CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative

Species:

Leishmania braziliensis

UniProt:

E9AIN3_LEIBR

TriTrypDb:

LbrM.20.6010 , LBRM2903_200075600

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0016192	vesicle-mediated transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0006906	vesicle fusion	6	1
GO:0006914	autophagy	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0034058	endosomal vesicle fusion	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0061919	process utilizing autophagic mechanism	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.227
CLV_C14_Caspase3-7	848	852	PF00656	0.447
CLV_NRD_NRD_1	144	146	PF00675	0.418
CLV_NRD_NRD_1	186	188	PF00675	0.444
CLV_NRD_NRD_1	630	632	PF00675	0.481
CLV_NRD_NRD_1	73	75	PF00675	0.549
CLV_NRD_NRD_1	782	784	PF00675	0.507
CLV_NRD_NRD_1	86	88	PF00675	0.473
CLV_NRD_NRD_1	925	927	PF00675	0.438
CLV_PCSK_KEX2_1	146	148	PF00082	0.551
CLV_PCSK_KEX2_1	499	501	PF00082	0.349
CLV_PCSK_KEX2_1	629	631	PF00082	0.469
CLV_PCSK_KEX2_1	73	75	PF00082	0.549
CLV_PCSK_KEX2_1	737	739	PF00082	0.458
CLV_PCSK_KEX2_1	782	784	PF00082	0.481
CLV_PCSK_KEX2_1	85	87	PF00082	0.507
CLV_PCSK_KEX2_1	896	898	PF00082	0.391
CLV_PCSK_KEX2_1	925	927	PF00082	0.428
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.551
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.349
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.539
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.325
CLV_PCSK_PC1ET2_1	896	898	PF00082	0.435
CLV_PCSK_SKI1_1	115	119	PF00082	0.511
CLV_PCSK_SKI1_1	146	150	PF00082	0.455
CLV_PCSK_SKI1_1	234	238	PF00082	0.523
CLV_PCSK_SKI1_1	306	310	PF00082	0.521
CLV_PCSK_SKI1_1	631	635	PF00082	0.479
CLV_PCSK_SKI1_1	658	662	PF00082	0.515
CLV_PCSK_SKI1_1	688	692	PF00082	0.505
CLV_PCSK_SKI1_1	78	82	PF00082	0.437
CLV_PCSK_SKI1_1	86	90	PF00082	0.357
DEG_APCC_DBOX_1	464	472	PF00400	0.443
DEG_APCC_DBOX_1	85	93	PF00400	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.704
DEG_SCF_FBW7_2	250	257	PF00400	0.598
DOC_CKS1_1	204	209	PF01111	0.582
DOC_CKS1_1	251	256	PF01111	0.596
DOC_CYCLIN_RxL_1	33	44	PF00134	0.455
DOC_CYCLIN_RxL_1	685	694	PF00134	0.408
DOC_CYCLIN_RxL_1	84	94	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.519
DOC_MAPK_gen_1	132	142	PF00069	0.424
DOC_MAPK_gen_1	499	507	PF00069	0.349
DOC_MAPK_gen_1	524	534	PF00069	0.480
DOC_MAPK_gen_1	715	725	PF00069	0.529
DOC_MAPK_gen_1	85	91	PF00069	0.499
DOC_MAPK_gen_1	925	935	PF00069	0.428
DOC_MAPK_MEF2A_6	527	536	PF00069	0.467
DOC_PP1_RVXF_1	171	178	PF00149	0.383
DOC_PP1_RVXF_1	246	252	PF00149	0.580
DOC_PP1_RVXF_1	34	41	PF00149	0.460
DOC_PP1_RVXF_1	656	662	PF00149	0.502
DOC_PP2B_LxvP_1	214	217	PF13499	0.480
DOC_PP4_FxxP_1	725	728	PF00568	0.604
DOC_USP7_MATH_1	198	202	PF00917	0.457
DOC_USP7_MATH_1	244	248	PF00917	0.579
DOC_USP7_MATH_1	321	325	PF00917	0.515
DOC_USP7_MATH_1	479	483	PF00917	0.594
DOC_USP7_MATH_1	652	656	PF00917	0.369
DOC_USP7_MATH_1	813	817	PF00917	0.616
DOC_USP7_MATH_1	866	870	PF00917	0.480
DOC_WW_Pin1_4	151	156	PF00397	0.332
DOC_WW_Pin1_4	203	208	PF00397	0.541
DOC_WW_Pin1_4	250	255	PF00397	0.503
DOC_WW_Pin1_4	332	337	PF00397	0.514
DOC_WW_Pin1_4	431	436	PF00397	0.593
DOC_WW_Pin1_4	683	688	PF00397	0.592
DOC_WW_Pin1_4	724	729	PF00397	0.566
DOC_WW_Pin1_4	749	754	PF00397	0.577
LIG_14-3-3_CanoR_1	145	151	PF00244	0.424
LIG_14-3-3_CanoR_1	17	22	PF00244	0.520
LIG_14-3-3_CanoR_1	351	355	PF00244	0.528
LIG_14-3-3_CanoR_1	465	469	PF00244	0.549
LIG_14-3-3_CanoR_1	630	640	PF00244	0.404
LIG_14-3-3_CanoR_1	658	666	PF00244	0.483
LIG_14-3-3_CanoR_1	704	710	PF00244	0.532
LIG_14-3-3_CanoR_1	78	83	PF00244	0.499
LIG_14-3-3_CanoR_1	836	844	PF00244	0.545
LIG_14-3-3_CanoR_1	884	892	PF00244	0.400
LIG_14-3-3_CanoR_1	897	905	PF00244	0.422
LIG_14-3-3_CanoR_1	906	914	PF00244	0.487
LIG_Actin_WH2_2	816	831	PF00022	0.457
LIG_BRCT_BRCA1_1	180	184	PF00533	0.269
LIG_BRCT_BRCA1_1	644	648	PF00533	0.290
LIG_BRCT_BRCA1_1	816	820	PF00533	0.317
LIG_Clathr_ClatBox_1	690	694	PF01394	0.262
LIG_FHA_1	163	169	PF00498	0.517
LIG_FHA_1	198	204	PF00498	0.526
LIG_FHA_1	299	305	PF00498	0.516
LIG_FHA_1	446	452	PF00498	0.397
LIG_FHA_1	465	471	PF00498	0.431
LIG_FHA_1	531	537	PF00498	0.482
LIG_FHA_1	612	618	PF00498	0.371
LIG_FHA_1	684	690	PF00498	0.564
LIG_FHA_1	706	712	PF00498	0.479
LIG_FHA_1	819	825	PF00498	0.521
LIG_FHA_1	836	842	PF00498	0.573
LIG_FHA_2	147	153	PF00498	0.464
LIG_FHA_2	154	160	PF00498	0.526
LIG_FHA_2	284	290	PF00498	0.593
LIG_FHA_2	553	559	PF00498	0.249
LIG_FHA_2	590	596	PF00498	0.552
LIG_FHA_2	729	735	PF00498	0.579
LIG_FHA_2	954	960	PF00498	0.420
LIG_FHA_2	965	971	PF00498	0.483
LIG_GBD_Chelix_1	692	700	PF00786	0.387
LIG_HCF-1_HBM_1	261	264	PF13415	0.522
LIG_LIR_Apic_2	201	207	PF02991	0.443
LIG_LIR_Apic_2	257	263	PF02991	0.418
LIG_LIR_Apic_2	722	728	PF02991	0.575
LIG_LIR_Gen_1	410	418	PF02991	0.307
LIG_LIR_Gen_1	591	601	PF02991	0.465
LIG_LIR_Gen_1	634	640	PF02991	0.379
LIG_LIR_Gen_1	694	705	PF02991	0.407
LIG_LIR_Gen_1	817	828	PF02991	0.422
LIG_LIR_Gen_1	862	873	PF02991	0.344
LIG_LIR_Gen_1	886	895	PF02991	0.383
LIG_LIR_Gen_1	963	971	PF02991	0.630
LIG_LIR_LC3C_4	94	98	PF02991	0.266
LIG_LIR_Nem_3	14	19	PF02991	0.483
LIG_LIR_Nem_3	189	193	PF02991	0.306
LIG_LIR_Nem_3	33	38	PF02991	0.511
LIG_LIR_Nem_3	333	337	PF02991	0.586
LIG_LIR_Nem_3	410	414	PF02991	0.396
LIG_LIR_Nem_3	591	597	PF02991	0.323
LIG_LIR_Nem_3	634	639	PF02991	0.407
LIG_LIR_Nem_3	645	651	PF02991	0.497
LIG_LIR_Nem_3	694	700	PF02991	0.381
LIG_LIR_Nem_3	714	720	PF02991	0.393
LIG_LIR_Nem_3	817	823	PF02991	0.433
LIG_LIR_Nem_3	862	868	PF02991	0.344
LIG_LIR_Nem_3	886	892	PF02991	0.383
LIG_LIR_Nem_3	963	968	PF02991	0.569
LIG_NRBOX	157	163	PF00104	0.583
LIG_NRBOX	232	238	PF00104	0.566
LIG_NRBOX	503	509	PF00104	0.449
LIG_NRBOX	531	537	PF00104	0.480
LIG_NRBOX	695	701	PF00104	0.279
LIG_NRBOX	719	725	PF00104	0.424
LIG_NRBOX	823	829	PF00104	0.432
LIG_PCNA_yPIPBox_3	583	597	PF02747	0.553
LIG_PDZ_Class_3	966	971	PF00595	0.579
LIG_PTAP_UEV_1	269	274	PF05743	0.627
LIG_REV1ctd_RIR_1	625	631	PF16727	0.501
LIG_RPA_C_Fungi	778	790	PF08784	0.541
LIG_SH2_CRK	16	20	PF00017	0.514
LIG_SH2_CRK	334	338	PF00017	0.533
LIG_SH2_CRK	35	39	PF00017	0.516
LIG_SH2_CRK	889	893	PF00017	0.408
LIG_SH2_GRB2like	763	766	PF00017	0.304
LIG_SH2_NCK_1	260	264	PF00017	0.521
LIG_SH2_SRC	260	263	PF00017	0.408
LIG_SH2_SRC	460	463	PF00017	0.401
LIG_SH2_SRC	542	545	PF00017	0.480
LIG_SH2_SRC	812	815	PF00017	0.628
LIG_SH2_STAP1	318	322	PF00017	0.576
LIG_SH2_STAP1	542	546	PF00017	0.447
LIG_SH2_STAP1	713	717	PF00017	0.500
LIG_SH2_STAP1	807	811	PF00017	0.420
LIG_SH2_STAT3	587	590	PF00017	0.515
LIG_SH2_STAT3	695	698	PF00017	0.520
LIG_SH2_STAT5	190	193	PF00017	0.386
LIG_SH2_STAT5	264	267	PF00017	0.422
LIG_SH2_STAT5	460	463	PF00017	0.444
LIG_SH2_STAT5	587	590	PF00017	0.492
LIG_SH2_STAT5	695	698	PF00017	0.487
LIG_SH2_STAT5	763	766	PF00017	0.467
LIG_SH3_3	163	169	PF00018	0.510
LIG_SH3_3	199	205	PF00018	0.353
LIG_SH3_3	214	220	PF00018	0.480
LIG_SH3_3	267	273	PF00018	0.545
LIG_SH3_3	378	384	PF00018	0.301
LIG_SH3_3	436	442	PF00018	0.641
LIG_SH3_3	677	683	PF00018	0.349
LIG_SH3_3	704	710	PF00018	0.593
LIG_SH3_3	854	860	PF00018	0.355
LIG_Sin3_3	212	219	PF02671	0.408
LIG_SUMO_SIM_anti_2	467	472	PF11976	0.550
LIG_SUMO_SIM_anti_2	838	846	PF11976	0.369
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.420
LIG_SUMO_SIM_par_1	164	170	PF11976	0.505
LIG_SUMO_SIM_par_1	17	23	PF11976	0.313
LIG_SUMO_SIM_par_1	335	343	PF11976	0.432
LIG_SUMO_SIM_par_1	466	472	PF11976	0.450
LIG_SUMO_SIM_par_1	532	537	PF11976	0.480
LIG_SUMO_SIM_par_1	688	694	PF11976	0.458
LIG_SxIP_EBH_1	559	568	PF03271	0.412
LIG_TRAF2_1	555	558	PF00917	0.227
LIG_TRAF2_1	569	572	PF00917	0.346
LIG_TYR_ITIM	332	337	PF00017	0.326
LIG_WRC_WIRS_1	868	873	PF05994	0.344
MOD_CDC14_SPxK_1	727	730	PF00782	0.659
MOD_CDK_SPK_2	203	208	PF00069	0.572
MOD_CDK_SPK_2	683	688	PF00069	0.592
MOD_CDK_SPxK_1	724	730	PF00069	0.609
MOD_CK1_1	31	37	PF00069	0.411
MOD_CK1_1	599	605	PF00069	0.606
MOD_CK1_1	900	906	PF00069	0.363
MOD_CK2_1	146	152	PF00069	0.441
MOD_CK2_1	409	415	PF00069	0.539
MOD_CK2_1	551	557	PF00069	0.327
MOD_CK2_1	589	595	PF00069	0.529
MOD_CK2_1	728	734	PF00069	0.538
MOD_Cter_Amidation	185	188	PF01082	0.503
MOD_Cter_Amidation	83	86	PF01082	0.546
MOD_GlcNHglycan	107	110	PF01048	0.594
MOD_GlcNHglycan	208	211	PF01048	0.536
MOD_GlcNHglycan	270	273	PF01048	0.570
MOD_GlcNHglycan	325	328	PF01048	0.596
MOD_GlcNHglycan	471	474	PF01048	0.599
MOD_GlcNHglycan	475	478	PF01048	0.613
MOD_GlcNHglycan	58	61	PF01048	0.589
MOD_GlcNHglycan	601	604	PF01048	0.646
MOD_GlcNHglycan	654	657	PF01048	0.362
MOD_GlcNHglycan	758	761	PF01048	0.541
MOD_GlcNHglycan	885	888	PF01048	0.367
MOD_GSK3_1	103	110	PF00069	0.452
MOD_GSK3_1	192	199	PF00069	0.537
MOD_GSK3_1	264	271	PF00069	0.488
MOD_GSK3_1	30	37	PF00069	0.524
MOD_GSK3_1	409	416	PF00069	0.570
MOD_GSK3_1	460	467	PF00069	0.405
MOD_GSK3_1	469	476	PF00069	0.420
MOD_GSK3_1	553	560	PF00069	0.271
MOD_GSK3_1	595	602	PF00069	0.548
MOD_GSK3_1	604	611	PF00069	0.582
MOD_GSK3_1	616	623	PF00069	0.403
MOD_GSK3_1	724	731	PF00069	0.578
MOD_GSK3_1	814	821	PF00069	0.589
MOD_LATS_1	781	787	PF00433	0.580
MOD_N-GLC_1	193	198	PF02516	0.328
MOD_N-GLC_1	795	800	PF02516	0.460
MOD_N-GLC_1	878	883	PF02516	0.434
MOD_N-GLC_2	845	847	PF02516	0.408
MOD_NEK2_1	162	167	PF00069	0.520
MOD_NEK2_1	178	183	PF00069	0.344
MOD_NEK2_1	192	197	PF00069	0.437
MOD_NEK2_1	349	354	PF00069	0.526
MOD_NEK2_1	471	476	PF00069	0.572
MOD_NEK2_1	491	496	PF00069	0.484
MOD_NEK2_1	748	753	PF00069	0.407
MOD_NEK2_2	789	794	PF00069	0.403
MOD_NEK2_2	807	812	PF00069	0.430
MOD_NEK2_2	953	958	PF00069	0.445
MOD_PIKK_1	308	314	PF00454	0.352
MOD_PIKK_1	460	466	PF00454	0.539
MOD_PIKK_1	479	485	PF00454	0.507
MOD_PIKK_1	544	550	PF00454	0.480
MOD_PIKK_1	631	637	PF00454	0.436
MOD_PK_1	28	34	PF00069	0.429
MOD_PKA_1	146	152	PF00069	0.418
MOD_PKA_2	146	152	PF00069	0.529
MOD_PKA_2	350	356	PF00069	0.532
MOD_PKA_2	464	470	PF00069	0.452
MOD_PKA_2	705	711	PF00069	0.452
MOD_PKA_2	828	834	PF00069	0.596
MOD_PKA_2	835	841	PF00069	0.518
MOD_PKA_2	883	889	PF00069	0.389
MOD_PKA_2	905	911	PF00069	0.486
MOD_PKB_1	629	637	PF00069	0.308
MOD_PKB_1	926	934	PF00069	0.480
MOD_Plk_1	288	294	PF00069	0.637
MOD_Plk_1	409	415	PF00069	0.572
MOD_Plk_1	802	808	PF00069	0.567
MOD_Plk_1	900	906	PF00069	0.298
MOD_Plk_2-3	410	416	PF00069	0.567
MOD_Plk_4	146	152	PF00069	0.489
MOD_Plk_4	173	179	PF00069	0.445
MOD_Plk_4	198	204	PF00069	0.598
MOD_Plk_4	445	451	PF00069	0.394
MOD_Plk_4	464	470	PF00069	0.400
MOD_Plk_4	530	536	PF00069	0.447
MOD_Plk_4	589	595	PF00069	0.349
MOD_Plk_4	61	67	PF00069	0.544
MOD_Plk_4	642	648	PF00069	0.471
MOD_Plk_4	728	734	PF00069	0.453
MOD_Plk_4	78	84	PF00069	0.506
MOD_Plk_4	867	873	PF00069	0.476
MOD_Plk_4	888	894	PF00069	0.237
MOD_Plk_4	928	934	PF00069	0.408
MOD_ProDKin_1	151	157	PF00069	0.337
MOD_ProDKin_1	203	209	PF00069	0.548
MOD_ProDKin_1	250	256	PF00069	0.503
MOD_ProDKin_1	332	338	PF00069	0.504
MOD_ProDKin_1	431	437	PF00069	0.601
MOD_ProDKin_1	683	689	PF00069	0.587
MOD_ProDKin_1	724	730	PF00069	0.578
MOD_ProDKin_1	749	755	PF00069	0.571
MOD_SUMO_for_1	498	501	PF00179	0.227
MOD_SUMO_rev_2	44	49	PF00179	0.478
TRG_AP2beta_CARGO_1	694	704	PF09066	0.545
TRG_DiLeu_BaEn_1	14	19	PF01217	0.423
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.492
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.513
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.533
TRG_ENDOCYTIC_2	16	19	PF00928	0.476
TRG_ENDOCYTIC_2	334	337	PF00928	0.577
TRG_ENDOCYTIC_2	35	38	PF00928	0.525
TRG_ENDOCYTIC_2	889	892	PF00928	0.408
TRG_ENDOCYTIC_2	965	968	PF00928	0.575
TRG_ER_diArg_1	145	148	PF00400	0.525
TRG_ER_diArg_1	628	631	PF00400	0.461
TRG_ER_diArg_1	703	706	PF00400	0.475
TRG_ER_diArg_1	738	741	PF00400	0.466
TRG_ER_diArg_1	769	772	PF00400	0.428
TRG_ER_diArg_1	86	88	PF00400	0.524
TRG_ER_diArg_1	925	928	PF00400	0.484
TRG_NES_CRM1_1	694	709	PF08389	0.449
TRG_NLS_Bipartite_1	73	89	PF00514	0.306
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	925	930	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT4	Leptomonas seymouri	50%	99%
A0A1X0NP42	Trypanosomatidae	29%	97%
A0A3R7M5A4	Trypanosoma rangeli	31%	99%
A0A3S7WSC2	Leishmania donovani	79%	100%
C9ZI46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AGJ5	Leishmania infantum	79%	100%
E9AP32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGF6	Leishmania major	78%	100%
V5BF34	Trypanosoma cruzi	31%	98%