LeishMANIAdb
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Ankyrin repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ankyrin repeat protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIS0_LEIBR
TriTrypDb:
LbrM.26.0310 , LBRM2903_260007900
Length:
198

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Expansion

Sequence features

E9AIS0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIS0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.314
CLV_NRD_NRD_1 140 142 PF00675 0.432
CLV_NRD_NRD_1 97 99 PF00675 0.509
CLV_PCSK_KEX2_1 140 142 PF00082 0.432
CLV_PCSK_KEX2_1 145 147 PF00082 0.458
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.316
CLV_PCSK_PC7_1 141 147 PF00082 0.434
CLV_PCSK_SKI1_1 119 123 PF00082 0.446
CLV_PCSK_SKI1_1 184 188 PF00082 0.492
DOC_USP7_UBL2_3 192 196 PF12436 0.346
LIG_14-3-3_CanoR_1 133 139 PF00244 0.476
LIG_14-3-3_CanoR_1 4 8 PF00244 0.481
LIG_BRCT_BRCA1_1 83 87 PF00533 0.248
LIG_FHA_1 113 119 PF00498 0.414
LIG_FHA_1 166 172 PF00498 0.419
LIG_FHA_1 186 192 PF00498 0.414
LIG_FHA_1 38 44 PF00498 0.557
LIG_FHA_1 71 77 PF00498 0.348
LIG_FHA_2 106 112 PF00498 0.444
LIG_LIR_Gen_1 39 46 PF02991 0.351
LIG_LIR_Gen_1 84 94 PF02991 0.525
LIG_LIR_Nem_3 39 45 PF02991 0.379
LIG_SH2_STAT5 169 172 PF00017 0.413
LIG_SH2_STAT5 194 197 PF00017 0.442
LIG_TRAF2_1 148 151 PF00917 0.556
MOD_CK1_1 6 12 PF00069 0.388
MOD_GlcNHglycan 128 131 PF01048 0.524
MOD_GSK3_1 170 177 PF00069 0.522
MOD_N-GLC_1 35 40 PF02516 0.453
MOD_NEK2_1 105 110 PF00069 0.367
MOD_NEK2_1 170 175 PF00069 0.458
MOD_NEK2_1 37 42 PF00069 0.517
MOD_NEK2_1 70 75 PF00069 0.334
MOD_NEK2_2 82 87 PF00069 0.466
MOD_NMyristoyl 1 7 PF02799 0.469
MOD_PKA_2 3 9 PF00069 0.494
MOD_Plk_4 134 140 PF00069 0.450
MOD_Plk_4 165 171 PF00069 0.504
MOD_Plk_4 190 196 PF00069 0.268
MOD_Plk_4 37 43 PF00069 0.519
MOD_Plk_4 76 82 PF00069 0.429
MOD_SUMO_for_1 178 181 PF00179 0.442
MOD_SUMO_rev_2 6 11 PF00179 0.440
TRG_DiLeu_BaEn_1 151 156 PF01217 0.488
TRG_ER_diArg_1 139 141 PF00400 0.430

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5J3 Leptomonas seymouri 72% 100%
A0A0S4IJA5 Bodo saltans 28% 78%
A0A1X0NST0 Trypanosomatidae 35% 100%
A0A3S7WZL3 Leishmania donovani 81% 98%
A0A422NVH2 Trypanosoma rangeli 40% 100%
A4I1W5 Leishmania infantum 80% 98%
C9ZS55 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9AY10 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q9G3 Leishmania major 81% 100%
V5DR87 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS