tRNA (Uracil-5-)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA (Uracil-5-)-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

E9AIL9_LEIBR

TriTrypDb:

LbrM.20.5870 , LBRM2903_200073900

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.318
CLV_NRD_NRD_1	274	276	PF00675	0.296
CLV_NRD_NRD_1	308	310	PF00675	0.452
CLV_NRD_NRD_1	425	427	PF00675	0.424
CLV_NRD_NRD_1	441	443	PF00675	0.373
CLV_NRD_NRD_1	504	506	PF00675	0.284
CLV_NRD_NRD_1	561	563	PF00675	0.469
CLV_PCSK_FUR_1	151	155	PF00082	0.397
CLV_PCSK_KEX2_1	123	125	PF00082	0.591
CLV_PCSK_KEX2_1	153	155	PF00082	0.445
CLV_PCSK_KEX2_1	307	309	PF00082	0.531
CLV_PCSK_KEX2_1	425	427	PF00082	0.288
CLV_PCSK_KEX2_1	441	443	PF00082	0.190
CLV_PCSK_KEX2_1	504	506	PF00082	0.284
CLV_PCSK_KEX2_1	561	563	PF00082	0.469
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.577
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.445
CLV_PCSK_SKI1_1	161	165	PF00082	0.394
CLV_PCSK_SKI1_1	354	358	PF00082	0.346
CLV_PCSK_SKI1_1	63	67	PF00082	0.382
DEG_APCC_DBOX_1	153	161	PF00400	0.414
DEG_APCC_DBOX_1	306	314	PF00400	0.491
DEG_SCF_FBW7_1	357	364	PF00400	0.331
DEG_SCF_FBW7_2	382	388	PF00400	0.334
DEG_SPOP_SBC_1	295	299	PF00917	0.410
DOC_CKS1_1	358	363	PF01111	0.335
DOC_CKS1_1	382	387	PF01111	0.334
DOC_CKS1_1	81	86	PF01111	0.432
DOC_MAPK_gen_1	151	159	PF00069	0.307
DOC_MAPK_gen_1	307	313	PF00069	0.236
DOC_MAPK_gen_1	422	432	PF00069	0.255
DOC_MAPK_MEF2A_6	191	198	PF00069	0.323
DOC_MAPK_MEF2A_6	284	293	PF00069	0.346
DOC_MAPK_MEF2A_6	425	432	PF00069	0.255
DOC_MAPK_MEF2A_6	475	482	PF00069	0.387
DOC_MAPK_MEF2A_6	70	79	PF00069	0.297
DOC_PP1_RVXF_1	352	359	PF00149	0.278
DOC_PP2B_LxvP_1	482	485	PF13499	0.255
DOC_PP4_FxxP_1	182	185	PF00568	0.277
DOC_PP4_FxxP_1	350	353	PF00568	0.363
DOC_PP4_FxxP_1	358	361	PF00568	0.282
DOC_PP4_FxxP_1	81	84	PF00568	0.401
DOC_USP7_MATH_1	107	111	PF00917	0.344
DOC_USP7_MATH_1	333	337	PF00917	0.424
DOC_USP7_MATH_1	584	588	PF00917	0.586
DOC_USP7_MATH_1	88	92	PF00917	0.433
DOC_USP7_UBL2_3	119	123	PF12436	0.610
DOC_USP7_UBL2_3	43	47	PF12436	0.458
DOC_USP7_UBL2_3	525	529	PF12436	0.255
DOC_WW_Pin1_4	1	6	PF00397	0.512
DOC_WW_Pin1_4	181	186	PF00397	0.343
DOC_WW_Pin1_4	357	362	PF00397	0.331
DOC_WW_Pin1_4	372	377	PF00397	0.253
DOC_WW_Pin1_4	381	386	PF00397	0.255
DOC_WW_Pin1_4	80	85	PF00397	0.437
LIG_14-3-3_CanoR_1	154	160	PF00244	0.310
LIG_14-3-3_CanoR_1	87	97	PF00244	0.513
LIG_Actin_WH2_2	174	189	PF00022	0.241
LIG_AP2alpha_1	174	178	PF02296	0.390
LIG_BRCT_BRCA1_1	196	200	PF00533	0.387
LIG_BRCT_BRCA1_1	346	350	PF00533	0.410
LIG_Clathr_ClatBox_1	26	30	PF01394	0.373
LIG_EH_1	533	537	PF12763	0.174
LIG_FHA_1	181	187	PF00498	0.439
LIG_FHA_1	204	210	PF00498	0.426
LIG_FHA_1	218	224	PF00498	0.311
LIG_FHA_1	297	303	PF00498	0.402
LIG_FHA_1	329	335	PF00498	0.329
LIG_FHA_1	358	364	PF00498	0.323
LIG_FHA_1	402	408	PF00498	0.337
LIG_FHA_1	411	417	PF00498	0.293
LIG_FHA_1	548	554	PF00498	0.255
LIG_FHA_2	296	302	PF00498	0.472
LIG_FHA_2	313	319	PF00498	0.279
LIG_FHA_2	360	366	PF00498	0.307
LIG_FHA_2	403	409	PF00498	0.255
LIG_FHA_2	580	586	PF00498	0.558
LIG_FHA_2	81	87	PF00498	0.417
LIG_IBAR_NPY_1	74	76	PF08397	0.282
LIG_Integrin_RGD_1	475	477	PF01839	0.331
LIG_LIR_Apic_2	347	353	PF02991	0.402
LIG_LIR_Apic_2	355	361	PF02991	0.466
LIG_LIR_Gen_1	263	273	PF02991	0.447
LIG_LIR_Gen_1	301	311	PF02991	0.438
LIG_LIR_Gen_1	33	41	PF02991	0.433
LIG_LIR_Nem_3	176	181	PF02991	0.332
LIG_LIR_Nem_3	263	268	PF02991	0.423
LIG_LIR_Nem_3	271	277	PF02991	0.432
LIG_LIR_Nem_3	301	306	PF02991	0.436
LIG_LIR_Nem_3	33	38	PF02991	0.433
LIG_LIR_Nem_3	377	382	PF02991	0.255
LIG_MYND_1	575	579	PF01753	0.471
LIG_NRBOX	61	67	PF00104	0.430
LIG_PCNA_yPIPBox_3	486	497	PF02747	0.331
LIG_PCNA_yPIPBox_3	54	66	PF02747	0.589
LIG_Pex14_2	174	178	PF04695	0.487
LIG_PTB_Apo_2	448	455	PF02174	0.255
LIG_SH2_CRK	35	39	PF00017	0.446
LIG_SH2_NCK_1	35	39	PF00017	0.446
LIG_SH2_STAT5	366	369	PF00017	0.426
LIG_SH2_STAT5	508	511	PF00017	0.255
LIG_SH2_STAT5	76	79	PF00017	0.408
LIG_SH3_3	2	8	PF00018	0.764
LIG_SH3_3	379	385	PF00018	0.359
LIG_SH3_3	575	581	PF00018	0.473
LIG_SH3_3	69	75	PF00018	0.324
LIG_SH3_4	525	532	PF00018	0.274
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.297
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.255
LIG_SUMO_SIM_par_1	309	318	PF11976	0.294
LIG_SUMO_SIM_par_1	404	411	PF11976	0.341
LIG_SUMO_SIM_par_1	477	483	PF11976	0.257
LIG_SUMO_SIM_par_1	554	560	PF11976	0.334
LIG_TRAF2_1	144	147	PF00917	0.295
LIG_TRFH_1	372	376	PF08558	0.255
LIG_UBA3_1	26	34	PF00899	0.373
LIG_UBA3_1	61	70	PF00899	0.420
LIG_WW_3	483	487	PF00397	0.255
MOD_CDC14_SPxK_1	184	187	PF00782	0.253
MOD_CDK_SPxK_1	181	187	PF00069	0.243
MOD_CDK_SPxxK_3	80	87	PF00069	0.449
MOD_CK1_1	108	114	PF00069	0.527
MOD_CK1_1	401	407	PF00069	0.387
MOD_CK1_1	465	471	PF00069	0.345
MOD_CK1_1	583	589	PF00069	0.551
MOD_CK1_1	9	15	PF00069	0.621
MOD_CK2_1	141	147	PF00069	0.462
MOD_CK2_1	212	218	PF00069	0.536
MOD_CK2_1	295	301	PF00069	0.325
MOD_CK2_1	312	318	PF00069	0.341
MOD_CK2_1	359	365	PF00069	0.311
MOD_CK2_1	579	585	PF00069	0.485
MOD_GlcNHglycan	206	209	PF01048	0.340
MOD_GlcNHglycan	270	273	PF01048	0.397
MOD_GlcNHglycan	410	413	PF01048	0.391
MOD_GlcNHglycan	434	437	PF01048	0.255
MOD_GlcNHglycan	467	470	PF01048	0.384
MOD_GlcNHglycan	582	585	PF01048	0.710
MOD_GlcNHglycan	586	589	PF01048	0.712
MOD_GSK3_1	340	347	PF00069	0.383
MOD_GSK3_1	357	364	PF00069	0.233
MOD_GSK3_1	398	405	PF00069	0.325
MOD_GSK3_1	408	415	PF00069	0.278
MOD_GSK3_1	521	528	PF00069	0.275
MOD_GSK3_1	579	586	PF00069	0.544
MOD_GSK3_1	89	96	PF00069	0.385
MOD_LATS_1	32	38	PF00433	0.310
MOD_N-GLC_1	194	199	PF02516	0.381
MOD_N-GLC_1	489	494	PF02516	0.331
MOD_N-GLC_2	249	251	PF02516	0.218
MOD_N-GLC_2	600	602	PF02516	0.454
MOD_NEK2_1	105	110	PF00069	0.429
MOD_NEK2_1	114	119	PF00069	0.481
MOD_NEK2_1	418	423	PF00069	0.376
MOD_NEK2_1	432	437	PF00069	0.178
MOD_NEK2_1	536	541	PF00069	0.327
MOD_NEK2_1	570	575	PF00069	0.688
MOD_NEK2_1	93	98	PF00069	0.338
MOD_NEK2_2	499	504	PF00069	0.299
MOD_PKA_2	521	527	PF00069	0.213
MOD_Plk_1	105	111	PF00069	0.420
MOD_Plk_1	194	200	PF00069	0.459
MOD_Plk_1	489	495	PF00069	0.331
MOD_Plk_2-3	141	147	PF00069	0.336
MOD_Plk_4	155	161	PF00069	0.244
MOD_Plk_4	212	218	PF00069	0.493
MOD_Plk_4	386	392	PF00069	0.376
MOD_Plk_4	402	408	PF00069	0.242
MOD_Plk_4	462	468	PF00069	0.343
MOD_Plk_4	489	495	PF00069	0.264
MOD_Plk_4	89	95	PF00069	0.309
MOD_ProDKin_1	1	7	PF00069	0.510
MOD_ProDKin_1	181	187	PF00069	0.346
MOD_ProDKin_1	357	363	PF00069	0.324
MOD_ProDKin_1	372	378	PF00069	0.253
MOD_ProDKin_1	381	387	PF00069	0.255
MOD_ProDKin_1	80	86	PF00069	0.433
MOD_SUMO_for_1	283	286	PF00179	0.459
MOD_SUMO_rev_2	510	516	PF00179	0.245
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.548
TRG_ENDOCYTIC_2	140	143	PF00928	0.505
TRG_ENDOCYTIC_2	171	174	PF00928	0.402
TRG_ENDOCYTIC_2	35	38	PF00928	0.442
TRG_ENDOCYTIC_2	76	79	PF00928	0.506
TRG_ER_diArg_1	100	103	PF00400	0.487
TRG_ER_diArg_1	306	309	PF00400	0.476
TRG_ER_diArg_1	424	426	PF00400	0.174
TRG_ER_diArg_1	503	505	PF00400	0.284
TRG_ER_diArg_1	561	563	PF00400	0.471
TRG_NLS_MonoExtN_4	151	156	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V8	Leptomonas seymouri	75%	100%
A0A1X0NXG3	Trypanosomatidae	59%	100%
A0A3Q8IAY6	Leishmania donovani	85%	100%
A0A3R7L6W3	Trypanosoma rangeli	63%	100%
A4HZ00	Leishmania infantum	85%	100%
A4QP75	Danio rerio	30%	100%
A5IBU7	Legionella pneumophila (strain Corby)	25%	100%
C9ZIM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AUV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O31545	Bacillus subtilis (strain 168)	26%	100%
P0DG16	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	24%	100%
P0DG17	Streptococcus pyogenes serotype M3 (strain SSI-1)	24%	100%
Q4QCN1	Leishmania major	85%	100%
Q5HEM5	Staphylococcus aureus (strain COL)	26%	100%
Q5HN37	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	23%	100%
Q5X5A8	Legionella pneumophila (strain Paris)	25%	100%
Q5XAU1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	25%	100%
Q6G836	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GFG0	Staphylococcus aureus (strain MRSA252)	26%	100%
Q73EJ5	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q7A4Q9	Staphylococcus aureus (strain N315)	26%	100%
Q814A6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	27%	100%
Q81ZD6	Bacillus anthracis	27%	100%
Q830R6	Enterococcus faecalis (strain ATCC 700802 / V583)	26%	100%
Q88SY9	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	29%	100%
Q891A0	Clostridium tetani (strain Massachusetts / E88)	26%	100%
Q892Z2	Clostridium tetani (strain Massachusetts / E88)	27%	100%
Q8BNV1	Mus musculus	34%	99%
Q8CRU6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	23%	100%
Q8IZ69	Homo sapiens	34%	97%
Q8KGF9	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	28%	100%
Q8NVT4	Staphylococcus aureus (strain MW2)	26%	100%
Q8P017	Streptococcus pyogenes serotype M18 (strain MGAS8232)	25%	100%
Q8R933	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	32%	100%
Q8YR05	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	28%	100%
Q92AQ7	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	28%	100%
Q97J51	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	29%	100%
Q99SY9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q99YP3	Streptococcus pyogenes serotype M1	24%	100%
Q9CDP0	Lactococcus lactis subsp. lactis (strain IL1403)	27%	100%
Q9CGB9	Lactococcus lactis subsp. lactis (strain IL1403)	27%	100%
V5ASX3	Trypanosoma cruzi	62%	100%