Metallo-beta-lactamase family-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIQ1_LEIBR

TriTrypDb:

LbrM.21.0730 , LBRM2903_210011900

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.385
CLV_C14_Caspase3-7	258	262	PF00656	0.430
CLV_NRD_NRD_1	101	103	PF00675	0.373
CLV_PCSK_KEX2_1	101	103	PF00082	0.527
CLV_PCSK_KEX2_1	190	192	PF00082	0.308
CLV_PCSK_KEX2_1	195	197	PF00082	0.319
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.308
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.319
CLV_PCSK_PC7_1	191	197	PF00082	0.308
CLV_PCSK_SKI1_1	101	105	PF00082	0.320
CLV_PCSK_SKI1_1	190	194	PF00082	0.243
CLV_PCSK_SKI1_1	276	280	PF00082	0.332
CLV_PCSK_SKI1_1	298	302	PF00082	0.523
CLV_PCSK_SKI1_1	319	323	PF00082	0.576
CLV_PCSK_SKI1_1	325	329	PF00082	0.550
CLV_PCSK_SKI1_1	77	81	PF00082	0.342
CLV_PCSK_SKI1_1	83	87	PF00082	0.372
DEG_SCF_FBW7_1	141	148	PF00400	0.320
DOC_CKS1_1	142	147	PF01111	0.320
DOC_CYCLIN_RxL_1	273	281	PF00134	0.532
DOC_CYCLIN_RxL_1	77	87	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.320
DOC_MAPK_gen_1	101	109	PF00069	0.320
DOC_MAPK_gen_1	219	229	PF00069	0.415
DOC_MAPK_MEF2A_6	101	109	PF00069	0.320
DOC_USP7_MATH_1	310	314	PF00917	0.478
DOC_USP7_MATH_1	329	333	PF00917	0.588
DOC_WW_Pin1_4	141	146	PF00397	0.320
DOC_WW_Pin1_4	256	261	PF00397	0.427
LIG_14-3-3_CanoR_1	319	326	PF00244	0.555
LIG_Actin_WH2_2	176	192	PF00022	0.243
LIG_Actin_WH2_2	248	266	PF00022	0.486
LIG_Actin_WH2_2	282	300	PF00022	0.511
LIG_Actin_WH2_2	310	327	PF00022	0.452
LIG_CtBP_PxDLS_1	290	294	PF00389	0.359
LIG_eIF4E_1	288	294	PF01652	0.501
LIG_FHA_1	136	142	PF00498	0.320
LIG_FHA_1	207	213	PF00498	0.406
LIG_FHA_1	326	332	PF00498	0.470
LIG_FHA_1	37	43	PF00498	0.341
LIG_FHA_2	117	123	PF00498	0.320
LIG_FHA_2	256	262	PF00498	0.460
LIG_FHA_2	3	9	PF00498	0.464
LIG_FHA_2	303	309	PF00498	0.512
LIG_FHA_2	42	48	PF00498	0.320
LIG_LIR_Gen_1	173	183	PF02991	0.320
LIG_LIR_Gen_1	301	310	PF02991	0.575
LIG_LIR_Nem_3	173	179	PF02991	0.320
LIG_LIR_Nem_3	301	306	PF02991	0.570
LIG_LIR_Nem_3	58	63	PF02991	0.520
LIG_NRBOX	274	280	PF00104	0.430
LIG_PTB_Apo_2	25	32	PF02174	0.465
LIG_PTB_Phospho_1	25	31	PF10480	0.461
LIG_SH2_CRK	31	35	PF00017	0.473
LIG_SH2_GRB2like	182	185	PF00017	0.330
LIG_SH2_STAT5	116	119	PF00017	0.330
LIG_SH2_STAT5	256	259	PF00017	0.532
LIG_SH2_STAT5	288	291	PF00017	0.431
LIG_SH2_STAT5	295	298	PF00017	0.372
LIG_SH2_STAT5	303	306	PF00017	0.594
LIG_SH2_STAT5	40	43	PF00017	0.320
LIG_SH3_3	139	145	PF00018	0.433
LIG_SH3_3	6	12	PF00018	0.412
LIG_SUMO_SIM_par_1	130	135	PF11976	0.243
LIG_TRAF2_1	44	47	PF00917	0.385
LIG_WRC_WIRS_1	176	181	PF05994	0.320
LIG_WRC_WIRS_1	303	308	PF05994	0.495
MOD_CK1_1	174	180	PF00069	0.320
MOD_CK2_1	2	8	PF00069	0.501
MOD_CK2_1	244	250	PF00069	0.334
MOD_CK2_1	302	308	PF00069	0.493
MOD_CK2_1	41	47	PF00069	0.320
MOD_GlcNHglycan	236	240	PF01048	0.515
MOD_GlcNHglycan	52	55	PF01048	0.320
MOD_GSK3_1	141	148	PF00069	0.320
MOD_GSK3_1	164	171	PF00069	0.320
MOD_GSK3_1	231	238	PF00069	0.516
MOD_GSK3_1	251	258	PF00069	0.497
MOD_GSK3_1	298	305	PF00069	0.458
MOD_GSK3_1	30	37	PF00069	0.398
MOD_GSK3_1	325	332	PF00069	0.576
MOD_LATS_1	242	248	PF00433	0.375
MOD_NEK2_1	251	256	PF00069	0.469
MOD_NEK2_1	34	39	PF00069	0.320
MOD_NEK2_1	41	46	PF00069	0.327
MOD_NEK2_1	84	89	PF00069	0.335
MOD_NEK2_2	182	187	PF00069	0.320
MOD_NEK2_2	310	315	PF00069	0.475
MOD_NEK2_2	96	101	PF00069	0.340
MOD_PIKK_1	111	117	PF00454	0.320
MOD_PK_1	244	250	PF00069	0.385
MOD_Plk_1	301	307	PF00069	0.569
MOD_Plk_1	310	316	PF00069	0.547
MOD_Plk_1	70	76	PF00069	0.320
MOD_Plk_2-3	302	308	PF00069	0.493
MOD_Plk_4	164	170	PF00069	0.320
MOD_Plk_4	171	177	PF00069	0.320
MOD_Plk_4	251	257	PF00069	0.469
MOD_Plk_4	36	42	PF00069	0.335
MOD_ProDKin_1	141	147	PF00069	0.320
MOD_ProDKin_1	256	262	PF00069	0.427
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.385
TRG_ENDOCYTIC_2	303	306	PF00928	0.574
TRG_ENDOCYTIC_2	31	34	PF00928	0.478
TRG_ENDOCYTIC_2	60	63	PF00928	0.320
TRG_ER_diArg_1	100	102	PF00400	0.527
TRG_NLS_MonoExtC_3	189	194	PF00514	0.243
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A067XMV3	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	37%	100%
A0A0N1I2E5	Leptomonas seymouri	66%	95%
A0A0S4JM93	Bodo saltans	41%	96%
A0A1L9WLF1	Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)	36%	100%
A0A2I1C3U0	Aspergillus novofumigatus (strain IBT 16806)	37%	100%
A0A3S7WWH9	Leishmania donovani	86%	99%
A0A411PQM3	Paecilomyces divaricatus	37%	100%
A0A4P8DJU1	Cryptosporiopsis sp. (strain 8999)	38%	100%
A0A5B8YUX5	Pestalotiopsis microspora	37%	100%
A1D8J2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	42%	100%
A2QX23	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	37%	100%
A4HZ66	Leishmania infantum	86%	99%
C5FM60	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	37%	97%
D4AWH0	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	38%	76%
D4CZZ5	Trichophyton verrucosum (strain HKI 0517)	37%	100%
D7PHZ8	Penicillium aethiopicum	35%	100%
E1ACR1	Aspergillus sp. (strain MF297-2)	34%	100%
E4V2N5	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	38%	100%
E9AV33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
F2PWS8	Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)	38%	100%
F2S702	Trichophyton tonsurans (strain CBS 112818)	38%	100%
F2T0M3	Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)	37%	100%
G3KLH5	Aspergillus niger	37%	100%
M1WCF7	Claviceps purpurea (strain 20.1)	36%	100%
M3ANL0	Pseudocercospora fijiensis (strain CIRAD86)	34%	100%
P0CU68	Passalora fulva	36%	100%
Q0CCY4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	38%	100%
Q0V9A9	Xenopus tropicalis	42%	100%
Q1LZ83	Bos taurus	43%	100%
Q4QCE8	Leishmania major	86%	100%
Q4W945	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q4WA58	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	40%	100%
Q4WQZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	79%
Q53H82	Homo sapiens	41%	100%
Q561R9	Rattus norvegicus	41%	100%
Q5AXB0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	98%
Q5B0C9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q5BH31	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q5XGR8	Xenopus laevis	42%	100%
Q6NYF0	Danio rerio	42%	100%
Q95Q18	Caenorhabditis elegans	39%	100%
Q99KR3	Mus musculus	41%	100%
Q9VLS9	Drosophila melanogaster	39%	100%