Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIN1_LEIBR

TriTrypDb:

LbrM.20.5990 , LBRM2903_200075400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.795
CLV_NRD_NRD_1	199	201	PF00675	0.455
CLV_NRD_NRD_1	224	226	PF00675	0.735
CLV_NRD_NRD_1	355	357	PF00675	0.496
CLV_NRD_NRD_1	412	414	PF00675	0.700
CLV_NRD_NRD_1	5	7	PF00675	0.532
CLV_PCSK_KEX2_1	179	181	PF00082	0.753
CLV_PCSK_KEX2_1	224	226	PF00082	0.729
CLV_PCSK_KEX2_1	257	259	PF00082	0.612
CLV_PCSK_KEX2_1	355	357	PF00082	0.527
CLV_PCSK_KEX2_1	412	414	PF00082	0.706
CLV_PCSK_KEX2_1	5	7	PF00082	0.532
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.669
CLV_PCSK_PC7_1	408	414	PF00082	0.543
CLV_PCSK_SKI1_1	181	185	PF00082	0.712
CLV_PCSK_SKI1_1	217	221	PF00082	0.568
DEG_SCF_FBW7_1	230	236	PF00400	0.584
DEG_SCF_FBW7_1	275	282	PF00400	0.747
DEG_SCF_FBW7_1	317	323	PF00400	0.675
DEG_SPOP_SBC_1	13	17	PF00917	0.535
DEG_SPOP_SBC_1	364	368	PF00917	0.458
DOC_CDC14_PxL_1	373	381	PF14671	0.594
DOC_CKS1_1	119	124	PF01111	0.794
DOC_CKS1_1	140	145	PF01111	0.784
DOC_CKS1_1	230	235	PF01111	0.550
DOC_CKS1_1	317	322	PF01111	0.561
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.606
DOC_MAPK_MEF2A_6	372	381	PF00069	0.530
DOC_PP2B_LxvP_1	138	141	PF13499	0.803
DOC_PP2B_LxvP_1	379	382	PF13499	0.506
DOC_USP7_MATH_1	13	17	PF00917	0.675
DOC_USP7_MATH_1	233	237	PF00917	0.725
DOC_USP7_MATH_1	238	242	PF00917	0.645
DOC_USP7_MATH_1	295	299	PF00917	0.519
DOC_USP7_MATH_1	328	332	PF00917	0.663
DOC_USP7_MATH_1	364	368	PF00917	0.579
DOC_WW_Pin1_4	118	123	PF00397	0.459
DOC_WW_Pin1_4	136	141	PF00397	0.753
DOC_WW_Pin1_4	18	23	PF00397	0.769
DOC_WW_Pin1_4	202	207	PF00397	0.710
DOC_WW_Pin1_4	219	224	PF00397	0.753
DOC_WW_Pin1_4	229	234	PF00397	0.694
DOC_WW_Pin1_4	275	280	PF00397	0.653
DOC_WW_Pin1_4	313	318	PF00397	0.560
DOC_WW_Pin1_4	428	433	PF00397	0.698
DOC_WW_Pin1_4	98	103	PF00397	0.540
LIG_14-3-3_CanoR_1	108	113	PF00244	0.611
LIG_14-3-3_CanoR_1	124	129	PF00244	0.788
LIG_14-3-3_CanoR_1	132	137	PF00244	0.772
LIG_14-3-3_CanoR_1	163	171	PF00244	0.795
LIG_14-3-3_CanoR_1	179	184	PF00244	0.759
LIG_14-3-3_CanoR_1	200	206	PF00244	0.605
LIG_14-3-3_CanoR_1	224	233	PF00244	0.733
LIG_14-3-3_CanoR_1	294	300	PF00244	0.522
LIG_14-3-3_CanoR_1	321	325	PF00244	0.728
LIG_14-3-3_CanoR_1	344	349	PF00244	0.554
LIG_14-3-3_CanoR_1	355	359	PF00244	0.533
LIG_14-3-3_CanoR_1	363	373	PF00244	0.409
LIG_14-3-3_CanoR_1	380	386	PF00244	0.324
LIG_14-3-3_CanoR_1	402	406	PF00244	0.750
LIG_14-3-3_CanoR_1	425	430	PF00244	0.796
LIG_14-3-3_CanoR_1	48	52	PF00244	0.389
LIG_BRCT_BRCA1_1	240	244	PF00533	0.443
LIG_FHA_1	132	138	PF00498	0.755
LIG_FHA_1	240	246	PF00498	0.584
LIG_FHA_1	285	291	PF00498	0.600
LIG_FHA_1	317	323	PF00498	0.594
LIG_FHA_1	334	340	PF00498	0.533
LIG_FHA_1	387	393	PF00498	0.553
LIG_FHA_2	108	114	PF00498	0.525
LIG_FHA_2	265	271	PF00498	0.515
LIG_FHA_2	302	308	PF00498	0.698
LIG_FHA_2	364	370	PF00498	0.453
LIG_LIR_Apic_2	289	295	PF02991	0.724
LIG_LIR_Gen_1	241	252	PF02991	0.612
LIG_LIR_Gen_1	298	308	PF02991	0.654
LIG_LIR_Gen_1	70	80	PF02991	0.369
LIG_LIR_Nem_3	241	247	PF02991	0.542
LIG_LIR_Nem_3	298	303	PF02991	0.636
LIG_LIR_Nem_3	50	54	PF02991	0.443
LIG_LIR_Nem_3	69	75	PF02991	0.337
LIG_MYND_3	103	107	PF01753	0.642
LIG_NRBOX	31	37	PF00104	0.560
LIG_PCNA_yPIPBox_3	27	36	PF02747	0.381
LIG_SH2_CRK	292	296	PF00017	0.650
LIG_SH2_CRK	73	77	PF00017	0.484
LIG_SH2_NCK_1	292	296	PF00017	0.650
LIG_SH2_SRC	338	341	PF00017	0.545
LIG_SH2_SRC	73	76	PF00017	0.523
LIG_SH2_STAP1	73	77	PF00017	0.532
LIG_SH2_STAT5	280	283	PF00017	0.712
LIG_SH2_STAT5	299	302	PF00017	0.637
LIG_SH2_STAT5	338	341	PF00017	0.535
LIG_SH2_STAT5	348	351	PF00017	0.517
LIG_SH2_STAT5	353	356	PF00017	0.598
LIG_SH2_STAT5	97	100	PF00017	0.550
LIG_SH3_2	119	124	PF14604	0.794
LIG_SH3_2	141	146	PF14604	0.659
LIG_SH3_3	113	119	PF00018	0.719
LIG_SH3_3	137	143	PF00018	0.671
LIG_SH3_3	203	209	PF00018	0.633
LIG_SH3_3	227	233	PF00018	0.631
LIG_SH3_3	314	320	PF00018	0.580
LIG_SUMO_SIM_par_1	134	139	PF11976	0.794
LIG_SUMO_SIM_par_1	30	37	PF11976	0.559
LIG_TRAF2_1	304	307	PF00917	0.497
LIG_WW_3	121	125	PF00397	0.806
MOD_CDC14_SPxK_1	222	225	PF00782	0.618
MOD_CDC14_SPxK_1	431	434	PF00782	0.758
MOD_CDK_SPK_2	219	224	PF00069	0.688
MOD_CDK_SPK_2	229	234	PF00069	0.600
MOD_CDK_SPK_2	316	321	PF00069	0.680
MOD_CDK_SPxK_1	118	124	PF00069	0.796
MOD_CDK_SPxK_1	219	225	PF00069	0.616
MOD_CDK_SPxK_1	428	434	PF00069	0.718
MOD_CDK_SPxxK_3	139	146	PF00069	0.788
MOD_CK1_1	127	133	PF00069	0.699
MOD_CK1_1	139	145	PF00069	0.703
MOD_CK1_1	14	20	PF00069	0.666
MOD_CK1_1	236	242	PF00069	0.727
MOD_CK1_1	333	339	PF00069	0.462
MOD_CK1_1	351	357	PF00069	0.494
MOD_CK1_1	365	371	PF00069	0.463
MOD_CK1_1	428	434	PF00069	0.731
MOD_CK2_1	107	113	PF00069	0.638
MOD_CK2_1	13	19	PF00069	0.786
MOD_CK2_1	264	270	PF00069	0.517
MOD_CK2_1	301	307	PF00069	0.514
MOD_GlcNHglycan	226	229	PF01048	0.715
MOD_GlcNHglycan	235	238	PF01048	0.714
MOD_GlcNHglycan	259	262	PF01048	0.653
MOD_GSK3_1	107	114	PF00069	0.707
MOD_GSK3_1	127	134	PF00069	0.788
MOD_GSK3_1	229	236	PF00069	0.664
MOD_GSK3_1	275	282	PF00069	0.641
MOD_GSK3_1	316	323	PF00069	0.652
MOD_GSK3_1	329	336	PF00069	0.538
MOD_GSK3_1	344	351	PF00069	0.568
MOD_GSK3_1	354	361	PF00069	0.513
MOD_GSK3_1	396	403	PF00069	0.524
MOD_GSK3_1	415	422	PF00069	0.481
MOD_GSK3_1	53	60	PF00069	0.588
MOD_GSK3_1	8	15	PF00069	0.672
MOD_LATS_1	255	261	PF00433	0.472
MOD_N-GLC_1	132	137	PF02516	0.637
MOD_NEK2_1	173	178	PF00069	0.766
MOD_NEK2_1	358	363	PF00069	0.582
MOD_NEK2_1	57	62	PF00069	0.487
MOD_PIKK_1	174	180	PF00454	0.715
MOD_PK_1	179	185	PF00069	0.537
MOD_PKA_1	179	185	PF00069	0.673
MOD_PKA_1	224	230	PF00069	0.673
MOD_PKA_1	257	263	PF00069	0.496
MOD_PKA_2	107	113	PF00069	0.691
MOD_PKA_2	131	137	PF00069	0.743
MOD_PKA_2	179	185	PF00069	0.722
MOD_PKA_2	199	205	PF00069	0.456
MOD_PKA_2	224	230	PF00069	0.680
MOD_PKA_2	233	239	PF00069	0.565
MOD_PKA_2	257	263	PF00069	0.660
MOD_PKA_2	293	299	PF00069	0.509
MOD_PKA_2	320	326	PF00069	0.687
MOD_PKA_2	351	357	PF00069	0.649
MOD_PKA_2	362	368	PF00069	0.645
MOD_PKA_2	401	407	PF00069	0.789
MOD_PKA_2	47	53	PF00069	0.433
MOD_PKB_1	163	171	PF00069	0.564
MOD_Plk_1	132	138	PF00069	0.631
MOD_Plk_1	269	275	PF00069	0.702
MOD_Plk_4	132	138	PF00069	0.752
MOD_Plk_4	239	245	PF00069	0.646
MOD_Plk_4	295	301	PF00069	0.584
MOD_Plk_4	425	431	PF00069	0.527
MOD_ProDKin_1	118	124	PF00069	0.465
MOD_ProDKin_1	136	142	PF00069	0.751
MOD_ProDKin_1	18	24	PF00069	0.765
MOD_ProDKin_1	202	208	PF00069	0.711
MOD_ProDKin_1	219	225	PF00069	0.756
MOD_ProDKin_1	229	235	PF00069	0.689
MOD_ProDKin_1	275	281	PF00069	0.655
MOD_ProDKin_1	313	319	PF00069	0.556
MOD_ProDKin_1	428	434	PF00069	0.696
MOD_ProDKin_1	98	104	PF00069	0.548
MOD_SUMO_rev_2	162	171	PF00179	0.699
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.634
TRG_ENDOCYTIC_2	51	54	PF00928	0.434
TRG_ENDOCYTIC_2	73	76	PF00928	0.442
TRG_ER_diArg_1	179	181	PF00400	0.737
TRG_ER_diArg_1	223	225	PF00400	0.625
TRG_ER_diArg_1	4	6	PF00400	0.766
TRG_ER_diArg_1	434	437	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F0	Leptomonas seymouri	47%	91%
A0A3R7KKI7	Trypanosoma rangeli	32%	97%
A0A3S7WS94	Leishmania donovani	62%	100%
C9ZI49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9AGJ7	Leishmania infantum	62%	100%
E9AP34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QGF4	Leishmania major	63%	100%