LeishMANIAdb
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Putative NAD-dependent SIR2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NAD-dependent SIR2
Gene product:
Silent information regulator 2 related protein 1
Species:
Leishmania braziliensis
UniProt:
E9AIR9_LEIBR
TriTrypDb:
LbrM.26.0210 , LBRM2903_260007200 *
Length:
284

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: ipemberton@photeomix.com
Publication title: The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design
Publication 1st author(s): Ronin
Publication Identifier(s): 29543820
Host organism: -1
Interaction detection method(s): x-ray crystallography
Interaction type: direct interaction
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: A0A6L0XH39
ID(s) interactor B: P04637
Taxid interactor A: Leishmania infantum
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AIR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR9

PDB structure(s): 5ol0_A , 5ol0_B

Function

Biological processes
Term Name Level Count
GO:0001775 cell activation 2 1
GO:0002274 myeloid leukocyte activation 3 1
GO:0002376 immune system process 1 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009605 response to external stimulus 2 1
GO:0009607 response to biotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042113 B cell activation 4 1
GO:0042116 macrophage activation 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043207 response to external biotic stimulus 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044419 biological process involved in interspecies interaction between organisms 1 1
GO:0045321 leukocyte activation 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046649 lymphocyte activation 3 1
GO:0050896 response to stimulus 1 1
GO:0051701 biological process involved in interaction with host 3 1
GO:0051707 response to other organism 2 1
GO:0051716 cellular response to stimulus 2 1
GO:0052167 modulation by symbiont of host innate immune response 7 1
GO:0052173 response to defenses of other organism 3 1
GO:0052200 response to host defenses 4 1
GO:0052553 modulation by symbiont of host immune response 6 1
GO:0052572 response to host immune response 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0075136 response to host 3 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0016740 transferase activity 2 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0051287 NAD binding 4 11
GO:0070403 NAD+ binding 4 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003950 NAD+ ADP-ribosyltransferase activity 5 1
GO:0004407 histone deacetylase activity 4 8
GO:0016757 glycosyltransferase activity 3 4
GO:0016763 pentosyltransferase activity 4 1
GO:0016787 hydrolase activity 2 9
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 8
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 8
GO:0017136 NAD-dependent histone deacetylase activity 5 8
GO:0019213 deacetylase activity 3 8
GO:0033558 protein lysine deacetylase activity 3 8
GO:0034979 NAD-dependent protein deacetylase activity 4 8
GO:0042903 tubulin deacetylase activity 4 1
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8
GO:0140096 catalytic activity, acting on a protein 2 8
GO:0008270 zinc ion binding 6 7
GO:0046914 transition metal ion binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.541
CLV_NRD_NRD_1 192 194 PF00675 0.626
CLV_PCSK_KEX2_1 176 178 PF00082 0.512
CLV_PCSK_KEX2_1 192 194 PF00082 0.588
CLV_PCSK_KEX2_1 263 265 PF00082 0.449
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.485
CLV_PCSK_PC1ET2_1 263 265 PF00082 0.451
CLV_PCSK_SKI1_1 236 240 PF00082 0.309
DEG_Nend_UBRbox_1 1 4 PF02207 0.310
DEG_SPOP_SBC_1 213 217 PF00917 0.686
DOC_MAPK_FxFP_2 158 161 PF00069 0.334
DOC_MAPK_MEF2A_6 141 148 PF00069 0.350
DOC_PP1_RVXF_1 234 241 PF00149 0.331
DOC_PP4_FxxP_1 158 161 PF00568 0.334
DOC_USP7_MATH_1 187 191 PF00917 0.674
DOC_USP7_MATH_1 213 217 PF00917 0.630
DOC_USP7_MATH_1 41 45 PF00917 0.357
DOC_USP7_MATH_1 51 55 PF00917 0.411
DOC_WW_Pin1_4 176 181 PF00397 0.663
DOC_WW_Pin1_4 183 188 PF00397 0.725
DOC_WW_Pin1_4 201 206 PF00397 0.751
DOC_WW_Pin1_4 62 67 PF00397 0.467
LIG_14-3-3_CanoR_1 28 37 PF00244 0.442
LIG_14-3-3_CanoR_1 83 90 PF00244 0.465
LIG_BIR_III_2 269 273 PF00653 0.513
LIG_CNOT1_NIM_1 222 231 PF04054 0.369
LIG_FHA_1 29 35 PF00498 0.431
LIG_GBD_Chelix_1 119 127 PF00786 0.303
LIG_Integrin_RGD_1 241 243 PF01839 0.471
LIG_LIR_Gen_1 104 115 PF02991 0.462
LIG_LIR_Gen_1 227 234 PF02991 0.466
LIG_LIR_Nem_3 104 110 PF02991 0.448
LIG_LIR_Nem_3 219 225 PF02991 0.490
LIG_LIR_Nem_3 227 231 PF02991 0.427
LIG_LIR_Nem_3 253 257 PF02991 0.370
LIG_Pex14_1 4 8 PF04695 0.411
LIG_Pex14_2 156 160 PF04695 0.258
LIG_SH2_CRK 228 232 PF00017 0.328
LIG_SH2_SRC 73 76 PF00017 0.465
LIG_SH2_STAT5 254 257 PF00017 0.369
LIG_SH2_STAT5 73 76 PF00017 0.549
LIG_SH3_3 158 164 PF00018 0.496
LIG_SUMO_SIM_anti_2 118 126 PF11976 0.426
LIG_SUMO_SIM_par_1 118 126 PF11976 0.486
MOD_CDK_SPK_2 201 206 PF00069 0.526
MOD_CK1_1 179 185 PF00069 0.786
MOD_CK1_1 214 220 PF00069 0.557
MOD_CK1_1 82 88 PF00069 0.552
MOD_GlcNHglycan 187 190 PF01048 0.685
MOD_GlcNHglycan 246 249 PF01048 0.228
MOD_GlcNHglycan 273 276 PF01048 0.637
MOD_GlcNHglycan 77 80 PF01048 0.287
MOD_GSK3_1 179 186 PF00069 0.667
MOD_GSK3_1 211 218 PF00069 0.592
MOD_GSK3_1 75 82 PF00069 0.483
MOD_N-GLC_1 276 281 PF02516 0.468
MOD_PIKK_1 179 185 PF00454 0.652
MOD_PIKK_1 28 34 PF00454 0.434
MOD_PK_1 264 270 PF00069 0.466
MOD_PKA_2 82 88 PF00069 0.545
MOD_ProDKin_1 176 182 PF00069 0.663
MOD_ProDKin_1 183 189 PF00069 0.723
MOD_ProDKin_1 201 207 PF00069 0.752
MOD_ProDKin_1 62 68 PF00069 0.467
TRG_DiLeu_BaLyEn_6 15 20 PF01217 0.443
TRG_DiLeu_BaLyEn_6 22 27 PF01217 0.404
TRG_ENDOCYTIC_2 228 231 PF00928 0.406
TRG_ENDOCYTIC_2 254 257 PF00928 0.369
TRG_Pf-PMV_PEXEL_1 18 22 PF00026 0.305

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVQ5 Leptomonas seymouri 59% 75%
A0A1X0NT02 Trypanosomatidae 48% 83%
A0A3Q8IDH7 Leishmania donovani 79% 76%
A0A422NVE3 Trypanosoma rangeli 49% 84%
A0A6L0XH39 Leishmania infantum 80% 76%
C9ZS62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 81%
E9AY03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 76%
F7EZ75 Macaca mulatta 31% 92%
Q25337 Leishmania major 78% 100%
Q57V41 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 47% 81%
Q5AW69 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 43% 79%
Q5R6G3 Pongo abelii 31% 92%
Q68FX9 Rattus norvegicus 32% 92%
Q9NXA8 Homo sapiens 31% 92%
V5BZF3 Trypanosoma cruzi 48% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS