Ribonuclease H1/H2 small subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIN5_LEIBR

TriTrypDb:

LbrM.20.6021 , LBRM2903_200075800

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032299	ribonuclease H2 complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006401	RNA catabolic process	5	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009057	macromolecule catabolic process	4	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0019439	aromatic compound catabolic process	4	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034655	nucleobase-containing compound catabolic process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	9
GO:0044270	cellular nitrogen compound catabolic process	4	9
GO:0046483	heterocycle metabolic process	3	9
GO:0046700	heterocycle catabolic process	4	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901361	organic cyclic compound catabolic process	4	9
GO:1901575	organic substance catabolic process	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.196
CLV_PCSK_SKI1_1	17	21	PF00082	0.293
DEG_SCF_FBW7_2	57	62	PF00400	0.196
DOC_CKS1_1	56	61	PF01111	0.202
DOC_CKS1_1	66	71	PF01111	0.173
DOC_CYCLIN_RxL_1	11	23	PF00134	0.374
DOC_PP1_RVXF_1	78	85	PF00149	0.324
DOC_PP4_FxxP_1	43	46	PF00568	0.243
DOC_PP4_FxxP_1	56	59	PF00568	0.296
DOC_USP7_MATH_1	76	80	PF00917	0.235
DOC_WW_Pin1_4	41	46	PF00397	0.333
DOC_WW_Pin1_4	55	60	PF00397	0.469
DOC_WW_Pin1_4	65	70	PF00397	0.173
LIG_14-3-3_CanoR_1	11	15	PF00244	0.351
LIG_LIR_Apic_2	42	46	PF02991	0.245
LIG_LIR_Apic_2	54	59	PF02991	0.213
LIG_LIR_Gen_1	97	106	PF02991	0.349
LIG_LIR_Nem_3	97	102	PF02991	0.349
LIG_SH2_SRC	30	33	PF00017	0.271
LIG_SH2_STAP1	30	34	PF00017	0.349
LIG_SH2_STAT5	81	84	PF00017	0.327
LIG_SH3_3	21	27	PF00018	0.266
LIG_SH3_3	42	48	PF00018	0.328
LIG_WRC_WIRS_1	53	58	PF05994	0.266
MOD_CK1_1	44	50	PF00069	0.492
MOD_CK1_1	52	58	PF00069	0.371
MOD_GlcNHglycan	49	52	PF01048	0.319
MOD_GSK3_1	32	39	PF00069	0.324
MOD_GSK3_1	47	54	PF00069	0.348
MOD_GSK3_1	88	95	PF00069	0.391
MOD_LATS_1	86	92	PF00433	0.266
MOD_N-GLC_1	39	44	PF02516	0.196
MOD_NEK2_1	1	6	PF00069	0.336
MOD_NEK2_1	105	110	PF00069	0.441
MOD_NEK2_2	10	15	PF00069	0.340
MOD_PIKK_1	94	100	PF00454	0.298
MOD_PKA_2	10	16	PF00069	0.239
MOD_PKA_2	2	8	PF00069	0.426
MOD_Plk_1	39	45	PF00069	0.196
MOD_Plk_4	52	58	PF00069	0.271
MOD_ProDKin_1	41	47	PF00069	0.333
MOD_ProDKin_1	55	61	PF00069	0.469
MOD_ProDKin_1	65	71	PF00069	0.173
TRG_ER_diArg_1	14	17	PF00400	0.273
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL20	Leptomonas seymouri	44%	78%
A0A1X0NN29	Trypanosomatidae	32%	74%
A0A3R7MWX3	Trypanosoma rangeli	33%	76%
A0A3S7WSA4	Leishmania donovani	64%	100%
C9ZI43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	70%
E9AGJ3	Leishmania infantum	64%	100%
Q4QGF8	Leishmania major	57%	100%