PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIM6_LEIBR

TriTrypDb:

LbrM.20.5940 , LBRM2903_200074800

Length:

1018

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIM6

Function

Biological processes
Term	Name	Level	Count
GO:0000966	RNA 5'-end processing	7	1
GO:0001682	tRNA 5'-leader removal	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0099116	tRNA 5'-end processing	8	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004526	ribonuclease P activity	6	1
GO:0004540	RNA nuclease activity	4	1
GO:0004549	tRNA-specific ribonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	700	704	PF00656	0.497
CLV_C14_Caspase3-7	868	872	PF00656	0.418
CLV_NRD_NRD_1	1013	1015	PF00675	0.609
CLV_NRD_NRD_1	44	46	PF00675	0.472
CLV_NRD_NRD_1	472	474	PF00675	0.448
CLV_NRD_NRD_1	567	569	PF00675	0.398
CLV_NRD_NRD_1	626	628	PF00675	0.437
CLV_NRD_NRD_1	629	631	PF00675	0.459
CLV_NRD_NRD_1	641	643	PF00675	0.487
CLV_NRD_NRD_1	834	836	PF00675	0.500
CLV_NRD_NRD_1	925	927	PF00675	0.518
CLV_NRD_NRD_1	975	977	PF00675	0.536
CLV_PCSK_FUR_1	627	631	PF00082	0.446
CLV_PCSK_KEX2_1	1013	1015	PF00082	0.634
CLV_PCSK_KEX2_1	44	46	PF00082	0.643
CLV_PCSK_KEX2_1	472	474	PF00082	0.448
CLV_PCSK_KEX2_1	567	569	PF00082	0.382
CLV_PCSK_KEX2_1	621	623	PF00082	0.437
CLV_PCSK_KEX2_1	625	627	PF00082	0.445
CLV_PCSK_KEX2_1	629	631	PF00082	0.459
CLV_PCSK_KEX2_1	641	643	PF00082	0.304
CLV_PCSK_KEX2_1	975	977	PF00082	0.590
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.437
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.445
CLV_PCSK_PC7_1	1009	1015	PF00082	0.652
CLV_PCSK_PC7_1	622	628	PF00082	0.432
CLV_PCSK_PC7_1	971	977	PF00082	0.639
CLV_PCSK_SKI1_1	1004	1008	PF00082	0.562
CLV_PCSK_SKI1_1	224	228	PF00082	0.362
CLV_PCSK_SKI1_1	268	272	PF00082	0.385
CLV_PCSK_SKI1_1	622	626	PF00082	0.433
CLV_PCSK_SKI1_1	687	691	PF00082	0.347
CLV_Separin_Metazoa	279	283	PF03568	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.662
DEG_ODPH_VHL_1	873	884	PF01847	0.525
DOC_CKS1_1	727	732	PF01111	0.623
DOC_MAPK_gen_1	157	164	PF00069	0.690
DOC_MAPK_gen_1	413	421	PF00069	0.363
DOC_MAPK_gen_1	472	479	PF00069	0.344
DOC_MAPK_gen_1	567	575	PF00069	0.374
DOC_MAPK_gen_1	641	648	PF00069	0.546
DOC_MAPK_gen_1	901	908	PF00069	0.556
DOC_MAPK_HePTP_8	469	481	PF00069	0.347
DOC_MAPK_MEF2A_6	415	423	PF00069	0.363
DOC_MAPK_MEF2A_6	472	481	PF00069	0.354
DOC_PP2B_LxvP_1	133	136	PF13499	0.698
DOC_PP2B_LxvP_1	672	675	PF13499	0.611
DOC_PP2B_LxvP_1	945	948	PF13499	0.492
DOC_PP4_FxxP_1	727	730	PF00568	0.588
DOC_USP7_MATH_1	7	11	PF00917	0.697
DOC_USP7_MATH_1	875	879	PF00917	0.447
DOC_USP7_MATH_1	883	887	PF00917	0.479
DOC_USP7_UBL2_3	243	247	PF12436	0.530
DOC_USP7_UBL2_3	621	625	PF12436	0.427
DOC_WW_Pin1_4	103	108	PF00397	0.467
DOC_WW_Pin1_4	11	16	PF00397	0.421
DOC_WW_Pin1_4	150	155	PF00397	0.781
DOC_WW_Pin1_4	268	273	PF00397	0.328
DOC_WW_Pin1_4	360	365	PF00397	0.404
DOC_WW_Pin1_4	650	655	PF00397	0.640
DOC_WW_Pin1_4	702	707	PF00397	0.488
DOC_WW_Pin1_4	726	731	PF00397	0.597
DOC_WW_Pin1_4	955	960	PF00397	0.584
DOC_WW_Pin1_4	977	982	PF00397	0.598
LIG_14-3-3_CanoR_1	102	107	PF00244	0.570
LIG_14-3-3_CanoR_1	116	122	PF00244	0.641
LIG_14-3-3_CanoR_1	396	404	PF00244	0.358
LIG_14-3-3_CanoR_1	418	424	PF00244	0.458
LIG_14-3-3_CanoR_1	567	571	PF00244	0.392
LIG_14-3-3_CanoR_1	604	608	PF00244	0.543
LIG_APCC_ABBAyCdc20_2	693	699	PF00400	0.486
LIG_BRCT_BRCA1_1	859	863	PF00533	0.594
LIG_deltaCOP1_diTrp_1	65	73	PF00928	0.456
LIG_deltaCOP1_diTrp_1	774	781	PF00928	0.533
LIG_FHA_1	118	124	PF00498	0.543
LIG_FHA_1	126	132	PF00498	0.504
LIG_FHA_1	156	162	PF00498	0.662
LIG_FHA_1	265	271	PF00498	0.333
LIG_FHA_1	310	316	PF00498	0.326
LIG_FHA_1	387	393	PF00498	0.413
LIG_FHA_1	490	496	PF00498	0.486
LIG_FHA_1	900	906	PF00498	0.674
LIG_FHA_2	151	157	PF00498	0.735
LIG_FHA_2	519	525	PF00498	0.414
LIG_FHA_2	708	714	PF00498	0.504
LIG_FHA_2	727	733	PF00498	0.456
LIG_FHA_2	82	88	PF00498	0.595
LIG_LIR_Apic_2	118	124	PF02991	0.516
LIG_LIR_Apic_2	51	55	PF02991	0.469
LIG_LIR_Apic_2	725	730	PF02991	0.582
LIG_LIR_Gen_1	137	147	PF02991	0.634
LIG_LIR_Gen_1	289	297	PF02991	0.475
LIG_LIR_Gen_1	389	397	PF02991	0.347
LIG_LIR_Gen_1	441	447	PF02991	0.478
LIG_LIR_Gen_1	535	542	PF02991	0.365
LIG_LIR_Gen_1	551	559	PF02991	0.361
LIG_LIR_Gen_1	569	578	PF02991	0.367
LIG_LIR_Gen_1	803	811	PF02991	0.540
LIG_LIR_Gen_1	889	898	PF02991	0.517
LIG_LIR_Gen_1	928	934	PF02991	0.459
LIG_LIR_LC3C_4	204	209	PF02991	0.529
LIG_LIR_LC3C_4	468	471	PF02991	0.395
LIG_LIR_Nem_3	137	143	PF02991	0.606
LIG_LIR_Nem_3	240	245	PF02991	0.403
LIG_LIR_Nem_3	289	293	PF02991	0.336
LIG_LIR_Nem_3	341	347	PF02991	0.403
LIG_LIR_Nem_3	389	394	PF02991	0.347
LIG_LIR_Nem_3	462	467	PF02991	0.367
LIG_LIR_Nem_3	533	537	PF02991	0.365
LIG_LIR_Nem_3	569	573	PF02991	0.382
LIG_LIR_Nem_3	833	837	PF02991	0.510
LIG_LIR_Nem_3	889	894	PF02991	0.493
LIG_LIR_Nem_3	928	933	PF02991	0.454
LIG_NRP_CendR_1	1016	1018	PF00754	0.763
LIG_PCNA_yPIPBox_3	21	29	PF02747	0.566
LIG_Pex14_1	518	522	PF04695	0.391
LIG_Pex14_1	936	940	PF04695	0.435
LIG_Rb_LxCxE_1	367	380	PF01857	0.424
LIG_SH2_CRK	121	125	PF00017	0.638
LIG_SH2_CRK	242	246	PF00017	0.403
LIG_SH2_CRK	290	294	PF00017	0.475
LIG_SH2_CRK	344	348	PF00017	0.390
LIG_SH2_CRK	353	357	PF00017	0.349
LIG_SH2_CRK	52	56	PF00017	0.469
LIG_SH2_CRK	791	795	PF00017	0.520
LIG_SH2_CRK	891	895	PF00017	0.508
LIG_SH2_GRB2like	303	306	PF00017	0.328
LIG_SH2_NCK_1	290	294	PF00017	0.410
LIG_SH2_NCK_1	303	307	PF00017	0.242
LIG_SH2_NCK_1	891	895	PF00017	0.509
LIG_SH2_PTP2	537	540	PF00017	0.353
LIG_SH2_SRC	303	306	PF00017	0.328
LIG_SH2_SRC	592	595	PF00017	0.409
LIG_SH2_SRC	842	845	PF00017	0.564
LIG_SH2_STAP1	16	20	PF00017	0.396
LIG_SH2_STAP1	290	294	PF00017	0.457
LIG_SH2_STAP1	353	357	PF00017	0.378
LIG_SH2_STAP1	453	457	PF00017	0.504
LIG_SH2_STAP1	467	471	PF00017	0.289
LIG_SH2_STAP1	534	538	PF00017	0.354
LIG_SH2_STAP1	570	574	PF00017	0.384
LIG_SH2_STAP1	69	73	PF00017	0.466
LIG_SH2_STAT3	69	72	PF00017	0.466
LIG_SH2_STAT5	121	124	PF00017	0.388
LIG_SH2_STAT5	177	180	PF00017	0.480
LIG_SH2_STAT5	410	413	PF00017	0.452
LIG_SH2_STAT5	537	540	PF00017	0.353
LIG_SH2_STAT5	592	595	PF00017	0.409
LIG_SH2_STAT5	638	641	PF00017	0.464
LIG_SH2_STAT5	932	935	PF00017	0.431
LIG_SH3_3	646	652	PF00018	0.677
LIG_SH3_3	665	671	PF00018	0.591
LIG_SH3_3	945	951	PF00018	0.503
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.498
LIG_SUMO_SIM_par_1	207	212	PF11976	0.391
LIG_SUMO_SIM_par_1	492	498	PF11976	0.504
LIG_TRAF2_1	580	583	PF00917	0.404
LIG_TRAF2_1	634	637	PF00917	0.452
LIG_TRAF2_1	74	77	PF00917	0.477
LIG_TRAF2_1	997	1000	PF00917	0.672
LIG_TRAF2_2	136	141	PF00917	0.725
LIG_TRFH_1	648	652	PF08558	0.684
LIG_TYR_ITSM	887	894	PF00017	0.627
LIG_UBA3_1	261	266	PF00899	0.344
LIG_WRC_WIRS_1	281	286	PF05994	0.385
MOD_CDK_SPK_2	268	273	PF00069	0.328
MOD_CDK_SPK_2	702	707	PF00069	0.488
MOD_CDK_SPxxK_3	150	157	PF00069	0.514
MOD_CK1_1	106	112	PF00069	0.506
MOD_CK1_1	182	188	PF00069	0.431
MOD_CK1_1	321	327	PF00069	0.526
MOD_CK1_1	566	572	PF00069	0.387
MOD_CK1_1	823	829	PF00069	0.553
MOD_CK1_1	886	892	PF00069	0.589
MOD_CK1_1	965	971	PF00069	0.621
MOD_CK2_1	123	129	PF00069	0.592
MOD_CK2_1	150	156	PF00069	0.741
MOD_CK2_1	31	37	PF00069	0.465
MOD_CK2_1	326	332	PF00069	0.438
MOD_CK2_1	518	524	PF00069	0.410
MOD_CK2_1	576	582	PF00069	0.383
MOD_CK2_1	689	695	PF00069	0.448
MOD_CK2_1	707	713	PF00069	0.485
MOD_CK2_1	81	87	PF00069	0.564
MOD_CK2_1	875	881	PF00069	0.444
MOD_CK2_1	994	1000	PF00069	0.617
MOD_CMANNOS	683	686	PF00535	0.446
MOD_GlcNHglycan	113	116	PF01048	0.533
MOD_GlcNHglycan	125	128	PF01048	0.549
MOD_GlcNHglycan	149	153	PF01048	0.742
MOD_GlcNHglycan	195	198	PF01048	0.482
MOD_GlcNHglycan	211	214	PF01048	0.312
MOD_GlcNHglycan	289	293	PF01048	0.475
MOD_GlcNHglycan	33	36	PF01048	0.480
MOD_GlcNHglycan	504	507	PF01048	0.341
MOD_GlcNHglycan	579	582	PF01048	0.382
MOD_GlcNHglycan	724	727	PF01048	0.514
MOD_GlcNHglycan	821	825	PF01048	0.545
MOD_GlcNHglycan	859	862	PF01048	0.481
MOD_GSK3_1	107	114	PF00069	0.508
MOD_GSK3_1	115	122	PF00069	0.471
MOD_GSK3_1	185	192	PF00069	0.502
MOD_GSK3_1	264	271	PF00069	0.358
MOD_GSK3_1	326	333	PF00069	0.421
MOD_GSK3_1	356	363	PF00069	0.501
MOD_GSK3_1	489	496	PF00069	0.445
MOD_GSK3_1	7	14	PF00069	0.596
MOD_GSK3_1	722	729	PF00069	0.459
MOD_GSK3_1	918	925	PF00069	0.746
MOD_GSK3_1	962	969	PF00069	0.546
MOD_GSK3_1	98	105	PF00069	0.477
MOD_GSK3_1	995	1002	PF00069	0.652
MOD_N-GLC_1	1009	1014	PF02516	0.489
MOD_N-GLC_1	185	190	PF02516	0.441
MOD_N-GLC_1	255	260	PF02516	0.442
MOD_N-GLC_1	386	391	PF02516	0.413
MOD_N-GLC_1	502	507	PF02516	0.489
MOD_N-GLC_2	461	463	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	246	251	PF00069	0.505
MOD_NEK2_1	280	285	PF00069	0.385
MOD_NEK2_1	330	335	PF00069	0.434
MOD_NEK2_1	356	361	PF00069	0.398
MOD_NEK2_1	424	429	PF00069	0.451
MOD_NEK2_1	576	581	PF00069	0.362
MOD_NEK2_1	689	694	PF00069	0.340
MOD_NEK2_1	966	971	PF00069	0.560
MOD_PIKK_1	134	140	PF00454	0.679
MOD_PIKK_1	248	254	PF00454	0.581
MOD_PIKK_1	358	364	PF00454	0.409
MOD_PIKK_1	395	401	PF00454	0.358
MOD_PIKK_1	918	924	PF00454	0.778
MOD_PIKK_1	980	986	PF00454	0.671
MOD_PK_1	189	195	PF00069	0.549
MOD_PKA_1	44	50	PF00069	0.505
MOD_PKA_1	687	693	PF00069	0.454
MOD_PKA_2	115	121	PF00069	0.637
MOD_PKA_2	2	8	PF00069	0.694
MOD_PKA_2	395	401	PF00069	0.358
MOD_PKA_2	44	50	PF00069	0.634
MOD_PKA_2	566	572	PF00069	0.394
MOD_PKA_2	603	609	PF00069	0.425
MOD_PKA_2	869	875	PF00069	0.439
MOD_PKA_2	925	931	PF00069	0.481
MOD_PKA_2	995	1001	PF00069	0.586
MOD_Plk_1	189	195	PF00069	0.525
MOD_Plk_1	255	261	PF00069	0.436
MOD_Plk_1	288	294	PF00069	0.475
MOD_Plk_1	309	315	PF00069	0.328
MOD_Plk_1	386	392	PF00069	0.407
MOD_Plk_1	502	508	PF00069	0.484
MOD_Plk_1	60	66	PF00069	0.433
MOD_Plk_1	676	682	PF00069	0.578
MOD_Plk_1	886	892	PF00069	0.477
MOD_Plk_2-3	165	171	PF00069	0.383
MOD_Plk_2-3	530	536	PF00069	0.380
MOD_Plk_4	189	195	PF00069	0.543
MOD_Plk_4	387	393	PF00069	0.328
MOD_Plk_4	419	425	PF00069	0.476
MOD_Plk_4	490	496	PF00069	0.303
MOD_Plk_4	603	609	PF00069	0.425
MOD_Plk_4	752	758	PF00069	0.472
MOD_Plk_4	886	892	PF00069	0.488
MOD_ProDKin_1	103	109	PF00069	0.469
MOD_ProDKin_1	11	17	PF00069	0.416
MOD_ProDKin_1	150	156	PF00069	0.782
MOD_ProDKin_1	268	274	PF00069	0.328
MOD_ProDKin_1	360	366	PF00069	0.411
MOD_ProDKin_1	650	656	PF00069	0.640
MOD_ProDKin_1	702	708	PF00069	0.489
MOD_ProDKin_1	726	732	PF00069	0.596
MOD_ProDKin_1	955	961	PF00069	0.572
MOD_ProDKin_1	977	983	PF00069	0.599
MOD_SUMO_for_1	706	709	PF00179	0.516
MOD_SUMO_rev_2	149	158	PF00179	0.671
MOD_SUMO_rev_2	258	267	PF00179	0.363
MOD_SUMO_rev_2	709	716	PF00179	0.557
TRG_DiLeu_BaEn_1	129	134	PF01217	0.550
TRG_DiLeu_BaEn_2	570	576	PF01217	0.454
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.476
TRG_ENDOCYTIC_2	140	143	PF00928	0.565
TRG_ENDOCYTIC_2	242	245	PF00928	0.404
TRG_ENDOCYTIC_2	290	293	PF00928	0.328
TRG_ENDOCYTIC_2	303	306	PF00928	0.328
TRG_ENDOCYTIC_2	344	347	PF00928	0.403
TRG_ENDOCYTIC_2	353	356	PF00928	0.350
TRG_ENDOCYTIC_2	442	445	PF00928	0.450
TRG_ENDOCYTIC_2	467	470	PF00928	0.369
TRG_ENDOCYTIC_2	537	540	PF00928	0.353
TRG_ENDOCYTIC_2	570	573	PF00928	0.370
TRG_ENDOCYTIC_2	791	794	PF00928	0.515
TRG_ENDOCYTIC_2	891	894	PF00928	0.590
TRG_ENDOCYTIC_2	930	933	PF00928	0.475
TRG_ER_diArg_1	1013	1016	PF00400	0.622
TRG_ER_diArg_1	368	371	PF00400	0.421
TRG_ER_diArg_1	43	45	PF00400	0.633
TRG_ER_diArg_1	471	473	PF00400	0.405
TRG_ER_diArg_1	626	629	PF00400	0.442
TRG_ER_diArg_1	974	976	PF00400	0.580
TRG_NLS_Bipartite_1	609	629	PF00514	0.427
TRG_NLS_MonoExtC_3	624	629	PF00514	0.433
TRG_NLS_MonoExtC_3	925	931	PF00514	0.563
TRG_NLS_MonoExtN_4	622	629	PF00514	0.435
TRG_NLS_MonoExtN_4	924	930	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS7	Leptomonas seymouri	81%	100%
A0A0S4JPI2	Bodo saltans	49%	94%
A0A1X0NWA5	Trypanosomatidae	66%	100%
A0A3Q8IBP6	Leishmania donovani	91%	100%
A0A422NTN1	Trypanosoma rangeli	65%	100%
A4HZ12	Leishmania infantum	91%	100%
C9ZIL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9AUV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCM3	Leishmania major	90%	100%
V5B8D4	Trypanosoma cruzi	66%	98%