WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIM8_LEIBR

TriTrypDb:

LbrM.20.5960 , LBRM2903_200075000

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.422
CLV_C14_Caspase3-7	670	674	PF00656	0.325
CLV_C14_Caspase3-7	716	720	PF00656	0.549
CLV_NRD_NRD_1	199	201	PF00675	0.327
CLV_NRD_NRD_1	598	600	PF00675	0.396
CLV_NRD_NRD_1	615	617	PF00675	0.564
CLV_NRD_NRD_1	8	10	PF00675	0.628
CLV_PCSK_KEX2_1	598	600	PF00082	0.396
CLV_PCSK_KEX2_1	615	617	PF00082	0.503
CLV_PCSK_KEX2_1	778	780	PF00082	0.281
CLV_PCSK_KEX2_1	8	10	PF00082	0.549
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.281
CLV_PCSK_SKI1_1	268	272	PF00082	0.473
CLV_PCSK_SKI1_1	367	371	PF00082	0.374
CLV_PCSK_SKI1_1	411	415	PF00082	0.444
CLV_PCSK_SKI1_1	610	614	PF00082	0.428
CLV_PCSK_SKI1_1	623	627	PF00082	0.608
CLV_PCSK_SKI1_1	712	716	PF00082	0.549
CLV_PCSK_SKI1_1	759	763	PF00082	0.446
CLV_PCSK_SKI1_1	88	92	PF00082	0.424
DEG_APCC_DBOX_1	622	630	PF00400	0.478
DEG_Nend_Nbox_1	1	3	PF02207	0.519
DOC_CKS1_1	798	803	PF01111	0.314
DOC_CYCLIN_RxL_1	262	275	PF00134	0.436
DOC_MAPK_gen_1	598	606	PF00069	0.356
DOC_MAPK_MEF2A_6	482	489	PF00069	0.386
DOC_MAPK_MEF2A_6	537	546	PF00069	0.324
DOC_MAPK_MEF2A_6	599	608	PF00069	0.341
DOC_MAPK_MEF2A_6	804	811	PF00069	0.401
DOC_MAPK_MEF2A_6	957	964	PF00069	0.398
DOC_MAPK_MEF2A_6	970	978	PF00069	0.575
DOC_PP1_RVXF_1	20	27	PF00149	0.366
DOC_PP2B_LxvP_1	1001	1004	PF13499	0.380
DOC_PP2B_LxvP_1	369	372	PF13499	0.487
DOC_PP2B_PxIxI_1	804	810	PF00149	0.435
DOC_PP4_FxxP_1	993	996	PF00568	0.450
DOC_USP7_MATH_1	272	276	PF00917	0.517
DOC_USP7_MATH_1	326	330	PF00917	0.293
DOC_USP7_MATH_1	400	404	PF00917	0.440
DOC_USP7_MATH_1	446	450	PF00917	0.511
DOC_USP7_MATH_1	651	655	PF00917	0.550
DOC_USP7_MATH_1	70	74	PF00917	0.284
DOC_USP7_MATH_1	853	857	PF00917	0.376
DOC_USP7_MATH_1	867	871	PF00917	0.319
DOC_USP7_MATH_1	938	942	PF00917	0.544
DOC_WW_Pin1_4	238	243	PF00397	0.474
DOC_WW_Pin1_4	405	410	PF00397	0.413
DOC_WW_Pin1_4	504	509	PF00397	0.375
DOC_WW_Pin1_4	615	620	PF00397	0.546
DOC_WW_Pin1_4	797	802	PF00397	0.544
DOC_WW_Pin1_4	934	939	PF00397	0.434
DOC_WW_Pin1_4	984	989	PF00397	0.376
DOC_WW_Pin1_4	992	997	PF00397	0.361
LIG_14-3-3_CanoR_1	200	204	PF00244	0.352
LIG_14-3-3_CanoR_1	244	248	PF00244	0.569
LIG_14-3-3_CanoR_1	411	418	PF00244	0.424
LIG_14-3-3_CanoR_1	445	454	PF00244	0.538
LIG_14-3-3_CanoR_1	588	594	PF00244	0.386
LIG_14-3-3_CanoR_1	610	615	PF00244	0.550
LIG_14-3-3_CanoR_1	860	864	PF00244	0.431
LIG_14-3-3_CanoR_1	88	93	PF00244	0.524
LIG_APCC_ABBA_1	345	350	PF00400	0.314
LIG_APCC_ABBA_1	425	430	PF00400	0.389
LIG_BRCT_BRCA1_1	165	169	PF00533	0.336
LIG_BRCT_BRCA1_1	608	612	PF00533	0.347
LIG_Clathr_ClatBox_1	311	315	PF01394	0.423
LIG_DLG_GKlike_1	970	977	PF00625	0.394
LIG_eIF4E_1	288	294	PF01652	0.436
LIG_FHA_1	103	109	PF00498	0.466
LIG_FHA_1	19	25	PF00498	0.384
LIG_FHA_1	244	250	PF00498	0.524
LIG_FHA_1	272	278	PF00498	0.494
LIG_FHA_1	307	313	PF00498	0.459
LIG_FHA_1	320	326	PF00498	0.303
LIG_FHA_1	378	384	PF00498	0.458
LIG_FHA_1	40	46	PF00498	0.475
LIG_FHA_1	412	418	PF00498	0.412
LIG_FHA_1	430	436	PF00498	0.299
LIG_FHA_1	438	444	PF00498	0.373
LIG_FHA_1	57	63	PF00498	0.365
LIG_FHA_1	588	594	PF00498	0.535
LIG_FHA_1	713	719	PF00498	0.429
LIG_FHA_1	917	923	PF00498	0.369
LIG_FHA_2	146	152	PF00498	0.399
LIG_FHA_2	238	244	PF00498	0.478
LIG_FHA_2	714	720	PF00498	0.334
LIG_FHA_2	826	832	PF00498	0.407
LIG_FHA_2	916	922	PF00498	0.434
LIG_HCF-1_HBM_1	316	319	PF13415	0.463
LIG_IRF3_LxIS_1	954	961	PF10401	0.290
LIG_LIR_Apic_2	302	307	PF02991	0.461
LIG_LIR_Apic_2	992	996	PF02991	0.484
LIG_LIR_Gen_1	151	161	PF02991	0.415
LIG_LIR_Gen_1	243	253	PF02991	0.507
LIG_LIR_Gen_1	331	340	PF02991	0.268
LIG_LIR_Gen_1	379	389	PF02991	0.399
LIG_LIR_Gen_1	421	428	PF02991	0.444
LIG_LIR_Gen_1	551	560	PF02991	0.481
LIG_LIR_Gen_1	673	682	PF02991	0.419
LIG_LIR_Gen_1	689	699	PF02991	0.331
LIG_LIR_Gen_1	747	758	PF02991	0.433
LIG_LIR_Gen_1	821	830	PF02991	0.326
LIG_LIR_Gen_1	86	93	PF02991	0.482
LIG_LIR_LC3C_4	541	546	PF02991	0.478
LIG_LIR_Nem_3	148	153	PF02991	0.429
LIG_LIR_Nem_3	243	248	PF02991	0.540
LIG_LIR_Nem_3	255	261	PF02991	0.610
LIG_LIR_Nem_3	287	291	PF02991	0.419
LIG_LIR_Nem_3	331	337	PF02991	0.283
LIG_LIR_Nem_3	421	427	PF02991	0.447
LIG_LIR_Nem_3	551	555	PF02991	0.441
LIG_LIR_Nem_3	609	614	PF02991	0.545
LIG_LIR_Nem_3	673	678	PF02991	0.423
LIG_LIR_Nem_3	689	694	PF02991	0.419
LIG_LIR_Nem_3	747	753	PF02991	0.450
LIG_LIR_Nem_3	800	806	PF02991	0.342
LIG_LIR_Nem_3	821	826	PF02991	0.378
LIG_LIR_Nem_3	86	92	PF02991	0.485
LIG_LIR_Nem_3	955	959	PF02991	0.444
LIG_MLH1_MIPbox_1	608	612	PF16413	0.347
LIG_NRBOX	457	463	PF00104	0.505
LIG_NRBOX	561	567	PF00104	0.436
LIG_Pex14_1	26	30	PF04695	0.455
LIG_Pex14_2	169	173	PF04695	0.427
LIG_Pex14_2	607	611	PF04695	0.485
LIG_Pex14_2	810	814	PF04695	0.418
LIG_Pex14_2	981	985	PF04695	0.441
LIG_Pex14_2	993	997	PF04695	0.461
LIG_PTB_Apo_2	75	82	PF02174	0.288
LIG_PTB_Apo_2	814	821	PF02174	0.448
LIG_PTB_Phospho_1	814	820	PF10480	0.449
LIG_REV1ctd_RIR_1	605	614	PF16727	0.359
LIG_SH2_CRK	153	157	PF00017	0.303
LIG_SH2_CRK	245	249	PF00017	0.561
LIG_SH2_CRK	288	292	PF00017	0.437
LIG_SH2_CRK	304	308	PF00017	0.516
LIG_SH2_CRK	334	338	PF00017	0.385
LIG_SH2_CRK	424	428	PF00017	0.427
LIG_SH2_CRK	579	583	PF00017	0.323
LIG_SH2_CRK	691	695	PF00017	0.516
LIG_SH2_NCK_1	153	157	PF00017	0.303
LIG_SH2_NCK_1	304	308	PF00017	0.486
LIG_SH2_NCK_1	579	583	PF00017	0.410
LIG_SH2_PTP2	806	809	PF00017	0.441
LIG_SH2_SRC	127	130	PF00017	0.419
LIG_SH2_SRC	806	809	PF00017	0.412
LIG_SH2_STAP1	245	249	PF00017	0.561
LIG_SH2_STAP1	483	487	PF00017	0.516
LIG_SH2_STAP1	510	514	PF00017	0.417
LIG_SH2_STAP1	552	556	PF00017	0.316
LIG_SH2_STAP1	691	695	PF00017	0.608
LIG_SH2_STAP1	820	824	PF00017	0.260
LIG_SH2_STAT5	10	13	PF00017	0.399
LIG_SH2_STAT5	245	248	PF00017	0.619
LIG_SH2_STAT5	334	337	PF00017	0.310
LIG_SH2_STAT5	792	795	PF00017	0.418
LIG_SH2_STAT5	806	809	PF00017	0.319
LIG_SH2_STAT5	89	92	PF00017	0.272
LIG_SH2_STAT5	980	983	PF00017	0.403
LIG_SH3_3	1000	1006	PF00018	0.504
LIG_SH3_3	136	142	PF00018	0.424
LIG_SH3_3	212	218	PF00018	0.534
LIG_SH3_3	406	412	PF00018	0.387
LIG_SH3_3	660	666	PF00018	0.556
LIG_SH3_3	959	965	PF00018	0.348
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.565
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.493
LIG_SUMO_SIM_anti_2	540	547	PF11976	0.339
LIG_SUMO_SIM_anti_2	918	924	PF11976	0.263
LIG_SUMO_SIM_anti_2	971	978	PF11976	0.457
LIG_SUMO_SIM_par_1	104	111	PF11976	0.479
LIG_SUMO_SIM_par_1	154	160	PF11976	0.296
LIG_SUMO_SIM_par_1	245	251	PF11976	0.579
LIG_SUMO_SIM_par_1	273	280	PF11976	0.384
LIG_SUMO_SIM_par_1	309	316	PF11976	0.442
LIG_SUMO_SIM_par_1	918	924	PF11976	0.426
LIG_SUMO_SIM_par_1	958	963	PF11976	0.559
LIG_TRAF2_1	205	208	PF00917	0.304
LIG_TRAF2_1	313	316	PF00917	0.409
LIG_TRAF2_1	743	746	PF00917	0.383
LIG_TRFH_1	797	801	PF08558	0.307
LIG_TYR_ITIM	422	427	PF00017	0.441
LIG_TYR_ITIM	978	983	PF00017	0.413
LIG_UBA3_1	368	373	PF00899	0.489
LIG_UBA3_1	678	683	PF00899	0.273
LIG_UBA3_1	807	816	PF00899	0.332
LIG_Vh1_VBS_1	263	281	PF01044	0.389
LIG_WRC_WIRS_1	944	949	PF05994	0.570
LIG_WRPW_2	803	806	PF00400	0.297
MOD_CDC14_SPxK_1	241	244	PF00782	0.418
MOD_CDC14_SPxK_1	408	411	PF00782	0.493
MOD_CDK_SPxK_1	238	244	PF00069	0.419
MOD_CDK_SPxK_1	405	411	PF00069	0.479
MOD_CDK_SPxxK_3	797	804	PF00069	0.299
MOD_CK1_1	107	113	PF00069	0.550
MOD_CK1_1	154	160	PF00069	0.387
MOD_CK1_1	238	244	PF00069	0.714
MOD_CK1_1	384	390	PF00069	0.381
MOD_CK1_1	39	45	PF00069	0.496
MOD_CK1_1	429	435	PF00069	0.421
MOD_CK1_1	468	474	PF00069	0.623
MOD_CK1_1	491	497	PF00069	0.434
MOD_CK1_1	634	640	PF00069	0.570
MOD_CK1_1	647	653	PF00069	0.424
MOD_CK1_1	686	692	PF00069	0.351
MOD_CK1_1	737	743	PF00069	0.417
MOD_CK1_1	835	841	PF00069	0.469
MOD_CK1_1	865	871	PF00069	0.395
MOD_CK1_1	943	949	PF00069	0.517
MOD_CK2_1	145	151	PF00069	0.390
MOD_CK2_1	237	243	PF00069	0.533
MOD_CK2_1	292	298	PF00069	0.448
MOD_CK2_1	503	509	PF00069	0.530
MOD_CK2_1	703	709	PF00069	0.472
MOD_CK2_1	921	927	PF00069	0.410
MOD_GlcNHglycan	330	333	PF01048	0.610
MOD_GlcNHglycan	4	7	PF01048	0.417
MOD_GlcNHglycan	467	470	PF01048	0.506
MOD_GlcNHglycan	493	496	PF01048	0.638
MOD_GlcNHglycan	511	514	PF01048	0.256
MOD_GlcNHglycan	573	576	PF01048	0.402
MOD_GlcNHglycan	633	636	PF01048	0.435
MOD_GlcNHglycan	649	652	PF01048	0.323
MOD_GlcNHglycan	68	71	PF01048	0.314
MOD_GlcNHglycan	727	730	PF01048	0.393
MOD_GlcNHglycan	834	837	PF01048	0.494
MOD_GlcNHglycan	841	844	PF01048	0.572
MOD_GlcNHglycan	904	907	PF01048	0.436
MOD_GlcNHglycan	913	916	PF01048	0.335
MOD_GlcNHglycan	950	953	PF01048	0.540
MOD_GSK3_1	377	384	PF00069	0.414
MOD_GSK3_1	504	511	PF00069	0.486
MOD_GSK3_1	521	528	PF00069	0.441
MOD_GSK3_1	544	551	PF00069	0.538
MOD_GSK3_1	577	584	PF00069	0.405
MOD_GSK3_1	606	613	PF00069	0.524
MOD_GSK3_1	647	654	PF00069	0.374
MOD_GSK3_1	66	73	PF00069	0.435
MOD_GSK3_1	766	773	PF00069	0.389
MOD_GSK3_1	835	842	PF00069	0.436
MOD_GSK3_1	84	91	PF00069	0.474
MOD_GSK3_1	867	874	PF00069	0.435
MOD_GSK3_1	911	918	PF00069	0.389
MOD_GSK3_1	921	928	PF00069	0.324
MOD_GSK3_1	934	941	PF00069	0.394
MOD_GSK3_1	948	955	PF00069	0.541
MOD_N-GLC_1	374	379	PF02516	0.487
MOD_N-GLC_1	725	730	PF02516	0.339
MOD_N-GLC_1	915	920	PF02516	0.383
MOD_N-GLC_1	938	943	PF02516	0.542
MOD_NEK2_1	165	170	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.422
MOD_NEK2_1	248	253	PF00069	0.584
MOD_NEK2_1	270	275	PF00069	0.505
MOD_NEK2_1	381	386	PF00069	0.426
MOD_NEK2_1	428	433	PF00069	0.312
MOD_NEK2_1	447	452	PF00069	0.401
MOD_NEK2_1	503	508	PF00069	0.557
MOD_NEK2_1	521	526	PF00069	0.333
MOD_NEK2_1	544	549	PF00069	0.440
MOD_NEK2_1	589	594	PF00069	0.484
MOD_NEK2_1	606	611	PF00069	0.399
MOD_NEK2_1	614	619	PF00069	0.549
MOD_NEK2_1	628	633	PF00069	0.469
MOD_NEK2_1	644	649	PF00069	0.337
MOD_NEK2_1	703	708	PF00069	0.594
MOD_NEK2_1	734	739	PF00069	0.486
MOD_NEK2_1	744	749	PF00069	0.572
MOD_NEK2_1	859	864	PF00069	0.418
MOD_NEK2_1	871	876	PF00069	0.469
MOD_NEK2_1	948	953	PF00069	0.605
MOD_NEK2_2	174	179	PF00069	0.340
MOD_NEK2_2	299	304	PF00069	0.433
MOD_NEK2_2	787	792	PF00069	0.268
MOD_NEK2_2	952	957	PF00069	0.456
MOD_OFUCOSY	35	40	PF10250	0.309
MOD_OFUCOSY	520	525	PF10250	0.485
MOD_PIKK_1	447	453	PF00454	0.461
MOD_PIKK_1	683	689	PF00454	0.452
MOD_PIKK_1	70	76	PF00454	0.434
MOD_PIKK_1	841	847	PF00454	0.611
MOD_PIKK_1	853	859	PF00454	0.445
MOD_PK_1	893	899	PF00069	0.436
MOD_PKA_2	114	120	PF00069	0.521
MOD_PKA_2	199	205	PF00069	0.331
MOD_PKA_2	243	249	PF00069	0.625
MOD_PKA_2	447	453	PF00069	0.405
MOD_PKA_2	587	593	PF00069	0.605
MOD_PKA_2	614	620	PF00069	0.596
MOD_PKA_2	647	653	PF00069	0.354
MOD_PKA_2	859	865	PF00069	0.518
MOD_Plk_1	377	383	PF00069	0.498
MOD_Plk_1	689	695	PF00069	0.650
MOD_Plk_1	915	921	PF00069	0.467
MOD_Plk_1	970	976	PF00069	0.426
MOD_Plk_2-3	921	927	PF00069	0.410
MOD_Plk_4	104	110	PF00069	0.497
MOD_Plk_4	122	128	PF00069	0.431
MOD_Plk_4	151	157	PF00069	0.306
MOD_Plk_4	243	249	PF00069	0.526
MOD_Plk_4	272	278	PF00069	0.522
MOD_Plk_4	299	305	PF00069	0.366
MOD_Plk_4	306	312	PF00069	0.396
MOD_Plk_4	377	383	PF00069	0.443
MOD_Plk_4	41	47	PF00069	0.444
MOD_Plk_4	468	474	PF00069	0.471
MOD_Plk_4	488	494	PF00069	0.292
MOD_Plk_4	525	531	PF00069	0.425
MOD_Plk_4	63	69	PF00069	0.543
MOD_Plk_4	689	695	PF00069	0.457
MOD_Plk_4	727	733	PF00069	0.424
MOD_Plk_4	787	793	PF00069	0.485
MOD_Plk_4	846	852	PF00069	0.430
MOD_Plk_4	88	94	PF00069	0.431
MOD_Plk_4	893	899	PF00069	0.415
MOD_Plk_4	943	949	PF00069	0.581
MOD_Plk_4	972	978	PF00069	0.488
MOD_ProDKin_1	238	244	PF00069	0.474
MOD_ProDKin_1	405	411	PF00069	0.420
MOD_ProDKin_1	504	510	PF00069	0.361
MOD_ProDKin_1	615	621	PF00069	0.540
MOD_ProDKin_1	797	803	PF00069	0.537
MOD_ProDKin_1	934	940	PF00069	0.444
MOD_ProDKin_1	984	990	PF00069	0.371
MOD_ProDKin_1	992	998	PF00069	0.364
MOD_SUMO_rev_2	767	772	PF00179	0.479
MOD_SUMO_rev_2	927	934	PF00179	0.450
MOD_SUMO_rev_2	97	106	PF00179	0.350
TRG_DiLeu_BaEn_1	151	156	PF01217	0.605
TRG_DiLeu_BaEn_1	972	977	PF01217	0.463
TRG_DiLeu_BaEn_2	228	234	PF01217	0.538
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.428
TRG_ENDOCYTIC_2	153	156	PF00928	0.312
TRG_ENDOCYTIC_2	245	248	PF00928	0.562
TRG_ENDOCYTIC_2	288	291	PF00928	0.441
TRG_ENDOCYTIC_2	334	337	PF00928	0.431
TRG_ENDOCYTIC_2	424	427	PF00928	0.425
TRG_ENDOCYTIC_2	552	555	PF00928	0.321
TRG_ENDOCYTIC_2	579	582	PF00928	0.406
TRG_ENDOCYTIC_2	691	694	PF00928	0.446
TRG_ENDOCYTIC_2	806	809	PF00928	0.418
TRG_ENDOCYTIC_2	823	826	PF00928	0.234
TRG_ENDOCYTIC_2	89	92	PF00928	0.272
TRG_ENDOCYTIC_2	980	983	PF00928	0.403
TRG_ER_diArg_1	597	599	PF00400	0.413
TRG_ER_diArg_1	614	616	PF00400	0.515
TRG_ER_diArg_1	8	10	PF00400	0.483
TRG_NES_CRM1_1	583	596	PF08389	0.367
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY6	Leptomonas seymouri	52%	100%
A0A3R7M4E0	Trypanosoma rangeli	26%	88%
A0A3S7WWC6	Leishmania donovani	76%	100%
A4HZ14	Leishmania infantum	76%	100%
C9ZIL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	85%
E9AUW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QCM1	Leishmania major	76%	100%