Cytochrome c oxidase assembly protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIQ2_LEIBR

TriTrypDb:

LbrM.21.0780 , LBRM2903_210012400

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.543
CLV_NRD_NRD_1	131	133	PF00675	0.480
CLV_NRD_NRD_1	217	219	PF00675	0.508
CLV_NRD_NRD_1	224	226	PF00675	0.502
CLV_NRD_NRD_1	50	52	PF00675	0.474
CLV_PCSK_FUR_1	215	219	PF00082	0.507
CLV_PCSK_KEX2_1	131	133	PF00082	0.480
CLV_PCSK_KEX2_1	217	219	PF00082	0.508
CLV_PCSK_KEX2_1	50	52	PF00082	0.475
CLV_PCSK_SKI1_1	151	155	PF00082	0.460
CLV_PCSK_SKI1_1	178	182	PF00082	0.409
CLV_PCSK_SKI1_1	50	54	PF00082	0.464
DEG_Nend_UBRbox_2	1	3	PF02207	0.405
DEG_SCF_FBW7_2	305	311	PF00400	0.613
DEG_SPOP_SBC_1	333	337	PF00917	0.591
DOC_CKS1_1	305	310	PF01111	0.641
DOC_CYCLIN_RxL_1	47	57	PF00134	0.427
DOC_MAPK_gen_1	131	139	PF00069	0.484
DOC_MAPK_MEF2A_6	202	210	PF00069	0.466
DOC_PP1_RVXF_1	130	137	PF00149	0.510
DOC_PP1_RVXF_1	149	155	PF00149	0.522
DOC_PP1_RVXF_1	176	183	PF00149	0.398
DOC_PP2B_LxvP_1	164	167	PF13499	0.447
DOC_USP7_MATH_1	333	337	PF00917	0.628
DOC_WW_Pin1_4	123	128	PF00397	0.425
DOC_WW_Pin1_4	289	294	PF00397	0.681
DOC_WW_Pin1_4	304	309	PF00397	0.681
DOC_WW_Pin1_4	334	339	PF00397	0.615
DOC_WW_Pin1_4	40	45	PF00397	0.612
LIG_14-3-3_CanoR_1	131	135	PF00244	0.357
LIG_14-3-3_CanoR_1	23	29	PF00244	0.513
LIG_14-3-3_CanoR_1	50	59	PF00244	0.560
LIG_Actin_WH2_2	263	280	PF00022	0.287
LIG_APCC_ABBA_1	204	209	PF00400	0.304
LIG_BRCT_BRCA1_1	335	339	PF00533	0.545
LIG_BRCT_BRCA1_1	42	46	PF00533	0.522
LIG_CtBP_PxDLS_1	88	92	PF00389	0.392
LIG_EH_1	204	208	PF12763	0.430
LIG_EH1_1	230	238	PF00400	0.414
LIG_eIF4E_1	231	237	PF01652	0.470
LIG_FHA_1	156	162	PF00498	0.538
LIG_FHA_1	168	174	PF00498	0.374
LIG_FHA_1	321	327	PF00498	0.641
LIG_FHA_1	40	46	PF00498	0.664
LIG_FHA_1	54	60	PF00498	0.601
LIG_FHA_1	98	104	PF00498	0.617
LIG_GBD_Chelix_1	251	259	PF00786	0.524
LIG_LIR_Gen_1	118	128	PF02991	0.547
LIG_LIR_Gen_1	133	140	PF02991	0.378
LIG_LIR_Gen_1	197	206	PF02991	0.442
LIG_LIR_Gen_1	209	219	PF02991	0.361
LIG_LIR_Gen_1	26	37	PF02991	0.402
LIG_LIR_Nem_3	118	123	PF02991	0.570
LIG_LIR_Nem_3	133	139	PF02991	0.418
LIG_LIR_Nem_3	197	201	PF02991	0.413
LIG_LIR_Nem_3	2	6	PF02991	0.527
LIG_LIR_Nem_3	209	214	PF02991	0.299
LIG_LIR_Nem_3	26	32	PF02991	0.409
LIG_LIR_Nem_3	92	98	PF02991	0.542
LIG_Pex14_2	182	186	PF04695	0.363
LIG_Pex14_2	207	211	PF04695	0.370
LIG_Pex14_2	28	32	PF04695	0.656
LIG_SH2_SRC	231	234	PF00017	0.360
LIG_SH2_STAP1	296	300	PF00017	0.472
LIG_SH2_STAT3	282	285	PF00017	0.488
LIG_SH2_STAT5	147	150	PF00017	0.420
LIG_SH2_STAT5	231	234	PF00017	0.448
LIG_SH2_STAT5	282	285	PF00017	0.657
LIG_SH2_STAT5	296	299	PF00017	0.670
LIG_SH2_STAT5	306	309	PF00017	0.705
LIG_SH2_STAT6	119	123	PF00017	0.443
LIG_SH3_3	302	308	PF00018	0.500
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.437
LIG_SUMO_SIM_par_1	135	141	PF11976	0.361
LIG_TRAF2_1	64	67	PF00917	0.605
LIG_TRAF2_1	69	72	PF00917	0.586
LIG_WRC_WIRS_1	120	125	PF05994	0.439
LIG_WRC_WIRS_1	29	34	PF05994	0.404
LIG_WW_3	300	304	PF00397	0.588
MOD_CK1_1	238	244	PF00069	0.419
MOD_CK1_1	294	300	PF00069	0.668
MOD_CK1_1	320	326	PF00069	0.458
MOD_CK1_1	54	60	PF00069	0.568
MOD_CK2_1	61	67	PF00069	0.618
MOD_Cter_Amidation	223	226	PF01082	0.493
MOD_Cter_Amidation	48	51	PF01082	0.430
MOD_GlcNHglycan	103	106	PF01048	0.539
MOD_GlcNHglycan	148	151	PF01048	0.466
MOD_GlcNHglycan	222	225	PF01048	0.379
MOD_GlcNHglycan	63	66	PF01048	0.671
MOD_GSK3_1	119	126	PF00069	0.577
MOD_GSK3_1	232	239	PF00069	0.400
MOD_GSK3_1	24	31	PF00069	0.674
MOD_GSK3_1	247	254	PF00069	0.447
MOD_GSK3_1	291	298	PF00069	0.726
MOD_GSK3_1	97	104	PF00069	0.532
MOD_NEK2_1	101	106	PF00069	0.566
MOD_NEK2_1	146	151	PF00069	0.399
MOD_NEK2_1	236	241	PF00069	0.351
MOD_NEK2_1	255	260	PF00069	0.490
MOD_NEK2_1	28	33	PF00069	0.585
MOD_NEK2_1	39	44	PF00069	0.564
MOD_NEK2_1	52	57	PF00069	0.555
MOD_NEK2_1	8	13	PF00069	0.544
MOD_PIKK_1	105	111	PF00454	0.401
MOD_PIKK_1	11	17	PF00454	0.357
MOD_PKA_2	130	136	PF00069	0.358
MOD_PKA_2	22	28	PF00069	0.592
MOD_Plk_4	141	147	PF00069	0.442
MOD_Plk_4	232	238	PF00069	0.414
MOD_Plk_4	24	30	PF00069	0.501
MOD_Plk_4	291	297	PF00069	0.665
MOD_Plk_4	54	60	PF00069	0.528
MOD_ProDKin_1	123	129	PF00069	0.423
MOD_ProDKin_1	289	295	PF00069	0.679
MOD_ProDKin_1	304	310	PF00069	0.683
MOD_ProDKin_1	334	340	PF00069	0.622
MOD_ProDKin_1	40	46	PF00069	0.612
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.574
TRG_ENDOCYTIC_2	120	123	PF00928	0.687
TRG_ENDOCYTIC_2	29	32	PF00928	0.499
TRG_ENDOCYTIC_2	82	85	PF00928	0.486
TRG_ENDOCYTIC_2	95	98	PF00928	0.486
TRG_ER_diArg_1	214	217	PF00400	0.482
TRG_ER_diArg_1	50	52	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD8	Leptomonas seymouri	61%	100%
A0A0S4JBH7	Bodo saltans	28%	100%
A0A1X0NXM4	Trypanosomatidae	35%	100%
A0A3Q8IF37	Leishmania donovani	77%	94%
A0A3R7NME4	Trypanosoma rangeli	32%	100%
A4HZ71	Leishmania infantum	77%	94%
D0A1H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AV38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCE3	Leishmania major	76%	100%