CHORD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CHORD, putative

Species:

Leishmania braziliensis

UniProt:

E9AIN0_LEIBR

TriTrypDb:

LbrM.20.5980 , LBRM2903_200075200

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIN0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0051298	centrosome duplication	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0008270	zinc ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.484
CLV_C14_Caspase3-7	33	37	PF00656	0.273
CLV_NRD_NRD_1	148	150	PF00675	0.230
CLV_NRD_NRD_1	95	97	PF00675	0.409
CLV_PCSK_FUR_1	51	55	PF00082	0.299
CLV_PCSK_KEX2_1	53	55	PF00082	0.500
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.500
CLV_PCSK_SKI1_1	149	153	PF00082	0.270
DEG_Nend_UBRbox_1	1	4	PF02207	0.375
DEG_SPOP_SBC_1	186	190	PF00917	0.361
DOC_CYCLIN_RxL_1	38	49	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.373
DOC_MAPK_FxFP_2	175	178	PF00069	0.593
DOC_MAPK_gen_1	179	187	PF00069	0.392
DOC_MAPK_gen_1	48	58	PF00069	0.490
DOC_MAPK_MEF2A_6	179	187	PF00069	0.645
DOC_PP1_RVXF_1	274	281	PF00149	0.534
DOC_PP1_RVXF_1	39	46	PF00149	0.434
DOC_PP2B_LxvP_1	183	186	PF13499	0.639
DOC_PP4_FxxP_1	175	178	PF00568	0.561
DOC_USP7_MATH_1	186	190	PF00917	0.529
DOC_USP7_MATH_1	193	197	PF00917	0.550
LIG_14-3-3_CanoR_1	167	175	PF00244	0.571
LIG_14-3-3_CanoR_1	206	214	PF00244	0.572
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.503
LIG_BRCT_BRCA1_1	239	243	PF00533	0.373
LIG_deltaCOP1_diTrp_1	153	157	PF00928	0.448
LIG_FHA_2	47	53	PF00498	0.264
LIG_LIR_Gen_1	153	161	PF02991	0.446
LIG_LIR_Gen_1	279	287	PF02991	0.448
LIG_LIR_Gen_1	83	91	PF02991	0.363
LIG_LIR_Nem_3	153	157	PF02991	0.446
LIG_LIR_Nem_3	279	283	PF02991	0.448
LIG_LIR_Nem_3	83	88	PF02991	0.366
LIG_PCNA_yPIPBox_3	73	82	PF02747	0.256
LIG_REV1ctd_RIR_1	43	52	PF16727	0.442
LIG_SH2_NCK_1	85	89	PF00017	0.326
LIG_SH2_STAT5	4	7	PF00017	0.323
LIG_SH2_STAT5	89	92	PF00017	0.385
LIG_SH3_3	17	23	PF00018	0.433
LIG_SH3_3	281	287	PF00018	0.448
LIG_TRAF2_2	224	229	PF00917	0.567
LIG_WRC_WIRS_1	78	83	PF05994	0.257
MOD_CK1_1	80	86	PF00069	0.408
MOD_CK2_1	217	223	PF00069	0.510
MOD_CK2_1	46	52	PF00069	0.303
MOD_GSK3_1	193	200	PF00069	0.589
MOD_N-GLC_1	18	23	PF02516	0.450
MOD_NEK2_1	123	128	PF00069	0.552
MOD_NEK2_1	187	192	PF00069	0.607
MOD_NEK2_1	262	267	PF00069	0.448
MOD_NEK2_1	46	51	PF00069	0.353
MOD_PIKK_1	187	193	PF00454	0.581
MOD_PIKK_1	217	223	PF00454	0.462
MOD_PKA_2	106	112	PF00069	0.389
MOD_PKA_2	166	172	PF00069	0.599
MOD_PKA_2	205	211	PF00069	0.509
MOD_Plk_2-3	153	159	PF00069	0.553
MOD_Plk_4	61	67	PF00069	0.286
MOD_Plk_4	77	83	PF00069	0.311
MOD_SUMO_rev_2	223	232	PF00179	0.465
TRG_DiLeu_BaEn_2	278	284	PF01217	0.460
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.467
TRG_ENDOCYTIC_2	85	88	PF00928	0.351
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I9	Leptomonas seymouri	66%	100%
A0A0S4J9B3	Bodo saltans	49%	98%
A0A1X0NW45	Trypanosomatidae	49%	97%
A0A3Q8IAQ6	Leishmania donovani	76%	100%
A0A3R7MVQ5	Trypanosoma rangeli	52%	99%
A4HZ16	Leishmania infantum	76%	100%
A9YUB1	Sus scrofa	31%	89%
C9ZIN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
D4A4T9	Rattus norvegicus	31%	89%
E9AUW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
G5EEI8	Caenorhabditis elegans	30%	92%
Q29RL2	Bos taurus	31%	89%
Q462R2	Sus scrofa	31%	86%
Q4QCL9	Leishmania major	75%	100%
Q4R7U2	Macaca fascicularis	31%	89%
Q5RD91	Pongo abelii	31%	89%
Q5ZML4	Gallus gallus	31%	89%
Q6EPW7	Oryza sativa subsp. japonica	31%	100%
Q6NUA0	Xenopus laevis	32%	89%
Q7T3F7	Danio rerio	30%	87%
Q9D1P4	Mus musculus	31%	89%
Q9R000	Mus musculus	30%	85%
Q9SE33	Arabidopsis thaliana	33%	100%
Q9UHD1	Homo sapiens	32%	89%
Q9UKP3	Homo sapiens	31%	85%
Q9VCC0	Drosophila melanogaster	28%	84%
V5D8W5	Trypanosoma cruzi	52%	86%