RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIM2_LEIBR

TriTrypDb:

LbrM.20.5900 , LBRM2903_200074200

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.462
CLV_NRD_NRD_1	246	248	PF00675	0.510
CLV_NRD_NRD_1	25	27	PF00675	0.408
CLV_PCSK_FUR_1	244	248	PF00082	0.465
CLV_PCSK_KEX2_1	123	125	PF00082	0.537
CLV_PCSK_KEX2_1	172	174	PF00082	0.514
CLV_PCSK_KEX2_1	246	248	PF00082	0.472
CLV_PCSK_KEX2_1	25	27	PF00082	0.443
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.602
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.476
CLV_PCSK_PC7_1	168	174	PF00082	0.516
CLV_PCSK_SKI1_1	269	273	PF00082	0.421
CLV_PCSK_SKI1_1	7	11	PF00082	0.690
CLV_Separin_Metazoa	152	156	PF03568	0.323
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_SCF_FBW7_2	87	94	PF00400	0.405
DOC_CKS1_1	3	8	PF01111	0.449
DOC_CYCLIN_RxL_1	4	13	PF00134	0.580
DOC_MAPK_gen_1	172	181	PF00069	0.528
DOC_MAPK_gen_1	293	300	PF00069	0.536
DOC_MAPK_MEF2A_6	155	163	PF00069	0.437
DOC_MAPK_RevD_3	159	173	PF00069	0.628
DOC_MAPK_RevD_3	281	296	PF00069	0.475
DOC_PP4_FxxP_1	51	54	PF00568	0.302
DOC_USP7_UBL2_3	80	84	PF12436	0.467
DOC_WW_Pin1_4	100	105	PF00397	0.641
DOC_WW_Pin1_4	171	176	PF00397	0.533
DOC_WW_Pin1_4	2	7	PF00397	0.582
DOC_WW_Pin1_4	50	55	PF00397	0.534
DOC_WW_Pin1_4	87	92	PF00397	0.595
LIG_14-3-3_CanoR_1	173	179	PF00244	0.465
LIG_14-3-3_CanoR_1	99	104	PF00244	0.697
LIG_Actin_WH2_2	140	157	PF00022	0.320
LIG_Clathr_ClatBox_1	72	76	PF01394	0.443
LIG_FHA_1	107	113	PF00498	0.510
LIG_FHA_2	11	17	PF00498	0.505
LIG_FHA_2	263	269	PF00498	0.426
LIG_FHA_2	59	65	PF00498	0.499
LIG_FXI_DFP_1	273	277	PF00024	0.378
LIG_LIR_Apic_2	48	54	PF02991	0.400
LIG_LIR_Gen_1	232	240	PF02991	0.328
LIG_LIR_Nem_3	131	135	PF02991	0.510
LIG_LIR_Nem_3	232	236	PF02991	0.317
LIG_LIR_Nem_3	261	266	PF02991	0.456
LIG_LIR_Nem_3	46	52	PF02991	0.541
LIG_NRBOX	40	46	PF00104	0.525
LIG_SH2_STAP1	110	114	PF00017	0.412
LIG_SH2_STAP1	266	270	PF00017	0.321
LIG_SH2_STAT5	233	236	PF00017	0.455
LIG_SH2_STAT5	282	285	PF00017	0.329
LIG_SH3_3	208	214	PF00018	0.455
LIG_SH3_3	280	286	PF00018	0.349
LIG_SUMO_SIM_anti_2	204	212	PF11976	0.487
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.326
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.489
LIG_SUMO_SIM_par_1	71	78	PF11976	0.453
LIG_UBA3_1	288	296	PF00899	0.420
MOD_CDK_SPK_2	100	105	PF00069	0.514
MOD_CDK_SPK_2	171	176	PF00069	0.533
MOD_CDK_SPK_2	2	7	PF00069	0.454
MOD_CK1_1	206	212	PF00069	0.401
MOD_CK1_1	34	40	PF00069	0.532
MOD_CK2_1	10	16	PF00069	0.452
MOD_CK2_1	50	56	PF00069	0.501
MOD_CK2_1	58	64	PF00069	0.431
MOD_GlcNHglycan	219	222	PF01048	0.552
MOD_GlcNHglycan	33	36	PF01048	0.438
MOD_GSK3_1	100	107	PF00069	0.721
MOD_GSK3_1	202	209	PF00069	0.441
MOD_GSK3_1	213	220	PF00069	0.426
MOD_GSK3_1	258	265	PF00069	0.399
MOD_GSK3_1	71	78	PF00069	0.334
MOD_NEK2_1	10	15	PF00069	0.594
MOD_NEK2_1	36	41	PF00069	0.451
MOD_NEK2_2	58	63	PF00069	0.377
MOD_PIKK_1	258	264	PF00454	0.483
MOD_PIKK_1	36	42	PF00454	0.433
MOD_PK_1	203	209	PF00069	0.567
MOD_PKA_2	98	104	PF00069	0.628
MOD_Plk_1	203	209	PF00069	0.425
MOD_Plk_4	110	116	PF00069	0.560
MOD_Plk_4	128	134	PF00069	0.637
MOD_Plk_4	203	209	PF00069	0.445
MOD_Plk_4	229	235	PF00069	0.456
MOD_Plk_4	284	290	PF00069	0.414
MOD_ProDKin_1	100	106	PF00069	0.631
MOD_ProDKin_1	171	177	PF00069	0.520
MOD_ProDKin_1	2	8	PF00069	0.580
MOD_ProDKin_1	50	56	PF00069	0.535
MOD_ProDKin_1	87	93	PF00069	0.611
TRG_ENDOCYTIC_2	132	135	PF00928	0.462
TRG_ENDOCYTIC_2	233	236	PF00928	0.322
TRG_ER_diArg_1	124	127	PF00400	0.485
TRG_ER_diArg_1	24	26	PF00400	0.408
TRG_ER_diArg_1	243	246	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB90	Leptomonas seymouri	61%	100%
A0A1X0NW23	Trypanosomatidae	40%	100%
A0A3Q8IBV6	Leishmania donovani	83%	100%
A0A422NTN5	Trypanosoma rangeli	40%	88%
A4HZ03	Leishmania infantum	83%	100%
C9ZIL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
E9AUV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCM8	Leishmania major	83%	100%
V5BHE7	Trypanosoma cruzi	38%	80%