FGGY_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIR8_LEIBR

TriTrypDb:

LbrM.26.0081 , LBRM2903_260005800

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.549
CLV_PCSK_KEX2_1	183	185	PF00082	0.477
CLV_PCSK_SKI1_1	112	116	PF00082	0.391
CLV_PCSK_SKI1_1	123	127	PF00082	0.513
CLV_Separin_Metazoa	180	184	PF03568	0.350
DEG_APCC_DBOX_1	230	238	PF00400	0.288
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DOC_CKS1_1	136	141	PF01111	0.433
DOC_MAPK_gen_1	183	191	PF00069	0.443
DOC_MAPK_MEF2A_6	250	257	PF00069	0.382
DOC_MAPK_NFAT4_5	250	258	PF00069	0.375
DOC_PP2B_LxvP_1	47	50	PF13499	0.492
DOC_PP4_FxxP_1	136	139	PF00568	0.434
DOC_WW_Pin1_4	135	140	PF00397	0.356
LIG_BRCT_BRCA1_1	19	23	PF00533	0.276
LIG_CSL_BTD_1	259	262	PF09270	0.318
LIG_FHA_1	102	108	PF00498	0.419
LIG_FHA_1	136	142	PF00498	0.355
LIG_FHA_1	159	165	PF00498	0.379
LIG_FHA_1	174	180	PF00498	0.319
LIG_FHA_1	234	240	PF00498	0.357
LIG_FHA_1	89	95	PF00498	0.341
LIG_FHA_2	158	164	PF00498	0.378
LIG_FHA_2	41	47	PF00498	0.472
LIG_LIR_Apic_2	83	87	PF02991	0.466
LIG_LIR_Gen_1	212	223	PF02991	0.461
LIG_LIR_LC3C_4	124	128	PF02991	0.340
LIG_LIR_Nem_3	150	156	PF02991	0.685
LIG_LIR_Nem_3	168	174	PF02991	0.464
LIG_LIR_Nem_3	212	218	PF02991	0.486
LIG_NRBOX	57	63	PF00104	0.430
LIG_PDZ_Class_1	264	269	PF00595	0.307
LIG_PDZ_Wminus1_1	267	269	PF00595	0.407
LIG_SH2_CRK	90	94	PF00017	0.426
LIG_SH2_STAP1	90	94	PF00017	0.426
LIG_SH2_STAT5	215	218	PF00017	0.412
LIG_SH2_STAT5	90	93	PF00017	0.361
LIG_SH3_3	159	165	PF00018	0.536
LIG_TYR_ITIM	88	93	PF00017	0.435
LIG_UBA3_1	61	67	PF00899	0.280
MOD_CK1_1	195	201	PF00069	0.567
MOD_CK2_1	40	46	PF00069	0.313
MOD_GlcNHglycan	123	126	PF01048	0.448
MOD_GlcNHglycan	145	148	PF01048	0.503
MOD_GlcNHglycan	19	22	PF01048	0.460
MOD_GlcNHglycan	257	260	PF01048	0.466
MOD_GlcNHglycan	43	46	PF01048	0.397
MOD_GSK3_1	101	108	PF00069	0.409
MOD_GSK3_1	15	22	PF00069	0.377
MOD_NEK2_1	15	20	PF00069	0.446
MOD_NEK2_1	255	260	PF00069	0.390
MOD_NEK2_1	80	85	PF00069	0.413
MOD_NEK2_1	88	93	PF00069	0.342
MOD_OFUCOSY	193	199	PF10250	0.455
MOD_PIKK_1	105	111	PF00454	0.428
MOD_PKA_1	183	189	PF00069	0.406
MOD_PKA_2	183	189	PF00069	0.418
MOD_PKA_2	195	201	PF00069	0.484
MOD_Plk_1	241	247	PF00069	0.362
MOD_Plk_4	148	154	PF00069	0.607
MOD_Plk_4	233	239	PF00069	0.353
MOD_Plk_4	261	267	PF00069	0.586
MOD_Plk_4	88	94	PF00069	0.506
MOD_ProDKin_1	135	141	PF00069	0.359
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.496
TRG_ENDOCYTIC_2	215	218	PF00928	0.292
TRG_ENDOCYTIC_2	90	93	PF00928	0.361
TRG_ER_diArg_1	182	184	PF00400	0.364
TRG_NES_CRM1_1	212	226	PF08389	0.328
TRG_NES_CRM1_1	229	242	PF08389	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y9	Leptomonas seymouri	34%	95%
A0A3Q8IDH0	Leishmania donovani	65%	100%
E9ACT2	Leishmania major	67%	100%
E9AHA7	Leishmania infantum	65%	100%
E9AXZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%