Major vault protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major vault protein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIP9_LEIBR

TriTrypDb:

LbrM.21.0270 , LBRM2903_210007000

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0005737	cytoplasm	2	6
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

E9AIP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.477
CLV_C14_Caspase3-7	30	34	PF00656	0.448
CLV_C14_Caspase3-7	373	377	PF00656	0.413
CLV_NRD_NRD_1	110	112	PF00675	0.277
CLV_NRD_NRD_1	209	211	PF00675	0.394
CLV_NRD_NRD_1	514	516	PF00675	0.388
CLV_NRD_NRD_1	536	538	PF00675	0.322
CLV_NRD_NRD_1	62	64	PF00675	0.452
CLV_PCSK_KEX2_1	110	112	PF00082	0.277
CLV_PCSK_KEX2_1	209	211	PF00082	0.394
CLV_PCSK_KEX2_1	516	518	PF00082	0.348
CLV_PCSK_KEX2_1	62	64	PF00082	0.447
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.400
CLV_PCSK_PC7_1	58	64	PF00082	0.275
CLV_PCSK_SKI1_1	110	114	PF00082	0.197
CLV_PCSK_SKI1_1	403	407	PF00082	0.288
CLV_PCSK_SKI1_1	437	441	PF00082	0.287
CLV_PCSK_SKI1_1	85	89	PF00082	0.217
CLV_Separin_Metazoa	457	461	PF03568	0.306
CLV_Separin_Metazoa	512	516	PF03568	0.307
DEG_APCC_DBOX_1	454	462	PF00400	0.307
DEG_Nend_UBRbox_3	1	2	PF02207	0.428
DEG_SPOP_SBC_1	149	153	PF00917	0.480
DOC_CKS1_1	362	367	PF01111	0.373
DOC_CYCLIN_RxL_1	107	115	PF00134	0.373
DOC_MAPK_gen_1	515	522	PF00069	0.388
DOC_MAPK_HePTP_8	285	297	PF00069	0.373
DOC_MAPK_MEF2A_6	288	297	PF00069	0.422
DOC_MAPK_MEF2A_6	408	416	PF00069	0.475
DOC_MAPK_MEF2A_6	437	444	PF00069	0.293
DOC_MAPK_NFAT4_5	437	445	PF00069	0.295
DOC_PP4_FxxP_1	244	247	PF00568	0.373
DOC_PP4_FxxP_1	321	324	PF00568	0.509
DOC_PP4_FxxP_1	88	91	PF00568	0.373
DOC_USP7_MATH_1	116	120	PF00917	0.582
DOC_USP7_MATH_1	131	135	PF00917	0.361
DOC_USP7_MATH_1	149	153	PF00917	0.480
DOC_USP7_MATH_1	166	170	PF00917	0.505
DOC_USP7_MATH_1	305	309	PF00917	0.480
DOC_USP7_MATH_1	333	337	PF00917	0.415
DOC_USP7_MATH_1	367	371	PF00917	0.409
DOC_USP7_MATH_1	420	424	PF00917	0.444
DOC_USP7_MATH_1	471	475	PF00917	0.309
DOC_USP7_MATH_1	501	505	PF00917	0.390
DOC_USP7_MATH_1	561	565	PF00917	0.369
DOC_WW_Pin1_4	162	167	PF00397	0.520
DOC_WW_Pin1_4	249	254	PF00397	0.463
DOC_WW_Pin1_4	361	366	PF00397	0.373
DOC_WW_Pin1_4	493	498	PF00397	0.308
DOC_WW_Pin1_4	586	591	PF00397	0.602
DOC_WW_Pin1_4	607	612	PF00397	0.465
LIG_14-3-3_CanoR_1	103	112	PF00244	0.495
LIG_14-3-3_CanoR_1	117	121	PF00244	0.360
LIG_14-3-3_CanoR_1	525	529	PF00244	0.372
LIG_Actin_WH2_2	105	123	PF00022	0.373
LIG_BIR_III_2	494	498	PF00653	0.307
LIG_BRCT_BRCA1_1	376	380	PF00533	0.495
LIG_CtBP_PxDLS_1	253	257	PF00389	0.373
LIG_FHA_1	151	157	PF00498	0.568
LIG_FHA_1	240	246	PF00498	0.393
LIG_FHA_1	387	393	PF00498	0.373
LIG_FHA_1	402	408	PF00498	0.258
LIG_FHA_1	454	460	PF00498	0.500
LIG_FHA_1	5	11	PF00498	0.561
LIG_FHA_1	79	85	PF00498	0.509
LIG_FHA_2	140	146	PF00498	0.375
LIG_FHA_2	26	32	PF00498	0.550
LIG_FHA_2	33	39	PF00498	0.364
LIG_FHA_2	386	392	PF00498	0.509
LIG_FHA_2	464	470	PF00498	0.299
LIG_FHA_2	543	549	PF00498	0.369
LIG_LIR_Apic_2	242	247	PF02991	0.373
LIG_LIR_Apic_2	318	324	PF02991	0.510
LIG_LIR_Apic_2	86	91	PF02991	0.373
LIG_LIR_Apic_2	98	104	PF02991	0.373
LIG_LIR_Gen_1	174	180	PF02991	0.469
LIG_LIR_Gen_1	545	554	PF02991	0.337
LIG_LIR_Nem_3	174	179	PF02991	0.473
LIG_LIR_Nem_3	249	254	PF02991	0.509
LIG_LIR_Nem_3	302	306	PF02991	0.511
LIG_LIR_Nem_3	346	350	PF02991	0.508
LIG_LIR_Nem_3	41	46	PF02991	0.463
LIG_LIR_Nem_3	545	550	PF02991	0.332
LIG_Pex14_2	88	92	PF04695	0.373
LIG_Rb_pABgroove_1	221	229	PF01858	0.373
LIG_SH2_CRK	211	215	PF00017	0.476
LIG_SH2_CRK	56	60	PF00017	0.285
LIG_SH2_GRB2like	185	188	PF00017	0.401
LIG_SH2_NCK_1	29	33	PF00017	0.373
LIG_SH2_PTP2	51	54	PF00017	0.373
LIG_SH2_SRC	51	54	PF00017	0.582
LIG_SH2_STAP1	176	180	PF00017	0.466
LIG_SH2_STAP1	547	551	PF00017	0.342
LIG_SH2_STAP1	56	60	PF00017	0.285
LIG_SH2_STAT5	185	188	PF00017	0.401
LIG_SH2_STAT5	273	276	PF00017	0.373
LIG_SH2_STAT5	29	32	PF00017	0.373
LIG_SH2_STAT5	386	389	PF00017	0.373
LIG_SH2_STAT5	51	54	PF00017	0.509
LIG_SH2_STAT5	75	78	PF00017	0.509
LIG_SH3_3	234	240	PF00018	0.509
LIG_SH3_3	258	264	PF00018	0.509
LIG_SH3_3	42	48	PF00018	0.539
LIG_SUMO_SIM_anti_2	510	515	PF11976	0.304
LIG_SUMO_SIM_par_1	252	257	PF11976	0.509
LIG_SUMO_SIM_par_1	281	287	PF11976	0.511
LIG_SUMO_SIM_par_1	388	394	PF11976	0.373
LIG_SUMO_SIM_par_1	396	402	PF11976	0.362
LIG_SUMO_SIM_par_1	557	564	PF11976	0.370
LIG_TRAF2_1	134	137	PF00917	0.332
LIG_TYR_ITSM	543	550	PF00017	0.328
LIG_UBA3_1	550	556	PF00899	0.344
LIG_WW_1	53	56	PF00397	0.454
LIG_WW_3	200	204	PF00397	0.378
MOD_CDK_SPxK_1	493	499	PF00069	0.308
MOD_CK1_1	150	156	PF00069	0.481
MOD_CK1_1	165	171	PF00069	0.472
MOD_CK1_1	172	178	PF00069	0.462
MOD_CK1_1	370	376	PF00069	0.373
MOD_CK1_1	423	429	PF00069	0.309
MOD_CK1_1	463	469	PF00069	0.342
MOD_CK1_1	610	616	PF00069	0.460
MOD_CK2_1	123	129	PF00069	0.328
MOD_CK2_1	131	137	PF00069	0.302
MOD_CK2_1	139	145	PF00069	0.338
MOD_CK2_1	165	171	PF00069	0.472
MOD_CK2_1	25	31	PF00069	0.373
MOD_CK2_1	32	38	PF00069	0.364
MOD_CK2_1	463	469	PF00069	0.297
MOD_CK2_1	542	548	PF00069	0.364
MOD_GlcNHglycan	105	108	PF01048	0.172
MOD_GlcNHglycan	168	171	PF01048	0.472
MOD_GlcNHglycan	256	259	PF01048	0.309
MOD_GlcNHglycan	312	315	PF01048	0.173
MOD_GlcNHglycan	339	342	PF01048	0.215
MOD_GlcNHglycan	462	465	PF01048	0.408
MOD_GlcNHglycan	481	484	PF01048	0.500
MOD_GlcNHglycan	563	566	PF01048	0.454
MOD_GlcNHglycan	94	97	PF01048	0.213
MOD_GSK3_1	116	123	PF00069	0.530
MOD_GSK3_1	162	169	PF00069	0.523
MOD_GSK3_1	227	234	PF00069	0.477
MOD_GSK3_1	333	340	PF00069	0.403
MOD_GSK3_1	370	377	PF00069	0.400
MOD_GSK3_1	4	11	PF00069	0.421
MOD_GSK3_1	582	589	PF00069	0.551
MOD_GSK3_1	603	610	PF00069	0.552
MOD_N-GLC_1	352	357	PF02516	0.173
MOD_NEK2_1	191	196	PF00069	0.381
MOD_NEK2_1	226	231	PF00069	0.373
MOD_NEK2_1	254	259	PF00069	0.509
MOD_NEK2_1	378	383	PF00069	0.498
MOD_NEK2_1	385	390	PF00069	0.469
MOD_NEK2_1	406	411	PF00069	0.475
MOD_NEK2_1	479	484	PF00069	0.300
MOD_NEK2_2	116	121	PF00069	0.415
MOD_NEK2_2	32	37	PF00069	0.373
MOD_PIKK_1	4	10	PF00454	0.361
MOD_PKA_2	116	122	PF00069	0.373
MOD_PKA_2	202	208	PF00069	0.475
MOD_PKA_2	524	530	PF00069	0.316
MOD_Plk_1	123	129	PF00069	0.328
MOD_Plk_1	131	137	PF00069	0.302
MOD_Plk_1	352	358	PF00069	0.373
MOD_Plk_2-3	391	397	PF00069	0.373
MOD_Plk_4	219	225	PF00069	0.375
MOD_Plk_4	239	245	PF00069	0.385
MOD_Plk_4	353	359	PF00069	0.373
MOD_Plk_4	367	373	PF00069	0.354
MOD_Plk_4	555	561	PF00069	0.552
MOD_ProDKin_1	162	168	PF00069	0.520
MOD_ProDKin_1	249	255	PF00069	0.463
MOD_ProDKin_1	361	367	PF00069	0.373
MOD_ProDKin_1	493	499	PF00069	0.308
MOD_ProDKin_1	586	592	PF00069	0.605
MOD_ProDKin_1	607	613	PF00069	0.465
MOD_SUMO_for_1	449	452	PF00179	0.383
MOD_SUMO_rev_2	394	402	PF00179	0.509
MOD_SUMO_rev_2	433	439	PF00179	0.292
MOD_SUMO_rev_2	564	571	PF00179	0.368
TRG_DiLeu_BaEn_1	17	22	PF01217	0.509
TRG_DiLeu_BaEn_1	219	224	PF01217	0.373
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.373
TRG_ENDOCYTIC_2	176	179	PF00928	0.471
TRG_ENDOCYTIC_2	211	214	PF00928	0.575
TRG_ENDOCYTIC_2	547	550	PF00928	0.339
TRG_ENDOCYTIC_2	56	59	PF00928	0.282
TRG_ER_diArg_1	109	111	PF00400	0.495
TRG_ER_diArg_1	208	210	PF00400	0.346
TRG_ER_diArg_1	292	295	PF00400	0.470
TRG_ER_diArg_1	514	517	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.173
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S9	Leptomonas seymouri	43%	74%
A0A0S4ISQ0	Bodo saltans	35%	72%
A0A0S4JL46	Bodo saltans	34%	73%
A0A1X0P8P2	Trypanosomatidae	30%	72%
A0A3S7WNY9	Leishmania donovani	43%	74%
A0A422NLE5	Trypanosoma rangeli	32%	71%
A0A422NYK3	Trypanosoma rangeli	34%	72%
A4HP51	Leishmania braziliensis	33%	100%
A4HSC9	Leishmania infantum	42%	74%
D0A336	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	72%
E9ASV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	70%
P54659	Dictyostelium discoideum	35%	73%
Q4CUM2	Trypanosoma cruzi (strain CL Brener)	34%	74%
Q4Q1N7	Leishmania major	33%	100%
Q4QJJ7	Leishmania major	43%	74%
Q5EAJ7	Strongylocentrotus purpuratus	34%	72%
Q5ZMI4	Gallus gallus	35%	73%
Q62667	Rattus norvegicus	35%	72%
Q90405	Diplobatis ommata	37%	72%
Q9EQK5	Mus musculus	35%	72%
V5AUX6	Trypanosoma cruzi	34%	74%