Arginine N-methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIN9_LEIBR

TriTrypDb:

LbrM.20.6060 , LBRM2903_200076200

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.188
CLV_NRD_NRD_1	110	112	PF00675	0.233
CLV_PCSK_KEX2_1	226	228	PF00082	0.303
CLV_PCSK_KEX2_1	324	326	PF00082	0.421
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.303
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.421
CLV_PCSK_SKI1_1	89	93	PF00082	0.210
DEG_Nend_UBRbox_1	1	4	PF02207	0.403
DOC_CKS1_1	286	291	PF01111	0.279
DOC_MAPK_gen_1	87	94	PF00069	0.407
DOC_MAPK_MEF2A_6	343	351	PF00069	0.310
DOC_MAPK_MEF2A_6	87	94	PF00069	0.407
DOC_PP4_FxxP_1	286	289	PF00568	0.277
DOC_PP4_MxPP_1	304	307	PF00568	0.471
DOC_USP7_MATH_1	18	22	PF00917	0.525
DOC_USP7_UBL2_3	324	328	PF12436	0.403
DOC_WW_Pin1_4	25	30	PF00397	0.592
DOC_WW_Pin1_4	285	290	PF00397	0.266
DOC_WW_Pin1_4	299	304	PF00397	0.337
LIG_14-3-3_CanoR_1	181	191	PF00244	0.208
LIG_14-3-3_CanoR_1	227	231	PF00244	0.300
LIG_14-3-3_CanoR_1	257	265	PF00244	0.231
LIG_14-3-3_CanoR_1	311	315	PF00244	0.271
LIG_14-3-3_CanoR_1	71	76	PF00244	0.275
LIG_APCC_ABBA_1	282	287	PF00400	0.262
LIG_APCC_ABBA_1	347	352	PF00400	0.223
LIG_BRCT_BRCA1_1	20	24	PF00533	0.426
LIG_BRCT_BRCA1_1	282	286	PF00533	0.275
LIG_BRCT_BRCA1_1	3	7	PF00533	0.390
LIG_deltaCOP1_diTrp_1	160	165	PF00928	0.262
LIG_deltaCOP1_diTrp_1	77	86	PF00928	0.245
LIG_eIF4E_1	316	322	PF01652	0.371
LIG_FHA_1	243	249	PF00498	0.340
LIG_FHA_1	266	272	PF00498	0.464
LIG_FHA_1	96	102	PF00498	0.407
LIG_FHA_2	257	263	PF00498	0.328
LIG_FHA_2	28	34	PF00498	0.552
LIG_FHA_2	72	78	PF00498	0.194
LIG_FXI_DFP_1	350	354	PF00024	0.276
LIG_IRF3_LxIS_1	342	348	PF10401	0.406
LIG_LIR_Apic_2	229	233	PF02991	0.293
LIG_LIR_Apic_2	283	289	PF02991	0.292
LIG_LIR_Gen_1	131	141	PF02991	0.424
LIG_LIR_Gen_1	221	230	PF02991	0.325
LIG_LIR_Nem_3	131	137	PF02991	0.418
LIG_LIR_Nem_3	159	164	PF02991	0.262
LIG_LIR_Nem_3	221	225	PF02991	0.314
LIG_LIR_Nem_3	50	56	PF02991	0.372
LIG_MLH1_MIPbox_1	3	7	PF16413	0.388
LIG_NRP_CendR_1	367	369	PF00754	0.321
LIG_Pex14_1	161	165	PF04695	0.261
LIG_Pex14_1	80	84	PF04695	0.418
LIG_Pex14_2	265	269	PF04695	0.329
LIG_Pex14_2	286	290	PF04695	0.262
LIG_REV1ctd_RIR_1	4	13	PF16727	0.396
LIG_SH2_PTP2	230	233	PF00017	0.309
LIG_SH2_SRC	230	233	PF00017	0.309
LIG_SH2_STAP1	168	172	PF00017	0.278
LIG_SH2_STAP1	362	366	PF00017	0.322
LIG_SH2_STAT3	206	209	PF00017	0.453
LIG_SH2_STAT5	164	167	PF00017	0.262
LIG_SH2_STAT5	206	209	PF00017	0.351
LIG_SH2_STAT5	224	227	PF00017	0.215
LIG_SH2_STAT5	230	233	PF00017	0.293
LIG_SH2_STAT5	52	55	PF00017	0.359
LIG_SH3_3	300	306	PF00018	0.361
LIG_SH3_3	336	342	PF00018	0.503
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.427
LIG_SUMO_SIM_anti_2	151	160	PF11976	0.365
LIG_SUMO_SIM_par_1	295	302	PF11976	0.352
LIG_UBA3_1	137	144	PF00899	0.388
LIG_UBA3_1	317	324	PF00899	0.326
LIG_WRC_WIRS_1	250	255	PF05994	0.282
MOD_CK1_1	264	270	PF00069	0.300
MOD_CK1_1	27	33	PF00069	0.514
MOD_CK2_1	226	232	PF00069	0.324
MOD_CK2_1	256	262	PF00069	0.346
MOD_CK2_1	27	33	PF00069	0.636
MOD_GlcNHglycan	192	195	PF01048	0.434
MOD_GSK3_1	132	139	PF00069	0.463
MOD_GSK3_1	167	174	PF00069	0.276
MOD_GSK3_1	261	268	PF00069	0.428
MOD_GSK3_1	39	46	PF00069	0.591
MOD_GSK3_1	95	102	PF00069	0.421
MOD_N-GLC_1	299	304	PF02516	0.451
MOD_N-GLC_1	329	334	PF02516	0.393
MOD_NEK2_1	1	6	PF00069	0.404
MOD_NEK2_1	12	17	PF00069	0.499
MOD_NEK2_1	167	172	PF00069	0.275
MOD_NEK2_1	220	225	PF00069	0.368
MOD_NEK2_1	234	239	PF00069	0.352
MOD_NEK2_1	24	29	PF00069	0.500
MOD_NEK2_1	263	268	PF00069	0.458
MOD_NEK2_1	345	350	PF00069	0.422
MOD_NEK2_2	329	334	PF00069	0.473
MOD_NEK2_2	99	104	PF00069	0.407
MOD_PIKK_1	27	33	PF00454	0.421
MOD_PKA_1	226	232	PF00069	0.301
MOD_PKA_2	1	7	PF00069	0.476
MOD_PKA_2	18	24	PF00069	0.432
MOD_PKA_2	226	232	PF00069	0.301
MOD_PKA_2	256	262	PF00069	0.334
MOD_PKA_2	310	316	PF00069	0.269
MOD_PKA_2	70	76	PF00069	0.280
MOD_Plk_1	220	226	PF00069	0.311
MOD_Plk_1	261	267	PF00069	0.365
MOD_Plk_1	329	335	PF00069	0.528
MOD_Plk_1	345	351	PF00069	0.321
MOD_Plk_4	167	173	PF00069	0.276
MOD_Plk_4	226	232	PF00069	0.308
MOD_Plk_4	310	316	PF00069	0.286
MOD_Plk_4	99	105	PF00069	0.422
MOD_ProDKin_1	25	31	PF00069	0.592
MOD_ProDKin_1	285	291	PF00069	0.278
MOD_ProDKin_1	299	305	PF00069	0.340
MOD_SUMO_rev_2	146	154	PF00179	0.398
MOD_SUMO_rev_2	180	190	PF00179	0.312
MOD_SUMO_rev_2	203	211	PF00179	0.405
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.308
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.375
TRG_ENDOCYTIC_2	164	167	PF00928	0.262
TRG_ENDOCYTIC_2	168	171	PF00928	0.285
TRG_ER_diArg_1	366	369	PF00400	0.334
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	25%	92%
A0A0N0P6T9	Leptomonas seymouri	88%	100%
A0A0N0P7Z0	Leptomonas seymouri	30%	100%
A0A0S4IRB2	Bodo saltans	25%	82%
A0A0S4JDH7	Bodo saltans	30%	100%
A0A0S4JQD8	Bodo saltans	27%	99%
A0A0S4JWH9	Bodo saltans	73%	100%
A0A1X0NKR3	Trypanosomatidae	27%	77%
A0A1X0NMC6	Trypanosomatidae	76%	100%
A0A1X0P0F1	Trypanosomatidae	31%	100%
A0A1X0PA69	Trypanosomatidae	24%	88%
A0A3R7MAM8	Trypanosoma rangeli	30%	100%
A0A3R7NHM3	Trypanosoma rangeli	26%	97%
A0A3S5H6M7	Leishmania donovani	92%	100%
A0A3S7WTR5	Leishmania donovani	30%	100%
A0A422NV18	Trypanosoma rangeli	73%	100%
A0A422NZF0	Trypanosoma rangeli	25%	87%
A0A451EJR0	Leishmania donovani	25%	91%
A2XYY8	Oryza sativa subsp. indica	37%	97%
A2Y953	Oryza sativa subsp. indica	33%	97%
A2YPT7	Oryza sativa subsp. indica	33%	70%
A2Z0C0	Oryza sativa subsp. indica	48%	95%
A2Z8S0	Oryza sativa subsp. indica	37%	93%
A3KPF2	Arabidopsis thaliana	32%	70%
A4H8A2	Leishmania braziliensis	25%	100%
A4H8D0	Leishmania braziliensis	31%	100%
A4HWQ2	Leishmania infantum	31%	100%
A8IEF3	Chlamydomonas reinhardtii	49%	100%
B0JYW5	Xenopus tropicalis	35%	100%
B3DLB3	Xenopus tropicalis	33%	85%
B3M1E1	Drosophila ananassae	34%	69%
B3P4N5	Drosophila erecta	36%	70%
B4GZ20	Drosophila persimilis	35%	69%
B4HJC0	Drosophila sechellia	36%	70%
B4JXV2	Drosophila grimshawi	35%	68%
B4KA23	Drosophila mojavensis	35%	68%
B4LVS8	Drosophila virilis	34%	69%
B4NKI9	Drosophila willistoni	34%	69%
B4PVH6	Drosophila yakuba	36%	70%
B4QVW6	Drosophila simulans	36%	70%
C9ZI39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
C9ZPS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	95%
D0A264	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	95%
D9IVE5	Xenopus laevis	33%	85%
E9ACK5	Leishmania major	24%	100%
E9AG49	Leishmania infantum	25%	91%
E9AGI9	Leishmania infantum	92%	100%
E9AJU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AQF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O13648	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	68%
O60678	Homo sapiens	43%	69%
O70467	Rattus norvegicus	42%	70%
O82210	Arabidopsis thaliana	49%	100%
P38074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P55345	Homo sapiens	35%	85%
Q08A71	Arabidopsis thaliana	36%	85%
Q0J2C6	Oryza sativa subsp. japonica	48%	95%
Q28F07	Xenopus tropicalis	49%	100%
Q29B63	Drosophila pseudoobscura pseudoobscura	35%	69%
Q4QF17	Leishmania major	32%	100%
Q4QGG2	Leishmania major	91%	100%
Q54EF2	Dictyostelium discoideum	48%	100%
Q54HI0	Dictyostelium discoideum	40%	72%
Q582G4	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	25%	95%
Q5E9L5	Bos taurus	34%	98%
Q5RGQ2	Danio rerio	46%	88%
Q63009	Rattus norvegicus	48%	100%
Q68EZ3	Xenopus laevis	35%	100%
Q6NWG4	Danio rerio	41%	100%
Q6NZB1	Mus musculus	36%	98%
Q6PAK3	Mus musculus	45%	94%
Q6VRB0	Xenopus laevis	49%	100%
Q75G68	Oryza sativa subsp. japonica	37%	93%
Q7XI75	Oryza sativa subsp. japonica	33%	70%
Q7XKC0	Oryza sativa subsp. japonica	36%	94%
Q84W92	Arabidopsis thaliana	32%	69%
Q8AV13	Xenopus laevis	48%	100%
Q922H1	Mus musculus	42%	70%
Q96LA8	Homo sapiens	35%	98%
Q99873	Homo sapiens	50%	99%
Q9JIF0	Mus musculus	50%	99%
Q9MAT5	Arabidopsis thaliana	32%	96%
Q9NR22	Homo sapiens	46%	94%
Q9R144	Mus musculus	35%	82%
Q9SNQ2	Oryza sativa subsp. japonica	33%	97%
Q9SU94	Arabidopsis thaliana	47%	95%
Q9U2X0	Caenorhabditis elegans	49%	100%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
Q9VH48	Drosophila melanogaster	36%	70%
V5ARC3	Trypanosoma cruzi	28%	94%
V5BF38	Trypanosoma cruzi	73%	100%
V5BT47	Trypanosoma cruzi	25%	84%
V5BXE6	Trypanosoma cruzi	26%	96%