Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIN8_LEIBR

TriTrypDb:

LbrM.20.6050 , LBRM2903_200076100

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.569
CLV_C14_Caspase3-7	265	269	PF00656	0.505
CLV_C14_Caspase3-7	335	339	PF00656	0.539
CLV_C14_Caspase3-7	617	621	PF00656	0.681
CLV_MEL_PAP_1	141	147	PF00089	0.553
CLV_NRD_NRD_1	118	120	PF00675	0.754
CLV_NRD_NRD_1	138	140	PF00675	0.503
CLV_NRD_NRD_1	143	145	PF00675	0.684
CLV_NRD_NRD_1	190	192	PF00675	0.759
CLV_NRD_NRD_1	20	22	PF00675	0.590
CLV_NRD_NRD_1	353	355	PF00675	0.548
CLV_NRD_NRD_1	385	387	PF00675	0.552
CLV_NRD_NRD_1	44	46	PF00675	0.763
CLV_NRD_NRD_1	600	602	PF00675	0.511
CLV_NRD_NRD_1	87	89	PF00675	0.761
CLV_PCSK_FUR_1	116	120	PF00082	0.755
CLV_PCSK_FUR_1	598	602	PF00082	0.590
CLV_PCSK_KEX2_1	118	120	PF00082	0.738
CLV_PCSK_KEX2_1	138	140	PF00082	0.663
CLV_PCSK_KEX2_1	143	145	PF00082	0.684
CLV_PCSK_KEX2_1	190	192	PF00082	0.759
CLV_PCSK_KEX2_1	20	22	PF00082	0.580
CLV_PCSK_KEX2_1	353	355	PF00082	0.548
CLV_PCSK_KEX2_1	385	387	PF00082	0.552
CLV_PCSK_KEX2_1	44	46	PF00082	0.763
CLV_PCSK_KEX2_1	592	594	PF00082	0.610
CLV_PCSK_KEX2_1	598	600	PF00082	0.517
CLV_PCSK_KEX2_1	87	89	PF00082	0.761
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.420
CLV_PCSK_PC7_1	139	145	PF00082	0.554
CLV_PCSK_SKI1_1	138	142	PF00082	0.555
CLV_PCSK_SKI1_1	198	202	PF00082	0.549
CLV_PCSK_SKI1_1	470	474	PF00082	0.763
CLV_PCSK_SKI1_1	478	482	PF00082	0.668
CLV_PCSK_SKI1_1	559	563	PF00082	0.749
CLV_PCSK_SKI1_1	593	597	PF00082	0.569
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DEG_SCF_FBW7_1	561	566	PF00400	0.735
DEG_SPOP_SBC_1	200	204	PF00917	0.541
DOC_ANK_TNKS_1	506	513	PF00023	0.591
DOC_CKS1_1	36	41	PF01111	0.735
DOC_CKS1_1	428	433	PF01111	0.741
DOC_CKS1_1	560	565	PF01111	0.745
DOC_MAPK_FxFP_2	207	210	PF00069	0.545
DOC_MAPK_gen_1	353	361	PF00069	0.541
DOC_MAPK_gen_1	87	93	PF00069	0.765
DOC_MAPK_MEF2A_6	316	325	PF00069	0.561
DOC_MAPK_RevD_3	73	88	PF00069	0.558
DOC_PP1_RVXF_1	555	561	PF00149	0.558
DOC_PP4_FxxP_1	207	210	PF00568	0.545
DOC_PP4_FxxP_1	36	39	PF00568	0.555
DOC_PP4_FxxP_1	560	563	PF00568	0.556
DOC_PP4_MxPP_1	501	504	PF00568	0.580
DOC_USP7_MATH_1	104	108	PF00917	0.752
DOC_USP7_MATH_1	156	160	PF00917	0.669
DOC_USP7_MATH_1	166	170	PF00917	0.648
DOC_USP7_MATH_1	212	216	PF00917	0.556
DOC_USP7_MATH_1	225	229	PF00917	0.537
DOC_USP7_MATH_1	260	264	PF00917	0.635
DOC_USP7_MATH_1	28	32	PF00917	0.695
DOC_USP7_MATH_1	362	366	PF00917	0.603
DOC_USP7_MATH_1	570	574	PF00917	0.679
DOC_USP7_UBL2_3	592	596	PF12436	0.415
DOC_WW_Pin1_4	13	18	PF00397	0.767
DOC_WW_Pin1_4	133	138	PF00397	0.569
DOC_WW_Pin1_4	169	174	PF00397	0.640
DOC_WW_Pin1_4	210	215	PF00397	0.638
DOC_WW_Pin1_4	314	319	PF00397	0.758
DOC_WW_Pin1_4	348	353	PF00397	0.578
DOC_WW_Pin1_4	35	40	PF00397	0.741
DOC_WW_Pin1_4	427	432	PF00397	0.690
DOC_WW_Pin1_4	460	465	PF00397	0.574
DOC_WW_Pin1_4	472	477	PF00397	0.600
DOC_WW_Pin1_4	48	53	PF00397	0.604
DOC_WW_Pin1_4	530	535	PF00397	0.699
DOC_WW_Pin1_4	536	541	PF00397	0.651
DOC_WW_Pin1_4	544	549	PF00397	0.551
DOC_WW_Pin1_4	55	60	PF00397	0.485
DOC_WW_Pin1_4	559	564	PF00397	0.524
DOC_WW_Pin1_4	573	578	PF00397	0.590
LIG_14-3-3_CanoR_1	108	117	PF00244	0.640
LIG_14-3-3_CanoR_1	198	207	PF00244	0.546
LIG_14-3-3_CanoR_1	233	241	PF00244	0.652
LIG_14-3-3_CanoR_1	247	251	PF00244	0.527
LIG_14-3-3_CanoR_1	301	308	PF00244	0.550
LIG_14-3-3_CanoR_1	386	394	PF00244	0.658
LIG_14-3-3_CanoR_1	47	52	PF00244	0.694
LIG_14-3-3_CanoR_1	488	494	PF00244	0.591
LIG_14-3-3_CanoR_1	550	560	PF00244	0.601
LIG_14-3-3_CanoR_1	87	91	PF00244	0.765
LIG_BIR_III_2	255	259	PF00653	0.560
LIG_BRCT_BRCA1_1	203	207	PF00533	0.587
LIG_BRCT_BRCA1_1	235	239	PF00533	0.587
LIG_BRCT_BRCA1_1	32	36	PF00533	0.571
LIG_BRCT_BRCA1_1	49	53	PF00533	0.528
LIG_CSL_BTD_1	359	362	PF09270	0.687
LIG_FHA_1	104	110	PF00498	0.689
LIG_FHA_1	201	207	PF00498	0.733
LIG_FHA_1	335	341	PF00498	0.665
LIG_FHA_1	388	394	PF00498	0.653
LIG_FHA_1	428	434	PF00498	0.749
LIG_FHA_1	581	587	PF00498	0.522
LIG_FHA_2	206	212	PF00498	0.549
LIG_FHA_2	250	256	PF00498	0.697
LIG_FHA_2	342	348	PF00498	0.722
LIG_IRF3_LxIS_1	64	71	PF10401	0.542
LIG_LIR_Apic_2	204	210	PF02991	0.545
LIG_LIR_Apic_2	33	39	PF02991	0.562
LIG_LIR_Gen_1	300	308	PF02991	0.595
LIG_PDZ_Class_3	617	622	PF00595	0.687
LIG_Pex14_1	443	447	PF04695	0.558
LIG_PTAP_UEV_1	213	218	PF05743	0.565
LIG_RPA_C_Fungi	446	458	PF08784	0.552
LIG_SH3_2	39	44	PF14604	0.731
LIG_SH3_3	160	166	PF00018	0.551
LIG_SH3_3	186	192	PF00018	0.598
LIG_SH3_3	211	217	PF00018	0.635
LIG_SH3_3	315	321	PF00018	0.737
LIG_SH3_3	356	362	PF00018	0.543
LIG_SH3_3	36	42	PF00018	0.734
LIG_SH3_3	416	422	PF00018	0.633
LIG_SH3_3	425	431	PF00018	0.599
LIG_SH3_3	497	503	PF00018	0.585
LIG_SH3_3	54	60	PF00018	0.515
LIG_SH3_CIN85_PxpxPR_1	540	545	PF14604	0.592
LIG_SUMO_SIM_par_1	161	169	PF11976	0.564
LIG_TRAF2_1	228	231	PF00917	0.575
LIG_WW_2	431	434	PF00397	0.530
LIG_WW_2	503	506	PF00397	0.579
LIG_WW_3	467	471	PF00397	0.583
MOD_CDC14_SPxK_1	475	478	PF00782	0.586
MOD_CDK_SPK_2	133	138	PF00069	0.569
MOD_CDK_SPK_2	348	353	PF00069	0.543
MOD_CDK_SPK_2	536	541	PF00069	0.656
MOD_CDK_SPK_2	573	578	PF00069	0.574
MOD_CDK_SPxK_1	133	139	PF00069	0.568
MOD_CDK_SPxK_1	348	354	PF00069	0.545
MOD_CDK_SPxK_1	460	466	PF00069	0.574
MOD_CDK_SPxK_1	472	478	PF00069	0.549
MOD_CDK_SPxK_1	544	550	PF00069	0.735
MOD_CDK_SPxxK_3	13	20	PF00069	0.577
MOD_CDK_SPxxK_3	573	580	PF00069	0.571
MOD_CK1_1	112	118	PF00069	0.567
MOD_CK1_1	169	175	PF00069	0.686
MOD_CK1_1	196	202	PF00069	0.666
MOD_CK1_1	215	221	PF00069	0.628
MOD_CK1_1	249	255	PF00069	0.730
MOD_CK1_1	300	306	PF00069	0.685
MOD_CK1_1	314	320	PF00069	0.605
MOD_CK1_1	332	338	PF00069	0.650
MOD_CK1_1	343	349	PF00069	0.587
MOD_CK1_1	370	376	PF00069	0.611
MOD_CK1_1	387	393	PF00069	0.604
MOD_CK1_1	48	54	PF00069	0.730
MOD_CK1_1	483	489	PF00069	0.713
MOD_CK1_1	490	496	PF00069	0.744
MOD_CK1_1	552	558	PF00069	0.755
MOD_CK1_1	573	579	PF00069	0.733
MOD_CK1_1	58	64	PF00069	0.638
MOD_CK1_1	71	77	PF00069	0.572
MOD_CK2_1	108	114	PF00069	0.757
MOD_CK2_1	205	211	PF00069	0.548
MOD_CK2_1	225	231	PF00069	0.603
MOD_CK2_1	401	407	PF00069	0.600
MOD_Cter_Amidation	18	21	PF01082	0.579
MOD_GlcNHglycan	130	133	PF01048	0.757
MOD_GlcNHglycan	145	148	PF01048	0.537
MOD_GlcNHglycan	150	153	PF01048	0.495
MOD_GlcNHglycan	158	161	PF01048	0.607
MOD_GlcNHglycan	168	171	PF01048	0.520
MOD_GlcNHglycan	198	201	PF01048	0.730
MOD_GlcNHglycan	214	217	PF01048	0.599
MOD_GlcNHglycan	227	230	PF01048	0.697
MOD_GlcNHglycan	262	265	PF01048	0.667
MOD_GlcNHglycan	280	283	PF01048	0.664
MOD_GlcNHglycan	293	296	PF01048	0.626
MOD_GlcNHglycan	32	35	PF01048	0.571
MOD_GlcNHglycan	364	367	PF01048	0.599
MOD_GlcNHglycan	368	372	PF01048	0.629
MOD_GlcNHglycan	390	393	PF01048	0.609
MOD_GlcNHglycan	404	407	PF01048	0.536
MOD_GlcNHglycan	454	457	PF01048	0.701
MOD_GlcNHglycan	489	492	PF01048	0.645
MOD_GlcNHglycan	521	524	PF01048	0.713
MOD_GlcNHglycan	572	575	PF01048	0.711
MOD_GlcNHglycan	586	589	PF01048	0.499
MOD_GSK3_1	104	111	PF00069	0.631
MOD_GSK3_1	165	172	PF00069	0.727
MOD_GSK3_1	196	203	PF00069	0.739
MOD_GSK3_1	215	222	PF00069	0.640
MOD_GSK3_1	225	232	PF00069	0.694
MOD_GSK3_1	235	242	PF00069	0.659
MOD_GSK3_1	245	252	PF00069	0.652
MOD_GSK3_1	256	263	PF00069	0.658
MOD_GSK3_1	289	296	PF00069	0.660
MOD_GSK3_1	307	314	PF00069	0.566
MOD_GSK3_1	332	339	PF00069	0.690
MOD_GSK3_1	341	348	PF00069	0.664
MOD_GSK3_1	367	374	PF00069	0.596
MOD_GSK3_1	384	391	PF00069	0.540
MOD_GSK3_1	468	475	PF00069	0.697
MOD_GSK3_1	476	483	PF00069	0.678
MOD_GSK3_1	48	55	PF00069	0.602
MOD_GSK3_1	530	537	PF00069	0.627
MOD_GSK3_1	540	547	PF00069	0.680
MOD_GSK3_1	559	566	PF00069	0.637
MOD_GSK3_1	576	583	PF00069	0.537
MOD_GSK3_1	584	591	PF00069	0.588
MOD_N-GLC_1	552	557	PF02516	0.757
MOD_N-GLC_1	613	618	PF02516	0.624
MOD_NEK2_1	193	198	PF00069	0.669
MOD_NEK2_1	201	206	PF00069	0.662
MOD_NEK2_1	266	271	PF00069	0.648
MOD_NEK2_1	293	298	PF00069	0.648
MOD_NEK2_1	311	316	PF00069	0.526
MOD_NEK2_1	340	345	PF00069	0.643
MOD_NEK2_1	367	372	PF00069	0.553
MOD_NEK2_1	447	452	PF00069	0.653
MOD_NEK2_1	565	570	PF00069	0.599
MOD_NEK2_1	68	73	PF00069	0.577
MOD_NEK2_2	476	481	PF00069	0.585
MOD_PIKK_1	193	199	PF00454	0.568
MOD_PIKK_1	239	245	PF00454	0.567
MOD_PIKK_1	293	299	PF00454	0.548
MOD_PIKK_1	407	413	PF00454	0.766
MOD_PIKK_1	483	489	PF00454	0.681
MOD_PKA_1	143	149	PF00069	0.555
MOD_PKA_1	353	359	PF00069	0.544
MOD_PKA_2	112	118	PF00069	0.567
MOD_PKA_2	143	149	PF00069	0.736
MOD_PKA_2	246	252	PF00069	0.595
MOD_PKA_2	300	306	PF00069	0.709
MOD_PKA_2	353	359	PF00069	0.568
MOD_PKA_2	384	390	PF00069	0.648
MOD_PKA_2	487	493	PF00069	0.823
MOD_PKA_2	549	555	PF00069	0.574
MOD_PKA_2	86	92	PF00069	0.765
MOD_PKB_1	45	53	PF00069	0.766
MOD_Plk_1	286	292	PF00069	0.670
MOD_Plk_1	613	619	PF00069	0.633
MOD_Plk_4	201	207	PF00069	0.723
MOD_Plk_4	377	383	PF00069	0.602
MOD_ProDKin_1	13	19	PF00069	0.766
MOD_ProDKin_1	133	139	PF00069	0.568
MOD_ProDKin_1	169	175	PF00069	0.641
MOD_ProDKin_1	210	216	PF00069	0.639
MOD_ProDKin_1	314	320	PF00069	0.755
MOD_ProDKin_1	348	354	PF00069	0.580
MOD_ProDKin_1	35	41	PF00069	0.738
MOD_ProDKin_1	427	433	PF00069	0.692
MOD_ProDKin_1	460	466	PF00069	0.574
MOD_ProDKin_1	472	478	PF00069	0.601
MOD_ProDKin_1	48	54	PF00069	0.605
MOD_ProDKin_1	530	536	PF00069	0.699
MOD_ProDKin_1	540	546	PF00069	0.608
MOD_ProDKin_1	55	61	PF00069	0.486
MOD_ProDKin_1	559	565	PF00069	0.512
MOD_ProDKin_1	573	579	PF00069	0.588
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.636
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.553
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.623
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.559
TRG_ER_diArg_1	116	119	PF00400	0.751
TRG_ER_diArg_1	137	139	PF00400	0.714
TRG_ER_diArg_1	142	144	PF00400	0.681
TRG_ER_diArg_1	189	191	PF00400	0.759
TRG_ER_diArg_1	352	354	PF00400	0.537
TRG_ER_diArg_1	44	47	PF00400	0.766
TRG_ER_diArg_1	557	560	PF00400	0.724
TRG_ER_diArg_1	598	601	PF00400	0.593
TRG_ER_diArg_1	79	82	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	593	597	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSA2	Leishmania donovani	50%	97%
E9AGJ0	Leishmania infantum	50%	97%
E9AP28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
Q4QGG1	Leishmania major	50%	100%