LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIS3_LEIBR
TriTrypDb:
LbrM.26.1760 , LBRM2903_230029600
Length:
869

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 336 340 PF00656 0.663
CLV_C14_Caspase3-7 657 661 PF00656 0.606
CLV_C14_Caspase3-7 662 666 PF00656 0.601
CLV_C14_Caspase3-7 89 93 PF00656 0.507
CLV_NRD_NRD_1 258 260 PF00675 0.619
CLV_NRD_NRD_1 263 265 PF00675 0.580
CLV_NRD_NRD_1 417 419 PF00675 0.783
CLV_NRD_NRD_1 856 858 PF00675 0.620
CLV_PCSK_FUR_1 279 283 PF00082 0.536
CLV_PCSK_FUR_1 854 858 PF00082 0.566
CLV_PCSK_KEX2_1 258 260 PF00082 0.621
CLV_PCSK_KEX2_1 263 265 PF00082 0.569
CLV_PCSK_KEX2_1 281 283 PF00082 0.519
CLV_PCSK_KEX2_1 417 419 PF00082 0.783
CLV_PCSK_KEX2_1 856 858 PF00082 0.620
CLV_PCSK_PC1ET2_1 281 283 PF00082 0.549
CLV_PCSK_PC7_1 259 265 PF00082 0.415
CLV_PCSK_PC7_1 277 283 PF00082 0.522
CLV_PCSK_SKI1_1 268 272 PF00082 0.427
CLV_PCSK_SKI1_1 27 31 PF00082 0.726
DEG_Nend_Nbox_1 1 3 PF02207 0.596
DEG_SPOP_SBC_1 406 410 PF00917 0.647
DEG_SPOP_SBC_1 43 47 PF00917 0.547
DEG_SPOP_SBC_1 501 505 PF00917 0.619
DOC_ANK_TNKS_1 624 631 PF00023 0.654
DOC_CDC14_PxL_1 158 166 PF14671 0.532
DOC_CKS1_1 207 212 PF01111 0.537
DOC_CKS1_1 719 724 PF01111 0.693
DOC_CYCLIN_RxL_1 263 275 PF00134 0.408
DOC_MAPK_DCC_7 193 203 PF00069 0.525
DOC_MAPK_FxFP_2 506 509 PF00069 0.532
DOC_MAPK_gen_1 190 200 PF00069 0.527
DOC_PP2B_LxvP_1 128 131 PF13499 0.585
DOC_PP2B_LxvP_1 228 231 PF13499 0.620
DOC_PP2B_LxvP_1 592 595 PF13499 0.702
DOC_PP4_FxxP_1 506 509 PF00568 0.532
DOC_PP4_FxxP_1 805 808 PF00568 0.678
DOC_USP7_MATH_1 110 114 PF00917 0.574
DOC_USP7_MATH_1 22 26 PF00917 0.502
DOC_USP7_MATH_1 232 236 PF00917 0.664
DOC_USP7_MATH_1 368 372 PF00917 0.681
DOC_USP7_MATH_1 38 42 PF00917 0.623
DOC_USP7_MATH_1 398 402 PF00917 0.618
DOC_USP7_MATH_1 406 410 PF00917 0.754
DOC_USP7_MATH_1 43 47 PF00917 0.635
DOC_USP7_MATH_1 501 505 PF00917 0.721
DOC_USP7_MATH_1 58 62 PF00917 0.537
DOC_USP7_MATH_1 764 768 PF00917 0.728
DOC_USP7_MATH_1 777 781 PF00917 0.503
DOC_USP7_MATH_1 829 833 PF00917 0.604
DOC_USP7_MATH_2 187 193 PF00917 0.541
DOC_USP7_UBL2_3 510 514 PF12436 0.529
DOC_WW_Pin1_4 122 127 PF00397 0.577
DOC_WW_Pin1_4 171 176 PF00397 0.616
DOC_WW_Pin1_4 206 211 PF00397 0.612
DOC_WW_Pin1_4 396 401 PF00397 0.802
DOC_WW_Pin1_4 474 479 PF00397 0.573
DOC_WW_Pin1_4 509 514 PF00397 0.678
DOC_WW_Pin1_4 580 585 PF00397 0.681
DOC_WW_Pin1_4 600 605 PF00397 0.497
DOC_WW_Pin1_4 645 650 PF00397 0.725
DOC_WW_Pin1_4 718 723 PF00397 0.671
DOC_WW_Pin1_4 807 812 PF00397 0.532
DOC_WW_Pin1_4 818 823 PF00397 0.540
LIG_14-3-3_CanoR_1 167 171 PF00244 0.661
LIG_14-3-3_CanoR_1 190 200 PF00244 0.527
LIG_14-3-3_CanoR_1 220 224 PF00244 0.571
LIG_14-3-3_CanoR_1 263 267 PF00244 0.560
LIG_14-3-3_CanoR_1 678 684 PF00244 0.610
LIG_14-3-3_CanoR_1 696 705 PF00244 0.545
LIG_14-3-3_CanoR_1 750 755 PF00244 0.642
LIG_APCC_ABBA_1 518 523 PF00400 0.522
LIG_BIR_III_4 665 669 PF00653 0.526
LIG_BRCT_BRCA1_1 196 200 PF00533 0.635
LIG_BRCT_BRCA1_1 400 404 PF00533 0.544
LIG_BRCT_BRCA1_1 441 445 PF00533 0.567
LIG_BRCT_BRCA1_1 705 709 PF00533 0.519
LIG_BRCT_BRCA1_1 800 804 PF00533 0.620
LIG_CSL_BTD_1 592 595 PF09270 0.702
LIG_deltaCOP1_diTrp_1 330 335 PF00928 0.618
LIG_deltaCOP1_diTrp_1 568 578 PF00928 0.521
LIG_DLG_GKlike_1 750 757 PF00625 0.509
LIG_eIF4E_1 561 567 PF01652 0.523
LIG_EVH1_1 228 232 PF00568 0.624
LIG_EVH1_1 718 722 PF00568 0.532
LIG_FHA_1 118 124 PF00498 0.557
LIG_FHA_1 149 155 PF00498 0.641
LIG_FHA_1 243 249 PF00498 0.480
LIG_FHA_1 294 300 PF00498 0.552
LIG_FHA_1 67 73 PF00498 0.594
LIG_FHA_1 95 101 PF00498 0.551
LIG_FHA_2 117 123 PF00498 0.550
LIG_FHA_2 350 356 PF00498 0.551
LIG_FHA_2 411 417 PF00498 0.520
LIG_FHA_2 454 460 PF00498 0.565
LIG_FHA_2 487 493 PF00498 0.532
LIG_FHA_2 646 652 PF00498 0.639
LIG_FHA_2 726 732 PF00498 0.562
LIG_Integrin_RGD_1 457 459 PF01839 0.565
LIG_Integrin_RGD_1 771 773 PF01839 0.501
LIG_IRF3_LxIS_1 803 810 PF10401 0.516
LIG_LIR_Apic_2 503 509 PF02991 0.530
LIG_LIR_Gen_1 197 204 PF02991 0.522
LIG_LIR_Gen_1 496 502 PF02991 0.516
LIG_LIR_Gen_1 568 579 PF02991 0.522
LIG_LIR_Gen_1 589 599 PF02991 0.554
LIG_LIR_Nem_3 197 203 PF02991 0.641
LIG_LIR_Nem_3 222 228 PF02991 0.539
LIG_LIR_Nem_3 309 314 PF02991 0.574
LIG_LIR_Nem_3 330 335 PF02991 0.531
LIG_LIR_Nem_3 496 500 PF02991 0.517
LIG_LIR_Nem_3 568 574 PF02991 0.515
LIG_LIR_Nem_3 801 807 PF02991 0.627
LIG_SH2_CRK 225 229 PF00017 0.528
LIG_SH2_CRK 311 315 PF00017 0.568
LIG_SH2_CRK 619 623 PF00017 0.619
LIG_SH2_GRB2like 543 546 PF00017 0.531
LIG_SH2_NCK_1 311 315 PF00017 0.568
LIG_SH2_NCK_1 619 623 PF00017 0.583
LIG_SH2_STAP1 543 547 PF00017 0.553
LIG_SH2_STAT3 344 347 PF00017 0.541
LIG_SH2_STAT3 793 796 PF00017 0.702
LIG_SH2_STAT5 344 347 PF00017 0.783
LIG_SH2_STAT5 488 491 PF00017 0.534
LIG_SH2_STAT5 591 594 PF00017 0.546
LIG_SH3_1 226 232 PF00018 0.539
LIG_SH3_1 716 722 PF00018 0.691
LIG_SH3_2 172 177 PF14604 0.510
LIG_SH3_3 167 173 PF00018 0.589
LIG_SH3_3 207 213 PF00018 0.755
LIG_SH3_3 226 232 PF00018 0.493
LIG_SH3_3 374 380 PF00018 0.796
LIG_SH3_3 394 400 PF00018 0.516
LIG_SH3_3 475 481 PF00018 0.599
LIG_SH3_3 570 576 PF00018 0.672
LIG_SH3_3 623 629 PF00018 0.647
LIG_SH3_3 646 652 PF00018 0.631
LIG_SH3_3 716 722 PF00018 0.747
LIG_SH3_3 805 811 PF00018 0.617
LIG_SH3_3 823 829 PF00018 0.614
LIG_SUMO_SIM_anti_2 74 81 PF11976 0.529
LIG_SUMO_SIM_par_1 81 89 PF11976 0.510
LIG_TRAF2_1 302 305 PF00917 0.640
LIG_TYR_ITIM 223 228 PF00017 0.538
LIG_WW_3 174 178 PF00397 0.515
LIG_WW_3 827 831 PF00397 0.581
MOD_CDC14_SPxK_1 174 177 PF00782 0.519
MOD_CDK_SPK_2 509 514 PF00069 0.528
MOD_CDK_SPK_2 645 650 PF00069 0.541
MOD_CDK_SPxK_1 171 177 PF00069 0.514
MOD_CK1_1 113 119 PF00069 0.564
MOD_CK1_1 185 191 PF00069 0.697
MOD_CK1_1 192 198 PF00069 0.739
MOD_CK1_1 218 224 PF00069 0.555
MOD_CK1_1 236 242 PF00069 0.624
MOD_CK1_1 293 299 PF00069 0.652
MOD_CK1_1 340 346 PF00069 0.618
MOD_CK1_1 399 405 PF00069 0.644
MOD_CK1_1 410 416 PF00069 0.502
MOD_CK1_1 569 575 PF00069 0.514
MOD_CK1_1 61 67 PF00069 0.618
MOD_CK1_1 687 693 PF00069 0.608
MOD_CK1_1 724 730 PF00069 0.695
MOD_CK1_1 74 80 PF00069 0.671
MOD_CK1_1 812 818 PF00069 0.723
MOD_CK2_1 238 244 PF00069 0.576
MOD_CK2_1 299 305 PF00069 0.663
MOD_CK2_1 349 355 PF00069 0.548
MOD_CK2_1 410 416 PF00069 0.521
MOD_CK2_1 486 492 PF00069 0.533
MOD_CK2_1 569 575 PF00069 0.538
MOD_CK2_1 64 70 PF00069 0.611
MOD_CK2_1 645 651 PF00069 0.658
MOD_CK2_1 725 731 PF00069 0.556
MOD_GlcNHglycan 24 27 PF01048 0.498
MOD_GlcNHglycan 240 243 PF01048 0.618
MOD_GlcNHglycan 339 343 PF01048 0.609
MOD_GlcNHglycan 46 49 PF01048 0.723
MOD_GlcNHglycan 568 571 PF01048 0.542
MOD_GlcNHglycan 596 599 PF01048 0.575
MOD_GlcNHglycan 63 66 PF01048 0.575
MOD_GlcNHglycan 657 660 PF01048 0.700
MOD_GlcNHglycan 689 692 PF01048 0.608
MOD_GlcNHglycan 705 708 PF01048 0.474
MOD_GlcNHglycan 735 739 PF01048 0.681
MOD_GlcNHglycan 747 750 PF01048 0.537
MOD_GlcNHglycan 80 83 PF01048 0.636
MOD_GlcNHglycan 840 843 PF01048 0.537
MOD_GSK3_1 109 116 PF00069 0.573
MOD_GSK3_1 117 124 PF00069 0.626
MOD_GSK3_1 162 169 PF00069 0.599
MOD_GSK3_1 185 192 PF00069 0.742
MOD_GSK3_1 211 218 PF00069 0.589
MOD_GSK3_1 232 239 PF00069 0.715
MOD_GSK3_1 262 269 PF00069 0.473
MOD_GSK3_1 333 340 PF00069 0.755
MOD_GSK3_1 38 45 PF00069 0.638
MOD_GSK3_1 388 395 PF00069 0.804
MOD_GSK3_1 406 413 PF00069 0.626
MOD_GSK3_1 486 493 PF00069 0.645
MOD_GSK3_1 594 601 PF00069 0.567
MOD_GSK3_1 60 67 PF00069 0.579
MOD_GSK3_1 607 614 PF00069 0.653
MOD_GSK3_1 650 657 PF00069 0.727
MOD_GSK3_1 692 699 PF00069 0.642
MOD_GSK3_1 703 710 PF00069 0.559
MOD_GSK3_1 721 728 PF00069 0.569
MOD_GSK3_1 74 81 PF00069 0.589
MOD_GSK3_1 745 752 PF00069 0.572
MOD_GSK3_1 785 792 PF00069 0.676
MOD_GSK3_1 794 801 PF00069 0.647
MOD_GSK3_1 814 821 PF00069 0.688
MOD_N-GLC_1 337 342 PF02516 0.601
MOD_N-GLC_1 745 750 PF02516 0.519
MOD_N-GLC_1 817 822 PF02516 0.565
MOD_N-GLC_1 848 853 PF02516 0.594
MOD_N-GLC_2 141 143 PF02516 0.529
MOD_NEK2_1 191 196 PF00069 0.534
MOD_NEK2_1 2 7 PF00069 0.571
MOD_NEK2_1 233 238 PF00069 0.550
MOD_NEK2_1 266 271 PF00069 0.526
MOD_NEK2_1 566 571 PF00069 0.519
MOD_NEK2_1 637 642 PF00069 0.666
MOD_NEK2_1 692 697 PF00069 0.588
MOD_NEK2_1 708 713 PF00069 0.679
MOD_NEK2_1 778 783 PF00069 0.542
MOD_NEK2_2 441 446 PF00069 0.714
MOD_PIKK_1 349 355 PF00454 0.681
MOD_PIKK_1 417 423 PF00454 0.531
MOD_PIKK_1 534 540 PF00454 0.670
MOD_PIKK_1 58 64 PF00454 0.616
MOD_PIKK_1 778 784 PF00454 0.571
MOD_PIKK_1 794 800 PF00454 0.594
MOD_PKA_1 417 423 PF00069 0.633
MOD_PKA_2 13 19 PF00069 0.473
MOD_PKA_2 166 172 PF00069 0.537
MOD_PKA_2 189 195 PF00069 0.541
MOD_PKA_2 2 8 PF00069 0.563
MOD_PKA_2 219 225 PF00069 0.544
MOD_PKA_2 262 268 PF00069 0.507
MOD_PKA_2 349 355 PF00069 0.609
MOD_PKA_2 38 44 PF00069 0.680
MOD_PKA_2 417 423 PF00069 0.585
MOD_PKA_2 460 466 PF00069 0.640
MOD_PKA_2 490 496 PF00069 0.520
MOD_PKA_2 607 613 PF00069 0.544
MOD_PKA_2 749 755 PF00069 0.531
MOD_PKA_2 829 835 PF00069 0.705
MOD_PKA_2 862 868 PF00069 0.600
MOD_Plk_1 218 224 PF00069 0.543
MOD_Plk_1 266 272 PF00069 0.407
MOD_Plk_1 368 374 PF00069 0.678
MOD_Plk_1 428 434 PF00069 0.528
MOD_Plk_1 789 795 PF00069 0.549
MOD_Plk_4 166 172 PF00069 0.513
MOD_Plk_4 340 346 PF00069 0.592
MOD_Plk_4 407 413 PF00069 0.532
MOD_Plk_4 490 496 PF00069 0.545
MOD_Plk_4 650 656 PF00069 0.701
MOD_Plk_4 74 80 PF00069 0.596
MOD_Plk_4 809 815 PF00069 0.601
MOD_ProDKin_1 122 128 PF00069 0.579
MOD_ProDKin_1 171 177 PF00069 0.624
MOD_ProDKin_1 206 212 PF00069 0.606
MOD_ProDKin_1 396 402 PF00069 0.802
MOD_ProDKin_1 474 480 PF00069 0.573
MOD_ProDKin_1 509 515 PF00069 0.680
MOD_ProDKin_1 580 586 PF00069 0.680
MOD_ProDKin_1 600 606 PF00069 0.499
MOD_ProDKin_1 645 651 PF00069 0.725
MOD_ProDKin_1 718 724 PF00069 0.674
MOD_ProDKin_1 807 813 PF00069 0.535
MOD_ProDKin_1 818 824 PF00069 0.541
MOD_SUMO_for_1 513 516 PF00179 0.531
MOD_SUMO_rev_2 250 257 PF00179 0.549
TRG_DiLeu_BaLyEn_6 24 29 PF01217 0.716
TRG_ENDOCYTIC_2 225 228 PF00928 0.537
TRG_ENDOCYTIC_2 311 314 PF00928 0.570
TRG_ENDOCYTIC_2 591 594 PF00928 0.546
TRG_ER_diArg_1 276 279 PF00400 0.532
TRG_ER_diArg_1 364 367 PF00400 0.670
TRG_ER_diArg_1 739 742 PF00400 0.544
TRG_ER_diArg_1 834 837 PF00400 0.682
TRG_ER_diArg_1 854 857 PF00400 0.568
TRG_NLS_Bipartite_1 263 285 PF00514 0.421
TRG_NLS_MonoExtN_4 279 285 PF00514 0.540

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7G5 Leishmania donovani 58% 99%
A4I2B6 Leishmania infantum 58% 100%
E9AYG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
Q4Q909 Leishmania major 57% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS