Putative ribosome biogenesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIL5_LEIBR

TriTrypDb:

LbrM.20.5830 , LBRM2903_200073500

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.161
CLV_NRD_NRD_1	274	276	PF00675	0.442
CLV_NRD_NRD_1	280	282	PF00675	0.473
CLV_PCSK_KEX2_1	101	103	PF00082	0.161
CLV_PCSK_KEX2_1	274	276	PF00082	0.442
CLV_PCSK_KEX2_1	280	282	PF00082	0.473
CLV_PCSK_KEX2_1	7	9	PF00082	0.553
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.553
CLV_PCSK_SKI1_1	10	14	PF00082	0.480
CLV_PCSK_SKI1_1	170	174	PF00082	0.219
CLV_PCSK_SKI1_1	186	190	PF00082	0.219
CLV_PCSK_SKI1_1	60	64	PF00082	0.467
CLV_PCSK_SKI1_1	74	78	PF00082	0.229
CLV_PCSK_SKI1_1	81	85	PF00082	0.195
DEG_APCC_DBOX_1	242	250	PF00400	0.495
DEG_APCC_DBOX_1	80	88	PF00400	0.419
DOC_CKS1_1	196	201	PF01111	0.419
DOC_CYCLIN_RxL_1	167	176	PF00134	0.419
DOC_CYCLIN_RxL_1	61	75	PF00134	0.396
DOC_MAPK_DCC_7	243	251	PF00069	0.513
DOC_MAPK_gen_1	167	175	PF00069	0.419
DOC_MAPK_gen_1	186	196	PF00069	0.419
DOC_MAPK_gen_1	79	87	PF00069	0.453
DOC_MAPK_MEF2A_6	167	175	PF00069	0.419
DOC_MAPK_MEF2A_6	79	87	PF00069	0.450
DOC_PP4_FxxP_1	124	127	PF00568	0.513
DOC_PP4_FxxP_1	196	199	PF00568	0.419
DOC_USP7_MATH_1	19	23	PF00917	0.676
DOC_USP7_MATH_1	26	30	PF00917	0.456
DOC_USP7_MATH_1	303	307	PF00917	0.524
DOC_WW_Pin1_4	195	200	PF00397	0.419
DOC_WW_Pin1_4	230	235	PF00397	0.517
LIG_14-3-3_CanoR_1	101	107	PF00244	0.513
LIG_14-3-3_CanoR_1	186	192	PF00244	0.419
LIG_14-3-3_CanoR_1	211	216	PF00244	0.513
LIG_14-3-3_CanoR_1	243	247	PF00244	0.419
LIG_14-3-3_CanoR_1	55	62	PF00244	0.466
LIG_14-3-3_CanoR_1	74	83	PF00244	0.542
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.419
LIG_BRCT_BRCA1_1	120	124	PF00533	0.433
LIG_BRCT_BRCA1_1	204	208	PF00533	0.419
LIG_CaM_IQ_9	53	69	PF13499	0.361
LIG_Clathr_ClatBox_1	172	176	PF01394	0.419
LIG_CtBP_PxDLS_1	309	313	PF00389	0.456
LIG_DLG_GKlike_1	211	218	PF00625	0.513
LIG_FHA_1	101	107	PF00498	0.452
LIG_FHA_2	103	109	PF00498	0.513
LIG_FHA_2	153	159	PF00498	0.437
LIG_FHA_2	75	81	PF00498	0.473
LIG_LIR_Apic_2	121	127	PF02991	0.513
LIG_LIR_Gen_1	131	141	PF02991	0.427
LIG_LIR_Gen_1	214	222	PF02991	0.475
LIG_LIR_Nem_3	131	137	PF02991	0.427
LIG_LIR_Nem_3	214	218	PF02991	0.490
LIG_Pex14_1	223	227	PF04695	0.419
LIG_Pex14_2	175	179	PF04695	0.443
LIG_SH2_CRK	168	172	PF00017	0.450
LIG_SH2_CRK	227	231	PF00017	0.473
LIG_SH2_SRC	227	230	PF00017	0.432
LIG_SH2_STAT5	134	137	PF00017	0.475
LIG_SH3_3	138	144	PF00018	0.419
LIG_SH3_3	228	234	PF00018	0.517
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.568
LIG_TRFH_1	179	183	PF08558	0.513
LIG_TRFH_1	244	248	PF08558	0.411
LIG_WRC_WIRS_1	212	217	PF05994	0.475
MOD_CDK_SPK_2	195	200	PF00069	0.419
MOD_CK1_1	142	148	PF00069	0.513
MOD_CK1_1	233	239	PF00069	0.513
MOD_CK1_1	75	81	PF00069	0.510
MOD_CK2_1	152	158	PF00069	0.432
MOD_CK2_1	233	239	PF00069	0.452
MOD_GlcNHglycan	10	13	PF01048	0.660
MOD_GlcNHglycan	141	144	PF01048	0.313
MOD_GlcNHglycan	21	24	PF01048	0.617
MOD_GlcNHglycan	28	32	PF01048	0.584
MOD_GlcNHglycan	305	308	PF01048	0.567
MOD_GSK3_1	229	236	PF00069	0.467
MOD_GSK3_1	56	63	PF00069	0.520
MOD_N-GLC_2	253	255	PF02516	0.309
MOD_NEK2_1	166	171	PF00069	0.431
MOD_PKA_1	6	12	PF00069	0.684
MOD_PKA_1	60	66	PF00069	0.446
MOD_PKA_2	100	106	PF00069	0.504
MOD_PKA_2	242	248	PF00069	0.419
MOD_Plk_1	130	136	PF00069	0.477
MOD_Plk_4	118	124	PF00069	0.449
MOD_Plk_4	130	136	PF00069	0.455
MOD_Plk_4	187	193	PF00069	0.432
MOD_Plk_4	211	217	PF00069	0.490
MOD_Plk_4	233	239	PF00069	0.463
MOD_ProDKin_1	195	201	PF00069	0.419
MOD_ProDKin_1	230	236	PF00069	0.517
MOD_SUMO_rev_2	272	279	PF00179	0.470
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.419
TRG_ENDOCYTIC_2	134	137	PF00928	0.419
TRG_ENDOCYTIC_2	227	230	PF00928	0.452
TRG_ER_diArg_1	100	102	PF00400	0.361
TRG_ER_diArg_1	279	281	PF00400	0.471
TRG_NLS_MonoExtC_3	5	10	PF00514	0.683
TRG_NLS_MonoExtN_4	6	11	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.232

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X5	Leptomonas seymouri	81%	97%
A0A0S4IP78	Bodo saltans	60%	100%
A0A1X0P6M8	Trypanosomatidae	69%	100%
A0A3S7WW54	Leishmania donovani	90%	100%
A4HYZ6	Leishmania infantum	90%	100%
D0A0C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AUU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O13823	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P34524	Caenorhabditis elegans	40%	90%
Q08235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q3SZZ0	Bos taurus	36%	90%
Q4QCN5	Leishmania major	91%	100%
Q4QQT6	Rattus norvegicus	36%	90%
Q54JN0	Dictyostelium discoideum	39%	97%
Q5RAN2	Pongo abelii	40%	90%
Q6BYD9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	100%
Q755T8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q8TDN6	Homo sapiens	40%	90%
Q8UVY2	Xenopus laevis	40%	93%
Q9C928	Arabidopsis thaliana	31%	99%
Q9DCA5	Mus musculus	36%	90%
Q9HGL6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q9LE16	Arabidopsis thaliana	36%	100%
Q9VZE6	Drosophila melanogaster	39%	88%
V5C1R2	Trypanosoma cruzi	69%	100%