EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania braziliensis

UniProt:

E9AIR7_LEIBR

TriTrypDb:

LbrM.25.1890 , LBRM2903_250032200

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AIR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.602
CLV_C14_Caspase3-7	157	161	PF00656	0.559
CLV_C14_Caspase3-7	172	176	PF00656	0.561
CLV_C14_Caspase3-7	27	31	PF00656	0.414
CLV_C14_Caspase3-7	276	280	PF00656	0.466
CLV_C14_Caspase3-7	640	644	PF00656	0.495
CLV_NRD_NRD_1	214	216	PF00675	0.457
CLV_NRD_NRD_1	260	262	PF00675	0.473
CLV_NRD_NRD_1	370	372	PF00675	0.693
CLV_NRD_NRD_1	441	443	PF00675	0.522
CLV_NRD_NRD_1	548	550	PF00675	0.528
CLV_NRD_NRD_1	593	595	PF00675	0.514
CLV_PCSK_FUR_1	272	276	PF00082	0.367
CLV_PCSK_FUR_1	485	489	PF00082	0.437
CLV_PCSK_KEX2_1	214	216	PF00082	0.428
CLV_PCSK_KEX2_1	260	262	PF00082	0.483
CLV_PCSK_KEX2_1	274	276	PF00082	0.555
CLV_PCSK_KEX2_1	370	372	PF00082	0.645
CLV_PCSK_KEX2_1	441	443	PF00082	0.522
CLV_PCSK_KEX2_1	487	489	PF00082	0.443
CLV_PCSK_KEX2_1	547	549	PF00082	0.522
CLV_PCSK_KEX2_1	593	595	PF00082	0.514
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.533
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.443
CLV_PCSK_SKI1_1	147	151	PF00082	0.486
CLV_PCSK_SKI1_1	214	218	PF00082	0.356
CLV_PCSK_SKI1_1	227	231	PF00082	0.367
CLV_PCSK_SKI1_1	260	264	PF00082	0.479
CLV_PCSK_SKI1_1	381	385	PF00082	0.386
CLV_PCSK_SKI1_1	477	481	PF00082	0.465
CLV_PCSK_SKI1_1	571	575	PF00082	0.337
CLV_PCSK_SKI1_1	79	83	PF00082	0.449
DEG_APCC_DBOX_1	78	86	PF00400	0.300
DOC_CDC14_PxL_1	85	93	PF14671	0.465
DOC_CYCLIN_RxL_1	211	219	PF00134	0.445
DOC_CYCLIN_RxL_1	567	575	PF00134	0.351
DOC_MAPK_gen_1	547	555	PF00069	0.560
DOC_MAPK_HePTP_8	564	576	PF00069	0.428
DOC_MAPK_MEF2A_6	567	576	PF00069	0.456
DOC_MAPK_MEF2A_6	583	591	PF00069	0.489
DOC_MAPK_MEF2A_6	90	98	PF00069	0.521
DOC_PP4_FxxP_1	584	587	PF00568	0.403
DOC_PP4_FxxP_1	98	101	PF00568	0.577
DOC_USP7_MATH_1	169	173	PF00917	0.452
DOC_USP7_MATH_1	296	300	PF00917	0.609
DOC_USP7_MATH_1	319	323	PF00917	0.577
DOC_USP7_MATH_1	329	333	PF00917	0.522
DOC_USP7_MATH_1	617	621	PF00917	0.546
DOC_USP7_MATH_1	623	627	PF00917	0.539
DOC_USP7_MATH_1	633	637	PF00917	0.539
DOC_USP7_UBL2_3	396	400	PF12436	0.417
DOC_WW_Pin1_4	325	330	PF00397	0.690
DOC_WW_Pin1_4	344	349	PF00397	0.501
DOC_WW_Pin1_4	539	544	PF00397	0.549
DOC_WW_Pin1_4	553	558	PF00397	0.717
LIG_14-3-3_CanoR_1	25	30	PF00244	0.544
LIG_14-3-3_CanoR_1	334	341	PF00244	0.654
LIG_14-3-3_CanoR_1	362	367	PF00244	0.741
LIG_14-3-3_CanoR_1	539	543	PF00244	0.464
LIG_14-3-3_CanoR_1	90	95	PF00244	0.498
LIG_Actin_WH2_2	412	428	PF00022	0.395
LIG_APCC_ABBA_1	585	590	PF00400	0.263
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BRCT_BRCA1_1	643	647	PF00533	0.413
LIG_BRCT_BRCA1_1	94	98	PF00533	0.299
LIG_CtBP_PxDLS_1	56	60	PF00389	0.456
LIG_DLG_GKlike_1	25	32	PF00625	0.428
LIG_EVH1_2	352	356	PF00568	0.496
LIG_FHA_1	146	152	PF00498	0.494
LIG_FHA_1	373	379	PF00498	0.532
LIG_FHA_1	390	396	PF00498	0.254
LIG_FHA_1	432	438	PF00498	0.378
LIG_FHA_1	524	530	PF00498	0.499
LIG_FHA_1	65	71	PF00498	0.391
LIG_FHA_2	121	127	PF00498	0.476
LIG_FHA_2	155	161	PF00498	0.524
LIG_FHA_2	176	182	PF00498	0.529
LIG_FHA_2	195	201	PF00498	0.332
LIG_FHA_2	25	31	PF00498	0.508
LIG_FHA_2	271	277	PF00498	0.365
LIG_FHA_2	335	341	PF00498	0.674
LIG_FHA_2	638	644	PF00498	0.418
LIG_LIR_Apic_2	95	101	PF02991	0.354
LIG_LIR_Gen_1	165	176	PF02991	0.470
LIG_LIR_Gen_1	181	190	PF02991	0.309
LIG_LIR_Gen_1	373	380	PF02991	0.513
LIG_LIR_Gen_1	568	576	PF02991	0.371
LIG_LIR_Gen_1	586	592	PF02991	0.294
LIG_LIR_Gen_1	607	615	PF02991	0.375
LIG_LIR_Nem_3	165	171	PF02991	0.452
LIG_LIR_Nem_3	179	185	PF02991	0.312
LIG_LIR_Nem_3	219	225	PF02991	0.432
LIG_LIR_Nem_3	256	262	PF02991	0.483
LIG_LIR_Nem_3	373	377	PF02991	0.627
LIG_LIR_Nem_3	462	468	PF02991	0.357
LIG_LIR_Nem_3	510	516	PF02991	0.356
LIG_LIR_Nem_3	558	564	PF02991	0.499
LIG_LIR_Nem_3	568	572	PF02991	0.365
LIG_LIR_Nem_3	586	591	PF02991	0.257
LIG_LIR_Nem_3	607	611	PF02991	0.347
LIG_LYPXL_S_1	560	564	PF13949	0.328
LIG_LYPXL_yS_3	561	564	PF13949	0.310
LIG_PTB_Apo_2	417	424	PF02174	0.289
LIG_PTB_Apo_2	515	522	PF02174	0.433
LIG_PTB_Phospho_1	417	423	PF10480	0.285
LIG_PTB_Phospho_1	515	521	PF10480	0.431
LIG_SH2_CRK	416	420	PF00017	0.355
LIG_SH2_GRB2like	185	188	PF00017	0.447
LIG_SH2_GRB2like	418	421	PF00017	0.284
LIG_SH2_PTP2	588	591	PF00017	0.480
LIG_SH2_SRC	588	591	PF00017	0.256
LIG_SH2_STAP1	218	222	PF00017	0.379
LIG_SH2_STAP1	247	251	PF00017	0.456
LIG_SH2_STAP1	255	259	PF00017	0.398
LIG_SH2_STAP1	391	395	PF00017	0.433
LIG_SH2_STAT3	418	421	PF00017	0.284
LIG_SH2_STAT5	391	394	PF00017	0.481
LIG_SH2_STAT5	416	419	PF00017	0.358
LIG_SH2_STAT5	536	539	PF00017	0.483
LIG_SH2_STAT5	588	591	PF00017	0.447
LIG_SH3_3	347	353	PF00018	0.715
LIG_SH3_3	93	99	PF00018	0.428
LIG_SUMO_SIM_par_1	66	72	PF11976	0.400
LIG_TRAF2_1	101	104	PF00917	0.541
LIG_TRAF2_1	178	181	PF00917	0.491
LIG_TRAF2_1	198	201	PF00917	0.311
LIG_TRAF2_1	292	295	PF00917	0.592
LIG_UBA3_1	386	394	PF00899	0.480
LIG_UBA3_1	479	487	PF00899	0.345
LIG_WRC_WIRS_1	1	6	PF05994	0.558
LIG_WRC_WIRS_1	638	643	PF05994	0.421
MOD_CDK_SPK_2	539	544	PF00069	0.383
MOD_CK1_1	194	200	PF00069	0.588
MOD_CK1_1	92	98	PF00069	0.429
MOD_CK2_1	125	131	PF00069	0.508
MOD_CK2_1	175	181	PF00069	0.464
MOD_CK2_1	194	200	PF00069	0.330
MOD_CK2_1	296	302	PF00069	0.611
MOD_CK2_1	45	51	PF00069	0.472
MOD_CK2_1	615	621	PF00069	0.488
MOD_GlcNHglycan	15	18	PF01048	0.555
MOD_GlcNHglycan	160	163	PF01048	0.531
MOD_GlcNHglycan	21	24	PF01048	0.510
MOD_GlcNHglycan	248	251	PF01048	0.558
MOD_GlcNHglycan	319	322	PF01048	0.670
MOD_GlcNHglycan	58	62	PF01048	0.315
MOD_GSK3_1	13	20	PF00069	0.401
MOD_GSK3_1	154	161	PF00069	0.481
MOD_GSK3_1	317	324	PF00069	0.627
MOD_GSK3_1	325	332	PF00069	0.656
MOD_GSK3_1	357	364	PF00069	0.665
MOD_GSK3_1	372	379	PF00069	0.417
MOD_GSK3_1	523	530	PF00069	0.553
MOD_GSK3_1	633	640	PF00069	0.397
MOD_GSK3_1	64	71	PF00069	0.313
MOD_GSK3_1	655	662	PF00069	0.485
MOD_GSK3_1	90	97	PF00069	0.515
MOD_N-GLC_1	114	119	PF02516	0.425
MOD_N-GLC_1	334	339	PF02516	0.587
MOD_N-GLC_1	45	50	PF02516	0.441
MOD_NEK2_1	19	24	PF00069	0.480
MOD_NEK2_1	270	275	PF00069	0.490
MOD_NEK2_1	330	335	PF00069	0.702
MOD_NEK2_1	339	344	PF00069	0.685
MOD_NEK2_1	45	50	PF00069	0.454
MOD_NEK2_1	528	533	PF00069	0.358
MOD_NEK2_1	57	62	PF00069	0.409
MOD_NEK2_1	641	646	PF00069	0.447
MOD_NEK2_1	655	660	PF00069	0.480
MOD_NEK2_1	68	73	PF00069	0.327
MOD_NEK2_1	94	99	PF00069	0.480
MOD_NEK2_2	163	168	PF00069	0.400
MOD_NEK2_2	296	301	PF00069	0.492
MOD_PIKK_1	176	182	PF00454	0.502
MOD_PIKK_1	354	360	PF00454	0.692
MOD_PIKK_1	633	639	PF00454	0.464
MOD_PKA_1	370	376	PF00069	0.659
MOD_PKA_2	24	30	PF00069	0.542
MOD_PKA_2	265	271	PF00069	0.551
MOD_PKA_2	317	323	PF00069	0.767
MOD_PKA_2	333	339	PF00069	0.572
MOD_PKA_2	361	367	PF00069	0.712
MOD_PKA_2	370	376	PF00069	0.608
MOD_PKA_2	407	413	PF00069	0.399
MOD_PKA_2	538	544	PF00069	0.496
MOD_PKA_2	89	95	PF00069	0.458
MOD_Plk_1	114	120	PF00069	0.584
MOD_Plk_1	17	23	PF00069	0.532
MOD_Plk_1	334	340	PF00069	0.628
MOD_Plk_1	523	529	PF00069	0.565
MOD_Plk_1	57	63	PF00069	0.436
MOD_Plk_4	163	169	PF00069	0.540
MOD_Plk_4	414	420	PF00069	0.270
MOD_Plk_4	528	534	PF00069	0.281
MOD_Plk_4	607	613	PF00069	0.417
MOD_Plk_4	623	629	PF00069	0.554
MOD_ProDKin_1	325	331	PF00069	0.690
MOD_ProDKin_1	344	350	PF00069	0.499
MOD_ProDKin_1	539	545	PF00069	0.559
MOD_ProDKin_1	553	559	PF00069	0.713
MOD_SUMO_for_1	4	7	PF00179	0.471
MOD_SUMO_for_1	63	66	PF00179	0.304
MOD_SUMO_rev_2	360	369	PF00179	0.726
TRG_DiLeu_BaEn_2	462	468	PF01217	0.365
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.483
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.335
TRG_DiLeu_BaLyEn_6	568	573	PF01217	0.446
TRG_ENDOCYTIC_2	416	419	PF00928	0.358
TRG_ENDOCYTIC_2	561	564	PF00928	0.314
TRG_ENDOCYTIC_2	588	591	PF00928	0.480
TRG_ER_diArg_1	214	216	PF00400	0.470
TRG_ER_diArg_1	259	261	PF00400	0.451
TRG_ER_diArg_1	370	372	PF00400	0.705
TRG_ER_diArg_1	440	442	PF00400	0.516
TRG_ER_diArg_1	547	549	PF00400	0.588
TRG_ER_diArg_1	592	594	PF00400	0.503
TRG_NES_CRM1_1	563	575	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P4	Leptomonas seymouri	63%	99%
A0A0S4IQL8	Bodo saltans	25%	100%
A0A0S4J4H6	Bodo saltans	39%	97%
A0A1X0NY28	Trypanosomatidae	40%	97%
A0A3R7KSG2	Trypanosoma rangeli	41%	97%
A0A3S7WZE2	Leishmania donovani	79%	100%
A4I1T0	Leishmania infantum	79%	100%
E9AXW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q95ZB7	Leishmania major	79%	100%
V5ASI1	Trypanosoma cruzi	39%	90%