Structure-specific endonuclease subunit SLX1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GIY-YIG catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIR5_LEIBR

TriTrypDb:

LbrM.25.1030 , LBRM2903_250019500

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0033557	Slx1-Slx4 complex	3	7
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

E9AIR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006302	double-strand break repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0017108	5'-flap endonuclease activity	7	7
GO:0048256	flap endonuclease activity	6	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0005488	binding	1	2
GO:0008821	crossover junction DNA endonuclease activity	7	1
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	6	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	1
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.485
CLV_NRD_NRD_1	144	146	PF00675	0.534
CLV_NRD_NRD_1	302	304	PF00675	0.715
CLV_NRD_NRD_1	32	34	PF00675	0.346
CLV_NRD_NRD_1	46	48	PF00675	0.310
CLV_NRD_NRD_1	50	52	PF00675	0.247
CLV_NRD_NRD_1	513	515	PF00675	0.583
CLV_NRD_NRD_1	547	549	PF00675	0.610
CLV_NRD_NRD_1	554	556	PF00675	0.530
CLV_NRD_NRD_1	582	584	PF00675	0.698
CLV_NRD_NRD_1	622	624	PF00675	0.731
CLV_NRD_NRD_1	97	99	PF00675	0.453
CLV_PCSK_KEX2_1	144	146	PF00082	0.531
CLV_PCSK_KEX2_1	302	304	PF00082	0.715
CLV_PCSK_KEX2_1	32	34	PF00082	0.346
CLV_PCSK_KEX2_1	46	48	PF00082	0.310
CLV_PCSK_KEX2_1	50	52	PF00082	0.247
CLV_PCSK_KEX2_1	513	515	PF00082	0.583
CLV_PCSK_KEX2_1	541	543	PF00082	0.531
CLV_PCSK_KEX2_1	547	549	PF00082	0.578
CLV_PCSK_KEX2_1	554	556	PF00082	0.565
CLV_PCSK_KEX2_1	573	575	PF00082	0.635
CLV_PCSK_KEX2_1	581	583	PF00082	0.665
CLV_PCSK_KEX2_1	621	623	PF00082	0.743
CLV_PCSK_KEX2_1	97	99	PF00082	0.453
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.531
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.667
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.561
CLV_PCSK_PC7_1	46	52	PF00082	0.346
CLV_PCSK_SKI1_1	145	149	PF00082	0.559
CLV_PCSK_SKI1_1	229	233	PF00082	0.518
CLV_PCSK_SKI1_1	241	245	PF00082	0.544
CLV_PCSK_SKI1_1	537	541	PF00082	0.512
CLV_PCSK_SKI1_1	68	72	PF00082	0.346
DEG_APCC_DBOX_1	469	477	PF00400	0.448
DEG_COP1_1	605	612	PF00400	0.532
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DEG_SPOP_SBC_1	198	202	PF00917	0.548
DEG_SPOP_SBC_1	603	607	PF00917	0.536
DOC_CKS1_1	215	220	PF01111	0.650
DOC_MAPK_gen_1	144	150	PF00069	0.504
DOC_MAPK_gen_1	537	545	PF00069	0.530
DOC_MAPK_gen_1	85	92	PF00069	0.567
DOC_MAPK_RevD_3	534	548	PF00069	0.378
DOC_PP2B_LxvP_1	243	246	PF13499	0.674
DOC_PP2B_LxvP_1	377	380	PF13499	0.669
DOC_PP4_FxxP_1	360	363	PF00568	0.802
DOC_USP7_MATH_1	187	191	PF00917	0.736
DOC_USP7_MATH_1	198	202	PF00917	0.699
DOC_USP7_MATH_1	293	297	PF00917	0.807
DOC_USP7_MATH_1	338	342	PF00917	0.618
DOC_USP7_MATH_1	356	360	PF00917	0.667
DOC_USP7_MATH_1	366	370	PF00917	0.592
DOC_USP7_MATH_1	385	389	PF00917	0.479
DOC_USP7_MATH_1	459	463	PF00917	0.488
DOC_USP7_MATH_1	640	644	PF00917	0.564
DOC_USP7_MATH_1	645	649	PF00917	0.790
DOC_USP7_MATH_1	656	660	PF00917	0.589
DOC_USP7_MATH_1	669	673	PF00917	0.621
DOC_USP7_MATH_1	682	686	PF00917	0.727
DOC_USP7_MATH_1	80	84	PF00917	0.600
DOC_USP7_UBL2_3	537	541	PF12436	0.527
DOC_WW_Pin1_4	155	160	PF00397	0.806
DOC_WW_Pin1_4	179	184	PF00397	0.729
DOC_WW_Pin1_4	214	219	PF00397	0.645
DOC_WW_Pin1_4	259	264	PF00397	0.567
DOC_WW_Pin1_4	312	317	PF00397	0.632
DOC_WW_Pin1_4	359	364	PF00397	0.780
DOC_WW_Pin1_4	408	413	PF00397	0.673
DOC_WW_Pin1_4	494	499	PF00397	0.765
DOC_WW_Pin1_4	507	512	PF00397	0.704
DOC_WW_Pin1_4	623	628	PF00397	0.755
DOC_WW_Pin1_4	643	648	PF00397	0.451
DOC_WW_Pin1_4	652	657	PF00397	0.793
LIG_14-3-3_CanoR_1	111	115	PF00244	0.578
LIG_14-3-3_CanoR_1	169	174	PF00244	0.758
LIG_14-3-3_CanoR_1	320	329	PF00244	0.811
LIG_14-3-3_CanoR_1	358	363	PF00244	0.712
LIG_14-3-3_CanoR_1	46	54	PF00244	0.514
LIG_14-3-3_CanoR_1	470	480	PF00244	0.457
LIG_14-3-3_CanoR_1	585	594	PF00244	0.602
LIG_14-3-3_CanoR_1	602	612	PF00244	0.616
LIG_14-3-3_CanoR_1	625	631	PF00244	0.699
LIG_BRCT_BRCA1_1	218	222	PF00533	0.513
LIG_BRCT_BRCA1_1	356	360	PF00533	0.551
LIG_BRCT_BRCA1_1	385	389	PF00533	0.524
LIG_BRCT_BRCA1_1	647	651	PF00533	0.542
LIG_Clathr_ClatBox_1	221	225	PF01394	0.516
LIG_deltaCOP1_diTrp_1	286	292	PF00928	0.762
LIG_deltaCOP1_diTrp_1	74	77	PF00928	0.546
LIG_EVH1_1	377	381	PF00568	0.495
LIG_FHA_1	103	109	PF00498	0.393
LIG_FHA_1	119	125	PF00498	0.281
LIG_FHA_1	207	213	PF00498	0.623
LIG_FHA_1	215	221	PF00498	0.539
LIG_FHA_1	299	305	PF00498	0.701
LIG_FHA_1	372	378	PF00498	0.541
LIG_FHA_1	604	610	PF00498	0.622
LIG_FHA_1	87	93	PF00498	0.488
LIG_FHA_2	10	16	PF00498	0.546
LIG_FHA_2	248	254	PF00498	0.542
LIG_FHA_2	487	493	PF00498	0.465
LIG_LIR_Apic_2	357	363	PF02991	0.776
LIG_LIR_Apic_2	74	80	PF02991	0.546
LIG_LIR_Gen_1	113	122	PF02991	0.571
LIG_LIR_Gen_1	2	11	PF02991	0.411
LIG_LIR_Nem_3	113	118	PF02991	0.587
LIG_LIR_Nem_3	2	8	PF02991	0.480
LIG_LIR_Nem_3	21	26	PF02991	0.546
LIG_LIR_Nem_3	270	274	PF02991	0.622
LIG_LYPXL_SIV_4	100	108	PF13949	0.537
LIG_MYND_1	214	218	PF01753	0.560
LIG_MYND_1	633	637	PF01753	0.527
LIG_PDZ_Class_3	696	701	PF00595	0.501
LIG_PDZ_Wminus1_1	699	701	PF00595	0.501
LIG_Pex14_2	73	77	PF04695	0.546
LIG_RPA_C_Fungi	543	555	PF08784	0.656
LIG_SH2_NCK_1	101	105	PF00017	0.534
LIG_SH2_NCK_1	482	486	PF00017	0.571
LIG_SH2_STAP1	274	278	PF00017	0.611
LIG_SH2_STAT3	550	553	PF00017	0.548
LIG_SH2_STAT5	23	26	PF00017	0.411
LIG_SH2_STAT5	307	310	PF00017	0.704
LIG_SH2_STAT5	402	405	PF00017	0.547
LIG_SH2_STAT5	460	463	PF00017	0.520
LIG_SH2_STAT5	9	12	PF00017	0.411
LIG_SH3_1	514	520	PF00018	0.522
LIG_SH3_2	414	419	PF14604	0.610
LIG_SH3_2	508	513	PF14604	0.759
LIG_SH3_3	153	159	PF00018	0.535
LIG_SH3_3	180	186	PF00018	0.657
LIG_SH3_3	212	218	PF00018	0.537
LIG_SH3_3	360	366	PF00018	0.772
LIG_SH3_3	375	381	PF00018	0.545
LIG_SH3_3	411	417	PF00018	0.610
LIG_SH3_3	449	455	PF00018	0.440
LIG_SH3_3	502	508	PF00018	0.761
LIG_SH3_3	514	520	PF00018	0.406
LIG_SH3_3	621	627	PF00018	0.692
LIG_SH3_3	631	637	PF00018	0.760
LIG_SH3_CIN85_PxpxPR_1	410	415	PF14604	0.734
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.605
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.446
LIG_SUMO_SIM_par_1	688	694	PF11976	0.763
LIG_SUMO_SIM_par_1	88	94	PF11976	0.455
LIG_TRAF2_2	174	179	PF00917	0.584
MOD_CDC14_SPxK_1	317	320	PF00782	0.768
MOD_CDC14_SPxK_1	510	513	PF00782	0.750
MOD_CDK_SPK_2	155	160	PF00069	0.806
MOD_CDK_SPxK_1	314	320	PF00069	0.718
MOD_CDK_SPxK_1	507	513	PF00069	0.760
MOD_CDK_SPxxK_3	408	415	PF00069	0.580
MOD_CDK_SPxxK_3	507	514	PF00069	0.751
MOD_CK1_1	167	173	PF00069	0.839
MOD_CK1_1	262	268	PF00069	0.716
MOD_CK1_1	288	294	PF00069	0.698
MOD_CK1_1	347	353	PF00069	0.739
MOD_CK1_1	359	365	PF00069	0.599
MOD_CK1_1	370	376	PF00069	0.697
MOD_CK1_1	62	68	PF00069	0.290
MOD_CK1_1	626	632	PF00069	0.737
MOD_CK1_1	643	649	PF00069	0.567
MOD_CK1_1	654	660	PF00069	0.621
MOD_CK1_1	685	691	PF00069	0.672
MOD_CK2_1	293	299	PF00069	0.804
MOD_CK2_1	338	344	PF00069	0.628
MOD_CK2_1	480	486	PF00069	0.341
MOD_CK2_1	626	632	PF00069	0.692
MOD_DYRK1A_RPxSP_1	155	159	PF00069	0.703
MOD_DYRK1A_RPxSP_1	623	627	PF00069	0.808
MOD_GlcNHglycan	169	172	PF01048	0.632
MOD_GlcNHglycan	264	267	PF01048	0.790
MOD_GlcNHglycan	346	349	PF01048	0.745
MOD_GlcNHglycan	385	388	PF01048	0.674
MOD_GlcNHglycan	588	591	PF01048	0.707
MOD_GlcNHglycan	61	64	PF01048	0.404
MOD_GlcNHglycan	658	661	PF01048	0.693
MOD_GlcNHglycan	671	674	PF01048	0.704
MOD_GlcNHglycan	82	85	PF01048	0.603
MOD_GSK3_1	155	162	PF00069	0.741
MOD_GSK3_1	198	205	PF00069	0.757
MOD_GSK3_1	310	317	PF00069	0.697
MOD_GSK3_1	354	361	PF00069	0.689
MOD_GSK3_1	366	373	PF00069	0.725
MOD_GSK3_1	573	580	PF00069	0.716
MOD_GSK3_1	604	611	PF00069	0.755
MOD_GSK3_1	643	650	PF00069	0.706
MOD_GSK3_1	652	659	PF00069	0.643
MOD_GSK3_1	669	676	PF00069	0.589
MOD_N-GLC_1	179	184	PF02516	0.574
MOD_N-GLC_1	383	388	PF02516	0.769
MOD_N-GLC_1	676	681	PF02516	0.542
MOD_NEK2_1	118	123	PF00069	0.409
MOD_NEK2_1	140	145	PF00069	0.398
MOD_NEK2_1	199	204	PF00069	0.686
MOD_NEK2_1	264	269	PF00069	0.743
MOD_NEK2_1	367	372	PF00069	0.633
MOD_NEK2_1	394	399	PF00069	0.637
MOD_NEK2_1	403	408	PF00069	0.502
MOD_NEK2_1	651	656	PF00069	0.552
MOD_NEK2_2	102	107	PF00069	0.528
MOD_PIKK_1	164	170	PF00454	0.782
MOD_PIKK_1	187	193	PF00454	0.720
MOD_PIKK_1	367	373	PF00454	0.545
MOD_PIKK_1	499	505	PF00454	0.702
MOD_PIKK_1	515	521	PF00454	0.383
MOD_PK_1	169	175	PF00069	0.585
MOD_PKA_1	46	52	PF00069	0.367
MOD_PKA_1	573	579	PF00069	0.762
MOD_PKA_2	110	116	PF00069	0.574
MOD_PKA_2	45	51	PF00069	0.411
MOD_PKA_2	573	579	PF00069	0.762
MOD_PKA_2	586	592	PF00069	0.648
MOD_PKA_2	86	92	PF00069	0.459
MOD_PKB_1	51	59	PF00069	0.411
MOD_PKB_1	581	589	PF00069	0.705
MOD_PKB_1	623	631	PF00069	0.559
MOD_Plk_1	118	124	PF00069	0.410
MOD_Plk_1	274	280	PF00069	0.659
MOD_Plk_1	367	373	PF00069	0.632
MOD_Plk_1	676	682	PF00069	0.654
MOD_Plk_1	685	691	PF00069	0.727
MOD_Plk_4	110	116	PF00069	0.574
MOD_Plk_4	216	222	PF00069	0.527
MOD_Plk_4	274	280	PF00069	0.597
MOD_Plk_4	385	391	PF00069	0.611
MOD_Plk_4	453	459	PF00069	0.333
MOD_Plk_4	685	691	PF00069	0.741
MOD_ProDKin_1	155	161	PF00069	0.808
MOD_ProDKin_1	179	185	PF00069	0.725
MOD_ProDKin_1	214	220	PF00069	0.651
MOD_ProDKin_1	259	265	PF00069	0.564
MOD_ProDKin_1	312	318	PF00069	0.632
MOD_ProDKin_1	359	365	PF00069	0.774
MOD_ProDKin_1	408	414	PF00069	0.669
MOD_ProDKin_1	494	500	PF00069	0.763
MOD_ProDKin_1	507	513	PF00069	0.695
MOD_ProDKin_1	623	629	PF00069	0.755
MOD_ProDKin_1	643	649	PF00069	0.454
MOD_ProDKin_1	652	658	PF00069	0.792
MOD_SUMO_for_1	71	74	PF00179	0.411
TRG_DiLeu_BaEn_4	434	440	PF01217	0.606
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.595
TRG_ER_diArg_1	302	304	PF00400	0.715
TRG_ER_diArg_1	31	33	PF00400	0.400
TRG_ER_diArg_1	50	53	PF00400	0.214
TRG_ER_diArg_1	512	514	PF00400	0.617
TRG_ER_diArg_1	547	549	PF00400	0.680
TRG_ER_diArg_1	554	557	PF00400	0.549
TRG_ER_diArg_1	581	583	PF00400	0.733
TRG_ER_diArg_1	584	587	PF00400	0.699
TRG_ER_diArg_1	622	625	PF00400	0.565
TRG_ER_diArg_1	96	98	PF00400	0.493
TRG_NLS_MonoExtC_3	620	625	PF00514	0.557
TRG_NLS_MonoExtN_4	537	544	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G5	Leptomonas seymouri	49%	99%
A0A3S7WZ95	Leishmania donovani	77%	99%
A4I1H7	Leishmania infantum	77%	99%
E9AXL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q9W0	Leishmania major	74%	100%