Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIQ4_LEIBR

TriTrypDb:

LbrM.21.1530 , LBRM2903_210020900

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0051213	dioxygenase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.578
CLV_NRD_NRD_1	206	208	PF00675	0.426
CLV_NRD_NRD_1	321	323	PF00675	0.526
CLV_PCSK_KEX2_1	321	323	PF00082	0.534
CLV_PCSK_SKI1_1	134	138	PF00082	0.353
CLV_PCSK_SKI1_1	172	176	PF00082	0.374
CLV_PCSK_SKI1_1	20	24	PF00082	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_MAPK_DCC_7	105	114	PF00069	0.368
DOC_MAPK_DCC_7	337	347	PF00069	0.378
DOC_MAPK_gen_1	169	178	PF00069	0.337
DOC_MAPK_MEF2A_6	105	114	PF00069	0.601
DOC_PP2B_LxvP_1	151	154	PF13499	0.361
DOC_PP4_FxxP_1	160	163	PF00568	0.441
DOC_PP4_FxxP_1	37	40	PF00568	0.503
DOC_PP4_MxPP_1	188	191	PF00568	0.258
DOC_USP7_MATH_1	100	104	PF00917	0.381
DOC_USP7_MATH_1	177	181	PF00917	0.437
DOC_USP7_MATH_1	256	260	PF00917	0.348
DOC_WW_Pin1_4	181	186	PF00397	0.341
DOC_WW_Pin1_4	231	236	PF00397	0.461
LIG_14-3-3_CanoR_1	195	205	PF00244	0.422
LIG_14-3-3_CanoR_1	207	211	PF00244	0.299
LIG_BIR_III_4	311	315	PF00653	0.332
LIG_EH_1	254	258	PF12763	0.386
LIG_eIF4E_2	38	44	PF01652	0.365
LIG_FHA_1	115	121	PF00498	0.472
LIG_FHA_1	146	152	PF00498	0.442
LIG_FHA_1	16	22	PF00498	0.430
LIG_FHA_1	23	29	PF00498	0.468
LIG_FHA_1	240	246	PF00498	0.393
LIG_FHA_1	94	100	PF00498	0.379
LIG_FHA_2	248	254	PF00498	0.388
LIG_FHA_2	79	85	PF00498	0.438
LIG_Integrin_RGD_1	221	223	PF01839	0.440
LIG_LIR_Apic_2	35	41	PF02991	0.376
LIG_LIR_Gen_1	50	60	PF02991	0.320
LIG_LIR_Nem_3	201	206	PF02991	0.363
LIG_LIR_Nem_3	338	342	PF02991	0.455
LIG_LIR_Nem_3	50	55	PF02991	0.305
LIG_SH2_CRK	203	207	PF00017	0.348
LIG_SH2_CRK	38	42	PF00017	0.377
LIG_SH2_SRC	38	41	PF00017	0.406
LIG_SH2_STAP1	273	277	PF00017	0.277
LIG_SH2_STAT3	273	276	PF00017	0.448
LIG_SH2_STAT5	226	229	PF00017	0.365
LIG_SH2_STAT5	273	276	PF00017	0.346
LIG_SH2_STAT5	52	55	PF00017	0.300
LIG_SH3_3	151	157	PF00018	0.476
LIG_SH3_3	26	32	PF00018	0.407
LIG_SH3_3	96	102	PF00018	0.411
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.335
LIG_SUMO_SIM_par_1	174	180	PF11976	0.253
LIG_SUMO_SIM_par_1	190	197	PF11976	0.487
MOD_CDK_SPxxK_3	231	238	PF00069	0.461
MOD_CK1_1	125	131	PF00069	0.391
MOD_CK1_1	196	202	PF00069	0.386
MOD_CK2_1	257	263	PF00069	0.364
MOD_CK2_1	328	334	PF00069	0.398
MOD_CK2_1	78	84	PF00069	0.409
MOD_GlcNHglycan	124	127	PF01048	0.388
MOD_GlcNHglycan	259	262	PF01048	0.455
MOD_GSK3_1	125	132	PF00069	0.416
MOD_GSK3_1	141	148	PF00069	0.286
MOD_GSK3_1	177	184	PF00069	0.237
MOD_GSK3_1	239	246	PF00069	0.528
MOD_GSK3_1	267	274	PF00069	0.433
MOD_N-GLC_1	141	146	PF02516	0.322
MOD_N-GLC_1	280	285	PF02516	0.322
MOD_NEK2_1	193	198	PF00069	0.422
MOD_NEK2_1	206	211	PF00069	0.301
MOD_NEK2_1	257	262	PF00069	0.358
MOD_NEK2_1	267	272	PF00069	0.220
MOD_NEK2_1	345	350	PF00069	0.519
MOD_NEK2_1	55	60	PF00069	0.486
MOD_NEK2_2	177	182	PF00069	0.230
MOD_PIKK_1	196	202	PF00454	0.285
MOD_PK_1	161	167	PF00069	0.324
MOD_PKA_2	168	174	PF00069	0.349
MOD_PKA_2	194	200	PF00069	0.399
MOD_PKA_2	206	212	PF00069	0.307
MOD_Plk_1	141	147	PF00069	0.464
MOD_Plk_4	125	131	PF00069	0.390
MOD_Plk_4	161	167	PF00069	0.365
MOD_Plk_4	247	253	PF00069	0.545
MOD_Plk_4	268	274	PF00069	0.336
MOD_Plk_4	328	334	PF00069	0.493
MOD_ProDKin_1	181	187	PF00069	0.347
MOD_ProDKin_1	231	237	PF00069	0.458
MOD_SUMO_for_1	335	338	PF00179	0.495
TRG_DiLeu_BaEn_1	263	268	PF01217	0.424
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.410
TRG_DiLeu_LyEn_5	26	31	PF01217	0.411
TRG_ENDOCYTIC_2	203	206	PF00928	0.348
TRG_ENDOCYTIC_2	52	55	PF00928	0.300
TRG_ER_diArg_1	43	46	PF00400	0.268
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK0	Leptomonas seymouri	81%	97%
A0A0S4JR98	Bodo saltans	50%	100%
A0A1X0NXW7	Trypanosomatidae	62%	100%
A0A3S7WWQ0	Leishmania donovani	87%	99%
A0A422NSQ3	Trypanosoma rangeli	61%	100%
A4HZC9	Leishmania infantum	87%	99%
D0A155	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AVB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QC64	Leishmania major	88%	100%
V5BRD2	Trypanosoma cruzi	64%	100%