SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIN6_LEIBR

TriTrypDb:

LbrM.20.6030 , LBRM2903_200075900

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN6

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	154	160	PF00089	0.505
CLV_NRD_NRD_1	304	306	PF00675	0.372
CLV_NRD_NRD_1	450	452	PF00675	0.354
CLV_NRD_NRD_1	487	489	PF00675	0.539
CLV_NRD_NRD_1	521	523	PF00675	0.273
CLV_PCSK_FUR_1	448	452	PF00082	0.428
CLV_PCSK_KEX2_1	304	306	PF00082	0.334
CLV_PCSK_KEX2_1	329	331	PF00082	0.349
CLV_PCSK_KEX2_1	450	452	PF00082	0.354
CLV_PCSK_KEX2_1	487	489	PF00082	0.419
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.349
CLV_PCSK_SKI1_1	102	106	PF00082	0.395
CLV_PCSK_SKI1_1	257	261	PF00082	0.188
CLV_PCSK_SKI1_1	488	492	PF00082	0.516
CLV_PCSK_SKI1_1	522	526	PF00082	0.274
CLV_PCSK_SKI1_1	530	534	PF00082	0.257
CLV_PCSK_SKI1_1	581	585	PF00082	0.373
CLV_PCSK_SKI1_1	612	616	PF00082	0.489
DEG_APCC_DBOX_1	521	529	PF00400	0.302
DEG_APCC_DBOX_1	542	550	PF00400	0.325
DOC_CDC14_PxL_1	132	140	PF14671	0.510
DOC_CDC14_PxL_1	186	194	PF14671	0.474
DOC_CDC14_PxL_1	437	445	PF14671	0.482
DOC_CKS1_1	198	203	PF01111	0.493
DOC_CYCLIN_RxL_1	519	527	PF00134	0.407
DOC_CYCLIN_yClb1_LxF_4	543	549	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.444
DOC_MAPK_DCC_7	187	195	PF00069	0.470
DOC_MAPK_gen_1	173	183	PF00069	0.577
DOC_MAPK_gen_1	469	479	PF00069	0.279
DOC_MAPK_MEF2A_6	187	195	PF00069	0.470
DOC_MAPK_MEF2A_6	472	481	PF00069	0.274
DOC_PP1_RVXF_1	83	90	PF00149	0.269
DOC_PP2B_LxvP_1	306	309	PF13499	0.549
DOC_PP2B_PxIxI_1	190	196	PF00149	0.268
DOC_USP7_MATH_1	222	226	PF00917	0.363
DOC_USP7_MATH_1	3	7	PF00917	0.652
DOC_USP7_UBL2_3	254	258	PF12436	0.401
DOC_WW_Pin1_4	164	169	PF00397	0.604
DOC_WW_Pin1_4	197	202	PF00397	0.469
DOC_WW_Pin1_4	269	274	PF00397	0.549
LIG_14-3-3_CanoR_1	157	164	PF00244	0.543
LIG_14-3-3_CanoR_1	261	270	PF00244	0.546
LIG_14-3-3_CanoR_1	293	301	PF00244	0.554
LIG_14-3-3_CanoR_1	453	461	PF00244	0.461
LIG_14-3-3_CanoR_1	487	497	PF00244	0.454
LIG_14-3-3_CanoR_1	522	532	PF00244	0.395
LIG_14-3-3_CanoR_1	543	549	PF00244	0.343
LIG_AP2alpha_2	473	475	PF02296	0.460
LIG_BIR_III_4	618	622	PF00653	0.529
LIG_BRCT_BRCA1_1	5	9	PF00533	0.616
LIG_eIF4E_1	100	106	PF01652	0.446
LIG_FHA_1	149	155	PF00498	0.501
LIG_FHA_1	338	344	PF00498	0.547
LIG_FHA_1	36	42	PF00498	0.490
LIG_FHA_1	365	371	PF00498	0.505
LIG_FHA_1	423	429	PF00498	0.451
LIG_FHA_1	82	88	PF00498	0.384
LIG_FHA_2	140	146	PF00498	0.451
LIG_FHA_2	53	59	PF00498	0.461
LIG_FHA_2	8	14	PF00498	0.366
LIG_Integrin_isoDGR_2	248	250	PF01839	0.188
LIG_LIR_Gen_1	314	324	PF02991	0.521
LIG_LIR_Gen_1	368	377	PF02991	0.522
LIG_LIR_Nem_3	310	315	PF02991	0.496
LIG_LIR_Nem_3	368	374	PF02991	0.522
LIG_LIR_Nem_3	455	461	PF02991	0.465
LIG_LIR_Nem_3	491	497	PF02991	0.459
LIG_MYND_1	136	140	PF01753	0.502
LIG_MYND_3	135	139	PF01753	0.523
LIG_NRBOX	520	526	PF00104	0.374
LIG_NRBOX	563	569	PF00104	0.408
LIG_Rb_pABgroove_1	611	619	PF01858	0.259
LIG_REV1ctd_RIR_1	68	76	PF16727	0.272
LIG_SH2_CRK	270	274	PF00017	0.530
LIG_SH2_CRK	317	321	PF00017	0.549
LIG_SH2_NCK_1	133	137	PF00017	0.514
LIG_SH2_PTP2	371	374	PF00017	0.388
LIG_SH2_SRC	371	374	PF00017	0.388
LIG_SH2_STAP1	37	41	PF00017	0.485
LIG_SH2_STAT3	439	442	PF00017	0.350
LIG_SH2_STAT5	270	273	PF00017	0.462
LIG_SH2_STAT5	37	40	PF00017	0.456
LIG_SH2_STAT5	371	374	PF00017	0.530
LIG_SH2_STAT5	430	433	PF00017	0.462
LIG_SH2_STAT5	439	442	PF00017	0.340
LIG_SH2_STAT5	459	462	PF00017	0.191
LIG_SH2_STAT5	537	540	PF00017	0.320
LIG_SH3_3	349	355	PF00018	0.549
LIG_SH3_3	381	387	PF00018	0.475
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.482
LIG_SUMO_SIM_anti_2	611	618	PF11976	0.486
LIG_SUMO_SIM_par_1	191	197	PF11976	0.409
LIG_TYR_ITIM	315	320	PF00017	0.549
LIG_TYR_ITSM	367	374	PF00017	0.530
LIG_UBA3_1	356	362	PF00899	0.530
LIG_UBA3_1	524	530	PF00899	0.320
LIG_WRC_WIRS_1	402	407	PF05994	0.549
MOD_CK1_1	109	115	PF00069	0.595
MOD_CK1_1	197	203	PF00069	0.397
MOD_CK1_1	289	295	PF00069	0.388
MOD_CK1_1	300	306	PF00069	0.425
MOD_CK1_1	7	13	PF00069	0.382
MOD_CK2_1	138	144	PF00069	0.398
MOD_CK2_1	156	162	PF00069	0.459
MOD_CK2_1	52	58	PF00069	0.503
MOD_CK2_1	7	13	PF00069	0.382
MOD_GlcNHglycan	118	121	PF01048	0.505
MOD_GlcNHglycan	158	161	PF01048	0.448
MOD_GlcNHglycan	224	227	PF01048	0.425
MOD_GlcNHglycan	386	390	PF01048	0.276
MOD_GlcNHglycan	6	9	PF01048	0.631
MOD_GlcNHglycan	601	605	PF01048	0.475
MOD_GlcNHglycan	61	64	PF01048	0.403
MOD_GSK3_1	112	119	PF00069	0.570
MOD_GSK3_1	134	141	PF00069	0.337
MOD_GSK3_1	3	10	PF00069	0.588
MOD_GSK3_1	497	504	PF00069	0.455
MOD_N-GLC_1	406	411	PF02516	0.255
MOD_N-GLC_2	23	25	PF02516	0.530
MOD_NEK2_1	260	265	PF00069	0.388
MOD_NEK2_1	286	291	PF00069	0.479
MOD_NEK2_1	337	342	PF00069	0.530
MOD_NEK2_1	406	411	PF00069	0.459
MOD_NEK2_1	59	64	PF00069	0.457
MOD_NEK2_2	415	420	PF00069	0.579
MOD_NEK2_2	501	506	PF00069	0.393
MOD_PIKK_1	511	517	PF00454	0.497
MOD_PIKK_1	7	13	PF00454	0.382
MOD_PKA_2	156	162	PF00069	0.540
MOD_PKA_2	260	266	PF00069	0.546
MOD_PKA_2	289	295	PF00069	0.552
MOD_PKA_2	452	458	PF00069	0.507
MOD_Plk_1	286	292	PF00069	0.388
MOD_Plk_1	365	371	PF00069	0.388
MOD_Plk_1	406	412	PF00069	0.442
MOD_Plk_1	433	439	PF00069	0.451
MOD_Plk_2-3	134	140	PF00069	0.298
MOD_Plk_2-3	229	235	PF00069	0.537
MOD_Plk_4	194	200	PF00069	0.499
MOD_Plk_4	366	372	PF00069	0.520
MOD_Plk_4	401	407	PF00069	0.451
MOD_Plk_4	544	550	PF00069	0.342
MOD_ProDKin_1	164	170	PF00069	0.607
MOD_ProDKin_1	197	203	PF00069	0.463
MOD_ProDKin_1	269	275	PF00069	0.549
MOD_SUMO_for_1	253	256	PF00179	0.475
MOD_SUMO_for_1	361	364	PF00179	0.530
MOD_SUMO_rev_2	251	260	PF00179	0.499
MOD_SUMO_rev_2	590	600	PF00179	0.440
TRG_DiLeu_BaEn_1	194	199	PF01217	0.475
TRG_DiLeu_BaEn_2	455	461	PF01217	0.465
TRG_DiLeu_BaEn_4	365	371	PF01217	0.453
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.438
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.385
TRG_ENDOCYTIC_2	317	320	PF00928	0.535
TRG_ENDOCYTIC_2	371	374	PF00928	0.530
TRG_ENDOCYTIC_2	458	461	PF00928	0.526
TRG_ER_diArg_1	175	178	PF00400	0.361
TRG_ER_diArg_1	304	306	PF00400	0.499
TRG_ER_diArg_1	448	451	PF00400	0.359
TRG_ER_diArg_1	505	508	PF00400	0.479
TRG_NES_CRM1_1	558	571	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV1	Leptomonas seymouri	59%	100%
A0A0S4IJK9	Bodo saltans	39%	100%
A0A1X0NMI4	Trypanosomatidae	43%	100%
A0A3S7WS98	Leishmania donovani	85%	100%
A0A422NUZ8	Trypanosoma rangeli	45%	100%
C9ZI42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AGJ2	Leishmania infantum	84%	100%
E9AP30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGF9	Leishmania major	82%	100%
V5DFZ1	Trypanosoma cruzi	43%	100%