Structure-specific endonuclease subunit SLX1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GIY-YIG catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIR5_LEIBR

TriTrypDb:

LbrM.25.1030 , LBRM2903_250019500

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0033557	Slx1-Slx4 complex	3	7
GO:0140513	nuclear protein-containing complex	2	7

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Expansion

Sequence features

E9AIR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR5

Function

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Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0005488	binding	1	2
GO:0008821	crossover junction DNA endonuclease activity	7	1
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.485
CLV_NRD_NRD_1	144	146	PF00675	0.534
CLV_NRD_NRD_1	302	304	PF00675	0.715
CLV_NRD_NRD_1	32	34	PF00675	0.346
CLV_NRD_NRD_1	46	48	PF00675	0.310
CLV_NRD_NRD_1	50	52	PF00675	0.247
CLV_NRD_NRD_1	513	515	PF00675	0.583
CLV_NRD_NRD_1	547	549	PF00675	0.610
CLV_NRD_NRD_1	554	556	PF00675	0.530
CLV_NRD_NRD_1	582	584	PF00675	0.698

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G5	Leptomonas seymouri	49%	99%
A0A3S7WZ95	Leishmania donovani	77%	99%
A4I1H7	Leishmania infantum	77%	99%
E9AXL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q9W0	Leishmania major	74%	100%

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