LeishMANIAdb
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Putative NAD-dependent SIR2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NAD-dependent SIR2
Gene product:
Silent information regulator 2 related protein 1
Species:
Leishmania braziliensis
UniProt:
E9AIR9_LEIBR
TriTrypDb:
LbrM.26.0210 , LBRM2903_260007200 *
Length:
284

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: ipemberton@photeomix.com
Publication title: The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Publication 1st author(s): Ronin
Publication Identifier(s): 29543820
Host organism: -1
Interaction detection method(s): x-ray crystallography
Interaction type: direct interaction
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: A0A6L0XH39
ID(s) interactor B: P04637
Taxid interactor A: Leishmania infantum
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

E9AIR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR9

PDB structure(s): 5ol0_A , 5ol0_B

Function

Biological processes
TermNameLevelCount
GO:0001775 cell activation 2 1
GO:0002274 myeloid leukocyte activation 3 1
GO:0002376 immune system process 1 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0003950 NAD+ ADP-ribosyltransferase activity 5 1
GO:0004407 histone deacetylase activity 4 8
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 7
GO:0016740 transferase activity 2 11
GO:0016757 glycosyltransferase activity 3 4
GO:0016763 pentosyltransferase activity 4 1
GO:0016787 hydrolase activity 2 9
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 217 221 PF00656 0.541
CLV_NRD_NRD_1 192 194 PF00675 0.626
CLV_PCSK_KEX2_1 176 178 PF00082 0.512
CLV_PCSK_KEX2_1 192 194 PF00082 0.588
CLV_PCSK_KEX2_1 263 265 PF00082 0.449
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.485
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.451
CLV_PCSK_SKI1_1 236 240 PF00082 0.309
DEG_Nend_UBRbox_1 1 4 PF02207 0.310
DEG_SPOP_SBC_1 213 217 PF00917 0.686
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HVQ5 Leptomonas seymouri 59% 75%
A0A1X0NT02 Trypanosomatidae 48% 83%
A0A3Q8IDH7 Leishmania donovani 79% 76%
A0A422NVE3 Trypanosoma rangeli 49% 84%
A0A6L0XH39 Leishmania infantum 80% 76%
C9ZS62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 81%
E9AY03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 76%
F7EZ75 Macaca mulatta 31% 92%
Q25337 Leishmania major 78% 100%
Q57V41 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 47% 81%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS