Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 10, putative

Species:

Leishmania braziliensis

UniProt:

E9AIR6_LEIBR

TriTrypDb:

LbrM.25.1870 , LBRM2903_250032000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AIR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.512
CLV_C14_Caspase3-7	269	273	PF00656	0.568
CLV_NRD_NRD_1	113	115	PF00675	0.225
CLV_PCSK_KEX2_1	113	115	PF00082	0.225
CLV_PCSK_PC7_1	109	115	PF00082	0.238
CLV_PCSK_SKI1_1	214	218	PF00082	0.242
CLV_PCSK_SKI1_1	240	244	PF00082	0.227
DEG_MDM2_SWIB_1	134	142	PF02201	0.299
DOC_MAPK_gen_1	128	137	PF00069	0.428
DOC_MAPK_gen_1	255	263	PF00069	0.548
DOC_MAPK_MEF2A_6	131	139	PF00069	0.360
DOC_USP7_MATH_1	175	179	PF00917	0.280
DOC_USP7_MATH_1	63	67	PF00917	0.634
DOC_USP7_MATH_1	9	13	PF00917	0.174
LIG_14-3-3_CanoR_1	255	263	PF00244	0.609
LIG_BRCT_BRCA1_1	11	15	PF00533	0.300
LIG_BRCT_BRCA1_1	193	197	PF00533	0.317
LIG_FHA_1	17	23	PF00498	0.267
LIG_FHA_1	175	181	PF00498	0.236
LIG_FHA_1	207	213	PF00498	0.500
LIG_FHA_1	257	263	PF00498	0.647
LIG_FHA_1	281	287	PF00498	0.544
LIG_FHA_1	30	36	PF00498	0.295
LIG_FHA_1	8	14	PF00498	0.252
LIG_FHA_2	215	221	PF00498	0.418
LIG_FHA_2	255	261	PF00498	0.617
LIG_FHA_2	279	285	PF00498	0.615
LIG_GBD_Chelix_1	136	144	PF00786	0.387
LIG_LIR_Gen_1	12	23	PF02991	0.368
LIG_LIR_Gen_1	132	142	PF02991	0.350
LIG_LIR_Nem_3	12	18	PF02991	0.285
LIG_LIR_Nem_3	132	137	PF02991	0.274
LIG_LIR_Nem_3	194	200	PF02991	0.404
LIG_MYND_1	275	279	PF01753	0.561
LIG_PCNA_yPIPBox_3	153	164	PF02747	0.228
LIG_Pex14_2	134	138	PF04695	0.298
LIG_SH2_CRK	99	103	PF00017	0.421
LIG_SH2_SRC	210	213	PF00017	0.472
LIG_SH2_STAP1	91	95	PF00017	0.512
LIG_SH2_STAT3	73	76	PF00017	0.496
LIG_SH2_STAT5	106	109	PF00017	0.525
LIG_SH2_STAT5	133	136	PF00017	0.299
LIG_SH2_STAT5	184	187	PF00017	0.231
LIG_SH2_STAT5	210	213	PF00017	0.512
LIG_SH2_STAT5	73	76	PF00017	0.525
LIG_SH3_1	53	59	PF00018	0.637
LIG_SH3_3	272	278	PF00018	0.592
LIG_SH3_3	52	58	PF00018	0.582
LIG_SH3_3	92	98	PF00018	0.360
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.219
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.259
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.267
LIG_SUMO_SIM_par_1	187	194	PF11976	0.261
LIG_SUMO_SIM_par_1	4	10	PF11976	0.290
LIG_TRFH_1	184	188	PF08558	0.160
LIG_WRC_WIRS_1	192	197	PF05994	0.387
LIG_WRPW_2	96	99	PF00400	0.512
MOD_CK1_1	163	169	PF00069	0.297
MOD_CK1_1	174	180	PF00069	0.249
MOD_CK2_1	164	170	PF00069	0.177
MOD_CK2_1	254	260	PF00069	0.550
MOD_CK2_1	278	284	PF00069	0.552
MOD_GlcNHglycan	173	176	PF01048	0.454
MOD_GlcNHglycan	177	180	PF01048	0.444
MOD_GlcNHglycan	217	220	PF01048	0.335
MOD_GSK3_1	160	167	PF00069	0.231
MOD_GSK3_1	171	178	PF00069	0.248
MOD_GSK3_1	206	213	PF00069	0.311
MOD_GSK3_1	250	257	PF00069	0.585
MOD_GSK3_1	278	285	PF00069	0.677
MOD_GSK3_1	29	36	PF00069	0.381
MOD_LATS_1	162	168	PF00433	0.177
MOD_N-GLC_1	214	219	PF02516	0.218
MOD_N-GLC_2	266	268	PF02516	0.351
MOD_N-GLC_2	292	294	PF02516	0.331
MOD_NEK2_1	1	6	PF00069	0.256
MOD_NEK2_1	143	148	PF00069	0.283
MOD_NEK2_1	180	185	PF00069	0.230
MOD_NEK2_1	200	205	PF00069	0.397
MOD_NEK2_1	206	211	PF00069	0.331
MOD_NEK2_1	7	12	PF00069	0.256
MOD_OFUCOSY	118	124	PF10250	0.218
MOD_PK_1	164	170	PF00069	0.275
MOD_PKA_2	160	166	PF00069	0.288
MOD_PKA_2	171	177	PF00069	0.192
MOD_PKA_2	254	260	PF00069	0.522
MOD_Plk_4	1	7	PF00069	0.287
MOD_Plk_4	138	144	PF00069	0.270
MOD_Plk_4	151	157	PF00069	0.229
MOD_Plk_4	191	197	PF00069	0.389
MOD_Plk_4	206	212	PF00069	0.251
MOD_Plk_4	231	237	PF00069	0.545
MOD_Plk_4	9	15	PF00069	0.256
TRG_ENDOCYTIC_2	133	136	PF00928	0.255
TRG_ENDOCYTIC_2	99	102	PF00928	0.421
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B1	Leptomonas seymouri	24%	100%
A0A0N1I542	Leptomonas seymouri	60%	100%
A0A0S4IT15	Bodo saltans	26%	83%
A0A0S4J156	Bodo saltans	30%	82%
A0A0S4JRL4	Bodo saltans	27%	82%
A0A1X0NY30	Trypanosomatidae	41%	97%
A0A3R7P4J6	Trypanosoma rangeli	38%	99%
A0A3S7WZD9	Leishmania donovani	80%	91%
A4H7G8	Leishmania braziliensis	28%	100%
A4I1S8	Leishmania infantum	81%	91%
B3DN87	Arabidopsis thaliana	25%	88%
C9ZKD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	91%
F1R013	Danio rerio	29%	77%
O14345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	90%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	85%
O80685	Arabidopsis thaliana	29%	72%
P59267	Mus musculus	27%	81%
P59268	Mus musculus	26%	81%
Q0WQK2	Arabidopsis thaliana	32%	67%
Q14AK4	Mus musculus	24%	85%
Q2TGJ1	Rattus norvegicus	30%	77%
Q3EBC2	Arabidopsis thaliana	26%	75%
Q4Q9K8	Leishmania major	78%	100%
Q58CU4	Bos taurus	26%	79%
Q58DA8	Bos taurus	26%	82%
Q5PNZ1	Arabidopsis thaliana	25%	72%
Q5R5J8	Pongo abelii	26%	81%
Q5Y5T2	Mus musculus	30%	78%
Q6BHT4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	80%
Q6CG20	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	78%
Q6CQB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	83%
Q75CB4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	79%
Q7ZVN4	Danio rerio	27%	76%
Q8VYS8	Arabidopsis thaliana	29%	73%
Q9FLM3	Arabidopsis thaliana	30%	72%
Q9JKR5	Rattus norvegicus	27%	81%
Q9NUE0	Homo sapiens	27%	76%
Q9SB58	Arabidopsis thaliana	30%	73%
Q9UIJ5	Homo sapiens	26%	81%
Q9Y397	Homo sapiens	26%	81%
V5BCH8	Trypanosoma cruzi	42%	99%