACZ1	Leishmania major	72%	100%
E9AYR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%