LeishMANIAdb
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Structure-specific endonuclease subunit SLX1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Structure-specific endonuclease subunit SLX1 homolog
Gene product:
GIY-YIG catalytic domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
E9AIR5_LEIBR
TriTrypDb:
LbrM.25.1030 , LBRM2903_250019500
Length:
701

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0032991 protein-containing complex 1 7
GO:0033557 Slx1-Slx4 complex 3 7
GO:0140513 nuclear protein-containing complex 2 7
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Expansion

Sequence features

E9AIR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIR5

Function

Biological processes
TermNameLevelCount
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006259 DNA metabolic process 4 7
GO:0006281 DNA repair 5 7
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0006950 response to stress 2 7
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 7
GO:0004518 nuclease activity 4 7
GO:0004519 endonuclease activity 5 7
GO:0004520 DNA endonuclease activity 5 7
GO:0004536 DNA nuclease activity 4 7
GO:0005488 binding 1 2
GO:0008821 crossover junction DNA endonuclease activity 7 1
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 489 493 PF00656 0.485
CLV_NRD_NRD_1 144 146 PF00675 0.534
CLV_NRD_NRD_1 302 304 PF00675 0.715
CLV_NRD_NRD_1 32 34 PF00675 0.346
CLV_NRD_NRD_1 46 48 PF00675 0.310
CLV_NRD_NRD_1 50 52 PF00675 0.247
CLV_NRD_NRD_1 513 515 PF00675 0.583
CLV_NRD_NRD_1 547 549 PF00675 0.610
CLV_NRD_NRD_1 554 556 PF00675 0.530
CLV_NRD_NRD_1 582 584 PF00675 0.698
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I7G5 Leptomonas seymouri 49% 99%
A0A3S7WZ95 Leishmania donovani 77% 99%
A4I1H7 Leishmania infantum 77% 99%
E9AXL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4Q9W0 Leishmania major 74% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS