Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIQ9_LEIBR

TriTrypDb:

LbrM.23.1911 , LBRM2903_230030300

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.678
CLV_C14_Caspase3-7	255	259	PF00656	0.472
CLV_NRD_NRD_1	209	211	PF00675	0.524
CLV_NRD_NRD_1	314	316	PF00675	0.662
CLV_PCSK_FUR_1	207	211	PF00082	0.522
CLV_PCSK_FUR_1	312	316	PF00082	0.660
CLV_PCSK_KEX2_1	146	148	PF00082	0.512
CLV_PCSK_KEX2_1	209	211	PF00082	0.524
CLV_PCSK_KEX2_1	264	266	PF00082	0.464
CLV_PCSK_KEX2_1	312	314	PF00082	0.664
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.512
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.464
CLV_PCSK_PC7_1	309	315	PF00082	0.658
CLV_PCSK_SKI1_1	147	151	PF00082	0.502
CLV_PCSK_SKI1_1	209	213	PF00082	0.503
CLV_PCSK_SKI1_1	314	318	PF00082	0.503
DEG_SCF_TRCP1_1	252	257	PF00400	0.562
DEG_SPOP_SBC_1	296	300	PF00917	0.642
DOC_CYCLIN_RxL_1	206	216	PF00134	0.514
DOC_CYCLIN_RxL_1	217	227	PF00134	0.409
DOC_MAPK_gen_1	146	152	PF00069	0.500
DOC_PP1_RVXF_1	218	225	PF00149	0.559
DOC_PP2B_LxvP_1	150	153	PF13499	0.487
DOC_PP4_FxxP_1	27	30	PF00568	0.516
DOC_USP7_MATH_1	106	110	PF00917	0.600
DOC_USP7_MATH_1	131	135	PF00917	0.780
DOC_USP7_MATH_1	214	218	PF00917	0.378
DOC_USP7_MATH_1	233	237	PF00917	0.588
DOC_USP7_MATH_1	296	300	PF00917	0.642
DOC_USP7_MATH_1	34	38	PF00917	0.620
DOC_USP7_MATH_1	89	93	PF00917	0.546
DOC_WW_Pin1_4	12	17	PF00397	0.677
DOC_WW_Pin1_4	138	143	PF00397	0.658
DOC_WW_Pin1_4	163	168	PF00397	0.508
DOC_WW_Pin1_4	26	31	PF00397	0.617
DOC_WW_Pin1_4	292	297	PF00397	0.700
LIG_14-3-3_CanoR_1	12	16	PF00244	0.525
LIG_14-3-3_CanoR_1	209	219	PF00244	0.528
LIG_14-3-3_CanoR_1	313	323	PF00244	0.653
LIG_BIR_II_1	1	5	PF00653	0.765
LIG_BRCT_BRCA1_1	252	256	PF00533	0.496
LIG_BRCT_BRCA1_1	3	7	PF00533	0.499
LIG_CSL_BTD_1	190	193	PF09270	0.514
LIG_FHA_1	178	184	PF00498	0.668
LIG_FHA_1	187	193	PF00498	0.549
LIG_FHA_1	292	298	PF00498	0.488
LIG_FHA_1	51	57	PF00498	0.661
LIG_FHA_2	113	119	PF00498	0.620
LIG_FHA_2	6	12	PF00498	0.530
LIG_LIR_Nem_3	215	221	PF02991	0.534
LIG_LIR_Nem_3	286	290	PF02991	0.547
LIG_LIR_Nem_3	298	304	PF02991	0.606
LIG_LYPXL_yS_3	304	307	PF13949	0.498
LIG_MLH1_MIPbox_1	3	7	PF16413	0.499
LIG_PDZ_Class_2	325	330	PF00595	0.499
LIG_Rb_LxCxE_1	172	194	PF01857	0.587
LIG_SH2_SRC	80	83	PF00017	0.501
LIG_SH2_STAT5	301	304	PF00017	0.488
LIG_SH2_STAT5	80	83	PF00017	0.501
LIG_SH3_3	161	167	PF00018	0.502
LIG_SH3_3	229	235	PF00018	0.636
LIG_SH3_3	299	305	PF00018	0.488
LIG_SUMO_SIM_par_1	229	237	PF11976	0.481
LIG_TRAF2_1	17	20	PF00917	0.507
LIG_TYR_ITIM	302	307	PF00017	0.493
MOD_CDC14_SPxK_1	15	18	PF00782	0.659
MOD_CDC14_SPxK_1	29	32	PF00782	0.502
MOD_CDK_SPxK_1	12	18	PF00069	0.659
MOD_CDK_SPxK_1	26	32	PF00069	0.503
MOD_CK1_1	138	144	PF00069	0.694
MOD_CK1_1	165	171	PF00069	0.661
MOD_CK1_1	292	298	PF00069	0.689
MOD_CK1_1	92	98	PF00069	0.664
MOD_CK2_1	112	118	PF00069	0.653
MOD_CK2_1	315	321	PF00069	0.661
MOD_CK2_1	57	63	PF00069	0.687
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	101	104	PF01048	0.581
MOD_GlcNHglycan	107	111	PF01048	0.779
MOD_GlcNHglycan	112	115	PF01048	0.721
MOD_GlcNHglycan	133	136	PF01048	0.807
MOD_GlcNHglycan	252	255	PF01048	0.534
MOD_GlcNHglycan	291	294	PF01048	0.582
MOD_GlcNHglycan	58	62	PF01048	0.579
MOD_GlcNHglycan	82	86	PF01048	0.652
MOD_GSK3_1	1	8	PF00069	0.600
MOD_GSK3_1	106	113	PF00069	0.620
MOD_GSK3_1	131	138	PF00069	0.769
MOD_GSK3_1	165	172	PF00069	0.679
MOD_GSK3_1	173	180	PF00069	0.627
MOD_GSK3_1	182	189	PF00069	0.500
MOD_GSK3_1	191	198	PF00069	0.439
MOD_GSK3_1	210	217	PF00069	0.436
MOD_GSK3_1	250	257	PF00069	0.591
MOD_GSK3_1	291	298	PF00069	0.625
MOD_GSK3_1	322	329	PF00069	0.506
MOD_GSK3_1	89	96	PF00069	0.723
MOD_N-GLC_1	162	167	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	169	174	PF00069	0.625
MOD_NEK2_1	297	302	PF00069	0.644
MOD_NEK2_1	57	62	PF00069	0.614
MOD_NEK2_2	35	40	PF00069	0.536
MOD_PIKK_1	191	197	PF00454	0.522
MOD_PIKK_1	323	329	PF00454	0.495
MOD_PKA_1	314	320	PF00069	0.503
MOD_PKA_2	11	17	PF00069	0.543
MOD_PKA_2	314	320	PF00069	0.503
MOD_PKB_1	312	320	PF00069	0.652
MOD_Plk_1	214	220	PF00069	0.378
MOD_Plk_1	35	41	PF00069	0.537
MOD_Plk_2-3	283	289	PF00069	0.501
MOD_Plk_4	1	7	PF00069	0.503
MOD_Plk_4	186	192	PF00069	0.514
MOD_Plk_4	214	220	PF00069	0.457
MOD_Plk_4	297	303	PF00069	0.495
MOD_ProDKin_1	12	18	PF00069	0.678
MOD_ProDKin_1	138	144	PF00069	0.658
MOD_ProDKin_1	163	169	PF00069	0.508
MOD_ProDKin_1	26	32	PF00069	0.618
MOD_ProDKin_1	292	298	PF00069	0.700
TRG_DiLeu_BaEn_4	19	25	PF01217	0.512
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.510
TRG_ENDOCYTIC_2	218	221	PF00928	0.545
TRG_ENDOCYTIC_2	304	307	PF00928	0.656
TRG_ER_diArg_1	209	211	PF00400	0.524
TRG_ER_diArg_1	311	314	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICW3	Leishmania donovani	65%	86%
A4I2B0	Leishmania infantum	65%	87%
E9AYF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	87%
Q4Q915	Leishmania major	62%	100%