Middle S protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Middle S protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIQ6_LEIBR

TriTrypDb:

LbrM.22.0261

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AIQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.568
CLV_PCSK_KEX2_1	138	140	PF00082	0.467
CLV_PCSK_KEX2_1	2	4	PF00082	0.568
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.467
CLV_PCSK_SKI1_1	10	14	PF00082	0.553
CLV_PCSK_SKI1_1	108	112	PF00082	0.490
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DEG_SPOP_SBC_1	120	124	PF00917	0.434
DEG_SPOP_SBC_1	33	37	PF00917	0.625
DOC_CYCLIN_RxL_1	105	114	PF00134	0.381
DOC_MAPK_MEF2A_6	108	117	PF00069	0.496
DOC_MAPK_NFAT4_5	108	116	PF00069	0.390
DOC_PP2B_LxvP_1	132	135	PF13499	0.471
DOC_PP4_FxxP_1	28	31	PF00568	0.644
DOC_USP7_MATH_1	33	37	PF00917	0.614
DOC_WW_Pin1_4	116	121	PF00397	0.656
DOC_WW_Pin1_4	19	24	PF00397	0.508
DOC_WW_Pin1_4	41	46	PF00397	0.552
LIG_14-3-3_CanoR_1	10	17	PF00244	0.537
LIG_14-3-3_CanoR_1	2	6	PF00244	0.576
LIG_FHA_1	127	133	PF00498	0.452
LIG_FHA_1	24	30	PF00498	0.565
LIG_FHA_1	76	82	PF00498	0.456
LIG_FHA_2	122	128	PF00498	0.442
LIG_Integrin_RGD_1	125	127	PF01839	0.457
LIG_LIR_Apic_2	26	31	PF02991	0.561
LIG_NRBOX	72	78	PF00104	0.605
LIG_SH2_SRC	133	136	PF00017	0.476
LIG_UBA3_1	110	116	PF00899	0.392
LIG_UBA3_1	76	85	PF00899	0.587
MOD_CK1_1	119	125	PF00069	0.616
MOD_CK1_1	68	74	PF00069	0.593
MOD_GlcNHglycan	87	90	PF01048	0.484
MOD_GSK3_1	116	123	PF00069	0.427
MOD_GSK3_1	19	26	PF00069	0.529
MOD_GSK3_1	71	78	PF00069	0.570
MOD_GSK3_1	85	92	PF00069	0.563
MOD_N-GLC_1	97	102	PF02516	0.468
MOD_N-GLC_2	18	20	PF02516	0.544
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	111	116	PF00069	0.614
MOD_NEK2_1	121	126	PF00069	0.656
MOD_NEK2_1	34	39	PF00069	0.610
MOD_NEK2_1	76	81	PF00069	0.431
MOD_NEK2_1	8	13	PF00069	0.551
MOD_OFUCOSY	95	102	PF10250	0.501
MOD_PIKK_1	10	16	PF00454	0.561
MOD_PIKK_1	71	77	PF00454	0.606
MOD_PKA_2	1	7	PF00069	0.567
MOD_Plk_1	126	132	PF00069	0.446
MOD_Plk_4	128	134	PF00069	0.558
MOD_Plk_4	76	82	PF00069	0.461
MOD_Plk_4	89	95	PF00069	0.554
MOD_ProDKin_1	116	122	PF00069	0.656
MOD_ProDKin_1	19	25	PF00069	0.513
MOD_ProDKin_1	41	47	PF00069	0.553
TRG_ER_diArg_1	1	3	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX62	Leptomonas seymouri	68%	100%
A0A1X0NTL3	Trypanosomatidae	45%	100%
A0A3S7WWX1	Leishmania donovani	74%	100%
A0A422NSM5	Trypanosoma rangeli	44%	100%
A4HZQ5	Leishmania infantum	74%	100%
C9ZSE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AVL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QBW8	Leishmania major	69%	100%