Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIM0_LEIBR

TriTrypDb:

LbrM.20.5880 , LBRM2903_200074000

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.611
CLV_PCSK_KEX2_1	174	176	PF00082	0.438
CLV_PCSK_KEX2_1	307	309	PF00082	0.589
CLV_PCSK_KEX2_1	5	7	PF00082	0.611
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.473
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.589
CLV_Separin_Metazoa	119	123	PF03568	0.574
DEG_Nend_UBRbox_3	1	3	PF02207	0.449
DEG_SPOP_SBC_1	211	215	PF00917	0.691
DOC_MAPK_gen_1	159	168	PF00069	0.464
DOC_MAPK_MEF2A_6	269	278	PF00069	0.382
DOC_USP7_MATH_1	293	297	PF00917	0.538
DOC_USP7_MATH_1	75	79	PF00917	0.526
DOC_USP7_UBL2_3	157	161	PF12436	0.457
DOC_WW_Pin1_4	128	133	PF00397	0.516
DOC_WW_Pin1_4	212	217	PF00397	0.637
DOC_WW_Pin1_4	245	250	PF00397	0.388
DOC_WW_Pin1_4	73	78	PF00397	0.609
LIG_14-3-3_CanoR_1	175	181	PF00244	0.419
LIG_14-3-3_CanoR_1	5	12	PF00244	0.593
LIG_14-3-3_CanoR_1	80	88	PF00244	0.595
LIG_Actin_WH2_2	58	75	PF00022	0.574
LIG_BIR_III_2	74	78	PF00653	0.434
LIG_FHA_1	116	122	PF00498	0.510
LIG_FHA_1	18	24	PF00498	0.561
LIG_FHA_2	27	33	PF00498	0.464
LIG_FHA_2	89	95	PF00498	0.509
LIG_Integrin_isoDGR_2	267	269	PF01839	0.515
LIG_LIR_Apic_2	188	194	PF02991	0.320
LIG_LIR_Nem_3	104	109	PF02991	0.424
LIG_Pex14_2	172	176	PF04695	0.372
LIG_RPA_C_Fungi	296	308	PF08784	0.583
LIG_SH2_CRK	109	113	PF00017	0.424
LIG_SH2_GRB2like	283	286	PF00017	0.484
LIG_SH2_NCK_1	109	113	PF00017	0.424
LIG_SH2_PTP2	272	275	PF00017	0.353
LIG_SH2_SRC	272	275	PF00017	0.484
LIG_SH2_SRC	283	286	PF00017	0.540
LIG_SH2_STAP1	283	287	PF00017	0.536
LIG_SH2_STAT3	105	108	PF00017	0.495
LIG_SH2_STAT5	106	109	PF00017	0.417
LIG_SH2_STAT5	272	275	PF00017	0.353
LIG_SH3_3	190	196	PF00018	0.594
LIG_SH3_3	248	254	PF00018	0.555
LIG_SH3_3	273	279	PF00018	0.400
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.389
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.486
LIG_SUMO_SIM_par_1	274	282	PF11976	0.402
LIG_TRAF2_1	279	282	PF00917	0.487
LIG_UBA3_1	168	174	PF00899	0.376
LIG_WW_2	193	196	PF00397	0.462
MOD_CDK_SPxxK_3	73	80	PF00069	0.647
MOD_CK1_1	139	145	PF00069	0.672
MOD_CK1_1	214	220	PF00069	0.734
MOD_CK1_1	66	72	PF00069	0.535
MOD_CK1_1	78	84	PF00069	0.524
MOD_CK2_1	26	32	PF00069	0.468
MOD_CK2_1	293	299	PF00069	0.484
MOD_GlcNHglycan	137	141	PF01048	0.580
MOD_GlcNHglycan	208	211	PF01048	0.790
MOD_GlcNHglycan	239	242	PF01048	0.470
MOD_GlcNHglycan	68	71	PF01048	0.566
MOD_GlcNHglycan	7	10	PF01048	0.609
MOD_GlcNHglycan	80	83	PF01048	0.555
MOD_GSK3_1	111	118	PF00069	0.511
MOD_GSK3_1	128	135	PF00069	0.573
MOD_GSK3_1	17	24	PF00069	0.591
MOD_GSK3_1	176	183	PF00069	0.391
MOD_GSK3_1	200	207	PF00069	0.775
MOD_GSK3_1	210	217	PF00069	0.673
MOD_GSK3_1	293	300	PF00069	0.565
MOD_GSK3_1	80	87	PF00069	0.593
MOD_N-GLC_1	176	181	PF02516	0.406
MOD_N-GLC_1	211	216	PF02516	0.754
MOD_N-GLC_1	84	89	PF02516	0.592
MOD_NEK2_1	176	181	PF00069	0.388
MOD_NEK2_1	255	260	PF00069	0.389
MOD_NEK2_1	263	268	PF00069	0.373
MOD_PIKK_1	21	27	PF00454	0.514
MOD_PIKK_1	216	222	PF00454	0.506
MOD_PIKK_1	51	57	PF00454	0.627
MOD_PK_1	122	128	PF00069	0.563
MOD_PKA_1	5	11	PF00069	0.497
MOD_PKA_2	115	121	PF00069	0.335
MOD_PKA_2	26	32	PF00069	0.588
MOD_PKA_2	44	50	PF00069	0.504
MOD_PKA_2	5	11	PF00069	0.703
MOD_Plk_1	122	128	PF00069	0.432
MOD_Plk_1	176	182	PF00069	0.392
MOD_Plk_1	243	249	PF00069	0.391
MOD_Plk_1	84	90	PF00069	0.628
MOD_Plk_4	293	299	PF00069	0.560
MOD_Plk_4	56	62	PF00069	0.550
MOD_ProDKin_1	128	134	PF00069	0.525
MOD_ProDKin_1	212	218	PF00069	0.636
MOD_ProDKin_1	245	251	PF00069	0.399
MOD_ProDKin_1	73	79	PF00069	0.610
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.484
TRG_ENDOCYTIC_2	272	275	PF00928	0.353
TRG_ER_diArg_1	4	6	PF00400	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J0	Leptomonas seymouri	67%	100%
A0A1X0NWJ0	Trypanosomatidae	50%	100%
A0A3Q8IKS5	Leishmania donovani	84%	100%
A0A422NTQ6	Trypanosoma rangeli	48%	100%
A4HZ01	Leishmania infantum	83%	100%
C9ZIM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AUV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QCN0	Leishmania major	84%	100%
V5B8D6	Trypanosoma cruzi	49%	100%