Golgi apparatus membrane protein TVP23 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIM7_LEIBR

TriTrypDb:

LbrM.20.5950 , LBRM2903_200074900

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AIM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIM7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0070070	proton-transporting V-type ATPase complex assembly	7	7
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	7
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	8	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	93	97	PF00082	0.401
DEG_SCF_FBW7_1	35	41	PF00400	0.538
DOC_CKS1_1	35	40	PF01111	0.476
DOC_PP1_RVXF_1	91	97	PF00149	0.578
DOC_USP7_MATH_1	38	42	PF00917	0.537
DOC_WW_Pin1_4	34	39	PF00397	0.476
DOC_WW_Pin1_4	40	45	PF00397	0.487
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_FHA_1	86	92	PF00498	0.366
LIG_GBD_Chelix_1	28	36	PF00786	0.337
LIG_LIR_Gen_1	49	58	PF02991	0.337
LIG_LIR_Nem_3	49	53	PF02991	0.337
LIG_Pex14_1	75	79	PF04695	0.363
LIG_SH3_3	32	38	PF00018	0.454
LIG_SH3_3	63	69	PF00018	0.223
MOD_CK1_1	40	46	PF00069	0.466
MOD_CK2_1	16	22	PF00069	0.637
MOD_GlcNHglycan	97	100	PF01048	0.424
MOD_GSK3_1	34	41	PF00069	0.537
MOD_NEK2_1	84	89	PF00069	0.339
MOD_PIKK_1	101	107	PF00454	0.686
MOD_ProDKin_1	34	40	PF00069	0.476
TRG_DiLeu_BaEn_3	22	28	PF01217	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT94	Leptomonas seymouri	70%	100%
A0A0S4JU45	Bodo saltans	55%	69%
A0A1X0NXN8	Trypanosomatidae	57%	100%
A0A3Q8IA62	Leishmania donovani	82%	100%
A0A3R7KJJ5	Trypanosoma rangeli	55%	100%
A4HZ13	Leishmania infantum	82%	100%
C9ZIL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AUW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCM2	Leishmania major	79%	100%
V5B8F5	Trypanosoma cruzi	52%	100%