Serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Serine peptidase

Gene product:

Alpha/beta hydrolase domain-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AIN2_LEIBR

TriTrypDb:

LbrM.20.6000 , LBRM2903_200075500

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AIN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0008233	peptidase activity	3	3
GO:0008236	serine-type peptidase activity	4	3
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	406	410	PF00656	0.576
CLV_C14_Caspase3-7	6	10	PF00656	0.601
CLV_NRD_NRD_1	374	376	PF00675	0.393
CLV_NRD_NRD_1	443	445	PF00675	0.291
CLV_NRD_NRD_1	513	515	PF00675	0.628
CLV_PCSK_FUR_1	511	515	PF00082	0.602
CLV_PCSK_KEX2_1	374	376	PF00082	0.364
CLV_PCSK_KEX2_1	443	445	PF00082	0.505
CLV_PCSK_KEX2_1	513	515	PF00082	0.628
CLV_PCSK_SKI1_1	21	25	PF00082	0.576
CLV_PCSK_SKI1_1	266	270	PF00082	0.588
CLV_PCSK_SKI1_1	281	285	PF00082	0.513
CLV_PCSK_SKI1_1	306	310	PF00082	0.362
CLV_PCSK_SKI1_1	369	373	PF00082	0.518
CLV_PCSK_SKI1_1	502	506	PF00082	0.494
DEG_SCF_FBW7_2	104	111	PF00400	0.522
DOC_CDC14_PxL_1	411	419	PF14671	0.559
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.297
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.641
DOC_MAPK_gen_1	30	39	PF00069	0.297
DOC_MAPK_MEF2A_6	30	39	PF00069	0.297
DOC_MAPK_MEF2A_6	421	429	PF00069	0.448
DOC_MAPK_MEF2A_6	88	96	PF00069	0.415
DOC_PP1_RVXF_1	11	18	PF00149	0.536
DOC_PP1_RVXF_1	474	481	PF00149	0.366
DOC_PP2B_LxvP_1	155	158	PF13499	0.307
DOC_PP2B_LxvP_1	412	415	PF13499	0.622
DOC_PP4_FxxP_1	154	157	PF00568	0.545
DOC_PP4_FxxP_1	17	20	PF00568	0.455
DOC_PP4_FxxP_1	320	323	PF00568	0.363
DOC_USP7_MATH_1	308	312	PF00917	0.535
DOC_USP7_MATH_1	389	393	PF00917	0.487
DOC_USP7_MATH_1	90	94	PF00917	0.355
DOC_USP7_UBL2_3	518	522	PF12436	0.503
DOC_WW_Pin1_4	104	109	PF00397	0.566
DOC_WW_Pin1_4	143	148	PF00397	0.415
DOC_WW_Pin1_4	157	162	PF00397	0.319
DOC_WW_Pin1_4	284	289	PF00397	0.433
DOC_WW_Pin1_4	379	384	PF00397	0.364
DOC_WW_Pin1_4	432	437	PF00397	0.395
DOC_WW_Pin1_4	516	521	PF00397	0.490
LIG_14-3-3_CanoR_1	266	275	PF00244	0.571
LIG_14-3-3_CanoR_1	345	351	PF00244	0.356
LIG_14-3-3_CanoR_1	444	450	PF00244	0.490
LIG_14-3-3_CanoR_1	511	520	PF00244	0.651
LIG_14-3-3_CanoR_1	560	569	PF00244	0.547
LIG_Actin_WH2_2	497	515	PF00022	0.554
LIG_Actin_WH2_2	71	86	PF00022	0.491
LIG_BRCT_BRCA1_1	119	123	PF00533	0.239
LIG_BRCT_BRCA1_1	13	17	PF00533	0.532
LIG_BRCT_BRCA1_1	279	283	PF00533	0.355
LIG_BRCT_BRCA1_1	316	320	PF00533	0.500
LIG_BRCT_BRCA1_1	523	527	PF00533	0.573
LIG_deltaCOP1_diTrp_1	532	537	PF00928	0.446
LIG_FHA_1	196	202	PF00498	0.457
LIG_FHA_1	217	223	PF00498	0.554
LIG_FHA_1	267	273	PF00498	0.596
LIG_FHA_1	331	337	PF00498	0.429
LIG_FHA_1	394	400	PF00498	0.513
LIG_FHA_1	421	427	PF00498	0.496
LIG_FHA_1	433	439	PF00498	0.303
LIG_FHA_1	61	67	PF00498	0.412
LIG_FHA_2	302	308	PF00498	0.479
LIG_FHA_2	404	410	PF00498	0.564
LIG_FHA_2	42	48	PF00498	0.300
LIG_FHA_2	480	486	PF00498	0.440
LIG_HCF-1_HBM_1	223	226	PF13415	0.518
LIG_LIR_Apic_2	14	20	PF02991	0.463
LIG_LIR_Apic_2	317	323	PF02991	0.364
LIG_LIR_Apic_2	532	536	PF02991	0.448
LIG_LIR_Apic_2	600	606	PF02991	0.512
LIG_LIR_Gen_1	287	294	PF02991	0.381
LIG_LIR_Gen_1	300	310	PF02991	0.406
LIG_LIR_Gen_1	326	336	PF02991	0.358
LIG_LIR_Gen_1	349	358	PF02991	0.294
LIG_LIR_Gen_1	52	62	PF02991	0.354
LIG_LIR_Gen_1	524	534	PF02991	0.575
LIG_LIR_Gen_1	594	604	PF02991	0.508
LIG_LIR_Nem_3	120	125	PF02991	0.386
LIG_LIR_Nem_3	287	293	PF02991	0.333
LIG_LIR_Nem_3	300	305	PF02991	0.356
LIG_LIR_Nem_3	326	332	PF02991	0.365
LIG_LIR_Nem_3	349	353	PF02991	0.404
LIG_LIR_Nem_3	506	512	PF02991	0.492
LIG_LIR_Nem_3	52	58	PF02991	0.370
LIG_LIR_Nem_3	524	530	PF02991	0.593
LIG_LIR_Nem_3	551	557	PF02991	0.411
LIG_LIR_Nem_3	98	102	PF02991	0.335
LIG_MAD2	266	274	PF02301	0.590
LIG_MLH1_MIPbox_1	119	123	PF16413	0.239
LIG_MYND_1	157	161	PF01753	0.294
LIG_NRBOX	327	333	PF00104	0.364
LIG_PCNA_PIPBox_1	116	125	PF02747	0.489
LIG_PCNA_yPIPBox_3	116	127	PF02747	0.465
LIG_Pex14_2	150	154	PF04695	0.511
LIG_Rb_LxCxE_1	291	311	PF01857	0.305
LIG_REV1ctd_RIR_1	121	131	PF16727	0.263
LIG_SH2_CRK	350	354	PF00017	0.515
LIG_SH2_CRK	53	57	PF00017	0.375
LIG_SH2_CRK	603	607	PF00017	0.450
LIG_SH2_NCK_1	68	72	PF00017	0.470
LIG_SH2_PTP2	329	332	PF00017	0.376
LIG_SH2_SRC	68	71	PF00017	0.461
LIG_SH2_STAP1	290	294	PF00017	0.403
LIG_SH2_STAT3	226	229	PF00017	0.507
LIG_SH2_STAT3	242	245	PF00017	0.515
LIG_SH2_STAT5	122	125	PF00017	0.364
LIG_SH2_STAT5	128	131	PF00017	0.401
LIG_SH2_STAT5	242	245	PF00017	0.415
LIG_SH2_STAT5	329	332	PF00017	0.376
LIG_SH2_STAT5	350	353	PF00017	0.406
LIG_SH2_STAT5	55	58	PF00017	0.418
LIG_SH2_STAT5	557	560	PF00017	0.397
LIG_SH2_STAT5	593	596	PF00017	0.521
LIG_SH2_STAT5	85	88	PF00017	0.399
LIG_SH3_3	155	161	PF00018	0.290
LIG_SH3_3	202	208	PF00018	0.366
LIG_SH3_3	32	38	PF00018	0.436
LIG_SH3_5	553	557	PF00018	0.538
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.380
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.402
LIG_SUMO_SIM_par_1	197	204	PF11976	0.525
LIG_SUMO_SIM_par_1	217	223	PF11976	0.225
LIG_SUMO_SIM_par_1	422	431	PF11976	0.538
LIG_TRAF2_1	362	365	PF00917	0.521
LIG_TRAF2_1	526	529	PF00917	0.584
LIG_TRAF2_1	582	585	PF00917	0.519
LIG_TYR_ITIM	78	83	PF00017	0.355
MOD_CDC14_SPxK_1	519	522	PF00782	0.503
MOD_CDK_SPxK_1	516	522	PF00069	0.493
MOD_CK1_1	142	148	PF00069	0.252
MOD_CK1_1	255	261	PF00069	0.539
MOD_CK1_1	392	398	PF00069	0.358
MOD_CK1_1	516	522	PF00069	0.677
MOD_CK2_1	301	307	PF00069	0.533
MOD_CK2_1	392	398	PF00069	0.583
MOD_CK2_1	41	47	PF00069	0.288
MOD_CK2_1	425	431	PF00069	0.393
MOD_CK2_1	523	529	PF00069	0.621
MOD_CK2_1	572	578	PF00069	0.531
MOD_GlcNHglycan	119	122	PF01048	0.353
MOD_GlcNHglycan	131	134	PF01048	0.380
MOD_GlcNHglycan	255	258	PF01048	0.462
MOD_GlcNHglycan	297	300	PF01048	0.537
MOD_GlcNHglycan	312	315	PF01048	0.514
MOD_GlcNHglycan	540	543	PF01048	0.582
MOD_GlcNHglycan	562	565	PF01048	0.315
MOD_GlcNHglycan	598	602	PF01048	0.541
MOD_GlcNHglycan	98	102	PF01048	0.451
MOD_GSK3_1	139	146	PF00069	0.459
MOD_GSK3_1	21	28	PF00069	0.475
MOD_GSK3_1	212	219	PF00069	0.539
MOD_GSK3_1	273	280	PF00069	0.337
MOD_GSK3_1	297	304	PF00069	0.519
MOD_GSK3_1	306	313	PF00069	0.372
MOD_GSK3_1	389	396	PF00069	0.610
MOD_GSK3_1	41	48	PF00069	0.223
MOD_GSK3_1	498	505	PF00069	0.425
MOD_GSK3_1	512	519	PF00069	0.545
MOD_GSK3_1	568	575	PF00069	0.553
MOD_LATS_1	566	572	PF00433	0.358
MOD_N-GLC_1	295	300	PF02516	0.538
MOD_N-GLC_1	393	398	PF02516	0.635
MOD_N-GLC_1	502	507	PF02516	0.568
MOD_N-GLC_2	357	359	PF02516	0.567
MOD_NEK2_1	11	16	PF00069	0.446
MOD_NEK2_1	129	134	PF00069	0.346
MOD_NEK2_1	277	282	PF00069	0.330
MOD_NEK2_1	332	337	PF00069	0.348
MOD_NEK2_1	417	422	PF00069	0.511
MOD_NEK2_1	512	517	PF00069	0.541
MOD_NEK2_1	538	543	PF00069	0.421
MOD_NEK2_1	570	575	PF00069	0.524
MOD_NEK2_1	97	102	PF00069	0.368
MOD_NEK2_2	301	306	PF00069	0.385
MOD_NEK2_2	314	319	PF00069	0.520
MOD_NEK2_2	337	342	PF00069	0.297
MOD_NEK2_2	403	408	PF00069	0.536
MOD_OFUCOSY	400	407	PF10250	0.535
MOD_PIKK_1	178	184	PF00454	0.586
MOD_PK_1	88	94	PF00069	0.466
MOD_PKA_1	513	519	PF00069	0.456
MOD_PKA_2	231	237	PF00069	0.529
MOD_PKA_2	512	518	PF00069	0.434
MOD_PKA_2	538	544	PF00069	0.641
MOD_PKA_2	604	610	PF00069	0.509
MOD_PKB_1	264	272	PF00069	0.572
MOD_PKB_1	511	519	PF00069	0.434
MOD_Plk_1	110	116	PF00069	0.388
MOD_Plk_1	216	222	PF00069	0.533
MOD_Plk_1	88	94	PF00069	0.448
MOD_Plk_2-3	572	578	PF00069	0.568
MOD_Plk_4	11	17	PF00069	0.431
MOD_Plk_4	238	244	PF00069	0.524
MOD_Plk_4	255	261	PF00069	0.507
MOD_Plk_4	425	431	PF00069	0.425
MOD_Plk_4	591	597	PF00069	0.530
MOD_Plk_4	90	96	PF00069	0.376
MOD_ProDKin_1	104	110	PF00069	0.565
MOD_ProDKin_1	143	149	PF00069	0.415
MOD_ProDKin_1	157	163	PF00069	0.311
MOD_ProDKin_1	284	290	PF00069	0.433
MOD_ProDKin_1	379	385	PF00069	0.362
MOD_ProDKin_1	432	438	PF00069	0.391
MOD_ProDKin_1	516	522	PF00069	0.493
TRG_DiLeu_BaEn_2	456	462	PF01217	0.434
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.450
TRG_ENDOCYTIC_2	122	125	PF00928	0.372
TRG_ENDOCYTIC_2	128	131	PF00928	0.367
TRG_ENDOCYTIC_2	193	196	PF00928	0.397
TRG_ENDOCYTIC_2	290	293	PF00928	0.415
TRG_ENDOCYTIC_2	329	332	PF00928	0.376
TRG_ENDOCYTIC_2	350	353	PF00928	0.484
TRG_ENDOCYTIC_2	509	512	PF00928	0.530
TRG_ENDOCYTIC_2	53	56	PF00928	0.372
TRG_ENDOCYTIC_2	593	596	PF00928	0.496
TRG_ENDOCYTIC_2	80	83	PF00928	0.446
TRG_ER_diArg_1	373	375	PF00400	0.390
TRG_ER_diArg_1	442	444	PF00400	0.287
TRG_ER_diArg_1	511	514	PF00400	0.597
TRG_ER_diArg_1	559	562	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W3	Leptomonas seymouri	65%	100%
A0A1X0NMT5	Trypanosomatidae	38%	100%
A0A3S7WSC7	Leishmania donovani	82%	100%
A0A422NV23	Trypanosoma rangeli	39%	100%
C9ZI47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	83%
E9AGJ6	Leishmania infantum	82%	100%
E9AP33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QGF5	Leishmania major	82%	100%
V5BP52	Trypanosoma cruzi	39%	100%