Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

E9AIQ8_LEIBR

TriTrypDb:

LbrM.23.0381 , LBRM2903_230009600

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.682
CLV_C14_Caspase3-7	321	325	PF00656	0.584
CLV_NRD_NRD_1	310	312	PF00675	0.536
CLV_NRD_NRD_1	60	62	PF00675	0.668
CLV_NRD_NRD_1	73	75	PF00675	0.504
CLV_PCSK_KEX2_1	310	312	PF00082	0.583
CLV_PCSK_KEX2_1	73	75	PF00082	0.504
CLV_PCSK_SKI1_1	291	295	PF00082	0.432
CLV_PCSK_SKI1_1	310	314	PF00082	0.534
DEG_SPOP_SBC_1	134	138	PF00917	0.671
DEG_SPOP_SBC_1	253	257	PF00917	0.426
DOC_ANK_TNKS_1	24	31	PF00023	0.417
DOC_CDC14_PxL_1	277	285	PF14671	0.494
DOC_CKS1_1	269	274	PF01111	0.741
DOC_MAPK_gen_1	61	69	PF00069	0.706
DOC_MAPK_MEF2A_6	61	69	PF00069	0.472
DOC_PP2B_LxvP_1	128	131	PF13499	0.526
DOC_PP2B_LxvP_1	87	90	PF13499	0.494
DOC_PP4_FxxP_1	269	272	PF00568	0.720
DOC_SPAK_OSR1_1	233	237	PF12202	0.399
DOC_USP7_MATH_1	134	138	PF00917	0.710
DOC_USP7_MATH_1	177	181	PF00917	0.757
DOC_USP7_MATH_1	344	348	PF00917	0.772
DOC_WW_Pin1_4	139	144	PF00397	0.745
DOC_WW_Pin1_4	145	150	PF00397	0.512
DOC_WW_Pin1_4	268	273	PF00397	0.629
DOC_WW_Pin1_4	28	33	PF00397	0.630
DOC_WW_Pin1_4	310	315	PF00397	0.690
DOC_WW_Pin1_4	93	98	PF00397	0.459
LIG_14-3-3_CanoR_1	176	185	PF00244	0.742
LIG_14-3-3_CanoR_1	201	206	PF00244	0.443
LIG_14-3-3_CanoR_1	33	39	PF00244	0.653
LIG_14-3-3_CterR_2	352	355	PF00244	0.611
LIG_EH1_1	233	241	PF00400	0.381
LIG_FAT_LD_1	13	21	PF03623	0.583
LIG_FHA_1	134	140	PF00498	0.732
LIG_FHA_1	180	186	PF00498	0.479
LIG_FHA_1	206	212	PF00498	0.564
LIG_FHA_1	318	324	PF00498	0.670
LIG_FHA_2	316	322	PF00498	0.636
LIG_FHA_2	7	13	PF00498	0.498
LIG_LIR_Gen_1	150	161	PF02991	0.640
LIG_LIR_Gen_1	263	272	PF02991	0.487
LIG_LIR_Gen_1	347	354	PF02991	0.652
LIG_LIR_Nem_3	150	156	PF02991	0.650
LIG_LIR_Nem_3	158	163	PF02991	0.604
LIG_LIR_Nem_3	263	269	PF02991	0.473
LIG_LIR_Nem_3	347	353	PF02991	0.650
LIG_LIR_Nem_3	50	54	PF02991	0.487
LIG_LIR_Nem_3	99	104	PF02991	0.594
LIG_RPA_C_Fungi	69	81	PF08784	0.514
LIG_SH2_CRK	101	105	PF00017	0.605
LIG_SH2_CRK	45	49	PF00017	0.565
LIG_SH2_STAP1	45	49	PF00017	0.667
LIG_SH2_STAT5	168	171	PF00017	0.559
LIG_SH2_STAT5	245	248	PF00017	0.374
LIG_SH2_STAT5	45	48	PF00017	0.438
LIG_SH3_3	105	111	PF00018	0.602
LIG_SH3_3	275	281	PF00018	0.556
LIG_SH3_3	323	329	PF00018	0.580
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.469
LIG_SUMO_SIM_anti_2	9	17	PF11976	0.632
LIG_SUMO_SIM_par_1	178	187	PF11976	0.456
LIG_TRAF2_1	37	40	PF00917	0.548
LIG_TYR_ITIM	43	48	PF00017	0.546
LIG_TYR_ITSM	97	104	PF00017	0.504
LIG_WRC_WIRS_1	283	288	PF05994	0.429
MOD_CDK_SPK_2	139	144	PF00069	0.554
MOD_CDK_SPK_2	28	33	PF00069	0.665
MOD_CDK_SPxxK_3	310	317	PF00069	0.692
MOD_CK1_1	137	143	PF00069	0.678
MOD_CK1_1	148	154	PF00069	0.523
MOD_CK1_1	179	185	PF00069	0.544
MOD_CK1_1	223	229	PF00069	0.634
MOD_CK1_1	96	102	PF00069	0.494
MOD_CK2_1	229	235	PF00069	0.516
MOD_CK2_1	257	263	PF00069	0.533
MOD_CK2_1	315	321	PF00069	0.698
MOD_CK2_1	34	40	PF00069	0.506
MOD_CK2_1	6	12	PF00069	0.503
MOD_CK2_1	88	94	PF00069	0.714
MOD_CMANNOS	244	247	PF00535	0.522
MOD_GlcNHglycan	157	160	PF01048	0.712
MOD_GlcNHglycan	179	182	PF01048	0.613
MOD_GlcNHglycan	224	228	PF01048	0.696
MOD_GSK3_1	133	140	PF00069	0.704
MOD_GSK3_1	147	154	PF00069	0.756
MOD_GSK3_1	175	182	PF00069	0.601
MOD_GSK3_1	191	198	PF00069	0.587
MOD_GSK3_1	201	208	PF00069	0.585
MOD_GSK3_1	215	222	PF00069	0.635
MOD_GSK3_1	249	256	PF00069	0.427
MOD_N-GLC_1	124	129	PF02516	0.528
MOD_NEK2_1	215	220	PF00069	0.455
MOD_NEK2_1	34	39	PF00069	0.624
MOD_NEK2_1	56	61	PF00069	0.551
MOD_NEK2_1	83	88	PF00069	0.572
MOD_PIKK_1	56	62	PF00454	0.614
MOD_PK_1	201	207	PF00069	0.440
MOD_PKA_2	175	181	PF00069	0.758
MOD_PKA_2	205	211	PF00069	0.568
MOD_Plk_1	124	130	PF00069	0.581
MOD_Plk_4	148	154	PF00069	0.764
MOD_Plk_4	191	197	PF00069	0.584
MOD_Plk_4	235	241	PF00069	0.525
MOD_Plk_4	43	49	PF00069	0.413
MOD_Plk_4	96	102	PF00069	0.614
MOD_ProDKin_1	139	145	PF00069	0.745
MOD_ProDKin_1	268	274	PF00069	0.637
MOD_ProDKin_1	28	34	PF00069	0.629
MOD_ProDKin_1	310	316	PF00069	0.690
MOD_ProDKin_1	93	99	PF00069	0.456
TRG_DiLeu_BaEn_1	12	17	PF01217	0.633
TRG_DiLeu_BaEn_1	235	240	PF01217	0.367
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.500
TRG_ENDOCYTIC_2	101	104	PF00928	0.602
TRG_ENDOCYTIC_2	231	234	PF00928	0.670
TRG_ENDOCYTIC_2	45	48	PF00928	0.501
TRG_ER_diArg_1	22	25	PF00400	0.602
TRG_ER_diArg_1	310	312	PF00400	0.536
TRG_ER_diArg_1	72	74	PF00400	0.516
TRG_NES_CRM1_1	14	29	PF08389	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J7	Leptomonas seymouri	41%	91%
A0A3Q8IFQ9	Leishmania donovani	66%	97%
E9ACS3	Leishmania major	68%	100%
E9AH10	Leishmania infantum	67%	97%
E9AW39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	97%