FAM91_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAM91 N-terminus/FAM91 C-terminus, putative

Species:

Leishmania braziliensis

UniProt:

E9AIN4_LEIBR

TriTrypDb:

LbrM.20.6020 , LBRM2903_200075700

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.413
CLV_C14_Caspase3-7	3	7	PF00656	0.399
CLV_C14_Caspase3-7	698	702	PF00656	0.337
CLV_NRD_NRD_1	245	247	PF00675	0.255
CLV_NRD_NRD_1	59	61	PF00675	0.202
CLV_NRD_NRD_1	834	836	PF00675	0.341
CLV_PCSK_KEX2_1	190	192	PF00082	0.371
CLV_PCSK_KEX2_1	245	247	PF00082	0.308
CLV_PCSK_KEX2_1	397	399	PF00082	0.313
CLV_PCSK_KEX2_1	463	465	PF00082	0.372
CLV_PCSK_KEX2_1	59	61	PF00082	0.432
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.371
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.413
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.202
CLV_PCSK_SKI1_1	241	245	PF00082	0.454
CLV_PCSK_SKI1_1	398	402	PF00082	0.313
CLV_PCSK_SKI1_1	473	477	PF00082	0.313
CLV_Separin_Metazoa	70	74	PF03568	0.455
DEG_APCC_DBOX_1	297	305	PF00400	0.313
DEG_APCC_DBOX_1	472	480	PF00400	0.313
DEG_COP1_1	260	270	PF00400	0.202
DEG_Kelch_actinfilin_1	597	601	PF01344	0.202
DOC_CKS1_1	267	272	PF01111	0.202
DOC_CYCLIN_RxL_1	245	258	PF00134	0.202
DOC_CYCLIN_yCln2_LP_2	760	766	PF00134	0.413
DOC_MAPK_DCC_7	164	172	PF00069	0.308
DOC_MAPK_DCC_7	331	341	PF00069	0.338
DOC_MAPK_DCC_7	557	567	PF00069	0.338
DOC_MAPK_gen_1	557	567	PF00069	0.401
DOC_MAPK_MEF2A_6	164	172	PF00069	0.292
DOC_MAPK_MEF2A_6	560	569	PF00069	0.396
DOC_MIT_MIM_1	186	195	PF04212	0.413
DOC_PP1_RVXF_1	248	255	PF00149	0.202
DOC_PP1_RVXF_1	356	363	PF00149	0.546
DOC_PP1_RVXF_1	447	453	PF00149	0.455
DOC_PP2B_LxvP_1	222	225	PF13499	0.308
DOC_PP2B_LxvP_1	565	568	PF13499	0.338
DOC_PP2B_LxvP_1	760	763	PF13499	0.338
DOC_PP2B_PxIxI_1	527	533	PF00149	0.313
DOC_PP4_FxxP_1	213	216	PF00568	0.182
DOC_USP7_MATH_1	388	392	PF00917	0.730
DOC_USP7_MATH_1	393	397	PF00917	0.264
DOC_USP7_MATH_1	616	620	PF00917	0.250
DOC_WW_Pin1_4	193	198	PF00397	0.455
DOC_WW_Pin1_4	257	262	PF00397	0.430
DOC_WW_Pin1_4	266	271	PF00397	0.452
DOC_WW_Pin1_4	29	34	PF00397	0.413
DOC_WW_Pin1_4	519	524	PF00397	0.294
DOC_WW_Pin1_4	544	549	PF00397	0.313
DOC_WW_Pin1_4	94	99	PF00397	0.313
LIG_14-3-3_CanoR_1	146	150	PF00244	0.202
LIG_14-3-3_CanoR_1	278	286	PF00244	0.297
LIG_14-3-3_CanoR_1	298	304	PF00244	0.279
LIG_14-3-3_CanoR_1	464	470	PF00244	0.390
LIG_14-3-3_CanoR_1	507	511	PF00244	0.310
LIG_14-3-3_CanoR_1	806	811	PF00244	0.408
LIG_Actin_WH2_2	124	142	PF00022	0.202
LIG_AP2alpha_2	173	175	PF02296	0.413
LIG_AP2alpha_2	385	387	PF02296	0.501
LIG_APCC_ABBA_1	308	313	PF00400	0.202
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_2	775	779	PF00653	0.455
LIG_BIR_III_2	862	866	PF00653	0.697
LIG_Clathr_ClatBox_1	493	497	PF01394	0.413
LIG_Clathr_ClatBox_1	529	533	PF01394	0.413
LIG_Clathr_ClatBox_1	849	853	PF01394	0.413
LIG_deltaCOP1_diTrp_1	451	458	PF00928	0.455
LIG_FHA_1	140	146	PF00498	0.313
LIG_FHA_1	209	215	PF00498	0.413
LIG_FHA_1	219	225	PF00498	0.374
LIG_FHA_1	234	240	PF00498	0.357
LIG_FHA_1	261	267	PF00498	0.345
LIG_FHA_1	36	42	PF00498	0.416
LIG_FHA_1	406	412	PF00498	0.313
LIG_FHA_1	519	525	PF00498	0.313
LIG_FHA_1	709	715	PF00498	0.446
LIG_FHA_1	741	747	PF00498	0.255
LIG_FHA_1	809	815	PF00498	0.413
LIG_FHA_1	824	830	PF00498	0.413
LIG_FHA_2	121	127	PF00498	0.313
LIG_FHA_2	277	283	PF00498	0.297
LIG_FHA_2	292	298	PF00498	0.413
LIG_FHA_2	30	36	PF00498	0.413
LIG_FHA_2	696	702	PF00498	0.455
LIG_FHA_2	763	769	PF00498	0.413
LIG_LIR_Apic_2	211	216	PF02991	0.182
LIG_LIR_Apic_2	236	240	PF02991	0.392
LIG_LIR_Gen_1	103	110	PF02991	0.308
LIG_LIR_Gen_1	113	124	PF02991	0.325
LIG_LIR_Gen_1	262	270	PF02991	0.387
LIG_LIR_Gen_1	40	51	PF02991	0.201
LIG_LIR_Gen_1	408	416	PF02991	0.370
LIG_LIR_Gen_1	505	515	PF02991	0.308
LIG_LIR_Gen_1	546	555	PF02991	0.317
LIG_LIR_Gen_1	617	628	PF02991	0.413
LIG_LIR_Gen_1	65	76	PF02991	0.415
LIG_LIR_Gen_1	661	671	PF02991	0.372
LIG_LIR_Gen_1	722	732	PF02991	0.332
LIG_LIR_Gen_1	805	814	PF02991	0.370
LIG_LIR_Gen_1	853	863	PF02991	0.202
LIG_LIR_Nem_3	100	105	PF02991	0.337
LIG_LIR_Nem_3	113	119	PF02991	0.232
LIG_LIR_Nem_3	173	178	PF02991	0.413
LIG_LIR_Nem_3	262	267	PF02991	0.387
LIG_LIR_Nem_3	385	390	PF02991	0.635
LIG_LIR_Nem_3	40	46	PF02991	0.221
LIG_LIR_Nem_3	505	511	PF02991	0.308
LIG_LIR_Nem_3	546	552	PF02991	0.317
LIG_LIR_Nem_3	617	623	PF02991	0.413
LIG_LIR_Nem_3	661	666	PF02991	0.372
LIG_LIR_Nem_3	677	683	PF02991	0.124
LIG_LIR_Nem_3	722	728	PF02991	0.275
LIG_LIR_Nem_3	729	735	PF02991	0.373
LIG_LIR_Nem_3	799	803	PF02991	0.316
LIG_LIR_Nem_3	805	810	PF02991	0.317
LIG_LIR_Nem_3	853	859	PF02991	0.364
LIG_LYPXL_S_1	81	85	PF13949	0.338
LIG_LYPXL_yS_3	82	85	PF13949	0.338
LIG_MYND_1	333	337	PF01753	0.338
LIG_NRBOX	303	309	PF00104	0.313
LIG_Pex14_1	549	553	PF04695	0.313
LIG_Rb_pABgroove_1	397	405	PF01858	0.313
LIG_SH2_CRK	102	106	PF00017	0.403
LIG_SH2_CRK	116	120	PF00017	0.215
LIG_SH2_CRK	20	24	PF00017	0.370
LIG_SH2_CRK	289	293	PF00017	0.313
LIG_SH2_CRK	43	47	PF00017	0.224
LIG_SH2_CRK	508	512	PF00017	0.313
LIG_SH2_CRK	555	559	PF00017	0.406
LIG_SH2_CRK	603	607	PF00017	0.413
LIG_SH2_CRK	807	811	PF00017	0.338
LIG_SH2_GRB2like	157	160	PF00017	0.370
LIG_SH2_GRB2like	465	468	PF00017	0.413
LIG_SH2_NCK_1	437	441	PF00017	0.455
LIG_SH2_PTP2	264	267	PF00017	0.413
LIG_SH2_SRC	465	468	PF00017	0.370
LIG_SH2_STAP1	183	187	PF00017	0.413
LIG_SH2_STAP1	235	239	PF00017	0.343
LIG_SH2_STAP1	403	407	PF00017	0.313
LIG_SH2_STAT3	34	37	PF00017	0.406
LIG_SH2_STAT3	365	368	PF00017	0.528
LIG_SH2_STAT3	84	87	PF00017	0.392
LIG_SH2_STAT5	102	105	PF00017	0.249
LIG_SH2_STAT5	138	141	PF00017	0.312
LIG_SH2_STAT5	157	160	PF00017	0.182
LIG_SH2_STAT5	235	238	PF00017	0.345
LIG_SH2_STAT5	264	267	PF00017	0.413
LIG_SH2_STAT5	465	468	PF00017	0.338
LIG_SH2_STAT5	518	521	PF00017	0.313
LIG_SH2_STAT5	555	558	PF00017	0.342
LIG_SH2_STAT5	725	728	PF00017	0.413
LIG_SH2_STAT5	754	757	PF00017	0.427
LIG_SH2_STAT5	84	87	PF00017	0.339
LIG_SH2_STAT5	856	859	PF00017	0.202
LIG_SH2_STAT5	93	96	PF00017	0.297
LIG_SH3_3	262	268	PF00018	0.372
LIG_SH3_3	330	336	PF00018	0.338
LIG_SH3_3	387	393	PF00018	0.603
LIG_SH3_3	479	485	PF00018	0.338
LIG_SH3_3	642	648	PF00018	0.365
LIG_SH3_3	665	671	PF00018	0.325
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.308
LIG_SUMO_SIM_anti_2	626	632	PF11976	0.310
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.463
LIG_SUMO_SIM_par_1	306	314	PF11976	0.306
LIG_SUMO_SIM_par_1	528	533	PF11976	0.413
LIG_SUMO_SIM_par_1	626	632	PF11976	0.310
LIG_TRFH_1	20	24	PF08558	0.413
LIG_TYR_ITIM	18	23	PF00017	0.219
LIG_TYR_ITIM	287	292	PF00017	0.338
LIG_TYR_ITIM	41	46	PF00017	0.202
LIG_TYR_ITIM	601	606	PF00017	0.413
LIG_TYR_ITIM	618	623	PF00017	0.413
LIG_UBA3_1	446	453	PF00899	0.400
LIG_UBA3_1	550	557	PF00899	0.415
LIG_WRC_WIRS_1	254	259	PF05994	0.413
LIG_WRC_WIRS_1	725	730	PF05994	0.455
LIG_WRC_WIRS_1	849	854	PF05994	0.455
MOD_CK1_1	100	106	PF00069	0.313
MOD_CK1_1	208	214	PF00069	0.379
MOD_CK1_1	260	266	PF00069	0.373
MOD_CK1_1	522	528	PF00069	0.313
MOD_CK1_1	540	546	PF00069	0.300
MOD_CK1_1	589	595	PF00069	0.441
MOD_CK1_1	708	714	PF00069	0.455
MOD_CK1_1	740	746	PF00069	0.300
MOD_CK1_1	808	814	PF00069	0.342
MOD_CK1_1	822	828	PF00069	0.353
MOD_CK1_1	848	854	PF00069	0.202
MOD_CK2_1	495	501	PF00069	0.313
MOD_CK2_1	762	768	PF00069	0.470
MOD_GlcNHglycan	524	527	PF01048	0.413
MOD_GlcNHglycan	590	594	PF01048	0.455
MOD_GlcNHglycan	634	637	PF01048	0.421
MOD_GlcNHglycan	660	663	PF01048	0.264
MOD_GlcNHglycan	692	695	PF01048	0.375
MOD_GlcNHglycan	739	742	PF01048	0.270
MOD_GSK3_1	253	260	PF00069	0.458
MOD_GSK3_1	414	421	PF00069	0.329
MOD_GSK3_1	502	509	PF00069	0.312
MOD_GSK3_1	518	525	PF00069	0.247
MOD_GSK3_1	540	547	PF00069	0.297
MOD_GSK3_1	670	677	PF00069	0.424
MOD_GSK3_1	724	731	PF00069	0.345
MOD_GSK3_1	737	744	PF00069	0.360
MOD_GSK3_1	779	786	PF00069	0.456
MOD_GSK3_1	816	823	PF00069	0.374
MOD_GSK3_1	848	855	PF00069	0.431
MOD_N-GLC_1	120	125	PF02516	0.313
MOD_N-GLC_1	276	281	PF02516	0.313
MOD_N-GLC_1	414	419	PF02516	0.313
MOD_N-GLC_2	159	161	PF02516	0.202
MOD_NEK2_1	205	210	PF00069	0.406
MOD_NEK2_1	218	223	PF00069	0.304
MOD_NEK2_1	367	372	PF00069	0.515
MOD_NEK2_1	411	416	PF00069	0.313
MOD_NEK2_1	502	507	PF00069	0.413
MOD_NEK2_1	553	558	PF00069	0.379
MOD_NEK2_1	623	628	PF00069	0.381
MOD_NEK2_1	672	677	PF00069	0.363
MOD_NEK2_1	682	687	PF00069	0.281
MOD_NEK2_1	710	715	PF00069	0.383
MOD_NEK2_1	719	724	PF00069	0.287
MOD_NEK2_1	726	731	PF00069	0.238
MOD_NEK2_1	852	857	PF00069	0.338
MOD_PIKK_1	672	678	PF00454	0.387
MOD_PIKK_1	827	833	PF00454	0.370
MOD_PK_1	653	659	PF00069	0.413
MOD_PKA_2	139	145	PF00069	0.202
MOD_PKA_2	277	283	PF00069	0.307
MOD_PKA_2	297	303	PF00069	0.338
MOD_PKA_2	506	512	PF00069	0.310
MOD_PKA_2	805	811	PF00069	0.408
MOD_Plk_1	112	118	PF00069	0.313
MOD_Plk_1	120	126	PF00069	0.313
MOD_Plk_1	296	302	PF00069	0.334
MOD_Plk_1	403	409	PF00069	0.313
MOD_Plk_1	532	538	PF00069	0.393
MOD_Plk_1	616	622	PF00069	0.302
MOD_Plk_2-3	340	346	PF00069	0.413
MOD_Plk_4	224	230	PF00069	0.399
MOD_Plk_4	260	266	PF00069	0.308
MOD_Plk_4	299	305	PF00069	0.249
MOD_Plk_4	465	471	PF00069	0.331
MOD_Plk_4	506	512	PF00069	0.313
MOD_Plk_4	540	546	PF00069	0.297
MOD_Plk_4	561	567	PF00069	0.358
MOD_Plk_4	568	574	PF00069	0.370
MOD_Plk_4	623	629	PF00069	0.322
MOD_Plk_4	653	659	PF00069	0.202
MOD_Plk_4	695	701	PF00069	0.421
MOD_Plk_4	845	851	PF00069	0.360
MOD_Plk_4	852	858	PF00069	0.311
MOD_Plk_4	86	92	PF00069	0.378
MOD_Plk_4	97	103	PF00069	0.245
MOD_ProDKin_1	193	199	PF00069	0.455
MOD_ProDKin_1	257	263	PF00069	0.430
MOD_ProDKin_1	266	272	PF00069	0.452
MOD_ProDKin_1	29	35	PF00069	0.413
MOD_ProDKin_1	519	525	PF00069	0.294
MOD_ProDKin_1	544	550	PF00069	0.313
MOD_ProDKin_1	94	100	PF00069	0.313
MOD_SUMO_for_1	110	113	PF00179	0.283
MOD_SUMO_for_1	494	497	PF00179	0.313
MOD_SUMO_rev_2	448	455	PF00179	0.421
TRG_DiLeu_BaEn_1	768	773	PF01217	0.455
TRG_DiLeu_BaEn_2	798	804	PF01217	0.455
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.311
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.413
TRG_ENDOCYTIC_2	102	105	PF00928	0.124
TRG_ENDOCYTIC_2	116	119	PF00928	0.313
TRG_ENDOCYTIC_2	138	141	PF00928	0.312
TRG_ENDOCYTIC_2	20	23	PF00928	0.313
TRG_ENDOCYTIC_2	203	206	PF00928	0.370
TRG_ENDOCYTIC_2	264	267	PF00928	0.413
TRG_ENDOCYTIC_2	289	292	PF00928	0.313
TRG_ENDOCYTIC_2	43	46	PF00928	0.313
TRG_ENDOCYTIC_2	437	440	PF00928	0.455
TRG_ENDOCYTIC_2	508	511	PF00928	0.308
TRG_ENDOCYTIC_2	51	54	PF00928	0.314
TRG_ENDOCYTIC_2	555	558	PF00928	0.310
TRG_ENDOCYTIC_2	603	606	PF00928	0.413
TRG_ENDOCYTIC_2	620	623	PF00928	0.413
TRG_ENDOCYTIC_2	663	666	PF00928	0.338
TRG_ENDOCYTIC_2	68	71	PF00928	0.313
TRG_ENDOCYTIC_2	680	683	PF00928	0.202
TRG_ENDOCYTIC_2	725	728	PF00928	0.413
TRG_ENDOCYTIC_2	732	735	PF00928	0.413
TRG_ENDOCYTIC_2	807	810	PF00928	0.322
TRG_ENDOCYTIC_2	82	85	PF00928	0.338
TRG_ENDOCYTIC_2	856	859	PF00928	0.202
TRG_ER_diArg_1	244	246	PF00400	0.308
TRG_ER_diArg_1	58	60	PF00400	0.202
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	779	783	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY17	Leptomonas seymouri	71%	96%
A0A1X0NP10	Trypanosomatidae	44%	89%
A0A3Q8I8D6	Leishmania donovani	87%	100%
A0A3R7KTC9	Trypanosoma rangeli	42%	99%
E9AGJ4	Leishmania infantum	87%	100%
E9AP31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q3UVG3	Mus musculus	31%	100%
Q4QGF7	Leishmania major	87%	100%
Q658Y4	Homo sapiens	31%	100%
Q6TEP1	Danio rerio	31%	100%
V5AZM4	Trypanosoma cruzi	48%	100%